Gastroesophageal Reflux Disease in children – clinical picture, diagnostic methods, and treatment: A literature review
DOI:
https://doi.org/10.33448/rsd-v13i11.47345Keywords:
Gastroesophageal Reflux; Child health; Diagnostic procedures; Fundoplication.Abstract
Gastroesophageal reflux disease (GERD) is a common condition in children, characterized by the abnormal reflux of gastric contents, with variable presentations depending on age, and with potential clinical complications. This study aims to review the literature on gastroesophageal reflux disease in children, its diagnostic methods and available treatments. In addition, it is intended to be the final work of the Medical Residency in Pediatric Surgery at the State University of Piauí (UESPI). The methodology included the search for articles in databases such as PubMed, Scielo, Medline and Cochrane Library, using keywords related to the topic. Studies in Portuguese and English were selected, including original articles, systematic reviews and clinical guidelines. Exclusion criteria were applied to discard case reports and studies focusing on adults. The results indicated that the main symptoms of GERD in children vary according to age, including regurgitation, irritability, abdominal pain and respiratory difficulties. The most used diagnostic methods are esophageal pH monitoring and endoscopy, while treatment includes dietary measures, proton pump inhibitors, and surgery in severe cases. The study concluded that although there have been advances in the understanding and management of GERD in children, challenges remain, such as accurate diagnosis in atypical cases and choosing the most appropriate treatment for each age group. Further research is recommended to address these gaps and improve the effectiveness of therapeutic interventions.
References
Argon, M., Yılmaz, A., & Işık, G. (2006). Relação entre esvaziamento gástrico e refluxo gastroesofágico em bebês e crianças. Medicina Nuclear Clínica, 31 (5), 262-265.
Ayerbe, J. I. G., Hauser, B., Salvatore, S., & Vandenplas, Y. (2019). Diagnosis and management of gastroesophageal reflux disease in infants and children: From guidelines to clinical practice. Pediatric Gastroenterology, Hepatology & Nutrition, 22(2), 107. https://doi.org/10.5223/pghn.2019.22.2.107
Benninga, M. A., Nurko, S., Faure, C., Hyman, P. E., St. James Roberts, I., & Schechter, N. L. (2016). Childhood functional gastrointestinal disorders: Neonate/toddler. Gastroenterology, 150(6), 1443-1455.e2. https://doi.org/10.1053/j.gastro.2016.02.016
Ferguson, T. D. (2018). Gastroesophageal reflux. Critical Care Nursing Clinics of North America, 30(1), 167–177. https://doi.org/10.1016/j.cnc.2017.10.015
Fisher, R.S., Harker, L.A, & Johnson, L.F. (1976). Cintilografia gastroesofágica (GE) para detectar e quantificar refluxo GE. Gastroenterologia, 70(3), 301-308.
Fonkalsrud, E.W., Parikh, D.H., & McGowan, J.R. (1998). Tratamento cirúrgico do refluxo gastroesofágico em crianças: Um estudo hospitalar combinado de 7467 pacientes. Pediatrics, 101 (3), 419-422. https://doi.org/10.1542/peds.101.3.419
Friedman, C., Sarantos, G., Katz, S., & Geisler, S. (2021). Understanding gastroesophageal reflux disease in children. JAAPA: Official Journal of the American Academy of Physician Assistants, 34(2), 12–18. https://doi.org/10.1097/01.jaa.0000731488.99461.39
Gil, A.C. (2008). Métodos e técnicas de pesquisa social (6ª ed.). Atlas. ISBN 978-85-224-5142-5.
Jolley, S. G, Scott, A., & Langer, J. C. (1990). Procedimentos antirrefluxo para refluxo grave em crianças com deficiências do neurodesenvolvimento: Uma comparação de fundoplicatura de Nissen com e sem jejunostomia de alimentação. Journal of Pediatric Surgery, 25(10), 992-995. https://doi.org/10.1016/0022-3468(90)90541-7
Krishnan, U., Shaker, R., & Kauffman, H. (2019). Refluxo gastroesofágico e esofagite em crianças: da infância à adolescência. Annals of the New York Academy of Sciences, 1455(1), 87-98. https://doi.org/10.1111/nyas.14107
Leung, A. K. C., & Hon, K. L. (2019). Gastroesophageal reflux in children: an updated review. Drugs in context, 8, 1–12. https://doi.org/10.7573/dic.212591
Lightdale, J. R., Gremse, D. A., Section Of Gastroenterology, Hepatology, and Nutrition, Heitlinger, L. A., Cabana, M., Gilger, M. A., Gugig, R., & Hill, I. D. (2013). Gastroesophageal reflux: Management guidance for the pediatrician. Pediatrics, 131(5), e1684–e1695. https://doi.org/10.1542/peds.2013-0421
Marconi, M. de A., & Lakatos, E.M. (2003). Fundamentos de metodologia científica (5ª ed.). Atlas.
Mousa, H., & Hassan, M. (2017). Gastroesophageal reflux disease. Pediatric Clinics of North America, 64(3), 487–505. https://doi.org/10.1016/j.pcl.2017.01.003
Oliveira, R.F, & Almeida, T.M (2019). Limitações da seriografia no diagnóstico de refluxo gastroesofágico em pediatria. Revista de Pediatria, 45(3) 213-218.
Orenstein, S. R., Shalaby, T. M., Finch, R., Pfuetzer, R. H., DeVandry, S., Chensny, L. J., Barmada, M. M., & Whitcomb, D. C. (2002). Autosomal dominant infantile gastroesophageal reflux disease: exclusion of a 13q14 locus in five well characterized families. The American Journal of Gastroenterology, 97(11), 2725–2732. https://doi.org/10.1111/j.1572-0241.2002.07060.x
Papachrisanthou, M. M., & Davis, R. L. (2015). Clinical practice guidelines for the management of gastroesophageal reflux and gastroesophageal reflux disease: Birth to 1 year of age. Journal of Pediatric Health Care: Official Publication of National Association of Pediatric Nurse Associates & Practitioners, 29(6), 558–564. https://doi.org/10.1016/j.pedhc.2015.07.009
Quitadamo, P., Papadopoulou, A., Wenzl, T., Urbonas, V., Kneepkens, C. M. F., Roman, E., Orel, R., Pavkov, D. J., Dias, J. A., Vandenplas, Y., Kostovski, A., Miele, E., Villani, A., & Staiano, A. (2014). European pediatricians’ approach to children with GER symptoms: Survey of the implementation of 2009 NASPGHAN-ESPGHAN guidelines. Journal of Pediatric Gastroenterology and Nutrition, 58(4), 505–509. https://doi.org/10.1097/mpg.0b013e3182a69912
Rodrigues, J.F., et al. (2020). A importância da seriografia no diagnóstico de refluxo gastroesofágico em pediatria. Revista Brasileira de Gastroenterologia, 32(2) 123-130.
Rosen, R., Vandenplas, Y., Singendonk, M., Cabana, M., DiLorenzo, C., Gottrand, F., Gupta, S., Langendam, M., Staiano, A., Thapar, N., Tipnis, N., & Tabbers, M. (2018). Pediatric gastroesophageal reflux clinical practice guidelines: Joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 66(3), 516–554. https://doi.org/10.1097/mpg.0000000000001889
Rother, E.T. (2007). Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, 20(2), v-vi. https://doi.org/10.1590/S0103 -21002007000200001
Salvatore, S., Agosti, M., Baldassarre, M. E., D’Auria, E., Pensabene, L., Nosetti, L., & Vandenplas, Y. (2021). Cow’s milk allergy or gastroesophageal reflux disease can we solve the dilemma in infants? Nutrients, 13(2), 297. https://doi.org/10.3390/nu13020297
Silva, J.R., et al. (2021). Ultrassonografia abdominal na avaliação do refluxo gastroesofágico em crianças. Revista Brasileira de Pediatria, 67(3) 345-352.
Silva, T. A., & Santos, M. P. (2019) Seriografia como método diagnóstico para refluxo gastroesofágico em crianças. Jornal de Pediatria e Gastroenterologia, 28(1), 45-50.
Sullivan, J. S., & Sundaram, S. S. (2012). Gastroesophageal reflux. Pediatrics in Review, 33(6), 243–254. https://doi.org/10.1542/pir.33-6-243
Tighe, M., Afzal, N. A., Bevan, A., Hayen, A., Munro, A., & Beattie, R. M. (2014). Pharmacological treatment of children with gastro-oesophageal reflux. The Cochrane Library, 2016(11). https://doi.org/10.1002/14651858.cd008550.pub2
Tuncel, M., Kiratli, P. Ö., Aksoy, T., & Bozkurt, M. F. (2011). Gastroesophageal reflux scintigraphy: interpretation methods and inter-reader agreement. World Journal of Pediatrics: WJP, 7(3), 245–249. https://doi.org/10.1007/s12519-011-0322-4
Turco, R., Ummarino, D., & Staiano, A. (2017). Barium contrast radiography and scintigraphy. Em Esophageal and Gastric Disorders in Infancy and Childhood (p. 925–934). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_80
Vandenplas, Y., & Hauser, B. (2015). An updated review on gastro-esophageal reflux in pediatrics. Expert Review of Gastroenterology & Hepatology, 9(12), 1511–1521. https://doi.org/10.1586/17474124.2015.1093932
Vandenplas, Y., Rudolph, C. D., Committee Members: Di Lorenzo, C., Hassall, E., Liptak, G., Mazur, L., Sondheimer, J., Staiano, A., Thomson, M., Veereman-Wauters, G., & Wenzl, T. G. (2009). Pediatric gastroesophageal reflux clinical practice guidelines: Joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Journal of Pediatric Gastroenterology and Nutrition, 49(4), 498–547. https://doi.org/10.1097/mpg.0b013e3181b7f563
Ward, R. M., & Kearns, G. L. (2013). Proton pump inhibitors in pediatrics: Mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatric Drugs, 15(2), 119–131. https://doi.org/10.1007/s40272-013-0012-x
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Francisco Tiago de Sousa Amaral; Láyla Lorrana de Sousa Costa; Bruno Pinheiro Falcão
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.