Hyperplastic goiter in sheep in the semi-arid region of Paraiba, Brazil: case report
Keywords:Mineral deficiency; Iodine; Metabolism; Ruminant; Hormones.
The aim of this study was to describe the clinical and anatomopathological findings and serum concentrations of free triiodothyronine (T3) and thyroxine (T4) from an outbreak of iodine (I) deficiency in sheep in the semi-arid region of Brazil. The outbreak was observed in a property located in the municipality of Sousa, West of the State of Paraiba, a semi-arid zone of Northeast Brazil. The studied lot was composed of 14 animals, between 12 and 18 months old, male, and mixed breed. The animals presented an increase in volume in the proximal portion of the neck, ventral to the mandibular arch, of firm consistency, suggesting a goiter. Thyroid samples were collected from animals that presented gland hyperplasia. In addition, blood samples were collected for serum analysis of thyroid hormones. The clinical findings, macroscopic characteristics, and histological findings observed in these cases are identical to those described in the literature for acquired goiter and constitute evidence that allows the definitive diagnosis of this condition. The mean concentrations observed in animals were: Free T3 (0.5±0.08 pmol/L) and Free T4 (10.93±2.88 pmol/L). Based on the epidemiological findings, clinical signs, anatomopathological lesions, and serum analysis of thyroid hormones, we can affirm the outbreak of acquired goiter occurred due to inadequacies in feeding and mineral supplementation of the animals. Thus, in order to prevent the appearance of this nutritional disorder, it is of utmost importance that animals are provided with a balanced mineral diet and supplementation, taking into account the needs of the species and antithyroid feed substances.
Anderson, R. R., Nixon, D. A. & Akasha, M. A. (1988). Total and free thyroxine and triiodothyronine in blood serum of mammals. Comparative Biochemistry and Physiology Part A: Physiology, 89(3), 401-404.
Al-ani, F. K., Khamas, W. A., Al-qudah, K. M., & Al-rawashdeh, O. (1998). Ocurrence of congenial anomalies in Shami breed goats: 211 cases investigated in 19 herds. Small Ruminant Research, 28, 225-232.
Almeida, O., Carolina, A., Arenales Torres, A. A., Borges, I. L., De Simone Souza F., Luvizzoto R., Rozza M. A., & Bernadeted. (2013). Bócio hiperplásico difuso em caprino recém-nascido -relato de caso. Archives of Veterinary Science, 3, 32-33.
Atessahin, A., Pirincci, I., Gursu, F., & Cikim, G. (2002). Effects of selenium on thyroid hormone levels in sheep. Turkish Journal of Veterinary and Animal Sciences, 26(6), 1401-1404.
Behringer, V., Deimel, C., Hohmann, G., Negrey, J., Schaebs, F. S., & Deschner, T. (2018). Applications for non-invasive thyroid hormone measurements in mammalian ecology, growth, and maintenance. Hormones and Behavior, 105, 66–85.
Bowers, C. L., Friend, T. H., Grissom, K. K., & Lay Dc Jr. (1993). Confinement of lambs (Ovis aries) in metabolism stalls increased adrenal function, thyroxine and motivation for movement. Applied Animal Behavior Science, 36(2-3), 149-158.
Campbell, A. J. D., Croser, E. L., Milne, M. E., Hodge, J. P., & Webb Ware, J. K. (2012). An outbreak of severe iodine-deficiency goitre in a sheep flock in north-east Victoria. Australian Veterinary Journal, 90(6), 235–239.
Capen, C. C. (2007). Endocrine glands. In: Jubb, K. V. F. Pathology of domestic animals. Philadelphia: Saunders Elsevier. 2340 p.
Cheema, A. H. (2014). Congenital goiter in goats. Pakistan Veterinary Journal, 30, 58-60.
Ecco, R., & Langohr, I. M. (2010). Pathology of the endocrine system. In: Santos, R. L., Alessi, A. C. Veterinary pathology. São Paulo: Roca. 2010.
Farman, M., Tripathi, S. K., Tej, N. K., Nandi, S., Gupta, P. S. P., Mondal, S., & Venkatesh, G. K. (2018). Metabolic stress indicators in ewes (Ovis aries) under post-parturient and high protein diet conditions. Asian Journal of Animal and Veterinary Advances, 13(4), 360-368.
Fazio, E., Medica, P., Cravana, C., Messineo, C., & Ferlazzo. A. (2007). Total and free iodothyronine levels of growing Thoroughbred foals: effects of weaning and gender. Livestock Science, 110(3), 207-213.
Fazio, E., Ferlazzo, A., Cravana, C., & Medica, P. (2014). Effects of weaning on total and free iodothyronines in lambs. Veterinary Quarterly, 35(1), 1-6.
Forsythe, W. A. (1995). Soy protein, thyroid regulation and cholesterol metabolism. Journal of Nutrition, 3, 619–623.
Gonzalez, F. H. D., & Silva, S. C. (2017). Introduction to veterinary clinical biochemistry. 3 Ed.: Publisher of the Federal University of Rio Grande do Sul: Porto Alegre. 538.
Gouveia, S., Leitão, F., Ribeiro, C., & Carrilho, F. (2016). Interference factors in the study of thyroid function. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 11(2), 277–286.
Hassan, N., Randhawa, C. S., & Hussian, S. A. (2013). Treatment of congenital bilateral goitre in a kid-a case report. Indian journal of science and technology, 1(3), 19-20.
Huszenicza, G., Kulcsár, M., & Rudas, P. (2002). Clinical endocrinology of thyroid gland function in ruminants: a review of literature. Veterinarni Medicina, 47(7), 199-210.
Ikeda, T., Nishikawa, A., Imazawa, T., Kimura, S., & Hirose, M. (2000). Dramatic Synergism Between Excess Soybean Intake and Iodine Deficiency on the Development of Rat Thyroid Hyperplasia. Carcinogenesis, 21(4), 707-713.
Iveta, P., Seidel. H., Nagy, O., Csilla, T., & Ková, G. (2011). Concentrations of thyroid hormones in various age categories of ruminants and swine. Acta Veterinaria, 61(5-6), 89-503.
Kallfelz. F., & Erali, R. P. (1973). Thyroid function tests in domesticated animals: free thyroxine index. American Journal of veterinary Research, 34(11), 1449-1451.
Knowles, S. O., & Grace, N. D. (2015). Serum total iodine concentrations in pasture-fed pregnant ewes and newborn lambs challenged by iodine supplementation and goitrogenic kale. Journal of Animal Science, 93(1), 425-32.
La Perle, K. M. D. (2013). Sistema endócrino. In: Zachary, J. F., & McGavin, M. D. Bases da patologia em veterinária. (5a ed.), Elsevier: Rio de Janeiro, 663-700.
Martins K. P. F., Fonseca T. R. S., Silva E. S., Munhoz T. C. P., Dias G. H. S., Galiza G. J. N., Oliveira L. G. S., & Boabaid F. M. (2018). Goiter in cattle. Pesquisa Veterinária Brasileira, 38(6), 1030-1037.
Macêdo, J. T. S. A., Lucena, R. B., Giaretta, P. R., Kommers, G. D., Fighera, R. A., Irigoyen, L. F., & Barros, C. S. L. (2011). Congenital defects in cattle from the Central Region of Rio Grande do Sul. Pesquisa Veterinária Brasileira, 31(4), 297-306.
Matamoros, R., Contreras, P. A., Phil, M., Wittwer, F., & Mayorga, M. I. (2003). Enormous hypothyroidism. Veterinary Medicine Archives, 35, 1-11.
Megale, F. (1949). Contribution to the study of congenital goiter in calves, in the State of Minas Gerais. Archivos da Escola de Veterinária, 2, 143-150.
Nazifi, S., Saeb, M., Abangah, E. & Karimi, T. (2008). Studies on the relationship between thyroid hormones and some trace elements in the blood serum of Iranian fat-tailed sheep. Veterinarski Arhives, 78(2), 159–165.
Osorio, J. H., Carvajal, D. C., & Pérez, J. E. (2017). Concentrations of thyroid stimulating hormone and free thyroxine in young sheep. Revista de Medicina Veterinaria, 33, 77-81.
Ozmen, O. (2005). Clinical and pathological observations and treatment of congenital goiter in kids. Bulletin of the Veterinary Institute in Pulawy, 49(2), 237-241.
Panziera, W, Kowaski, A. P, Galiza, G. J. N, Bianchi, R. M, Espíndola, J. P, Cardoso, M. M, Vargas, A. C., & Fighera, R. A, (2014). Bócio congênito em caprinos no Noroeste do Rio Grande do Sul. Ciência Rural, 44(12), 2217-2220.
Reap, M., Cass, C., & Hightower, D. (1978). Thyroxine and triiodothyronine levels in ten species of animals. Southwestern Veterinary, 31, 31-34.
Riet-Correa, F. (2007). Carências minerais. In: Riet-Correa. Diseases of ruminants and equidae. Santa Maria: Pallotti, 223-263.
Son, H. Y., Nishikawa, A., Ikeda, T., Imazawa, T., Kimura, S., & Hirose, M. (2001). Lack of Effect of Soy Isoflavone on Thyroid Hyperplasia in Rats Receiving na Iodine-deficient Diet. Japonese Journal of Cancer Research, 92(2), 103–108.
Starling, J. M. C., Silva, R. G., Negrão, J. A., Maia, A. S. C., & Bueno, A. R. (2005). Seasonal variation of thyroid hormones and cortisol in sheep in a tropical environment. Revista Brasileira de Zootecnia, 34(6), 2064-2073.
Todini, L. (2007). Thyroid hormones in small ruminants: effects of endogenous, environmental and nutritional factors. Animal, 1(7), 997-1008.
Tokarnia, C. H, Peixoto, P. V, Barbosa, J. D, Brito, M. F., & Döbereiner, J. (2010). Mineral deficiencies in farm animals. Helianthus: Rio de Janeiro. 191.
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Copyright (c) 2020 Mikael Leandro Duarte de Lima Tolentino, Ediane Freitas Rocha, Emanuel Felipe de Oliveira Filho, Daniel Nunes de Araújo Gonçalves, Gian Libânio da Silveira, Eldinê Gomes Miranda Neto, Antônio Flávio Medeiros Dantas, Pierre Castro Soares, Tatiane Rodrigues da Silva
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