Clinical/nutritional parameters and gestational history of mothers of children living with cleft lip and palate
DOI:
https://doi.org/10.33448/rsd-v13i6.45915Keywords:
Cleft lip and palate; Prenatal; Gestation; Medicines; Stress; BMI.Abstract
Cleft lip and palate (CLP) originate from different stages of embryonic-fetal development and is associated with a multifactorial etiology, with risk factors in the Genetic-Environmental-Social context. In this study, we focused on the analysis of mothers of children with CLP – attended at a reference dental clinic in southern Minas Gerais, Brazil. Data obtained through a semi-structured questionnaire revealed a sample of 73 patients with CLP, predominantly aged 1-5 years (43.83%, CI 95% 32.41; 55.91), white (72.60%, CI 95% 60.71; 82.08), with maternal age among the 73 mothers interviewed, mostly between 20-35 years old (69.86%, CI 95% 57.85; 79.76), and having completed high school. In the medical/nutritional history, there was no significant relationship with comorbidities (Diabetes Mellitus, Systemic Arterial Hypertension and Dyslipidemia), but through the BMI, it was possible to report the presence of varying degrees of nutritional dysfunctions [malnutrition, overweight and obesity levels]. Most mothers had prenatal care (97.26%, CI 95% 87.85; 100) and, during pregnancy, a considerable frequency of alcohol use, tobacco and illicit drugs was observed, and 36.99% (CI 95% 8.99; 43.06) of the studied mothers had an infection during pregnancy and/or used medication with teratogenic risks. Of note, 72% of mothers underwent through stressful situations during pregnancy, which is a risk factor in the etiology of FLP. As a factor in preventing CLP, most respondents used folic acid during pregnancy. The importance of prospecting risk factors for CLP in the prenatal period and monitoring mothers and newborns are highlighted, due to the multifactorial context of the disease.
References
Aguilar, S., Alves, M. J., & Serrano, F (2016). Gravidez e epilepsia. Acta Obstet Ginecol Port. 10(2): 120-129.
Alarcón, K. M. G., & Sá, A. J. D. A (2017). Perfil epidemiológico dos pacientes portadores de fissuras labiopalatinas atendidos por equipe cirúrgicade referência no Estado do Amazonas. Revista Brasileira de Cirurgia Plástica. 32(4): 486-490.
Bertolossi, H. S (2014). Avaliação epidemiológica e investigação de polimorfismos em genes do reparo do DNA na fissura lábio-palatina não sindrômica. Tese (Doutorado). Faculdade de Odontologia de Piracicaba (FOP) da Universidade Estadual de Campinas (UNICAMP).
Borges, V. M., Moura, F., Cerdeira, C. D., & Santos-Barros, G. B (2018). Uso de medicamentos entre gestantes de um município no sul de Minas Gerais, Brasil. Infarma. 30(1): 30-43.
Candotto, V., Oberti, L., Gabrione, F., et al (2019). Current concepts on cleft lip and palate etiology. Journal of Biological Regulators and Homeostatic Agents. 33(3 Suppl. 1), 145–151.
Carvalho, A. C. L. M., Martins, P. C., Araujo, R. B., Cerdeira, C. D., Silva, R. B. V., & Santos-Barros, G. B (2018). Nutritional Parameters in Patients with Cancer attended at a Reference Center in the south of Minas Gerais state, Brazil. Revista Brasileira de Cancerologia. 64(2): 157-163.
Corsini, S. L. S., Carvalho, L. F., Araújo, L. C., Moreira, K. B., Silvério, A. S. D., Santos, G. B., Cerdeira, C. D., & Lopes, A. C (2020). Condições sociais e clínicas associadas à promoção de saúde em pacientes com fissuras labiopalatais atendidos em um centro de referência. Vittalle – Revista de Ciências da Saúde. 32(3): 56-64.
Cymrot, M., Sales, F. C. D., et al (2010). Prevalência dos tipos de fissura em pacientes com fissuras labiopalatinas atendidos em um hospital pediátrico do nordeste brasileiro. Revista Brasileira De Cirurgia Plástica. 25(4): 648-51.
Estrela, C (2018), Metodologia científica: ciência, ensino e pesquisa. Ed. Artes Médicas.
Liu, H., Yan, F., Sun, H. P., et al (2017). Ultrasonography of fetal cleft lip and palate in first-trimester. Clinical and Experimental Obstetrics & Gynecology. 44(3), 408–412.
Marginean, C., Sasarean, V., Marginean, C. O., et al (2018). Prenatal diagnosis of cleft lip and cleft lip palate - a case series. Medical Ultrasonography. 20(4), 531–535.
Mendes, R., Santos, J. M. J., Prado, D. S., et al (2020). Avaliação da qualidade do pré-natal a partir das recomendações do Programa de Humanização no Pré-natal e Nascimento. Ciência & Saúde Coletiva. 25(3): 793-804.
Plasencia, E., Díaz-Vélez, C., & Dueñas-Roque, M. M (2020). Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención. Un estudio de casos y controles. Acta Médica Peruana. 37(3), 304-311.
Santos, M. H. R. C., Lima, C. A. C., & Silva, T. B (2017). Fissuras labiopalatinas, aspectos etiológicos e tratamento. Revista Científica InFOC. 2 (2).
Shibukawa, B. M. C., Rissi, G. P., Higarashi, I. H., et al (2019). Fatores associados à presença de fissura labial e/ou fenda palatina em recém-nascidos brasileiros. Revista Brasileira Saúde Materno Infantil. 19(4): 947-956.
Silva, H. P. V., Rezende, A. A. (2018). Risk factors and comorbidities in Brazilian patients with orofacial clefts. Brazilian Oral Research. 32: 1-12.
Silva, J. J., Silva, T. A., Almeida, H., Neto, M. F. R., Cerdeira, C. D., Höfling, J. F., & Boriollo, M. F. G (2018). Candida species biotypes in the oral cavity of infants and children with orofacial clefts under surgical rehabilitation. Microbial Pathogenesis. 124: 203–215.
Sousa, G. F. T., Roncalli, A. G (2017). Orofacial clefts in Brazil and surgical rehabilitation under the Brazilian National Health System. Journal of Colloid and Interface Science. 31: e23.
Sreejith, V. P., Arun, V., Devarajan, A. P., et al (2018). Psychological effect of prenatal diagnosis of cleft lip and palate: a systematic review. Contemp Clin Dent. 9(2): 304-308.
Tettamanti, L., et al (2017). Novos insights sobre fissura orofacial: estudos epidemiológicos e genéticos em amostras italianas. Oral Implantol (Rome). 10(1): 11-19.
Tomson, T., Battino, D., Bromley, R., et al (2019). Management of epilepsy in pregnancy: a report from the International League Against Epilepsy Task Force on Women and Pregnancy. Epileptic disorders: International Epilepsy Journal with Videotape. 21(6), 497–517.
Zheng, W., Li, B., Zou, Y., et al (2019). The prenatal diagnosis and classification of cleft palate: the role and value of magnetic resonance imaging. European Radiology. 29(10), 5600–5606.
Wallace, G. H., Arellano, J. M., Gruner, T. M., et al (2011). Non-syndromic cleft lip and palate: could stress be a causal factor? Women Birth. 24(1): 40-46.
Worley, M. L., Patel, K. G., & Kilpatrick, L. A. (2018). Cleft Lip and Palate. Clinics in Perinatology. 45(4), 661–678.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Malu Labecca Selicani; Beatriz Barraqui Nardo; Lanna Antunes de Faria Lima; Natasha Maganin Amboni; Cláudio Daniel Cerdeira; Roberta Bessa Veloso Silva; Gérsika Bitencourt Santos
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.