Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review




Drug therapy; Models, animal; Fluorouracil.


Introduction: mucositis is one of the most common side effects that manifest during chemotherapy treatments against severe cancers. Such treatments have prominent drug 5-Fluorouracil (5-FU). However, patients undergoing anti-cancer treatments that include 5-FU and other cytotoxic drugs in chemotherapy suffer severe side effects. Objectives: the present article aims to assess which is the most promising treatment, in an animal model, to prevent intestinal mucositis induced by 5-FU. Methodology: a digital search was carried out in the main online databases in the health field, such as: “Pubmed”, “BVS”, “ScienceDirect”, “SciELO” and MEDLINE”. The search strategy in all databases was to enter the descriptors “treatment AND intestinal mucositis AND 5-Fluorouracil”. Results: at that time, 191 articles were found. After analyzing the inclusion and exclusion criteria, 51 articles were chosen for a thorough analysis of the methodology and results. As for the analysis parameters of the articles in this review, the following will be included: the methodology used; the possible study biases; and the results obtained from histological, enzymatic, cytosine, and, above all, clinical analyzes. The working groups that used as substances were analyzed: probiotics; phytotherapy; allopathic; selenium and others. Conclusion:  it was possible to perceive more promising results in the group of probiotics, especially Bidens pilosa L. (Asteraceae).


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How to Cite

Oliveira, J. K. S. de, Paiva, D. F. F., Araújo, A. A. de, Silva, G. G. da, Oliveira, F. J. D. de, Silva, L. A. M. da, Silva, C. A., & Xavier Filho, L. G. (2020). Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review. Research, Society and Development, 9(9), e273997221.



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