Epidemiological profile of sepsis hospitalization in the Southern Region from 2019 to 2023: A cross-sectional study
DOI:
https://doi.org/10.33448/rsd-v14i5.48873Keywords:
Sepsis; Early diagnosis; Septic shock; Mortality; Public Health.Abstract
Sepsis is an inappropriate response of the body to infections, which can lead to multiple organ failure. Early detection and rapid intervention are essential to reduce the mortality associated with this condition. This study aimed to analyze the epidemiological profile of patients hospitalized due to sepsis in the southern region of Brazil, using data from the SUS Hospital Morbidity Information System (SIH/SUS) covering the period from 2019 to 2023. The research was quantitative, descriptive, and deductive in nature, conducted through a cross-sectional and retrospective analysis. The data were tabulated and analyzed in Excel, with the creation of tables and graphs to represent the distribution by age group, gender, and race. The results showed that 2023 had the highest incidence of hospitalizations due to sepsis, followed by 2022, with a predominance of white patients (77.2%), male patients (51.5%), and those in the 70 to 79 age group (21.8%). Over the five-year period, 135,618 hospitalizations were recorded in the region, indicating a high occurrence of the disease, which is often underestimated. It is concluded that the increase in sepsis incidence, especially in the post-pandemic years, underscores the need for ongoing studies and preventive measures to reduce the mortality and morbidity associated with the disease.
References
Almeida, N. R. C. de, Pontes, G. F., Jacob, F. L., Deprá, J. V. S., Porto, J. P. P., Lima, F. R. de, & Albuquerque, M. R. T. C. de. (2022). Análise de tendência de mortalidade por sepse no Brasil e por regiões de 2010 a 2019. Revista de Saúde Pública, 56, 25. https://doi.org/10.11606/s1518-8787.2022056003789
Ayar, A., et al. (2008). A multicentre, prospective study to evaluate costs of septic patients in Brazilian intensive care units. Pharmacoeconomics, 26(5), 425–434.
Barreto, M. F. C., Dellaroza, M. S. G., Kerbauy, G., & Grion, C. M. C. (2016). Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization. Revista da Escola de Enfermagem da USP, 50(2), 0302–0308. https://doi.org/10.1590/S0080-623420160000200017
Barros, L. L. dos S., Maia, C. do S. F., & Monteiro, M. C. (2016). Fatores de risco associados ao agravamento de sepse em pacientes em Unidade de Terapia Intensiva. Cadernos de Saúde Coletiva, 24(4), 388–396. https://doi.org/10.1590/1414-462X201600040091
Dias, F. S. (2017). Sepsis definitions. Revista Brasileira de Terapia Intensiva, 29(4), 520–521. https://doi.org/10.5935/0103-507X.20170074
Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2023). Immunology of aging: the birth of inflammaging. Clinical Reviews in Allergy & Immunology, 64(2), 109–122. https://doi.org/10.1007/s12016-021-08899-6
Gil, A. C. (2017). Como elaborar projetos de pesquisa (6ª ed.). Editora Atlas.
Li, J., Pu, S., Shu, L., Guo, M., & He, Z. (2024). Identification of diagnostic candidate genes in COVID-19 patients with sepsis. Immunity, Inflammation and Disease, 12(10), e70033. https://doi.org/10.1002/iid3.70033
Macedo Júnior, A. M. de, & Gomes, J. T. (2020). Perfil epidemiológico dos óbitos ocasionados pela septicemia na região Nordeste do Brasil, estado do Rio Grande do Norte – RN. Revista Nordestina de Biologia, 28(1). https://doi.org/10.22478/ufpb.2236-1480.2020v28n1.53198
Ministério da Saúde. (2023). Dia Mundial da Sepse: Brasil tem alta taxa de mortalidade por sepse entre os países em desenvolvimento. https://www.gov.br/ebserh/pt-br/hospitais-universitarios/regiao-sudeste/hu-ufjf/comunicacao/noticias/2023/dia-mundial-da-sepse-brasil-tem-alta-taxa-de-mortalidade-por-sepse-dentre-os-paises-em-desenvolvimento
Moraes-Pinto, M. I., Suano-Souza, F., & Aranda, C. S. (2021). Immune system: development and acquisition of immunological competence. Jornal de Pediatria, 97(Supl. 1), S59–S66. https://doi.org/10.1016/j.jped.2020.10.006
Pereira, A. S., et al. (2018). Metodologia da pesquisa científica [Free e-book]. Editora da UAB/NTE/UFSM.
Procianoy, R. S., & Silveira, R. C. (2020). The challenges of neonatal sepsis management. Jornal de Pediatria (Rio de Janeiro), 96(Supl. 1), 80–86. https://doi.org/10.1016/j.jped.2019.10.004
Reinhart, K., Daniels, R., Kissoon, N., Machado, F. R., Schachter, R. D., & Finfer, S. (2017). Recognizing sepsis as a global health priority — A WHO Resolution. New England Journal of Medicine, 377(5), 414–417. https://doi.org/10.1056/NEJMp1707170
Rowe, T. A., & McKoy, J. M. (2017). Sepsis in older adults. Infectious Disease Clinics of North America, 31(4), 731–742. https://doi.org/10.1016/j.idc.2017.07.010
Rubio-Mora, E., Bloise-Sánchez, I., Quiles-Melero, I., Cacho-Calvo, J., & Cendejas-Bueno, E. (2025). Neonatal sepsis: Epidemiology and comparison between preterm and term newborns. Enfermedades Infecciosas y Microbiología Clínica (English Edition), 43(4), 197–204. https://doi.org/10.1016/j.eimce.2025.03.008
Santos, M. E. N. dos, Souza Neto, R. D. de, Romeu, W. R. O. G., Bezerra, G. D., Braga, S. T., & Pinheiro, W. R. (2022). O impacto econômico das internações por sepse no país. Revista Recien - Revista Científica de Enfermagem, 12(37), 115–124. https://doi.org/10.24276/rrecien2022.12.37.115-124
Santos, T. A., et al. (2023). Sepsis and COVID-19: outcomes in young adults in intensive care. Revista Brasileira de Enfermagem, 76(6), e20230037. https://doi.org/10.1590/0034-7167-2023-0037
Shitsuka, D. M., et al. (2014). Matemática fundamental para a tecnologia. Editora Érica.
Srzić, I., Nesek Adam, V., & Tunjić Pejak, D. (2022). Sepsis definition: what's new in the treatment guidelines. Acta Clinica Croatica, 61(Supl. 1), 67–72. https://doi.org/10.20471/acc.2022.61.s1.11
Vargas, A. E. A. T., et al. (2022). Sepse secundária a Covid-19: fisiopatologia e manejo clínico. Brazilian Journal of Health Review, 5(4), 13682–13692. https://doi.org/10.34119/bjhrv5n4-141
Vazquez Guillamet, M. C., Dodda, S., Liu, L., Kollef, M. H., & Micek, S. T. (2022). Race does not impact sepsis outcomes when considering socioeconomic factors in multilevel modeling. Critical Care Medicine, 50(3), 410–417. https://doi.org/10.1097/CCM.0000000000005217
World Health Organization. (2018). Sepsis: improving the prevention, diagnosis and clinical management of sepsis. https://www.who.int/sepsis/en/
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Copyright (c) 2025 Emelin Kissner; Laura Sulzbacher Dacome; Rafael Messias de Araújo; Hugo Razini Oliveira
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