A narrative review of the analysis of nanoparticulate systems in the formulation and efficacy of antitumor drugs

Authors

DOI:

https://doi.org/10.33448/rsd-v13i6.46082

Keywords:

Nanotechnology; Antineoplastics; Nanoparticle drug release systems.

Abstract

The treatment of cancer remains a significant challenge in the healthcare field due to the side effects of conventional treatments and the need for more effective therapies. Nanotechnology offers a promising approach to overcome these limitations, with the development of nanoparticles as carriers of antitumor drugs. This article comprehensively reviews the use of nanoparticles in cancer therapy, from the definition of nanotechnology to the potential toxicity of nanoparticles. We discuss the different types of nanoparticles used, such as polymer-based nanoparticles, lipid-based nanoparticles, nanoemulsions, and gold nanoparticles, highlighting their advantages and applications in the delivery of antitumor drugs. Additionally, we explore conventional cancer treatments, such as surgery, radiotherapy, and chemotherapy, comparing their efficacy and side effects with nanotechnology-based treatments. Finally, we discuss the efficacy of antitumor drugs of nanotechnological origin and the challenges related to the potential toxicity of nanoparticles. This review provides a comprehensive and updated overview of the role of nanoparticles in cancer therapy, highlighting their potential to improve clinical outcomes and patient quality of life. Thus, the objective of this article is to present a systematic review of the use of nanoparticulate systems as antitumor drugs.

References

Ahmad, T., Sarwar, R., Iqbal, A., Bashir, U., Farooq, U., Halim, S. A., Khan, A. & Harrasi, A. L. (2020). Recent Advances in Combinatorial Cancer Therapy Via Multifunctionalized Gold Nanoparticles. Nanomedicine, 15 (12), 1221-1237. https://doi.org/10.2217/nnm-2020-0051.

Bardin, L. (2011). Análise de conteúdo. Edições 70.

Bhatia, S. (2016). Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications. In Bhatia, S.. Natural Polymer Drug Delivery Systems: nanoparticles, plants, and algae (pp. 33-93). Springer. https://doi.org/10.1007/978-3-319-41129-3_2.

Brasil (2023a). Instituto Nacional De Câncer. Quimioterapia. https://www.gov.br/inca/pt-br/assuntos/cancer/tratamento/quimioterapia.

Brasil (2023b). Instituto Nacional De Câncer. Radioterapia. https://www.gov.br/inca/pt-br/assuntos/cancer/tratamento/radioterapia.

Cancino, J., Marangoni, V. S. & Zucolotto, V. (2014). Nanotechnology in medicine: concepts and concerns. Química Nova, 37 (3), 521-526. https://doi.org/10.5935/0100-4042.20140086.

ChaturvedI, V. K., Singh, A., Singh, V. & Singh, M. P. (2019). Cancer Nanotechnology: a new revolution for cancer diagnosis and therapy. Current Drug Metabolism, 20 (6), 416-429. https://doi.org/10.2174/1389200219666180918111528.

Estanqueiro, M., Amaral, M. H., Conceição, J. & Lobo, J. M. S. (2015). Nanotechnological carriers for cancer chemotherapy: the state of the art. Colloids And Surfaces B: Biointerfaces, 126, 631-648. https://doi.org/10.1016/j.colsurfb.2014.12.041.

Fan, D., Cao, Y., Cao, M., Wang, Y., Cao, Y. &Gong, T. (2023). Nanomedicine in cancer therapy. Signal Transduction And Targeted Therapy, 8(1), 1-34, 7. https://doi.org/10.1038/s41392-023-01536-y.

Joudeh, N. & Linke, D. (2022). Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. Journal Of Nanobiotechnology, 20 (1), 1-29. https://doi.org/10.1186/s12951-022-01477-8.

Katzung, B. G. & Trevor, A. J. (2015) Farmacologia básica e clínica. Amgh.

Khan, A. U., Khan, M., Cho, M. H. & Khan, M. M. (2020). Selected nanotechnologies and nanostructures for drug delivery, nanomedicine and cure. Bioprocess And Biosystems Engineering, 43 (8), 1339-1357. https://doi.org/10.1007/s00449-020-02330-8.

Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A. & Langer, R. (2020). Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery, 20 (2), 101-124. https://doi.org/10.1038/s41573-020-0090-8.

Najahi-Missaoui, W., Arnold, R. D. & Cummings, B. S. (2020). Safe Nanoparticles: are we there yet?. International Journal Of Molecular Sciences, 22 (1), 385-406. https://doi.org/10.3390/ijms22010385.

National Institutes Of Health (2015). National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/surgery.

National Institutes Of Health (2019). National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/radiation-therapy.

National Institutes Of Health (2022). National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/chemotherapy.

Pérez-Herrero, E. & Fernández-Medarde, A. (2015). Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. European Journal Of Pharmaceutics And Biopharmaceutics, 93, 52-79. https://doi.org/10.1016/j.ejpb.2015.03.018.

Venditto, V. J. & Szoka, F. C. (2013). Cancer nanomedicines: so many papers and so few drugs!. Advanced Drug Delivery Reviews, 65(1), 80-88. https://doi.org/10.1016/j.addr.2012.09.038.

Vinod, S. K. & Hau, E. (2020). Radiotherapy treatment for lung cancer: current status and future directions. Respirology, 25(2), 61-71. https://doi.org/10.1111/resp.13870.

Weinberg, R. A. (2013). The Biology of Cancer.W. W. Norton & Company.

Wyld, L., Audisio, R. A., & Poston, G. J. (2014). The evolution of cancer surgery and future perspectives. Nature Reviews Clinical Oncology, 12(2), 115-124. https://doi.org/10.1038/nrclinonc.2014.191.

Xu, X., Liu, C., Wang, Y., Koivisto, O., Zhou, J., Shu, Y. & Zhang, H. (2021). Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment. Advanced Drug Delivery Reviews, 176, 1-31. https://doi.org/10.1016/j.addr.2021.113891.

Published

14/06/2024

How to Cite

PEREIRA, G. J. V. .; MARTINS, M. M. .; MUNIZ, M. da S. . A narrative review of the analysis of nanoparticulate systems in the formulation and efficacy of antitumor drugs. Research, Society and Development, [S. l.], v. 13, n. 6, p. e7813646082, 2024. DOI: 10.33448/rsd-v13i6.46082. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46082. Acesso em: 30 jun. 2024.

Issue

Section

Health Sciences