Multisystem inflammatory syndrome associated with SARS-CoV-2 in pediatrics: A narrative review of diagnosis and treatment
DOI:
https://doi.org/10.33448/rsd-v13i8.46303Keywords:
COVID-19; Pediatrics; Therapeutics; Systemic inflammatory response syndrome; Diagnosis.Abstract
During the COVID-19 pandemic, initial studies investigating the impact of this disease on the pediatric population demonstrated evidence of little clinical impact in this population. However, the emergence of Multisystem Inflammatory Syndrome associated with SARS-CoV-2 (SIM-P) with more serious symptomatic repercussions, as well as a poor prognosis, raised alarm in the pediatric community in favor of developing a diagnostic and therapeutic consensus regarding the new syndrome. Given the relevance of the subject, this study proposes to visit review articles, guidelines, meta-analyses and clinical studies with the aim of discussing the best definitions regarding the multisystemic condition, as well as management. Through manual search in databases indexed to Pubmed, with the following descriptors: “MISC associated with COVID-19” and “treatment” in English. Both being searched with the Boolean “AND”, 29 articles were definitively chosen. Realizing the urgent need to define what SIM-P would be, as well as guide the diagnosis and treatment of cases, we used the best criteria to define this new clinical condition. Furthermore, this narrative review aims to contribute to the study of SIM-P associated with SARS-CoV-2 through a critical analysis of the literature, highlighting the consensus on its diagnosis and treatment.
References
Albanji, M. H., Baghafar, A. A., Alghanmi, Y. A., Shaaban, M. M., Alkashlan, E. A., Sende, H. H., Alzahrani, M. S., & Filfilan, N. N. (2023). Clinical Presentation and Management of Multisystem Inflammatory Syndrome in Children With COVID-19: A Systematic Review. Curēus. https://doi.org/10.7759/cureus.46918
Algarni, A. S., Alamri, N. M., Khayat, N. Z., Alabdali, R. A., Alsubhi, R. S., & Alghamdi, S. H. (2022). Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations. World Journal of Pediatrics, 18(2), 83–90. https://doi.org/10.1007/s12519-021-00499-w
Aronoff, S. C., Hall, A., & Del Vecchio, M. T. (2020). The Natural History of Severe Acute Respiratory Syndrome Coronavirus 2–Related Multisystem Inflammatory Syndrome in Children: A Systematic Review. Journal of the Pediatric Infectious Diseases Society. https://doi.org/10.1093/jpids/piaa112
Barrera Castro, M. E., Flores Montesinos, C. E., & Barrera Castro, A. R. (2023). Afectación cardiaca por Síndrome Inflamatorio Multisistémico asociado A SARS-CoV-2 en pacientes pediátricos. Vive (El Alto), 162–171. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1442269
Blatz, A. M., & Randolph, A. G. (2022). Severe COVID-19 and MIS-C In Children & Adolescents. Critical Care Clinics. https://doi.org/10.1016/j.ccc.2022.01.005
Bohn, M. K., Yousef, P., Steele, S., Sepiashvili, L., & Adeli, K. (2021). MultiInflammatory Syndrome in Children: A View into Immune Pathogenesis from a Laboratory Perspective. The Journal of Applied Laboratory Medicine, 7(1), 311–321. https://doi.org/10.1093/jalm/jfab114
Cannon, L., M. Jay Campbell, & Wu, E. Y. (2023). Multisystem Inflammatory Syndrome in Children and Kawasaki Disease: Parallels in Pathogenesis and Treatment. Current Allergy and Asthma Reports, 23(6), 341–350. https://doi.org/10.1007/s11882-023-01083-0
Dhar, D., Dey, T., Samim, M. M., Padmanabha, H., Chatterjee, A., Naznin, P., Chandra, S. R., Mallesh, K., Shah, R., Siddiqui, S., Pratik, K., Ameya, P., & Abhishek, G. (2022). Systemic inflammatory syndrome in COVID-19–SISCoV study: systematic review and meta-analysis. Pediatric Research, 91(6), 1334–1349. https://doi.org/10.1038/s41390-021-01545-z
Edinoff, A. N., Edward Sanders Alpaugh, Newgaard, O., Irza Wajid, Klapper, R. J., Cornett, E. M., Kaye, A. M., Iyer, P., & Kaye, A. D. (2023). Tocilizumab for Severe COVID-19 Infection and Multisystem Inflammatory Syndrome in Adults and Children. 13(4), 889–889. https://doi.org/10.3390/life13040889
Emeksiz, S., Çelikel Acar, B., Kibar, A. E., Özkaya Parlakay, A., Perk, O., Bayhan, G. İ., Cinel, G., Özbek, N., Azılı, M. N., Çelikel, E., Akça, H., Dibek Mısırlıoğlu, E., Bayrakçı, U. S., Çetin, İ. İ., Neşe Çıtak Kurt, A., Boyraz, M., Hızlı, Ş., & Şenel, E. (2021). Algorithm for the diagnosis and management of the multisystem inflammatory syndrome in children associated with COVID‐19. International Journal of Clinical Practice. https://doi.org/10.1111/ijcp.14471
Estrada-Luna, D., Carreón-Torres, E., González-Reyes, S., Martínez-Salazar, M. F., Ortiz-Rodríguez, M. A., Ramírez-Moreno, E., Arias-Rico, J., & Jiménez-Osorio, A. S. (2022). Nutraceuticals for Complementary Treatment of Multisystem Inflammatory Syndrome in Children: A Perspective from Their Use in COVID-19. Life, 12(10), 1652. https://doi.org/10.3390/life12101652
Folga, B. A., Karpenko, C. J., & Grygiel-Górniak, B. (2022). SARS-CoV-2 infection in the context of Kawasaki disease and multisystem inflammatory syndrome in children. Medical Microbiology and Immunology. https://doi.org/10.1007/s00430-022-00756-3
Fremed, M. A., & Farooqi, K. M. (2022). Longitudinal Outcomes and Monitoring of Patients With Multisystem Inflammatory Syndrome in Children. Frontiers in Pediatrics, 10. https://doi.org/10.3389/fped.2022.820229
Junior, H. S., Sakano, T. M. S., Rodrigues, R. M., Eisencraft, A. P., Carvalho, V. E. L. de, Schvartsman, C., & Reis, A. G. A. da C. (2020). Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician’s point of view. Jornal de Pediatria. https://doi.org/10.1016/j.jped.2020.08.004
Hançerli Törün, S., Yilmaz Çiftdoğan, D., & Kara, A. (2021). Multisystem inflammatory syndrome in childre. Turkish Journal of Medical Sciences, 51(SI-1), 3273–3283. https://doi.org/10.3906/sag-2105-342
Harahsheh, A. S., Portman, M. A., Khoury, M., Elias, M. D., Lee, S., Lin, J., & McCrindle, B. W. (2023). Management of Multisystem Inflammatory Syndrome in Children: Decision-Making Regarding a New Condition in the Absence of Clinical Trial Data. Canadian Journal of Cardiology, 39(6), 803–814. https://doi.org/10.1016/j.cjca.2022.11.011
Henderson, L. A., Canna, S. W., Friedman, K. G., Gorelik, M., Lapidus, S. K., Bassiri, H., Behrens, E. M., Ferris, A., Kernan, K. F., Schulert, G. S., Seo, P., Son, M. B. F., Tremoulet, A. H., Yeung, R. S. M., Mudano, A. S., Turner, A. S., Karp, D. R., & Mehta, J. J. (2021). American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 2. Arthritis & Rheumatology, 73(4). https://doi.org/10.1002/art.41616
Hoste, L., Van Paemel, R., & Haerynck, F. (2021). Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. European Journal of Pediatrics, 180(7), 2019–2034. https://doi.org/10.1007/s00431-021-03993-5
Kabeerdoss, J., Pilania, R. K., Karkhele, R., Kumar, T. S., Danda, D., & Singh, S. (2020). Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatology International, 41(1), 19–32. https://doi.org/10.1007/s00296-020-04749-4
Kumar, R., Rivkin, M. J., & Raffini, L. (2023). Thrombotic complications in children with Coronavirus disease 2019 and Multisystem Inflammatory Syndrome of Childhood. Journal of Thrombosis and Haemostasis, 21(9), 2313–2326. https://doi.org/10.1016/j.jtha.2023.05.020
Lee, K. H., Li, H., Lee, M. H., Park, S. J., Kim, J. S., Han, Y. J., Cho, K., Ha, B., Kim, S. J., Jacob, L., Koyanagi, A., Shin, J. I., Kim, J. H., & Smith, L. (2022). Clinical characteristics and treatments of multi-system inflammatory syndrome in children: a systematic review. DOAJ (DOAJ: Directory of Open Access Journals), 26(9), 3342–3350. https://doi.org/10.26355/eurrev_202205_28754
Long, F., Zhu, S., Wang, Z., Zhang, S., He, J., Ge, X., & Ning, J. (2023). Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19. Future Virology, 18(1), 63–74. https://doi.org/10.2217/fvl-2022-0048
McMurray, J. C., May, J. W., Cunningham, M. W., & Jones, O. Y. (2020). Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis-A Critical Review of Its Pathogenesis and Treatment. Frontiers in Pediatrics, 8, 626182. https://doi.org/10.3389/fped.2020.626182
Mendes, C. (2022). O que é revisão narrativa de literatura: Exemplos e considerações da metodologia. Www.youtube.com. https://www.youtube.com/watch?v=YlBWSVsxvRM
Molloy, E. J., Nakra, N., Gale, C., Dimitriades, V. R., & Lakshminrusimha, S. (2022). Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) associated with COVID-19: optimizing definition and management. Pediatric Research. https://doi.org/10.1038/s41390-022-02263-w
Mota de Sousa, L. M., Furtado Firmino, C., Alves Marques-Vieira, C. M., Silva Pedro Severino, S., & Castelão Figueira Carlos Pestana, H. (2018). Revisões da literatura científica: tipos, métodos e aplicações em enfermagem. Revista Portuguesa de Enfermagem de Reabilitação, 1(1), 45–55. https://doi.org/10.33194/rper.2018.v1.n1.07.4391
Patel, J. M. (2022). Multisystem Inflammatory Syndrome in Children (MIS-C). Current Allergy and Asthma Reports. https://doi.org/10.1007/s11882-022-01031-4
Radia, T., Williams, N., Agrawal, P., Harman, K., Weale, J., Cook, J., & Gupta, A. (2020). Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatric Respiratory Reviews, 38. https://doi.org/10.1016/j.prrv.2020.08.001
Roberts, J. E., & Henderson, L. A. (2021). Clinical features of multisystem inflammatory syndrome in children. Current Opinion in Rheumatology, Publish Ahead of Print. https://doi.org/10.1097/bor.0000000000000818
Santos, M. O., Gonçalves, L. C., Silva, P. A. N., Moreira, A. L. E., Ito, C. R. M., Peixoto, F. A. O., Wastowski, I. J., Carneiro, L. C., & Avelino, M. A. G. (2021). Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes. Jornal de Pediatria. https://doi.org/10.1016/j.jped.2021.08.006
Shati, A. A., Mahmood, S. E., Alsuheel Asseri, A., Alhanshani, A. A., Alqahtani, Y. A., & Ahmad, A. (2023). SARS-CoV-2 infections and MIS-C among children: A narrative review. Medicine, 102(31), e34475. https://doi.org/10.1097/MD.0000000000034475
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