The therapeutic applicability of tyrosol and hydroxytyrosol for Dentistry
DOI:
https://doi.org/10.33448/rsd-v9i8.6420Keywords:
Phenylethyl alcohol; Protective agents; Antioxidants; Natural products; Dentistry.Abstract
Tyrosol (2- (4-hydroxyphenyl) ethanol) and hydroxytyrosol (2- (3,4-dihydroxyphenyl) ethanol) are one of the major representatives of the phenolic compounds found in olives, olive oil and wine. They have high antioxidant, anti-inflammatory, antiviral and anti-tumor properties and are the target of several studies in the medical field. The aim of this work was to evaluate the results of tyrosol and hydroxytyrosol in the published literature with the intention of directing the information about the application of these phenolic compounds in the dental field. An integrative review of the literature published in the last 20 years was carried out, with the purpose of accessing the most recent evidence on the subject, without restriction on the language. It was concluded that, although there are few studies on the therapeutic application of tyrosol and hydroxytyrosol in dentistry, and many of them in vitro, the results shown the potential of these products for their application in dentistry. These compounds can be used in several clinical areas, mainly for anti-inflammatory, antioxidant and anti-tumor activities.
References
Ammar, S., Oturan, M., Labiadh, L., Guersalli, A., Abdelhédi, R., Oturan, N., & Brillas, E. (2015). Degradation of tyrosol by a novel electro-Fenton process using pyrite as heterogeneous source of iron catalyst. Water research, 74C, 77-87. doi: 10.1016/j.watres.2015.02.006
Arias, L. S., Delbem, A. C., Fernandes, R. A., Barbosa, D. B., & Monteiro, D. R. (2016). Activity of tyrosol against single and mixed-species oral biofilms. J Appl Microbiol, 120(5), 1240-1249. doi:10.1111/jam.13070
Avola, R., Graziano, A., Pannuzzo, G., Bonina, F., & Cardile, V. (2019). Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts. Journal of cellular physiology, 234(6), 9065–9076. https://doi.org/10.1002/jcp.27584
Bavabeedu, S. S., Mathew, V. B., Fahad, A. N., Al Hutaylah, M. S. H., Al Ahmari, S. A. O., & Al Yami, M. S. A. (2018). Evaluation of the Antibacterial Effect of Virgin Olive oil on Enterococcus Faecalis: An In Vitro Study. Int J Prev Clin Dent Res, 5(2), 1-4.
Bu, Y., Rho, S., Kim, J., Kim, M., Lee, D., Kim, S., & Kim, H. (2007). Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neuroscience letters, 414, 218-21. 10.1016/j.neulet.2006.08.094
Cano-Carrillo, P., Pons-Fuster, A., & López-Jornet, P. (2014). Efficacy of lycopene-enriched virgin olive oil for treating burning mouth syndrome: a double-blind randomised. Journal of oral rehabilitation, 41(4), 296–305. doi: 10.1111/joor.12147
Carranza Jr., F. A., Newman, M. G., & Takei, H. H. (2016). Periodontia clínica. Rio de Janeiro, Brasil: Guanabara Koogan.
Carvalho, M. B., Lenzi, J., Lehn, C. N., Fava, A. S., Amar, A., Kanda, J. L., ... & Raport, A. (2001). Características clínico-epidemológicas do carcinoma epidermóide de cavidade oral no sexo feminino. Rev. Assoc. Med. Bras., 47(3), 208-214. doi: 10.1590/S0104-42302001000300032
D'Archivio, M., Files,i C., Di Benedetto, R., Gargiulo, R., Giovannini, C., & Masella, R. (2007). Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita, 43(4), 348-361.
Escudero, C., Virga, C., Aguzzi, A., Hubert, S., & De Leonardi, G. (2016). Estudio Radiográfico de la Asociación de Antioxidantes y Bifosfonatos en Remodelación Ósea Peri-Implantar. Int. J. Odontostomat., 10(3), 531-537.
Brunton, L. L., et al. (2012). Goodman & Gilman: As Bases Farmacológicas da Terapêutica. Rio de Janeiro, Brasil: McGraw-Hill.
Lee, H., Im, S. W., Jung, C. H., Jang, Y. J., Ha, T. Y., & Ahn, J. (2016). Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis in pancreatic β-cell through JNK signaling. Biochemical and biophysical research communications, 469(3), 748–752. doi: 10.1016/j.bbrc.2015.12.036
Lopes, H. P., & Siqueira Jr., J. F. (2015). Endodontia Biologia e Técnica. Rio de Janeiro, Brasil: Guanabara Koogan.
Marković, K. A., Torić, J., Barbarić, M., & Brala, J. C. (2019). Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules, 24(10), 2001. doi: 10.3390/molecules24102001
Mazzotti, F., Benabdelkamel, H., Di Donna, L., Maiuolo, L., Napoli, A., & Sindona, G. (2012). Assay of tyrosol and hydroxytyrosol in olive oil by tandem mass spectrometry and isotope dilution method. Food chemistry, 135(3), 1006–1010. doi: 10.1016/j.foodchem.2012.05.005
Ramalho, M. A. S., Santos, B., Ramalho, D. F., Cunha, S. M. D., Anjos, R. M, Oliveira, H. M. B. F., & & Oliveira Filho, A. A. (2020). Antiadherent activity of essencial oils of Eucalyptus globulus and Eucalyptus citriodora against Klebsiella pneumoniae strains. Res., Soc. Dev., 9(7), 1-15. doi: 10.33448/rsd-v9i7.4245
Rôças, I. N., & Siqueira, J. F., Jr (2011). Comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study. Journal of endodontics, 37(2), 143–150. doi: 10.1016/j.joen.2010.11.006
Rocas, I., Siqueira Jr, J., & Santos, K. (2004). Association of Enterococcus faecalis With Different Forms of Periradicular Diseases. Journal of Endodontics, 30(5), 315–320. doi:10.1097/00004770-200405000-00004
Rodrigues, C. F., & Černáková, L. (2020). Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development. Genes, 11(4), 444. doi: 10.3390/genes11040444
Sebaa, S., Boucherit-Otmani, Z., & Courtois, P. (2019). Effects of tyrosol and farnesol on Candida albicans biofilm. Molecular medicine reports, 19(4), 3201–3209. doi: 10.3892/mmr.2019.9981
Silva, S. A. M., Michniak-Kohn, B., & Leonardi, G. R. (2017). An overview about oxidation in clinical practice of skin aging. An. Bras. Dermatol, 92(3), 367-374. doi: 10.1590/abd1806-4841.20175481
Simões, A. C. M. (2016). Da planta ao medicamento. Rio de Janeiro, Brasil: Guanabara Koogan.
Souza, J. A. S., Barbosa, D. B., Amaral, J. G., Monteiro, D., Gorup, L., Neto, F., & Delbem, A. (2019). Antimicrobial Activity of Compounds Containing Silver Nanoparticles and Calcium Glycerophosphate in Combination with Tyrosol. Indian Journal of Microbiology, 59. doi: 10.1007/s12088-019-00797-y
Salucci, S., Burattini, S., Battistelli, M., Buontempo, F., Canonico, B., Martelli, A. M., & Falcieri, E. (2015). Tyrosol prevents apoptosis in irradiated keratinocytes. Journal of dermatological science, 80(1), 61–68. doi: 10.1016/j.jdermsci.2015.07.002
Sun, Y., Zhou, D., & Shahidi, F. (2017). Antioxidant properties of tyrosol and hydroxytyrosol saturated fatty acid esters. Food Chemistry, 245. doi: 10.1016/j.foodchem.2017.11.051
Tedesco, A. (2019). Harmonização Facial: A nova face da Odontologia. São Paulo, Brasil: Napoleão-Quintessence.
Tsikopoulos, K., Bidossi, A., Drago, L., Petrenyov, D. R., Givissis, P., Mavridis, D., & Papaioannidou, P. (2019). Is Implant Coating With Tyrosol- and Antibiotic-loaded Hydrogel Effective in Reducing Cutibacterium (Propionibacterium) acnes Biofilm Formation? A Preliminary In Vitro Study. Clinical orthopaedics and related research, 477(7), 1736–1746. doi: 10.1097/CORR.0000000000000663
Vale, L., Delbem, A., Arias, L., Fernandes Scappaticci, R., Vieira, A., Barros Barbosa, D., & Monteiro, D. (2017). Differential effects of the combination of tyrosol with chlorhexidine gluconate on oral biofilms. Oral diseases, 23. doi: 10.1111/odi.12648
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Adriano Costa Ramos, Jhony Herick Cavalcanti Nunes Negreiros, Amanda Ketelly Melo De Lima, Mirella De Albuquerque Cordeiro, Gustavo Pina Godoy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.