The advantages of Stromal Vascular Fraction compared to Nanofat
DOI:
https://doi.org/10.33448/rsd-v13i7.46423Keywords:
Adipose tissue; Stromal vascular fraction; General surgery; Wound healing.Abstract
The Stromal Vascular Fraction (SVF) and nanofat are products of the extraction of regenerative cells from adipose tissue, mainly, or bone marrow. The biggest difference between them is whether or not enzymes are used to obtain these products. Therefore, the objective of this research is to discuss whether or not there is a difference between these techniques, enzymatic or mechanical, in the context of scarring and surgery. Methods: This article carried out under the systematic review model, using the electronic databases Pubmed, Scielo and Elsevier. Papers published from 2010 to 2014 in English or Portuguese were included. Results: FVE has a greater quantity of progenitor cells, being more effective, especially in the early stages of healing. Nanofat has the great advantage of, in addition to good amounts of growth factors and cytokines, lower legal implications. Conclusion: Therefore, there is apparent superiority of the enzymatic form over the mechanics, but more comparative studies are needed for this phenomenon to be confirmed, especially when taking into account that there are few studies that compare the two modalities.
References
Andia, I., Maffulli, N., & Burgos-Alonso, N. (2019). Stromal vascular fraction technologies and clinical applications. Expert Opin Biol Ther, 19(12), 1289-1305. https://doi.org/10.1080/14712598.2019.1671970
Aronowitz, J. A., Lockhart, R. A., & Hakakian, C. S. (2015). Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. Springerplus, 4, 713. https://doi.org/10.1186/s40064-015-1509-2
Behrangi, E., Moradi, S., Ghassemi, M., Goodarzi, A., Hanifnia, A., Zare, S., & Roohaninasab, M. (2022). The investigation of the efficacy and safety of stromal vascular fraction in the treatment of nanofat-treated acne scar: a randomized blinded controlled clinical trial. Stem Cell Res Ther, 13(1), 298. https://doi.org/10.1186/s13287-022-02957-2
Bellini, E., Grieco, M. P., & Raposio, E. (2017). The science behind autologous fat grafting. Annals of Medicine and Surgery, 24, 65-73.
Busato, A., De Francesco, F., Biswas, R., Mannucci, S., & Sbarbati, A. (2020). Simple and rapid non-enzymatic procedure allows the isolation of structurally preserved connective tissue micro-fragments enriched with SVF. Cells, 10(1), 36. https://doi.org/10.3390/cells10010036
Cai, J., Wang, J., Hu, W., & Lu, F. (2020). Mechanical micronization of lipoaspirates for the treatment of horizontal neck lines. Plast Reconstr Surg, 145(2), 345-353. https://doi.org/10.1097/PRS.0000000000006456
Cao, Y., Kan, H., Ma, X., Zhang, Y., Huang, J., & Long, X. (2023). Autologous fat or adipose-derived stem cell grafting in systemic sclerosis treatment: a systematic review and meta-analysis. Clin Exp Rheumatol, 41(8), 1659-1669. https://doi.org/10.55563/clinexprheumatol/ycy3k7
Copcu, H. E., & Oztan, S. (2021). Not stromal vascular fraction (SVF) or nanofat, but total stromal-cells (TOST): A new definition. Systemic review of mechanical stromal-cell extraction techniques. Tissue Eng Regen Med, 18(1), 25-36. https://doi.org/10.1007/s13770-020-00313-0
Han, X., Ji, D., Liu, Y., & Hu, S. (2023). Efficacy and safety of transplantation of autologous fat, platelet-rich plasma (PRP) and stromal vascular fraction (SVF) in the treatment of acne scar: Systematic review and meta-analysis. Aesthetic Plast Surg, 47(4), 1623-1632. https://doi.org/10.1007/s00266-023-03295-1
Kadry, A., Gamal, A., Alkhalifah, A., & Ibrahim, S. M. A. (2023). Efficacy of platelet-rich plasma versus autologous fat transfer with nanofat in the treatment of infraorbital dark circles: A single-blinded randomized comparative clinical trial. Dermatol Surg, 49(3), 247-252. https://doi.org/10.1097/DSS.0000000000003697
Kemaloğlu, C. A., Özyazgan, İ., & Gönen, Z. B. (2021). Immediate fat and nanofat-enriched fat grafting in breast reduction for scar management. J Plast Surg Hand Surg, 55(3), 173-180. https://doi.org/10.1080/2000656X.2020.1856678
Kim, K. I., Kim, M. S., & Kim, J. H. (2023). Intra-articular injection of autologous adipose-derived stem cells or stromal vascular fractions: Are they effective for patients with knee osteoarthritis? A systematic review with meta-analysis of randomized controlled trials. Am J Sports Med, 51(3), 837-848. https://doi.org/10.1177/03635465211053893
Kwon, H., Lee, S., Kim, J., & Song, S. H. (2023). Efficacy and safety of stromal vascular fraction on scar revision surgery: a prospective study. J Dermatolog Treat, 34(1), 2171260. https://doi.org/10.1080/09546634.2023.2171260
Nseir, I., Delaunay, F., Latrobe, C., Bonmarchand, A., Coquerel-Beghin, D., & Auquit-Auckbur, I. (2017). Use of adipose tissue and stromal vascular fraction in hand surgery. Orthopaedics & Traumatology: Surgery & Research, 103(6), 927-932. https://doi.org/10.1016/j.otsr.2017.05.017
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paulista de Enfermagem, 20(2). https://doi.org/10.1590/S0103-21002007000200001
Senesi, L., De Francesco, F., Farinelli, L., & Conti, G. (2019). Mechanical and enzymatic procedures to isolate the stromal vascular fraction from adipose tissue: Preliminary results. Front Cell Dev Biol, 7, 88. https://doi.org/10.3389/fcell.2019.00088
Shih, L., Davis, M. J., & Winocour, S. J. (2020). The science of fat grafting. In Seminars in Plastic Surgery (pp. 5-10). Thieme Medical Publishers.
Simonacci, F., Bertozzi, N., Grieco, M. P., Raposio, E., & Iacconi, P. (2017). Procedure, applications, and outcomes of autologous fat grafting. Annals of Medicine and Surgery, 20, 49-60.
Van Dongen, J. A., van Boxtel, J., Uguten, M., Brouwer, L. A., Vermeulen, K. M., Melenhorst, W. B., & van der Lei, B. (2022). Tissue stromal vascular fraction improves early scar healing: A prospective randomized multicenter clinical trial. Aesthet Surg J, 42(7), NP477-NP488. https://doi.org/10.1093/asj/sjab431
Yang, Z., Jin, S., He, Y., Zhang, X., & Li, F. (2021). Comparison of microfat, nanofat, and extracellular matrix/stromal vascular fraction gel for skin rejuvenation: Basic research and clinical applications. Aesthet Surg J, 41(11), NP1557-NP1570. https://doi.org/10.1093/asj/sjab033
Zhu, H., Ge, J., Chen, X., Lu, F., & Cai, J. (2019). Mechanical micronization of lipoaspirates for regenerative therapy. J Vis Exp, (145). https://doi.org/10.3791/58765
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ana Beatriz Gomes de Almeida; Marayah Sampaio Ruas da Fonseca; Gabriel Neves dos Santos Mosqueira Gomes
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
