Stem cell therapies in the treatment of neurodegenerative diseases: A Literature review
DOI:
https://doi.org/10.33448/rsd-v13i8.46515Keywords:
Stem cell therapies; Neurodegenerative diseases; Neurogenesis; Regenerative treatment.Abstract
Introduction: The advancement of stem cell therapies represents a significant milestone in regenerative medicine, offering new perspectives for the treatment of neurodegenerative diseases. Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) emerge as promising options for neuronal regeneration, particularly in conditions such as Parkinson's disease. However, the transition of these therapies from research to clinical practice faces considerable challenges. Objectives: This article aims to review the current literature on the use of stem cell therapies for treating neurodegenerative diseases, addressing recent advances, types of cells used, mechanisms of action, and ongoing challenges. The review seeks to provide a comprehensive view of the progress and limitations in this field, contributing to the development of more effective therapeutic strategies. Results: The review revealed that both iPSCs and ESCs have the potential to differentiate into various types of neuronal cells, enabling the replacement of damaged neurons. Clinical and preclinical trials indicate improvements in motor and cognitive function, with notable progress in the treatment of Parkinson's disease. However, the practical application of these therapies faces challenges such as tumor formation, immune rejection, and the need for functional integration of transplanted cells. Mesenchymal stem cells (MSCs) also show promise, particularly due to their lower ethical controversy and ease of procurement. Conclusion: Stem cell therapies have transformative potential for treating neurodegenerative diseases, offering hope for significant improvements in patient quality of life. However, overcoming associated challenges, such as long-term safety and efficacy, is crucial for the successful implementation of these therapies. Continued research and development are essential to fully realize the therapeutic potential of stem cells.
References
Bjorklund, A., & Lindvall, O. (2000). Cell replacement therapies for central nervous system disorders. Nature Neuroscience, 3(6), 537-544. https://doi.org/10.1038/75702
Blesch, A., & Tuszynski, M. H. (2009). Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression. Science, 243(4895), 1427-1430. https://doi.org/10.1126/science.256.5057.1550
Duncan, T., & Valenzuela, M. (2017). Alzheimer’s disease, dementia, and stem cell therapy. Stem Cell Research & Therapy, 8, 1-9. https://doi.org/10.1186/s13287-017-0567-5
Faria, E. D. A., & Araujo, L. F. (2022). Cuidados paliativos em idosos com doenças neurodegenerativas: ênfase na doença de Alzheimer. Revista Brasileira de Desenvolvimento, 8(6), 47448-47472. https://doi.org/10.34117/bjdv8n6-474
Freitas, E. M. S., & Silva, R. E. (2018). Técnicas de imagem de ressonância magnética para o diagnóstico de Doença de Parkinson. XC Congresso Metodista de Iniciação e Produção Científica e XX Seminário de Extensão. São Paulo.
Gadelkarim, M., et al. (2018). Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing. Biomedicine & Pharmacotherapy, 107, 625-633. https://doi.org/10.1016/j.biopha.2018.08.034
Goldman, S. A. (2016). Stem and progenitor cell-based therapy of the human central nervous system. Nature Biotechnology, 34(7), 743-754. https://doi.org/10.1038/nbt.3224
Grealish, S., Diguet, E., Kirkeby, A., et al. (2014). Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson’s disease. Cell Stem Cell, 15(5), 653-665. https://doi.org/10.1016/j.stem.2014.09.017
Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353-356. https://doi.org/10.1126/science.1072994
Kordower, J. H., Freeman, T. B., Snow, B. J., et al. (1995). Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. The New England Journal of Medicine, 332(17), 1118-1124. https://doi.org/10.1056/NEJM199504273321702
Lindvall, O., & Kokaia, Z. (2010). Stem cell research in stroke: How far from the clinic? Stroke, 41(10), 2369-2375. https://doi.org/10.1161/STROKEAHA.110.587238
Martino, G., & Pluchino, S. (2006). The therapeutic potential of neural stem cells. Nature Reviews Neuroscience, 7(5), 395-406. https://doi.org/10.1038/nrn1908
Minger, S. L. (2007). Therapeutic potential of stem cells in neurodegenerative diseases. British Medical Bulletin, 83(1), 259-271. https://doi.org/10.1093/bmb/ldm020
Milczarek, S., Kulig, P., Zuchmańska, A., et al. (2023). Safety of cryopreserved stem cell infusion through a peripherally inserted central venous catheter. Cancers, 15(4), 1338. https://doi.org/10.3390/cancers15041338
Neudert, C., Wasner, M., & Borasio, G. D. (2004). Individual quality of life is not correlated with health-related quality of life or physical function in patients with amyotrophic lateral sclerosis. Journal of Palliative Medicine, 7(4), 551-557. https://doi.org/10.1089/jpm.2004.7.551
Pereira, L. V. (2008). A importância do uso das células tronco para a saúde pública. Revista Ciência & Saúde Coletiva, 13, 7-14. https://doi.org/10.1590/S1413-81232008000100002
Pessoa, M. G. A., Ferraz, C. R., Albuquerque, E. L., Barroso, J. D. B., Vilar, L. G., Barros, L. L. A., Borba, L. N., Melo, P. E. S., Souto, R. L. F., & Souza, M. B. R. (2023). Terapias de células-tronco no tratamento de doenças neurodegenerativas: uma revisão da literatura. Research, Society and Development, 12(5). https://doi.org/10.33448/rsd-v12i5.29414
Takeuchi, C. A., & Tannuri, U. (2006). A polêmica da utilização de células-tronco embrionárias com fins terapêuticos [Editorial]. Revista da Associação Médica Brasileira, 52(2), 63. https://doi.org/10.1590/S0104-42302006000200002
Trounson, A., & McDonald, C. (2015). Stem cell therapies in clinical trials: Progress and challenges. Cell Stem Cell, 17(1), 11-22. https://doi.org/10.1016/j.stem.2015.06.007
Zhang, N., An, M. C., Montoro, D., & Ellerby, L. M. (2010). Characterization of Human Huntington’s Disease Cell Model from Induced Pluripotent Stem Cells. PLoS Currents, 2, RRN1193. https://doi.org/10.1371/currents.RRN1193
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Luis Miguel Carvalho Mendes; Lucas Arruda Lino; Antonio Alves de Castro Neto; Ana Carolyne Portela Radtke ; Carlos Henrique Aires Magalhães Seixas; Kallyne Rodrigues de Oliveira ; Lívia Peixoto Batista; Zaine Santos de Almeida; Alexandre Magno dos Santos Ferreira; Carlos Samuel Lemos Borges; Mariana Gomes de Lima; Gustavo Daniel dos Santos Sousa Aguiar
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.