Upper respiratory tract infection caused by Streptococcus pyogenes: physiopathology and diagnosis

Authors

DOI:

https://doi.org/10.33448/rsd-v9i8.6322

Keywords:

Streptococcus pyogenes; Rheumatic Fever; Arthritis; Myocarditis; Pharyngitis.

Abstract

Objective: To overview the pathophysiology of infections caused by Streptococcus pyogenes in the upper respiratory tract, their respective complications and how the microbiological diagnosis is performed. Methodology: This study was based on an integrative review of bibliographic research characterized by qualitative approach. The eletronic literature search were using PubMed and ScienceDirect-Elsevier. Articles written in Portuguese, English and Spanish with a search date between 2015 to 2020 were included. The keywords used to search the articles were: Streptococcus pyogenes AND Rheumatic Fever; Streptococcus pyogenes AND Arthritis; Streptococcus pyogenes AND Myocarditis; Streptococcus pyogenes AND Pharyngitis. A total of 2619 articles were found between both databases. 420 in PubMed and 2199 in ScienceDirect databases. At the end of the selection process, 22 articles were chosen to compose the present study. Results: For the spread of the microorganism to occur, it is necessary the interaction of the microorganism with host cells. Depending on characteristics such as pathogenicity, virulence, infectious load and infected region, the probability of invasion can increase considerably and evolve to chronic cases of acute rheumatic fever, post-streptococcal reactive arthritis and rheumatic heart disease. The gold standard for diagnosis is the culture of the oropharynx, however, there are limitations. Diagnosis alternatives are serological tests, such as Anti-streptolysin O (ASLO) and Anti-Deoxyribonuclease B (Anti-DNase B). Conclusion: Depending on the humoral or cellular immune response, the complications of a previous infection caused by S. pyogenes are alarming, since as the contagion evolves and become prominent and irreversible.

References

Edwards, R. J., Pyzio, M., Gierula, M., Turner, C. E., Abdul-Salam, V. B., & Sriskandan, S. (2018). Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenes. Scientific Reports, 8(1), 5950. https://doi.org/10.1038/s41598-018-24216-2

Hurst, J. R., Kasper, K. J., Sule, A. N., & McCormick, J. K. (2018). Streptococcal pharyngitis and rheumatic heart disease: the superantigen hypothesis revisited. Infection, Genetics and Evolution, 61, 160–175. https://doi.org/10.1016/j.meegid.2018.03.006

Imai, K., Tarumoto, N., Tachibana, H., Hanabusa, A., Sakai, J., Yokota, K., Mimura, T., & Maesaki, S. (2020). Endogenous endophthalmitis secondary to septic arthritis caused by group A Streptococcus infection: A case report and literature review. Journal of Infection and Chemotherapy, 26(1), 128–131. https://doi.org/10.1016/j.jiac.2019.06.008

Karthikeyan, G., & Guilherme, L. (2018). Acute rheumatic fever. The Lancet, 392(10142), 161–174. https://doi.org/10.1016/S0140-6736(18)30999-1

Khosravi, A. D., Ebrahimifard, N., Shamsizadeh, A., & Shoja, S. (2016). Isolation of Streptococcus pyogenes from children with pharyngitis and emm type analysis. Journal of the Chinese Medical Association, 79(5), 276–280. https://doi.org/10.1016/j.jcma.2016.01.002

Maciá, D. E., Flor Macián, E. M., Borrás, R., Poujois Gisbert, S., & Muñoz Bonet, J. I. (2018). Infección por Estreptococo pyogenes en la edad pediátrica: desde faringoamigdalitis aguda a infecciones invasivas. Anales de Pediatría, 88(2), 75–81. https://doi.org/10.1016/j.anpedi.2017.02.011

Martin, W. J., Steer, A. C., Smeesters, P. R., Keeble, J., Inouye, M., Carapetis, J., & Wicks, I. P. (2015). Post-infectious group A streptococcal autoimmune syndromes and the heart. Autoimmunity Reviews, 14(8), 710–725. https://doi.org/10.1016/j.autrev.2015.04.005

Oppegaard, O., Mylvaganam, H., Skrede, S., Jordal, S., Glambek, M., & Kittang, B. R. (2017). Clinical and molecular characteristics of infective β-hemolytic streptococcal endocarditis. Diagnostic Microbiology and Infectious Disease, 89(2), 135–142. https://doi.org/10.1016/j.diagmicrobio.2017.06.015

Reijtman, V., García, M. E., Mastroianni, A., Isasmendi, A., Pinheiro, J. L., Pérez, G., & Hernandez, C. (2020). Evaluation of a rapid diagnostic test for the detection of Streptococcus pyogenes in invasive infections. Revista Argentina de Microbiología, xx, 8–12. https://doi.org/10.1016/j.ram.2019.08.004

Sánchez-Encinales, V., Ludwig, G., Tamayo, E., García-Arenzana, J. M., Muñoz-Almagro, C., & Montes, M. (2019). Molecular Characterization of Streptococcus pyogenes Causing Invasive Disease in Pediatric Population in Spain A 12-year Study. The Pediatric Infectious Disease Journal, 38(12), 1168–1172. https://doi.org/10.1097/INF.0000000000002471

Sharma, N., & Toor, D. (2017). Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease. Cytokine, 90, 169–176. https://doi.org/10.1016/j.cyto.2016.11.010

Suárez-Arrabal, M. C., Sánchez Cámara, L. A., Navarro Gómez, M. L., Santos Sebastián, M. del M., Hernández-Sampelayo, T., Cercenado Mansilla, E., & Saavedra-Lozano, J. (2019). Invasive disease due to Streptococcus pyogenes: Changes in incidence and prognostic factors. Anales de Pediatría (English Edition), 91(5), 286–295. https://doi.org/10.1016/j.anpede.2018.12.007

Sykes, E. A., Wu, V., Beyea, M. M., Simpson, M. T. W., & Beyea, J. A. (2020). Pharyngitis: Approach to diagnosis and treatment. Canadian Family Physician Medecin de Famille Canadien, 66(4), 251–257. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/32273409

Wang, B., & Cleary, P. P. (2019). Intracellular Invasion by Streptococcus pyogenes: Invasins, Host Receptors, and Relevance to Human Disease. Microbiology Spectrum, 7(4). https://doi.org/10.1128/microbiolspec.GPP3-0049-2018

Yamaguchi, M. (2018). Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species. Journal of Oral Biosciences, 60(2), 36–40. https://doi.org/10.1016/j.job.2018.02.004

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Published

01/08/2020

How to Cite

BRITO, D. M. da S.; MENDES, G. S.; CASTRO, J. M. P.; SILVA FILHO, D. dos R.; MACHADO, M. G. S.; BORGES, W. E. de B.; PAULO, M. C. da S.; SILVA, M. do A.; OLIVEIRA, G. A. L. de. Upper respiratory tract infection caused by Streptococcus pyogenes: physiopathology and diagnosis. Research, Society and Development, [S. l.], v. 9, n. 8, p. e896986322, 2020. DOI: 10.33448/rsd-v9i8.6322. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/6322. Acesso em: 22 nov. 2024.

Issue

Vol. 9 No. 8

Section

Health Sciences

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Copyright (c) 2020 Mônica Silva, Maria Paulo, Wesley Borges, Marília Machado, David Silva Filho, Jessyca Castro, Geovane Mendes, Daiane Maria da Silva Brito, Guilherme Antônio Lopes de Oliveira

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