The importance of non-motor symptoms in the approach to Parkinson's Disease
DOI:
https://doi.org/10.33448/rsd-v13i11.47255Keywords:
Parkinson's disease; Complications; Propaedeutics.Abstract
Introduction: Parkinson's disease is a neurodegenerative condition which, in addition to the classic motor symptoms, presents various non-motor symptoms, such as sleep disorders, autonomic dysfunctions and neuropsychiatric alterations. These symptoms can precede motor symptoms and have a major impact on patients' quality of life, but they are often underdiagnosed. Objective: The aim of this study was to review contemporary and multidisciplinary approaches to non-motor symptoms in Parkinson's disease, highlighting the main points and scientific gaps. Materials and Methods: This is a narrative review of the literature on the non-motor symptoms of Parkinson's disease. The PICO strategy was used to develop the guiding question. In addition, the descriptors “Parkinson's Disease”; “Complications”; “Propaedeutics” were cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (VHL) databases. Results and Discussion: The studies show that the non-motor symptoms of Parkinson's disease present a varied spectrum of manifestations, ranging from sleep disorders to those related to the sensory system. Conclusion: The non-motor symptoms of Parkinson's disease play a central role in the progression of the disease and the impact on patients' quality of life. These symptoms result from neurodegeneration in various areas of the central and peripheral nervous system, highlighting the complexity of the disease. Thus, the recognition and effective management of non-motor symptoms are fundamental to improving prognosis.
References
Bang, Y., Lim, J., & Choi, H. J. (2021). Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: clues to early diagnosis and effective treatment. Archives of pharmacal research, 44, 588-604.
Bhome, R., Thomas, G. E. C., Zarkali, A., & Weil, R. S. (2023). Structural and Functional Imaging Correlates of Visual Hallucinations in Parkinson’s Disease. Current Neurology and Neuroscience Reports, 23(6), 287-299.
Bloem, B. R., Okun, M. S., & Klein, C. (2021). Parkinson's disease. The Lancet, 397(10291), 2284-2303.
Brum, C. D., Zuge, S. S., Rangel, R. F., Freitas, H. D., & Pieszak, G. M. (2015). Revisão narrativa da literatura: aspectos conceituais e metodológicos na construção do conhecimento da enfermagem. Metodologias da pesquisa para a enfermagem e saúde: da teoria à prática. Porto Alegre: Moriá.
Chen, Z., Li, G., & Liu, J. (2020). Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment. Neurobiology of disease, 134, 104700.
Chung, S. J., Lee, J. J., Ham, J. H., Ye, B. S., Lee, P. H., & Sohn, Y. H. (2016). Striatal dopamine depletion patterns and early non-motor burden in Parkinsons disease. PLoS One, 11(8), e0161316.
Cong, S., Xiang, C., Zhang, S., Zhang, T., Wang, H., & Cong, S. (2022). Prevalence and clinical aspects of depression in Parkinson’s disease: a systematic review and meta‑analysis of 129 studies. Neuroscience & Biobehavioral Reviews, 141, 104749.
Durcan, R., Wiblin, L., Lawson, R. A., Khoo, T. K., Yarnall, A. J., Duncan, G. W., ... & ICICLE‐PD Study Group. (2019). Prevalence and duration of non‐motor symptoms in prodromal Parkinson's disease. European journal of neurology, 26(7), 979-985.
Engels, G., Douw, L., Kerst, Y., Weinstein, H., Scherder, E., & Vlaar, A. (2019). Non-motor symptoms in Parkinson's disease: An explorative network study. Parkinsonism & related disorders, 66, 237-240.
Grażyńska, A., Urbaś, W., Antoniuk, S., Adamczewska, K., Bień, M., Chmiela, T., & Siuda, J. (2020). Comparative analysis of non-motor symptoms in patients with Parkinson’s Disease and atypical parkinsonisms. Clinical neurology and neurosurgery, 197, 106088.
Henderson, V. W. (2022). Sleep duration, insomnia, and Parkinson disease. Menopause, 29(3), 251-252.
Hoang, D. T., Xing, F., Nguyen, T. D., Nguyen, T. D., Tran, T. N., Nhu, S. D., ... & Truong, D. (2023). Pain is common in early onset Parkinson's disease and pain severity is associated with age and worsening of motor and non-motor symptoms. Journal of the Neurological Sciences, 455, 122784.
Kurita, A., Koshikawa, H., Akiba, T., Seki, K., Ishikawa, H., & Suzuki, M. (2020). Visual hallucinations and impaired conscious visual perception in Parkinson disease. Journal of geriatric psychiatry and neurology, 33(6), 377-385.
LeWitt, P. A., & Chaudhuri, K. R. (2020). Unmet needs in Parkinson disease: Motor and non-motor. Parkinsonism & Related Disorders, 80, S7-S12.
Marinus, J. et al. Risk factors for non-motor symptoms in Parkinson's disease. The Lancet Neurology, 17(6), 559-568, 2018.
Pfeiffer, R. F. (2016). Non-motor symptoms in Parkinson's disease. Parkinsonism & related disorders, 22, S119-S122.
Silva, A. B. R. L., de Oliveira, R. W. G., Diógenes, G. P., de Castro Aguiar, M. F., Sallem, C. C., Lima, M. P. P., ... & Dos Santos, J. C. C. (2023). Premotor, nonmotor and motor symptoms of Parkinson's disease: a new clinical state of the art. Ageing research reviews, 84, 101834.
Teive, H. A., Bertucci Filho, D. C., & Munhoz, R. P. (2016). Unusual motor and non-motor symptoms and signs in the early stage of Parkinson’s disease. Arquivos de Neuro-Psiquiatria, 74, 781-784.
Tolosa, E., Garrido, A., Scholz, S. W., & Poewe, W. (2021). Challenges in the diagnosis of Parkinson's disease. The Lancet Neurology, 20(5), 385-397.
Zhang, W. S., Gao, C., Tan, Y. Y., & Chen, S. D. (2021). Prevalence of freezing of gait in Parkinson’s disease: a systematic review and meta-analysis. Journal of neurology, 268, 4138-4150.
Zuzuárregui, J. R. P., & During, E. H. (2020). Sleep issues in Parkinson's disease and their management. Neurotherapeutics, 17(4), 1480-1494.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Isabelly Barra Ottoni; Paula Monique Mendes Reis; Jorge Gelvane Tostes
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
