Benefits and indications of hormone therapy for women in menopause: An integrative literature review
DOI:
https://doi.org/10.33448/rsd-v13i5.45789Keywords:
Hormone replacement therapy; Post-menopause; Estrogen progestin replacement therapy; Women's health.Abstract
Hormone replacement therapy (HRT) acts by replacing ovarian hormones, estrogen and progesterone, significantly alleviating the symptoms that arise during this phase of the female reproductive life and which interfere with the quality of life of many women. Therefore, it is the recommended treatment for most complaints related to this period, varying in terms of its composition, use, and indication. However, they can present significant health risks, contributing to the need for targeted clinical evaluation. The present study aimed to conduct an integrative review to evaluate the indications and benefits of hormone replacement therapy in menopause. Articles published in national and international journals, related to scientific research, were used, including studies published between 2019 and 2024, through the databases National Library of Medicine (PUBMED), Virtual Health Library (BVS), Latin American and Caribbean Literature in Health Sciences (LILACS), COCHRANE, and Scientific Electronic Library Online (SCIELO). After applying the inclusion and exclusion criteria, 13 studies were selected to compose the present review, which aims to explore various available studies regarding the proposed theme. Therefore, understanding the benefits and indications of hormone replacement therapy in menopause is important to provide, safely, better quality of life for women.
References
Acuña, M., Zamorano, C., Sanhueza, M., Torres, R., Toro, L., Valencia, M., & Valenzuela, A. (2019). Terapia Estrogénica y Prevención Cardiovascular Primaria. Revista chilena de obstetricia y ginecología, 84(6), 514-524.
Baccaro, L. F. C., Paiva, L. H. S. D. C., Nasser, E. J., Valadares, A. L. R., Silva, C. R. D., Nahas, E. A. P., & Pompei, L. D. M. (2022). Propedêutica mínima no climatério. Femina, 236-271.
Benetti-Pinto, C. L. (2022). Terapia de testosterona para mulheres: ainda há muitas perguntas a serem respondidas. Femina, 6-7.
Cano, A., Sánchez, E. G. A., Scott, M., & Núñez, A. O. (2023). Evaluación del impacto, los patrones de tratamiento y las percepciones de pacientes y clínicos de los síntomas vasomotores moderado-graves asociados a la menopausia en España. Clínica e Investigación en Ginecología y Obstetricia, 50(4), 100882.
Chlebowski, R. T., & Aragaki, A. K. (2023). The Women's Health Initiative randomized trials of menopausal hormone therapy and breast cancer: findings in context. Menopause, 30(4), 454-461.
Ferreira-Campos, L., Gabrielli, L., Almeida, M. D. C. C., Aquino, E. M. L., Matos, S. M. A., Griep, R. H., & Aras, R. (2022). Terapia Hormonal e Hipertensão em Mulheres na Pós-Menopausa: Resultados do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Arquivos Brasileiros de Cardiologia, 118, 905-913.
Genazzani, A. R., Divakar, H., Khadilkar, S. S., Monteleone, P., Evangelisti, B., Galal, A. F., ... & Benedetto, C. (2024). Counseling in menopausal women: How to address the benefits and risks of menopause hormone therapy. A FIGO position paper. South African General Practitioner, 5(1), 14-28.
Gu, Y., Han, F., Xue, M., Wang, M., & Huang, Y. (2024). The benefits and risks of menopause hormone therapy for the cardiovascular system in postmenopausal women: a systematic review and meta-analysis. BMC Women's Health, 24(1), 60.
Harlow, S. D., Gass, M., Hall, J. E., Lobo, R., Maki, P., Rebar, R. W., & STRAW+ 10 Collaborative Group. (2012). Executive summary of the Stages of Reproductive Aging Workshop+ 10: addressing the unfinished agenda of staging reproductive aging. The Journal of Clinical Endocrinology & Metabolism, 97(4), 1159-1168.
Hsiao, S. M., & Liao, S. C. (2024). Effect of tibolone vs hormone replacement therapy on climacteric symptoms and psychological distress. Journal of the Chinese Medical Association, 87(2), 189-195.
Kantarci, K., Tosakulwong, N., Lesnick, T. G., Kara, F., Kendall-Thomas, J., Kapoor, E., & Gleason, C. E. (2023). Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause, 10-1097.
Lara, L. A., Cartagena-Ramos, D., Figueiredo, J. B., Rosa-e-Silva, A. C. J., Ferriani, R. A., Martins, W. P., & Fuentealba-Torres, M. (2023). Hormone therapy for sexual function in perimenopausal and postmenopausal women. Cochrane Database of Systematic Reviews, (8).
Lee, S. R., Cho, M. K., Cho, Y. J., Chun, S., Hong, S. H., Hwang, K. R., & Kim, T. (2020). The 2020 menopausal hormone therapy guidelines. Journal of menopausal medicine, 26(2), 69.
Martin, K. A., & Barbieri, R. L. (2017). Treatment of menopausal symptoms with hormone therapy. Up-to-date, Crowley Jr. WF. (Jun 5, 2017). https://www.uptodate. com/contents/treatment-of-menopausal-symptoms-with-hormone therapy, 2-150.
Nácul, A. P., Rezende, G. P., Gomes, D. A. Y., Maranhão, T., Costa, L. O. B. F., Dos Reis, F. M., ... & Benetti-Pinto, C. L. (2021). Use of androgens at different stages of life: reproductive period. Revista Brasileira de Ginecologia e Obstetrícia/RBGO Gynecology and Obstetrics, 43(12), 988-994.
Sánchez-Delgado, J. C., Jácome-Hortúa, A. M., Uribe-Sarmiento, O. M., Philbois, S. V., Pereira, A. C., Rodrigues, K. P., & Souza, H. C. D. (2023). Combined effect of physical exercise and hormone replacement therapy on cardiovascular and metabolic health in postmenopausal women: A systematic review and meta-analysis. Brazilian Journal of Medical and Biological Research, 56, e12241.
Sarmento, A. C. A., Costa, A. P. F., Lírio, J., Eleutério Jr, J., Baptista, P. V., & Gonçalves, A. K. (2023). Efficacy of hormonal and nonhormonal approaches to vaginal atrophy and sexual dysfunctions in postmenopausal women: a systematic review. Revista Brasileira de Ginecologia e Obstetrícia, 44, 986-994.
Souza Santos, A., Moreira, A. B., & de Souza, M. L. R. (2023). Prevalência e severidade de sintomas em mulheres na menopausa: um estudo descritivo. DEMETRA: Alimentação, Nutrição & Saúde, 18, e72182-e72182.
Toronto, C. E., & Remington, R. (Eds.). (2020). A step-by-step guide to conducting an integrative review.
Trench, B., & Santos, C. G. D. (2005). Menopausa ou menopausas? Saúde e sociedade, 14, 91-100.
Yuk, J. S., Kim, T., Cho, H., & Gwak, G. (2024). Breast cancer risk association with postmenopausal hormone therapy: Health Insurance Database in South Korea–based cohort study. European Journal of Endocrinology, 190(1), 1-11.
Zhang, G. Q., Chen, J. L., Luo, Y., Mathur, M. B., Anagnostis, P., Nurmatov, U., & Nwaru, B. I. (2021). Menopausal hormone therapy and women’s health: An umbrella review. PLoS Medicine, 18(8), e1003731.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Lara Letycia Araujo Costa; Francielle Temer de Oliveira; Álvaro Carson Alves Vieira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
