Characterization of iatrogenic polypharmacy in the elderly as a public health problem: A literature review
DOI:
https://doi.org/10.33448/rsd-v13i12.47605Keywords:
Polymedication; Elderly; Iatrogenic disease.Abstract
Introduction: Iatrogenic is defined as any pathological modification, adverse effect, or complication caused in patients by healthcare professionals. Conversely, aging involves physical, psychological, social, and environmental changes. The continuous and simultaneous use of five or more medications by a single elderly patient (polypharmacy) constitutes a public health issue and should be consistently studied in this population. Objectives: To correlate polypharmacy with iatrogenic in the elderly in Brazil and characterize it as a public health issue, assessing its impact on quality of life, analyzing its recurrence and predisposing risk factors, and discussing its main complications. Methodology: This study is a literature review conducted through a bibliographic survey on PubMed, VHL (Virtual Health Library), SciELO (Scientific Electronic Library Online), and Lilacs (Latin American and Caribbean Health Sciences Literature) platforms. Publications were selected in Portuguese, English, or Spanish, between 2019 and 2023, using the descriptors "Aged," "iatrogenic disease," "Anti-inflammatory Agents," and "public health," combined through the Boolean operator “AND.” Results: Polypharmacy has become increasingly common and is associated with various health issues, including falls, cognitive impairments, depression, malnutrition, resistant infections, mobility loss, auditory and visual difficulties, dizziness, and even premature death. Conclusion: It can be concluded that iatrogenic caused by polypharmacy is preventable, and rational drug use should be promoted. Furthermore, the biological vulnerability of the elderly must be studied and disseminated to mitigate these risks.
References
Andrade, S. C. V., et al. (2020). Health profile of older adults assisted by the Elderly Caregiver Program of Health Care Network of the City of São Paulo. Einstein (São Paulo), 18, eAO5263.
Beinse, G., et al. (2019). Potential drug-drug interactions and risk of unplanned hospitalization in older patients with cancer: A survey of the prospective ELCAPA (ELderly CAncer PAtients) cohort. Journal of Geriatric Oncology, 10(10), 1010–6.
Carvalho, G. A. O., et al. (2020). Oral manifestations arising from polypharmacy in the elderly of a public shelter in Teresina – Piauí. Research, Society and Development, 9(7), 1–11.
Chaves, M. R. R., et al. (2020). Farmacovigilância em idosos: observações acerca de prática de polifarmácia. Brazilian Journal of Development, 6(11), 87568–78.
Correia, W., & Teston, A. P. M. (2020). Aspectos relacionados à polifarmácia em idosos: Um estudo de revisão. Brazilian Journal of Development, 6(11), 93454–69.
Crossetti, M. G. M. (2012). Revisión integradora de la investigación en enfermería el rigor científico que se le exige. Rev. Gaúcha Enferm. 33(2):8-9.
Damaceno, M. J. C. F., & Chirelli, M. Q. (2019). Implementação da Saúde do Idoso na Estratégia Saúde da Família: Visão dos profissionais e gestores. Ciência & Saúde Coletiva, 24, 1637–46.
Farias, N. A. S., & Rodrigues, R. V. (2022). A influência da polifarmácia em idosos adstritos de uma unidade de saúde da família de Porto Velho–RO. Brazilian Journal of Development, 8(4), 27459–88.
Galvão, A. K. A. A. (2023). Controle dos sintomas com idosos hospitalizados em cuidados paliativos: Estratégia centrada na pessoa idosa (Dissertação de Mestrado). Universidade Federal de Pernambuco.
IBGE – Instituto Brasileiro de Geografia e Estatística. (2020). Demográfico Censo. http://www.ibge.gov.br/censo
Júnior, D. C., et al. (2020). Ocorrência e riscos de iatrogenia em idosos: Uma revisão integrativa. Revista CPAQV – Centro de Pesquisas Avançadas em Qualidade de Vida, 12, 2.
Marques, P. P., et al. (2019). Polypharmacy in community-based older adults: Results of the Fibra study. Revista Brasileira de Geriatria e Gerontologia, 22(5), 1–16.
Mattos, P. C. (2015). Tipos de revisão de literatura. Unesp, 1-9. https://www.fca.unesp.br/Home/Biblioteca/tipos-de-evisao-de-literatura.pdf.
Maués, C. R., et al. (2019). Análise do uso de medicamentos em idosos. Revista Eletrônica Acervo Saúde, 2(34), e1356.
Mayer, R. F. (2023). Associação entre variáveis de estilo de vida e sociodemográficas com a condição de multimorbidade: Evidências para a população adulta brasileira. Dissertação (Mestrado) Programa de PósGraduação Stricto Sensu em Ciências da Saúde da Escola de Ciências da Vida, da Pontifícia Universidade Católica de Campinas.
Medeiros, M. G. M., et al. (2020). Implications of polypharmacy in elderly and the important role of pharmaceutical in this process. Brazilian Journal of Development, 6(5), 23391–4404.
Mercadante, A. C. C., et al. (2021). Fatores determinantes da polifarmácia entre idosos residentes em um grande centro urbano da região sudeste do Brasil. Revista Valore, 6(4), 167–82.
Oliveira, H. S. B., & Manso, M. E. G. (2019). The iatrogenic triad in a group of elderly women contracted to a health plan. Revista Brasileira de Geriatria e Gerontologia, 22(1), 1–15.
Oliveira, P. C., et al. (2021). Prevalência e fatores associados à polifarmácia em idosos atendidos na atenção primária à saúde em Belo Horizonte-MG, Brasil. Ciência & Saúde Coletiva, 26(4), 1553–64.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Romano-Lieber, N. S., et al. (2019). Sobrevida de idosos e exposição à polifarmácia no município de São Paulo: Estudo SABE. Revista Brasileira de Epidemiologia, 21(2). https://doi.org/10.1590/1980-549720180006.supl.2.
Sales, W. B., et al. (2023). Relação da iatrogenia e polifarmácia em idosos: Uma revisão integrativa. Revista Arquivos Científicos (IMMES), 6(1), 1–8.
Scursel, C. (2021). Multimorbidity and polypharmacy in elderly residents in the rural perimeter of the municipality of Seara-SC. Brazilian Journal of Development, 7(11), 7308–7323.
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-9.
Solis, M. Y. (2021). Nutrição e exercício no envelhecimento e nas doenças crônicas. Editora Senac São Paulo.
Theis, L. C., & Gouvêa, D. L. (2019). Percepção dos idosos em relação à vida sexual e as infecções sexualmente transmissíveis na terceira idade. Revista Brasileira de Ciências da Saúde, 197–204.
Tinôco, E. E. A., et al. (2021). Polifarmácia em idosos: Consequências de polimorbidades. Braz. J. Surg. Clin. Res., 35(2), 79–85.
Zerah, L., et al. (2020). Iatrogenesis and neurological manifestations in the elderly. Revista Neurológica, 176(19), 710–23.
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Copyright (c) 2024 Cyntya Halynne Ferreira da Ponte; André Luiz Oliveira Poleto; Karina Meneses Fortes Castelo Branco ; Emerson Alcantara de Sousa Filho ; Edmara Nayara Ferreira Cunha; Nadia Prospero de Santana ; José Lopes Pereira Junior
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