Neurotuberculosis as a complication of miliary tuberculosis in a vaccinated infant: Case report
DOI:
https://doi.org/10.33448/rsd-v13i12.47853Keywords:
Tuberculosis; Miliary tuberculosis; Neurotuberculosis; Pediatrics.Abstract
Tuberculosis (TB) is a disease of public importance, representing a frequent cause of death in all age groups. Caused by Mycobacterium tuberculosis, affecting humans pulmonary or extrapulmonary, as well as by hematogenous dissemination affecting multiple organs, receiving the name Miliary Tuberculosis. It gets its name from the radiological pattern, and in many cases is fatal if not diagnosed and treated properly. The goal is to report a case of miliary tuberculosis in an infant and with a positive contact in the pediatrics service of the Hospital Universitário Maria Aparecida Pedrossian (HUMAP). This is an observational, descriptive and reflective case report. Data were obtained through electronic medical records, after approval by the Research Ethics Committee. Patient 7 months old referred due to radiographic findings suggestive of miliary TB. During hospitalization, mother and patient received a confirmed diagnosis of TB. During treatment, the patient developed neurological impairment and was diagnosed with neurotuberculosis, developing permanent neurological sequelae. Furthermore, he was able to receive medical discharge following outpatient follow-up. It is concluded that TB is a disease of public importance, and its prevalence in the pediatric population is directly proportional to the efficiency of health actions.
References
Almeida, C. C. da C., Quinderé, J. A., & Schmitt, I. A. M. (2023). Perfil epidemiológico de tuberculose infantil no Brasil – um estudo retrospectivo. Brazilian Journal of Health Review, 6(5), 25708–25722. https://doi.org/10.5935/2346-019X.20230031
Borille, B. T., Rodrigues, A. V., Gonçalves, R., & Martinello, F. (2013). Tuberculous meningitis: A case report of a late diagnosis. Revista de Ciências Médicas e Biológicas, 12(1), 127–130. https://doi.org/10.9771/cmbio.v12i1.30347
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. (2010). Doenças infecciosas e parasitárias: Guia de bolso (8. ed.). Ministério da Saúde.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2018). Programa Nacional de Controle da Tuberculose.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2019). Manual de recomendações para o controle da tuberculose no Brasil (2. ed.). Ministério da Saúde.
Brasil. Sociedade Brasileira de Pneumologia e Tisiologia. (2009). III Diretrizes para Tuberculose da Sociedade Brasileira de Pneumologia e Tisiologia. Jornal Brasileiro de Pneumologia, 3, 1018–1048.
Chakaya, J., Khan, M., Ntoumi, F., & others. (2021). The WHO Global Tuberculosis 2021 report – not so good news and turning the tide back to End TB. International Journal of Infectious Diseases, 124, 1–3. https://doi.org/10.1016/j.ijid.2021.09.005
Ilyas, U., Azam, S. S., & Khan, S. A. (2022). Miliary tuberculosis: A case report highlighting the diagnostic challenges associated with the condition. Cureus, 14(9), e29339. https://doi.org/10.7759/cureus.29339
Loscalzo, J., Fauci, A. S., Kasper, D. L., Hauser, S. L., & Longo, D. L. (2021). Harrison: Medicina Interna (15. ed.). McGraw-Hill.
Montenegro, A. X. C. B., Oliveira, C. A. B., & Silva, R. A. (2018). Neurotuberculose em paciente imunocompetente: Desafio diagnóstico e tratamento. Revista de Medicina, 97(6), 581–584. https://doi.org/10.15343/0101-8890.2018976858584
Nakao, A., Naito, M., & Inoue, K. (2016). Disseminated tuberculosis with acute respiratory distress syndrome lacking granuloma formation in the lung. Journal of Infection and Chemotherapy, 22, 638–641. https://doi.org/10.1016/j.jiac.2016.04.003
Pereira, S. M., Almeida, M. G., & Goulart, D. A. (2007). Vacina BCG contra tuberculose: Efeito protetor e políticas de vacinação. Revista de Saúde Pública, 41(1), 59–66. https://doi.org/10.1590/S0034-89102007000100009
Sharma, S. K., & Mohan, A. (2016). Miliary tuberculosis. Microbiology Spectrum, 5(2). https://doi.org/10.1128/microbiolspec.TNMI7-0032-2016
Silva, M. E. N. S., Almeida, A. C. P., & Lima, S. M. (2018). Aspectos gerais da tuberculose: Uma atualização sobre o agente etiológico e o tratamento. RBAC, 50(3), 228–232. https://doi.org/10.5935/1676-1839.20180016
Trunz, B. B., Fine, P., & Dye, C. (2006). Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: A meta-analysis and assessment of cost-effectiveness. Lancet, 367(9517), 1173–1180. https://doi.org/10.1016/S0140-6736(06)68487-8
World Health Organization. (2014). Global tuberculosis report 2014. World Health Organization.
World Health Organization. (2021). Global tuberculosis report 2021. World Health Organization.
Zhu, J., Zhao, X., & Wang, W. (2023). Case report: Miliary tuberculosis complicated by pediatric acute respiratory distress syndrome in a 12-year-old girl. Frontiers in Pediatrics. https://doi.org/10.3389/fped.2023.877147
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Renan Galleno Pinto Rocha; Ana Lucia Lyrio de Oliveira Tognini; Natalia Comparin Anache
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.