Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7221

Keywords:

Drug therapy; Models, animal; Fluorouracil.

Abstract

Introduction: mucositis is one of the most common side effects that manifest during chemotherapy treatments against severe cancers. Such treatments have prominent drug 5-Fluorouracil (5-FU). However, patients undergoing anti-cancer treatments that include 5-FU and other cytotoxic drugs in chemotherapy suffer severe side effects. Objectives: the present article aims to assess which is the most promising treatment, in an animal model, to prevent intestinal mucositis induced by 5-FU. Methodology: a digital search was carried out in the main online databases in the health field, such as: “Pubmed”, “BVS”, “ScienceDirect”, “SciELO” and MEDLINE”. The search strategy in all databases was to enter the descriptors “treatment AND intestinal mucositis AND 5-Fluorouracil”. Results: at that time, 191 articles were found. After analyzing the inclusion and exclusion criteria, 51 articles were chosen for a thorough analysis of the methodology and results. As for the analysis parameters of the articles in this review, the following will be included: the methodology used; the possible study biases; and the results obtained from histological, enzymatic, cytosine, and, above all, clinical analyzes. The working groups that used as substances were analyzed: probiotics; phytotherapy; allopathic; selenium and others. Conclusion:  it was possible to perceive more promising results in the group of probiotics, especially Bidens pilosa L. (Asteraceae).

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17/08/2020

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OLIVEIRA, J. K. S. de; PAIVA, D. F. F.; ARAÚJO, A. A. de; SILVA, G. G. da; OLIVEIRA, F. J. D. de; SILVA, L. A. M. da; SILVA, C. A.; XAVIER FILHO, L. G. Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review. Research, Society and Development, [S. l.], v. 9, n. 9, p. e273997221, 2020. DOI: 10.33448/rsd-v9i9.7221. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/7221. Acesso em: 28 dec. 2024.

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Vol. 9 No. 9

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Health Sciences

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Copyright (c) 2020 Jennifer Kelly Silva de Oliveira; Daniel Felipe Fernandes Paiva; Aurigena Antunes de Araújo; Gabriel Gomes da Silva; Francisca Jennifer Duarte de Oliveira; Luana Amorim Morais da Silva; Camila Alexandre Silva; Luiz Gustavo Xavier Filho

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