Integration between asthma and gastroesophageal reflux disease mediated by bronchial hyperreactivity
DOI:
https://doi.org/10.33448/rsd-v14i2.48114Keywords:
Asthma; Gastroesophageal reflux disease; Pathophysiology.Abstract
Introduction: Asthma is one of the most prevalent atopic diseases in the world and its connection with gastroesophageal reflux disease (GERD) has become a relevant object of research in the contemporary medical scenario. Objective: The aim of this study was to characterize the pathophysiological mechanisms that integrate asthma and GERD, especially bronchial hyperresponsiveness, by building knowledge based on robust literature reviews. Materials and Methods: This is an integrative literature review on the general clinical characteristics of the pathophysiological correlation between asthma and gastroesophageal reflux disease. The PICO strategy was used to develop the guiding question. In addition, the descriptors “Asthma”; “Gastroesophageal Reflux Disease”; “Pathophysiology” were cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (VHL) databases. Results and Discussion: The studies show some evidence that corroborates the integration between the pathophysiological mechanisms of the diseases, hypothesizing that there is a feedback loop between the pathologies, where one can provoke and exacerbate the other. In particular, bronchial hyperresponsiveness, the microaspiration theory and the theory of pressure changes resulting from bronchoconstriction are the ones that best support this integration. Conclusion: There is a clear pathophysiological integration between the diseases; however, it has not yet been possible to use this knowledge to establish a propaedeutic consensus to improve the prognosis of asthmatic patients with GERD or vice versa.
References
Althoff, M. D., Ghincea, A., Wood, L. G., Holguin, F., & Sharma, S. (2021). Asthma and three colinear comorbidities: obesity, OSA, and GERD. The Journal of Allergy and Clinical Immunology: In Practice, 9(11), 3877-3884.
Althoff, M. D., & Sharma, S. (2023). Gastroesophageal reflux, atopic dermatitis, and asthma: finally evidence for causal links?. American Journal of Respiratory and Critical Care Medicine, 207(2), 117-118.
Alves, J. C. A. de O. (2017). Associação entre doença do refluxo gastroesofágico (DRGE) e asma: Revisão bibliográfica. [Trabalho de conclusão de curso, Centro Universitário de Brasília].
Benedictis, F. M., & Bush, A. (2018). Respiratory manifestations of gastro-oesophageal reflux in children. Archives of disease in childhood, 103(3), 292-296.
Bortoli, V. F., de Oliveira, G. A., Zonin, J. M., da Silva, L. N. A., Nunes, P. L. P., & Sinhorin, Y. N. (2021). Doença do refluxo gastroesofágico-uma revisão da literatura Gastroesophageal reflux disease-a review of the literature. Brazilian Journal of Health Review, 4(3), 14245-14253.
Brew, B. K., Almqvist, C., Lundholm, C., Andreasson, A., Lehto, K., Talley, N. J., & Gong, T. (2022). Comorbidity of atopic diseases and gastro‐oesophageal reflux: evidence of a shared cause. Clinical & Experimental Allergy, 52(7), 868-877.
Broers, C., Tack, J., & Pauwels, A. (2018). gastro‐oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Alimentary pharmacology & therapeutics, 47(2), 176-191.
Eugenia, Y. (2018). Interplay between asthma and gastroesophageal reflux disease: A controversial issue. Arch. Asthma Allergy Immunol, (2), 6.
Gong, T., Kuja-Halkola, R., Harder, A., Lundholm, C., Smew, A. I., Lehto, K., ... & Brew, B. K. (2024). Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases. Communications Biology, 7(1), 1077.
Grandes, X. A., Manjunatha, R. T., Habib, S., Sangaraju, S. L., & Yepez, D. (2022). Gastroesophageal reflux disease and asthma: A Narrative Review. Cureus, 14(5).
Griffiths, T. L., Nassar, M. A., & Soubani, A. O. (2020). Pulmonary manifestations of gastroesophageal reflux disease. Expert Review of Respiratory Medicine, 14(8), 767-775.
Guimarães, I. M. F., Corrêa, L. S. G., & Ferraz, A. R. (2022). Doença do Refluxo Gastroesofágico: revisão de literatura. Revista Eletrônica Acervo Médico, 15, e10828-e10828.
Guimarães, A. C. C. M., Ribeiro Filho, M. N., Silva, A. C. P., de Almeida Cunha, J., da Silva Neto, J. T., de Paula, L. R. F., ... & de Carvalho, N. R. (2024). Diagnóstico e tratamento da asma: uma revisão de literatura. Brazilian Journal of Implantology and Health Sciences, 6(8), 5230-5240.
Hait, E. J., & McDonald, D. R. (2019). Impact of gastroesophageal reflux disease on mucosal immunity and atopic disorders. Clinical reviews in allergy & immunology, 57(2), 213-225.
Kim, S. Y., Kim, H. R., Min, C., Oh, D. J., Park, B., & Choi, H. G. (2020). Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort. Pediatric Research, 88(2), 320-324.
Košec, A., Žaja, O., Matovinović, F., Jelavić, B., & Baudoin, T. (2020). Significance of Extra-Esophageal Symptoms in Pediatric Gastroesophageal Reflux Disease. International archives of otorhinolaryngology, 24(04), 472-476.
Lupu, V. V., Miron, I., Tarca, E., Trandafir, L. M., Anton-Paduraru, D. T., Moisa, S. M., ... & Lupu, A. (2022). Gastroesophageal reflux in children with asthma. Children, 9(3), 336.
Mallah, N., Turner, J. M., González‐Barcala, F. J., & Takkouche, B. (2022). Gastroesophageal reflux disease and asthma exacerbation: A systematic review and meta‐analysis. Pediatric Allergy and Immunology, 33(1), e13655.
Pacheco, A. (2018). The relationship between asthma and gastro-esophageal reflux. Reflux Aspiration and Lung Disease, 137-164.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Richter, J. E., & Rubenstein, J. H. (2018). Presentation and epidemiology of gastroesophageal reflux disease. Gastroenterology, 154(2), 267-276.
Rodrigues, E. B. S., Júnior, C. N. C., Pissolato, M. L. R., & de Sousa Flizikowski, R. T. (2024). Doença do refluxo gastroesofágico: uma revisão da literatura. Journal Archives of Health, 5(3), e2199-e2199.
Santini, J. X., Couto, L. C., Besagio, B. P., de Andrade, E. C., Cardoso, G. G., Bonadio, A. C., & de Carvalho, F. B. (2023). Asma brônquica: uma revisão de literatura. Brazilian Journal of Health Review, 6(4), 18355-18365.
Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.
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Copyright (c) 2025 Bruno Luís Silva; Bruna Espadinha Rossi de Barros; Luiza Albuquerque Miqueri da Costa; Maria Victoria Delmonte Dias da Motta; Arthur Moura de Matos; Pedro Henrique Lara Oliveira de Carvalho; João Aluizio Pimentel; João Ferreira Santos; Larah Lisier de Lima Palmeira Reis; Christopher Boaventura de Couto Ferreira; Júlia Cerize Kolling; João Gabriel Bruzadelli Barbosa
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