Acute kidney injury in felines: etiology, diagnosis and prevention

Authors

DOI:

https://doi.org/10.33448/rsd-v13i6.45913

Keywords:

Acute Kidney Injury; Azotemia; Cats.

Abstract

In small animal veterinary clinics, Acute Kidney Injury (AKI) in felines is a common illness. Kidney disease affects one in every three cats over twelve years of age, being one of the biggest causes of death in this species. ARF is a clinical syndrome caused by kidney damage, characterized by an increase in serum concentrations of urea and creatinine, causing the animal to present a series of clinical signs, such as inappetence, vomiting and stomatitis, which can even lead to death. Therefore, it is important for the veterinarian to identify and apply the protocol that best suits a patient with ARF. In the case of felines, ARF becomes even more worrying, due to the anatomical particularities of the species. In this sense, the aim of this work is to review the literature on the causes that lead to this disorder, point out the clinical signs of this disease and highlight some prevention guidelines for ARF in cats.

References

Souza, E M, Arndt, M H L, Gomes ,M G, Val, A P C & Leme, F O P. (2018). Cistatina C sérica em cães criticamente enfermos em UTI. Pesq Vet Bras [Internet]. 2018Oct;38(10):1981–8. Available from: Https://doi.org/10.1590/1678-5150-PVB-5695. ([s.d.]).

Agopian, R G, Guimarãe,s K P, Fernandes, R A, et al. (201¨). Estudo morfométrico de rins em felinos domésticos (Felis catus). Pesqui Veterinária Bras;36(4):329-338. Doi:10.1590/S0100-736X2016000400013. ([s.d.]).

Amann, K, Nichols, C, Törnig, J, et al. (1996). Effect of ramipril, nifedipine, and moxonidine on glomerular morphology and podocyte structure in experimental renal failure. Nephrol Dial Transplant.;11(6):1003-1011. Doi:10.1093/ndt/11.6.1003. ([s.d.]).

Bersenas ,A M E (2011). A clinical review of peritoneal dialysis. J Vet Emerg Crit Care.;21(6):n/a-n/a. Doi:10.1111/j.1476-4431.2011.00679.x. ([s.d.]). .

Boujon, C, Amberger, C & Lombard, C. (2004) Right ventricular aneurysm and atrial septal defect in a cat. J Vet Cardiol. ;6(2):44-48. Doi:10.1016/S1760-2734(06)70057-1. ([s.d.]).

Bragat,o N, Fioravanti, M C S, Braga, L G, Reis, D C & Borges, N C. (2015). Lesão renal tubular aguda em cães e gatos: Fisiopatogenia e diagnóstico ultrassonográfico. Enciclopédia Biosf. December:2092-2110. Doi:10.18677/Enciclopedia_Biosfera_2015_183. ([s.d.]).

Brown, S, Atkins, C, Bagley R, et al. (2007). Guidelines for the Identification, Evaluation, and Management of Systemic Hypertension in Dogs and Cats. J Vet Intern Med. ;21(3):542-558. Doi:10.1111/j.1939-1676.2007.tb03005.x. ([s.d.]).

Castro M C N, Bomfim A, Ii V, et al. (2010). Escore de condição corporal como indicador do prognóstico de gatos com doença renal crônica. Fev.;40(2):365-370. ([s.d.]).

Chacar, F C, Guimarães-Okamoto P T C, Oliveira J. & Melchert A. (2014). Diálise peritoneal em cães e gatos. Veterinária e Zootec.;21(2):229-237. ([s.d.]).

Chawl,a L S, Eggers, P W, Star, R A & Kimmel, P L. (2014). Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes. N Engl J Med.;371(1):58-66. Doi:10.1056/NEJMra1214243. ([s.d.]).

Coca, S G, Singanamala, S & Parikh, C R (2012). Chronic kidney disease after acute kidney injury: A systematic review and meta-analysis. Kidney Int.;81(5):442-448. Doi:10.1038/KI.2011.379. ([s.d.]).

Cole, L P, Mantis, P & Humm, K. (2018) Ultrasonographic findings in cats with acute kidney injury: A retrospective study. J Feline Med Surg. July:1098612X1878573. Doi:10.1177/1098612X18785738. ([s.d.]).

Curry, S L, Cogar, S M & Cook, J L. (2005). Nonsteroidal Antiinflammatory Drugs: A Review. J Am Anim Hosp Assoc.;41(5):298-309. Doi:10.5326/0410298. ([s.d.]).

De la Serna, (2006). F. Insuficiencia Cardiaca. Vol 9. Silver Horse S.R.L; ([s.d.]).

Degenhardt, L, Dorsch, R, Hartmann, K, Dörfelt, R. (2023). Serum amyloid A in cats with renal azotemia. Vet World. Aug;16(8):1673-1681. Doi: 10.14202/vetworld.2023.1673-1681. Epub 2023 Aug 19. PMID: 37766698; PMCID: PMC10521177. ([s.d.]).

Dzyban, L, Labato, M A, Ross, L A & Murtaugh, R J. (200). Peritoneal Dialysis: A Tool in Veterinary Critical Care. J Vet Emerg Crit Care.;10(2):91-102. Doi:10.1111/j.1476-4431.2000.tb00005.x. ([s.d.]).

Flury, S, Trachsler, J, Schwarz, A & Ambühl, P M (2015). Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis. BMC Nephrol. 16:174. Doi:10.1186/s12882-015-0171-9. ([s.d.]).

Freitas, G C, Veado, J C C & Carregaro, A B. (2014). Testes de avaliação de injúria renal precoce em cães e gatos. Semin Ciências Agrárias.;35(1):411. Doi:10.5433/1679-0359.2014v35n1p411. ([s.d.]).

Guiot, Ê G, Okamoto P T C G, Chacar F C, Gomide P, Lourenço M L G & Melchert A. (2015). Reversal of acute renal injury after peritoneal dialysis in a dog. Brazilian J Vet Med.;37(2). ([s.d.]).

Hall, J A, Yerramilli, M, Obare, E, Yerramilli, M & Jewell, D E. (2014). Comparison of Serum Concentrations of Symmetric Dimethylarginine and Creatinine as Kidney Function Biomarkers in Cats with Chronic Kidney Disease. J Vet Intern Med. ;28(6):1676-1683. Doi:10.1111/jvim.12445. ([s.d.]).

Hamper, B. (2016) Current Topics in Canine and Feline Obesity. Veterinary Clinics of North America—Small Animal Practice, v. 46, n. 5, p. 785–795. ([s.d.]).

International Federation of Clinical Chemistry certified reference material, ERM-DA471/IFCC). ([s.d.]). (2013). IRIS: International Renal Interest Society. Guidelines: IRIS Grading of Acute Kidney Injury (AKI)—IRIS Guideline Recommendations for Grading of AKI in Dogs and Cats. Http://www.iris-kidney.com/education/index.html. Accessed May 23, 2017. ([s.d.]).

Lamb, C R, Dirrig, H & Cortellini, S. (2018). Comparison of ultrasonographic findings in cats with and without azotaemia. J Feline Med Surg.;20(10):948-954. Doi:10.1177/1098612X17736657. ([s.d.]).

Langston, C. & Managing, (2008). Fluid and Electrolyte Disorders in Renal Failure. Doi:10.1016/j.cvsm.01.007. ([s.d.]).

Levey, A S, Becke,r C & Inker, L A. (2015). Glomerular Filtration Rate and Albuminuria for Detection and Staging of Acute and Chronic Kidney Disease in Adults. JAMA.;313(8):837. Doi:10.1001/jama.2015.0602. ([s.d.]).

Mayhew, I G, Houston, D M, Vanzellotti, I R & Nascimento, M D (2002). Exame Clínico e Diagnóstico Em Veterinária. Guanabara Koogan; ([s.d.]).

Mehta, R L, Kellum, J A, Shah, S V, et al. (2007). Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care;11(2): R31. Doi:10.1186/cc5713. ([s.d.]).

Moncrief, J W, Popovich, R P, Mullins-Blackson, C, et al. (2018). Development Of A Canine Model For Continuous Ambulatory Peritoneal Dialysis*. January 2018:99-108. Doi:10.1201/9781351073011-4. ([s.d.]).

Monteiro, M G, Mori da Cunha, C, Leuven, K U, et al. (2016). Fluid Therapy Rate in Postrenal Azotemia Stabilization in Cats Nephroprotective effect of Amniotic fluid stem cell on ischemia and reperfusion injury View project Acid-base balance in cats with obstructive acute kidney injury. View project. Doi:10.15226/2381-2907/2/2/00116. ([s.d.]).

Nasri, H & Rafieian-Kopaei, M. (2013). M. Tubular Kidney Protection by Antioxidants. Iran. J Public Health.;42(10):1194-1196. ([s.d.]).

Nelson, R. W.; Couto, C G. (2003). Injúria Renal. In: Medicina Interna de Pequenos Animais. 2nd ed. Rio de Janeiro: Guanabara Koogan:487-499. ([s.d.]).

Paul, M, Poyan Mehr, A & Kreutz, R. (2006). Physiology of Local Renin-Angiotensin Systems. Physiol Rev.;86(3):747-803. Doi:10.1152/physrev.00036.2005. ([s.d.]).

Peiró, J R & Mendes, L C. (2004). Semiologia do sistema digestório eqüino. In: F.L. Feitosa, ed. Semiologia Veterinária. A Arte Do Diagnóstico. Sao Paulo:428-448. ([s.d.]).

Pouchelon, J L; Atkins, C E; Bussadori, C, et al. (2015). Cardiovascular-renal axis disorders in the domestic dog and cat: A veterinary consensus statement. J Small Anim Pract. ;56(9):537-552. Doi:10.1111/jsap.12387. ([s.d.]).

Prowle, J R, Liu, Y-L & Licari, E. et al. (2011). Oliguria as predictive biomarker of acute kidney injury in critically ill patients. Crit Care.;15(4):R172. Doi:10.1186/cc10318. ([s.d.]).

Ross, L A & Labato, M A. (2013). Current techniques in peritoneal dialysis. J Vet Emerg Crit Care. 2013. Doi:10.1111/vec.12035. ([s.d.])

.

Rufato, F H F. (2011). Injúria Renal em cães e gatos. Interdiscip Rev Eletrônica da Univar. ;(6):167-173. ([s.d.]).

Santos, A D S (2012). Ativação do sistema reninaangiotensina-aldosterona em cães assintomáticos com doença mixomatosa valvular mitral. ([s.d.]).

Stein, V. M., Baumgärtner, W., Kreienbrock, L., Zurbriggen, A., Vandevelde, M., & Tipold, A. (2006). Canine microglial cells: Stereotypy in immunophenotype and specificity in function? Veterinary Immunology and Immunopathology, 113(3–4), 277–287. Recuperado outubro 25, 2023, de https://linkinghub.elsevier.com/retrieve/pii/S0165242706001590.

Teo, B W & Zhang L, Guh J-Y, et al. (2018). Glomerular Filtration Rates in Asians. Adv Chronic Kidney Dis. 25(1):41-48. Doi:10.1053/J.ACKD.2017.10.005. ([s.d.]).

Thornburg, B & Gray-Vickrey, P. (2016). Acute kidney injury. Nursing (Lond). 46(6):24-34. Doi:10.1097/01.NURSE.0000482865.61546.b4. ([s.d.]).

Tyagi A, Aeddula NR. Azotemia. (2023) May 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30844172. ([s.d.]). .

Valença, A C E P. (2016). Associação entre alterações cardíacas e taxa de filtração glomerular estimada pela creatinina e cistatina c em pacientes com doença renal crônica sob tratamento conservador. ([s.d.]).

Vandevelde, M., & Zurbriggen, A. (2005). Demyelination in canine distemper virus infection: A review. Acta Neuropathologica, 109(1), 56–68. Recuperado outubro 25, 2023, de http://link.springer.com/10.1007/s00401-004-0958-4.

Villanova Junior, J A; Catapan, D. C; Fraiz, F. V, et al. (2016). Utilização do meloxicam como anti-inflamatório e analgésico em gatos. Rev Acadêmica Ciência Anim. ;14(756):109. Doi:10.7213/academica.14.2016.12. ([s.d.]).

Wasung, M. E; Chawla, L. S. & Madero, M. (2015). Biomarkers of renal function, which and when? Clin Chim Acta. ;438:350-357. Doi:10.1016/J.CCA.2014.08.039. ([s.d.]).

Zukowski, M; Bohatyrewicz, R. & Krawczyk, A. A. (2007). Factors Influencing Serum Creatinine Level in Kidney Recipients in a Multivariate Analysis. Transplant Proc. 39(9):2724-2726. Doi:10.1016/j.transproceed.2007.09.012. ([s.d.]).

Published

07/06/2024

How to Cite

CIPRIANO, L. F. .; TINOCO, I. A. P. .; ELIAM, P. C. L. .; BARROS, C. M. B. .; MEDEIROS, D. R. .; PAES , A. C. .; MORGADO, D. C. da S. . Acute kidney injury in felines: etiology, diagnosis and prevention. Research, Society and Development, [S. l.], v. 13, n. 6, p. e3013645913, 2024. DOI: 10.33448/rsd-v13i6.45913. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45913. Acesso em: 4 dec. 2024.

Issue

Section

Review Article