Hypoallergenic effect of A2A2 milk proteins
DOI:
https://doi.org/10.33448/rsd-v13i5.45732Keywords:
A2A2 milk; Allergenic proteins; Beta-casein A1; Beta-casein A2; Lactose intolerance; Milk allergy.Abstract
The offer of hypoallergenic and nutritious foods is important for the physical and psychological well-being of consumers allergic to milk. Approximately 8% to 20% of infants and adults experience some condition due to milk consumption, such as lactose intolerance or allergies. The presence of proteins in milk with allergenic potential can cause digestive problems to skin rashes. Milk protein allergics express various reactions when exposed to this food. These manifestations depend on the degree of allergy and the type of protein involved, and are characterized by respiratory to gastrointestinal symptoms. Commonly, the development of this allergy in children occurs within the first year of age, or until the age of five in other cases. In light of this information, there has been the development of A2 milk, also known as A2A2, which comes from cows with the genotype that favors the synthesis of beta-casein A2 in milk. This selected milk reduces the development of discomfort in the bodies of individuals sensitive to beta-casein A1. In this context, milk containing only beta-casein A2 becomes an alternative for better digestion and quality in dairy consumption for those who are not allergic and who feel some discomfort when consuming milk. Therefore, the literature review aims to address the consumption of A2A2 milk, emphasizing the difference between beta-caseins A1 and A2, describing the characteristics of the allergic condition caused by them, and differentiating it from other conditions resulting from dairy consumption, such as lactose intolerance.
References
Anvisa (2021). Resolução-RE nº 4.769, de 22 de dezembro de 2021. Diário Oficial da União, 241(1), 547.
Barbosa, M. G., Souza, A. B., Tavares, G. M., & Antunes, A. E. C. (2019). Leites A1 e A2: revisão sobre seus potenciais efeitos no trato digestório. Segurança alimentar e nutricional, 26, e019004-e019004. http://dx.doi.org/10.20396/san.v26i0.8652981
Brooke-Taylor, S., Dwyer, K., Woodford, K., & Kost, N. (2017). Systematic review of the gastrointestinal effects of A1 compared with A2 β-casein. Advances in Nutrition. 8(5), 739-748. https://doi.org/10.3945/an.116.013953
Carvalho, L. C., Silva, S. C. M., Moraes, J. B., Pissolato, G. G., Fernandes, R. B., Faria, J. P., Júnior, J. A. F., Rodrigues, L. A., Gonçalves, R. M., & Grehs, M. L. (2022). A intolerância à lactose e a alergia à proteína do leite de vaca (APLV): as principais considerações clínicas. Research, Society and Development, 11(7), e4411729651-e4411729651.http://dx.doi.org/10.33448/rsd-v11i7.29651
Corozolla, W., & Rodrigues, A. G. (2016). Intolerância à lactose e alergia à proteína do leite de vaca e o desafio de como diferenciá-las. Saúde em Foco, 8, 219-228.
Cutrim, S. C. P. F. (2020). Alergia a Proteína do Leite de Vaca (APLV): avaliação do perfil imunológico em pacientes alérgicos submetidos ou não a terapia de indução de tolerância oral (Doctoral dissertation, Universidade de São Paulo). https://doi.org/10.11606/T.5.2020.tde-23062021-112125
Dantas, A., Kumar, H., Prudencio, E. S., Avila, L. B., Palma, P. O., Dosoki, N. S., Nepovimova, E., Kuca, K., Martins, N. C., Verma, R., Manickam, S., Valko, M. & Kumar, D. (2023). An approach on detection, quantification, technological properties, and trends market of A2 cow milk. Food Research International. 167 (2023), 112690. https://doi.org/10.1016/j.foodres.2023.112690
Diogo, B. S., Reis, E. M. B., Santos, B. R. C., Montagner, A. E. A. D., & Pinedo, L. A. (2023). Ocorrência de animais produtores de leite A2A2: estudo de caso em uma propriedade do município de Rio Branco – Acre. Brazilian Journal of Animal and Environmental Research, 6(3), 2808-2818. https://doi.org/10.34188/bjaerv6n3-065
Gomes, B. A. A., Farias, J. S., & Lage, M. C. G. R. (2021). Leite A2: a descoberta genética em prol de pessoas com alergia à proteína do leite de vaca. [A2 milk: the genetic discovery in favor of people with cow's milk protein allergy. Revista Sinapse Múltipla, 10(1), 114-116.
Guisso, I. V., Silva B. B., Braga, J., Jungbeck, M., & Montagner, P. (2020). Leite A2A2: uma nova alternativa para pessoas alérgicas à proteína do leite de vaca. XXV Seminário Interinstitucional de Ensino, Pesquisa e Extensão.
Ho, S., Woodford, K., Kukuljan, S., & Pal, S. (2014). Comparative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomised cross-over pilot study. European journal of clinical nutrition, 68(9), 994-1000. https://doi.org/10.1038/ejcn.2014.127
Jung, T. H., Hwang, H. J., Yun, S. S., Lee, W. J., Kim, J. W., Ahn, J. Y., Han, K. S. Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fraction of Goat Milk. Korean journal for food science of animal resources, 37(6), 940, 2017. https://doi.org/10.5851/kosfa.2017.37.6.940
Kaskous, S. (2020). A1-and A2-milk and their effect on human health. Journal of Food Engineering and Technology, 9(1), 15-21. https://doi.org/10.32732/jfet.2020.9.1.15
Lopes, A. L. C., Amancio, O. M. S., & Oliveira, F. L. C. (2020). Consumo do leite de vaca de 0 a 36 meses de idade. Sociedade Brasileira de Alimentação e Nutrição–SBAN.
Mendes, M. O., Morais, M. F., & Rodrigues, J. F. (2019). A2A2 milk: Brazilian consumers’ opinions and effect on sensory characteristics of Petit Suisse and Minas cheeses. LWT, 108, 207-213. https://doi.org/10.1016/j.lwt.2019.03.064
Oliveira, R. O. R. G., Souza, A. B. B., Folhas, R. D., da Silva, M. C., Sobreira, I. R. M., Pereira, M. S., Ferraz, J. B. S., Carvalho. M. E., Nepomuceno, L. L., Santos. H. D., Garcia J. A. S., & Ferreira, J. L. (2022). Profile of milk consumers and determinants of A2A2 milk consumption in the Tocantins State. Brazilian Journal of Veterinary Research and Animal Science, 59, e193432-e193432. https://doi.org/10.11606/issn.1678-4456.bjvras.2022.193432.
Pacchiarotti, V. L., Mendes, J. P. G., & Ferreira, L. M. (2020). Produção do leite A2 e melhoramento genético do rebanho. Revista Interdisciplinar de Saúde e Educação, 1(2), 208-226. https://doi.org/10.56344/2675-4827.v1n2a202012
Park, Y. W., & Haenlein, G. F. (2021). A2 bovine milk and caprine milk as a means of remedy for milk protein allergy. Dairy, 2(2), 191-201. https://doi.org/10.3390/dairy2020017.
Scott, B. A., Haile-Mariam, M., MacLeod, I. M., Xiang, R., & Pryce, J. E. (2023). Evaluating the potential impact of selection for the A2 milk allele on inbreeding and performance in Australian Holstein cattle. Frontiers in Animal Science, 4, 1142673. https://doi.org/10.3389/fanim.2023.1142673
Sheng, X., Li, Z., Ni, J., & Yelland, G. (2019). Effects of conventional milk versus milk containing only A2 β-casein on digestion in Chinese children: a randomized study. Journal of pediatric gastroenterology and nutrition, 69(3), 375-382. https://doi.org/10.1097/MPG.0000000000002437
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339. https://doi.org/10.1016/j.jbusres.2019.07.039
Sommer, S. F., & Richter, M. F. (2022). Milk quality and characterization of different geographic regions of Brazil: a literature review. Pesquisa Agropecuária Gaúcha, 28(1), 193-205. https://doi.org/10.36812/pag.2022281193-205
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Vittória Násser Pegoraro Ferreira; Wanymara Gullo Pichara; Gustavo Lucas Costa Valente
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.