Interval training, pressure reactivity and nitric oxide:a critical review
DOI:
https://doi.org/10.33448/rsd-v9i9.7029Keywords:
Arterial hypertension; Physical exercise; Nitric oxide.Abstract
Introduction: The control of blood pressure occurs through the interaction between the autonomic nervous system and substances secreted by different types of cells, including endothelial cells, causing changes in any of these mechanisms to lead to the development of arterial hypertension. The practice of physical exercises is shown as a non-pharmacological treatment capable of significantly reducing both systolic and diastolic blood pressure, attenuating pressure reactivity and increasing the bioavailability of nitric oxide. Objective: The objective of this critical review is to carry out a bibliographic survey of the main studies on interval exercises, pressure reactivity and nitric oxide. Methodology: Articles with such themes were selected and then classified into categories with the definitions of the concepts. Conclusion: Therefore, interval training is suggested to promote changes in vascular reactivity and nitric oxide concentrations will depend on the intensity and volume.
References
Ando, J., & Yamamoto, K. (2011). Effects of shear stress and stretch on endothelial function. Antioxidants & redox signaling, 15(5), 1389–1403. https://doi.org/10.1089/ars.2010.3361
Antunes-Correa, L. M., Nobre, T. S., Groehs, R. V., Alves, M. J., Fernandes, T., Couto, G. K., Rondon, M. U., Oliveira, P., Lima, M., Mathias, W., Brum, P. C., Mady, C., Almeida, D. R., Rossoni, L. V., Oliveira, E. M., Middlekauff, H. R., & Negrao, C. E. (2014). Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. American journal of physiology. Heart and circulatory physiology, 307(11), H1655–H1666. https://doi.org/10.1152/ajpheart.00136.2014
Buchheit, M., & Laursen, P. B. (2013). High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports medicine (Auckland, N.Z.), 43(5), 313–338. https://doi.org/10.1007/s40279-013-0029-x
Buchheit, M., & Laursen, P. B. (2013). High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports medicine (Auckland, N.Z.), 43(10), 927–954. https://doi.org/10.1007/s40279-013-0066-5
Bocalini, D. S., Bergamin, M., Evangelista, A. L., Rica, R. L., Pontes, F. L., Junior, Figueira, A., Junior, Serra, A. J., Rossi, E. M., Tucci, P., & Dos Santos, L. (2017). Post-exercise hypotension and heart rate variability response after water- and land-ergometry exercise in hypertensive patients. PloS one, 12(6), e0180216. https://doi.org/10.1371/journal.pone.0180216
Carvalho, R. S., Pires, C. M., Junqueira, G. C., Freitas, D., & Marchi-Alves, L. M. (2015). Hypotensive response magnitude and duration in hypertensives: continuous and interval exercise. Arquivos brasileiros de cardiologia, 104(3), 234–241. https://doi.org/10.5935/abc.20140193
Chen, J., Gu, D., Jaquish, C. E., Chen, C. S., Rao, D. C., Liu, D., Hixson, J. E., Hamm, L. L., Gu, C. C., Whelton, P. K., He, J., & GenSalt Collaborative Research Group (2008). Association between blood pressure responses to the cold pressor test and dietary sodium intervention in a Chinese population. Archives of internal medicine, 168(16), 1740–1746. https://doi.org/10.1001/archinte.168.16.1740
Chies, A. B., de Souza Rossignoli, P., & Daniel, E. F. (2010). Exercise increases the angiotensin II effects in isolated portal vein of trained rats. Peptides, 31(5), 883–888. https://doi.org/10.1016/j.peptides.2010.02.011
Cornelissen, V. A., & Smart, N. A. (2013). Exercise training for blood pressure: a systematic review and meta-analysis. Journal of the American Heart Association, 2(1), e004473. https://doi.org/10.1161/JAHA.112.004473
Del Vecchio, F., Galliano, L., & Coswig, V. (2014). Aplicações do Exercício Intermitente na Síndrome Metabólica. Revista Brasileira de Atividade Física e Saúde, 18(6), 669-687. http://dx.doi.org/10.12820/rbafs.v.18n6p669
De Leeuw P. W. (1999). How do angiotensin II receptor antagonists affect blood pressure?. The American journal of cardiology, 84(2A), 5K–6K. https://doi.org/10.1016/s0002-9149(99)00399-9
DeMartino, A. W., Kim-Shapiro, D. B., Patel, R. P., & Gladwin, M. T. (2019). Nitrite and nitrate chemical biology and signalling. British journal of pharmacology, 176(2), 228–245. https://doi.org/10.1111/bph.14484
Helms, C. C., Gladwin, M. T., & Kim-Shapiro, D. B. (2018). Erythrocytes and Vascular Function: Oxygen and Nitric Oxide. Frontiers in physiology, 9, 125. https://doi.org/10.3389/fphys.2018.00125
Faria, T., Targueta, G. P., Angeli, J. K., Almeida, E. A., Stefanon, I., Vassallo, D. V., & Lizardo, J. H. (2010). Acute resistance exercise reduces blood pressure and vascular reactivity, and increases endothelium-dependent relaxation in spontaneously hypertensive rats. European journal of applied physiology, 110(2), 359–366. https://doi.org/10.1007/s00421-010-1508-5
Fonseca, F. C. A., Coelho, R. Z., Nicolato, R., Malloy-Diniz, L. F., & Silva Filho, H. C. (2009). A influência de fatores emocionais sobre a hipertensão arterial. Jornal Brasileiro de Psiquiatria, 58(2), 128-134. https://doi.org/10.1590/S0047-20852009000200011.
Gayda, M., Normandin, E., Meyer, P., Juneau, M., Haykowsky, M., & Nigam, A. (2012). Central hemodynamic responses during acute high-intensity interval exercise and moderate continuous exercise in patients with heart failure. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 37(6), 1171–1178. https://doi.org/10.1139/h2012-109
Ghasemi, M., Mayasi, Y., Hannoun, A., Eslami, S. M., & Carandang, R. (2018). Nitric Oxide and Mitochondrial Function in Neurological Diseases. Neuroscience, 376, 48–71. https://doi.org/10.1016/j.neuroscience.2018.02.017
Ghisi, G. L., Durieux, A., Pinho, R., & Benetti, M. Physical exercise and endothelial dysfunction. Arq Bras Cardiol. 2010;95(5):e130-e137. https://doi.org/10.1590/s0066-782x2010001500025
Gibala, M. J., & Jones, A. M. (2013). Physiological and performance adaptations to high-intensity interval training. Nestle Nutrition Institute workshop series, 76, 51–60. https://doi.org/10.1159/000350256
Groehs, R. V., Toschi-Dias, E., Antunes-Correa, L. M., Trevizan, P. F., Rondon, M. U., Oliveira, P., Alves, M. J., Almeida, D. R., Middlekauff, H. R., & Negrão, C. E. (2015). Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. American journal of physiology. Heart and circulatory physiology, 308(9), H1096–H1102. https://doi.org/10.1152/ajpheart.00723.2014
Guiraud, T., Nigam, A., Gremeaux, V., Meyer, P., Juneau, M., & Bosquet, L. (2012). High-intensity interval training in cardiac rehabilitation. Sports medicine (Auckland, N.Z.), 42(7), 587–605. https://doi.org/10.2165/11631910-000000000-00000
Higashi, Y., & Yoshizumi, M. (2004). Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacology & therapeutics, 102(1), 87–96. https://doi.org/10.1016 /j.pharmthera.2004.02.003
Kemi, O. J., & Wisloff, U. (2010). High-intensity aerobic exercise training improves the heart in health and disease. Journal of cardiopulmonary rehabilitation and prevention, 30(1), 2–11. https://doi.org/10.1097/HCR.0b013e3181c56b89
Lobato, N. S., Filgueira, F. P., Akamine, E. H., Tostes, R. C., Carvalho, M. H., & Fortes, Z. B. (2012). Mechanisms of endothelial dysfunction in obesity-associated hypertension. Brazilian journal of medical and biological research, 45(5), 392–400. https://doi.org/10.1590/s0100-879x2012007500058.
Long, X., Bratz, I. N., Alloosh, M., Edwards, J. M., & Sturek, M. (2010). Short-term exercise training prevents micro- and macrovascular disease following coronary stenting. Journal of applied physiology (Bethesda, Md.: 1985), 108(6), 1766–1774. https://doi.org/10.1152/japplphysiol.01014.2009
Maeda S., Miyauchi, T., Kakiyama, T., Sugawara, J., Iemitsu, M., Irukayama-Tomobe, Y., Murakami, H., Kumagai, Y., Kuno, S., & Matsuda, M. (2001). Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life sciences, 69(9), 1005–1016. https://doi.org/10.1016/s0024-3205(01)01192-4
Malachias, M. V. B., Plavnik, F. L., Machado, C. A., Malta, D., Scala, L. C. N., & Fuchs, S. (2016). 7ª Diretriz Brasileira de Hipertensão Arterial: Capítulo 1 - Conceituação, Epidemiologia e Prevenção Primária. Arquivos Brasileiros de Cardiologia, 107(3, Suppl. 3), 1-6. https://doi.org/10.5935/abc.20160151.
Mantzarlis, K., Tsolaki, V., & Zakynthinos, E. (2017). Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies. Oxidative medicine and cellular longevity, 2017, 5985209. https://doi.org/10.1155/2017/5985209
Molmen-Hansen, H. E., Stolen, T., Tjonna, A. E., Aamot, I. L., Ekeberg, I. S., Tyldum, G. A., Wisloff, U., Ingul, C. B., & Stoylen, A. (2012). Aerobic interval training reduces blood pressure and improves myocardial function in hypertensive patients. European journal of preventive cardiology, 19(2), 151–160. https://doi.org/10.1177/1741826711400512
Münzel, T., & Daiber, A. (2018). Inorganic nitrite and nitrate in cardiovascular therapy: A better alternative to organic nitrates as nitric oxide donors?. Vascular pharmacology, 102, 1–10. https://doi.org/10.1016/j.vph.2017.11.003
Neves, J. A., Neves, J. A., & Oliveira, R. C. M. (2016). Biomarkers of endothelial function in cardiovascular diseases: hypertension. Jornal Vascular Brasileiro, 15(3), 224-233. Epub October 24, 2016.https://doi.org/10.1590/1677-5449.000316.
Neves, M. F., Cunha, A. R., Cunha, M. R., Gismondi, R. A., & Oigman, W. (2018). The Role of Renin-Angiotensin-Aldosterone System and Its New Components in Arterial Stiffness and Vascular Aging. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 25(2), 137–145. https://doi.org/10.1007/s40292-018-0252-5
Nobre, F., Coelho, E. B., Lopes, P. C., Geleilete, T. J. M. (2013). Hipertensão arterial sistêmica primária. Medicina (Ribeirão Preto), 46(3): 256-72. https://doi.org/10.11 606/issn.2176-7262.v46i3p256-272
Nogueira, I. C., Santos, Z. M. S. A., Mont'Alverne, D. G. B., Martins, A. B. T., Magalhães, C. B. A. (2012). Efeitos do exercício físico no controle da hipertensão arterial em idosos: uma revisão sistemática. Revista Brasileira de Geriatria e Gerontologia, 15(3), 587-601. https://doi.org/10.1590/S1809-98232012000300019
Ogrodowczyk, M., Dettlaff, K., & Jelinska, A. (2016). Beta-Blockers: Current State of Knowledge and Perspectives. Mini reviews in medicinal chemistry, 16(1), 40–54. https://doi.org/10.2174/1389557515666151016125948
Pereira, A. S., et al. (2018). Metodologia da pesquisa científica. [e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado de https://repositorio.ufsm.br/bitstream/handle /1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Pescatello, L. S., Franklin, B. A., Fagard, R., Farquhar, W. B., Kelley, G. A., Ray, C. A., & American College of Sports Medicine (2004). American College of Sports Medicine position stand. Exercise and hypertension. Medicine and science in sports and exercise, 36(3), 533–553. https://doi.org/10.1249/01.mss.0000115224.88514.3a
Pimenta, F. C., Montrezol, F. T., Dourado, V. Z., da Silva, L., Borba, G. A., de Oliveira Vieira, W., & Medeiros, A. (2019). High-intensity interval exercise promotes post-exercise hypotension of greater magnitude compared to moderate-intensity continuous exercise. European journal of applied physiology, 119(5), 1235–1243. https://doi.org/10.1007/s00421-019-04114-9
Pinho, R. A., Araújo, M. C., Ghisi, G. L., & Benetti, M. (2010). Doença arterial coronariana, exercício físico e estresse oxidativo [Coronary heart disease, physical exercise and oxidative stress]. Arquivos brasileiros de cardiologia, 94(4), 549–555. https://doi.org/10.1590/s0066-782x2010000400018
Sabbahi, A., Arena, R., Elokda, A., & Phillips, S. A. (2016). Exercise and Hypertension: Uncovering the Mechanisms of Vascular Control. Progress in cardiovascular diseases, 59(3), 226–234. https://doi.org/10.1016/j.pcad.2016.09.006
Schoenfeld, Brad & Dawes, Jay. (2009). High-Intensity Interval Training: Applications for General Fitness Training. Strength & Conditioning Journal. 31. 44-46. https://doi.org/10.1519/SSC.0b013e3181c2a844
Silva, I. B. M. M., Oliveira, A. C., Brito, R. S., Coertjens, M. (2013). Repercussões pressóricas do frio local: a crioterapia deve ser administrada com precaução em pacientes hipertensos? Fisioter Bras, 14(4). 306-311. http://dx.doi.org/10.33233/fb.v14i4
Souza, L. M. V., Costa, R. de A., Santos, J. D. M. dos, Santos, J. L. dos, Costa, L. S., Oliveira, J. U. de, Silva, R. J. dos S., & Estevam, C. dos S. (2020). Treinamento intervalado de alta intensidade e estresse oxidativo: uma breve apresentação. Research, Society and Development, 9(8), e741986478. https://doi.org/10.33448/rsd-v9i8.6478
Souza Junior, T. P., Asano, R. Y., Prestes, J., Sales, M. P. M., Coelho, J. M. O., & Simões, H. G. (2012). Óxido nítrico e exercício: uma revisão. Revista da Educação Física / UEM, 23(3), 469-481. https://doi.org/10.4025/reveducfis.v23i3.11738.
Stewart, K. J., Sung, J., Silber, H. A., Fleg, J. L., Kelemen, M. D., Turner, K. L., Bacher, A. C., Dobrosielski, D. A., DeRegis, J. R., Shapiro, E. P., & Ouyang, P. (2004). Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function. American journal of hypertension, 17(4), 314–320. https://doi.org/10.1016/S0895-7061(03)01003-3
Tousoulis, D., Kampoli, A. M., Tentolouris, C., Papageorgiou, N., & Stefanadis, C. (2012). The role of nitric oxide on endothelial function. Current vascular pharmacology, 10(1), 4–18. https://doi.org/10.2174/157016112798829760
Vieira, Fernando Luiz Herkenhoff & Lima, Eliudem Galvão. (2007). Laboratorial stress tests and arterial hypertension. Revista Brasileira de Hipertensão, 14(2): 98-103.
Weber, M. A., Schiffrin, E. L., White, W. B., Mann, S., Lindholm, L. H., Kenerson, J. G., Flack, J. M., Carter, B. L., Materson, B. J., Ram, C. V., Cohen, D. L., Cadet, J. C., Jean-Charles, R. R., Taler, S., Kountz, D., Townsend, R. R., Chalmers, J., Ramirez, A. J., Bakris, G. L., Wang, J., … Harrap, S. B. (2014). Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. Journal of clinical hypertension (Greenwich, Conn.), 16(1), 14–26. https://doi.org/10.1111/jch.12237.
Widmer, R. J., & Lerman, A. (2014). Endothelial dysfunction and cardiovascular disease. Global cardiology science & practice, 2014(3), 291–308. https://doi.org/10.5339/gcsp.2014.43.
Zanchetti A. (2004). Clinical pharmacodynamics of nebivolol: new evidence of nitric oxide-mediated vasodilating activity and peculiar haemodynamic properties in hypertensive patients. Blood pressure. Supplement, 1, 17–32. https://doi.org/10.1080/08038020410016548
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