Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7221

Keywords:

Drug therapy; Models, animal; Fluorouracil.

Abstract

Introduction: mucositis is one of the most common side effects that manifest during chemotherapy treatments against severe cancers. Such treatments have prominent drug 5-Fluorouracil (5-FU). However, patients undergoing anti-cancer treatments that include 5-FU and other cytotoxic drugs in chemotherapy suffer severe side effects. Objectives: the present article aims to assess which is the most promising treatment, in an animal model, to prevent intestinal mucositis induced by 5-FU. Methodology: a digital search was carried out in the main online databases in the health field, such as: “Pubmed”, “BVS”, “ScienceDirect”, “SciELO” and MEDLINE”. The search strategy in all databases was to enter the descriptors “treatment AND intestinal mucositis AND 5-Fluorouracil”. Results: at that time, 191 articles were found. After analyzing the inclusion and exclusion criteria, 51 articles were chosen for a thorough analysis of the methodology and results. As for the analysis parameters of the articles in this review, the following will be included: the methodology used; the possible study biases; and the results obtained from histological, enzymatic, cytosine, and, above all, clinical analyzes. The working groups that used as substances were analyzed: probiotics; phytotherapy; allopathic; selenium and others. Conclusion:  it was possible to perceive more promising results in the group of probiotics, especially Bidens pilosa L. (Asteraceae).

References

Abalo, R., Uranga, J., Pérez-García, I., de Andrés, R., Girón, R., & Vera, G. et al. (2016). May cannabinoids prevent the development of chemotherapy-induced diarrhea and intestinal mucositis? Experimental study in the rat. Neurogastroenterology & Motility, 29(3), e12952. https://doi.org/10.1111/nmo.12952

Al-Asmari, A., Khan, A., Al-Asmari, S., Al-Rawi, A., & Al-Omani, S. (2016). Alleviation of 5-fluorouracil-induced intestinal mucositis in rats by vitamin E via targeting oxidative stress and inflammatory markers. Journal Of Complementary And Integrative Medicine, 13(4). https://doi.org/10.1515/jcim-2016-0043

Ali, J., Khan, A., Shah, F., Ali, H., Islam, S., Kim, Y., & Khan, S. (2019). Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model. Life Sciences, 239, 116888. https://doi.org/10.1016/j.lfs.2019.116888

Alves, A., Maranhão, O., Janson, G., & Garib, D. (2017). Mandibular dental arch short and long-term spontaneous dentoalveolar changes after slow or rapid maxillary expansion: a systematic review. Dental Press Journal Of Orthodontics, 22(3), 55-63. https://doi.org/10.1590/2177-6709.22.3.055-063.oar

Atiq, A., Shal, B., Naveed, M., Khan, A., Ali, J., & Zeeshan, S. et al. (2019). Diadzein ameliorates 5-fluorouracil-induced intestinal mucositis by suppressing oxidative stress and inflammatory mediators in rodents. European Journal Of Pharmacology, 843, 292-306. https://doi.org/10.1016/j.ejphar.2018.12.014

Ávila, P., de Ávila, R., dos Santos Filho, E., Cunha Bastos, C., Batista, A., & Mendonça, E. et al. (2015). Mucoadhesive formulation of Bidens pilosa L. (Asteraceae) reduces intestinal injury from 5-fluorouracil-induced mucositis in mice. Toxicology Reports, 2, 563-573. https://doi.org/10.1016/j.toxrep.2015.03.003

Barros, P., Generoso, S., Andrade, M., da Gama, M., Lopes, F., & de Sales e Souza, É. et al. (2016). Effect of Conjugated Linoleic Acid-enriched Butter After 24 hours of Intestinal Mucositis Induction. Nutrition And Cancer, 69(1), 168-175. https://doi.org/10.1080/01635581.2016.1225100

Barros, P., Rabelo Andrade, M., de Vasconcelos Generoso, S., Mendes Miranda, S., dos Reis, D., & Lacerda Leocádio, P. et al. (2018). Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. Biomedicine & Pharmacotherapy, 103, 1567-1576. https://doi.org/10.1016/j.biopha.2018.04.133

Bastos, C., Ávila, P., Filho, E., Ávila, R., Batista, A., & Fonseca, S. et al. (2016). Use of Bidens pilosa L. (Asteraceae) and Curcuma longa L. (Zingiberaceae) to treat intestinal mucositis in mice: Toxico-pharmacological evaluations. Toxicology Reports, 3, 279-287. https://doi.org/10.1016/j.toxrep.2015.10.013

Cai, B., Wan, P., Sun, H., Chen, D., Chen, H., Chen, X., & Pan, J. (2018). Protective Effects of Enteral Nutrition Supplemented withCrassostrea hongkongensisPolysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats. Journal Of Medicinal Food, 21(4), 348-355. https://doi.org/10.1089/jmf.2017.4025

Chen, H., Zhang, F., Li, R., Liu, Y., Wang, X., & Zhang, X. et al. (2020). Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota. Biomedicine & Pharmacotherapy, 124, 109829. https://doi.org/10.1016/j.biopha.2020.109829

Chen, Y., Zheng, H., Zhang, J., Wang, L., Jin, Z., & Gao, W. (2016). Protective effect and potential mechanisms of Wei-Chang-An pill on high-dose 5-fluorouracil-induced intestinal mucositis in mice. Journal Of Ethnopharmacology, 190, 200-211. https://doi.org/10.1016/j.jep.2016.05.057

Freitas-Blanco, V., Monteiro, K., de Oliveira, P., de Oliveira, E., de Oliveira Braga, L., de Carvalho, J., & Ferreira Rodrigues, R. (2018). Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Planta Medica, 85(03), 203-209. https://doi.org/10.1055/a-0715-2002

Fu, C., Chu, J., Shen, A., Liu, L., Chen, H., & Lin, J. et al. (2017). Pien Tze Huang alleviates 5-fluorouracil-induced intestinal mucositis in CT-26 tumor-bearing mice. Experimental And Therapeutic Medicine, 14(3), 2291-2297. https://doi.org/10.3892/etm.2017.4755

Galdino, F., Andrade, M., Barros, P., Generoso, S., Alvarez-Leite, J., & Almeida-Leite, C. et al. (2018). Pretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in mice. Journal Of Functional Foods, 49, 485-492. https://doi.org/10.1016/j.jff.2018.09.012

Gan, Y., Ai, G., Wu, J., Luo, H., Chen, L., & Huang, Q. et al. (2020). Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport. Journal Of Ethnopharmacology, 250, 112519. https://doi.org/10.1016/j.jep.2019.112519

Gou, H., Gu, L., Shang, B., Xiong, Y., & Wang, C. (2016). Protective effect of Bu-Zhong-Yi-Qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced intestinal mucositis in mice. Human & Experimental Toxicology, 35(12), 1243-1251. https://doi.org/10.1177/0960327115627686

Jesus, L., Drumond, M., de Carvalho, A., Santos, S., Martins, F., & Ferreira, Ê. et al. (2019). Protective effect of Lactobacillus delbrueckii subsp. Lactis CIDCA 133 in a model of 5 Fluorouracil-Induced intestinal mucositis. Journal Of Functional Foods, 53, 197-207. https://doi.org/10.1016/j.jff.2018.12.027

Justino, P., Franco, A., Pontier-Bres, R., Monteiro, C., Barbosa, A., & Souza, M. et al. (2020). Modulation of 5-fluorouracil activation of toll-like/MyD88/NF-κB/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic. Cytokine, 125, 154791. https://doi.org/10.1016/j.cyto.2019.154791

Justino, P., Melo, L., Nogueira, A., Morais, C., Mendes, W., & Franco, A. et al. (2015). Regulatory role of Lactobacillus acidophilus on inflammation and gastric dysmotility in intestinal mucositis induced by 5-fluorouracil in mice. Cancer Chemotherapy And Pharmacology, 75(3), 559-567. https://doi.org/10.1007/s00280-014-2663-x

Kato, S., Hamouda, N., Kano, Y., Oikawa, Y., Tanaka, Y., & Matsumoto, K. et al. (2017). Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. Clinical And Experimental Pharmacology And Physiology, 44(10), 1017-1025. https://doi.org/10.1111/1440-1681.12792

Kato, S., Hayashi, S., Kitahara, Y., Nagasawa, K., Aono, H., & Shibata, J. et al. (2015). Saireito (TJ-114), a Japanese Traditional Herbal Medicine, Reduces 5-Fluorouracil-Induced Intestinal Mucositis in Mice by Inhibiting Cytokine-Mediated Apoptosis in Intestinal Crypt Cells. PLOS ONE, 10(1), e0116213. https://doi.org/10.1371/journal.pone.0116213

Kim, S., Chun, H., Choi, H., Kim, E., Keum, B., & Seo, Y. et al. (2018). Ursodeoxycholic acid attenuates 5 fluorouracil induced mucositis in a rat model. Oncology Letters. https://doi.org/10.3892/ol.2018.8893

Koizumi, R., Azuma, K., Izawa, H., Morimoto, M., Ochi, K., & Tsuka, T. et al. (2017). Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice. International Journal Of Molecular Sciences, 18(2), 279. https://doi.org/10.3390/ijms18020279

Lee, J., Chun, H., Choi, H., Kim, E., Seo, Y., & Jeen, Y. et al. (2017). Selenium Administration Attenuates 5-Flurouracil-Induced Intestinal Mucositis. Nutrition And Cancer, 69(4), 616-622. https://doi.org/10.1080/01635581.2017.1300289

Lee, J., Yoo, I., Lee, J., Kim, S., Choi, H., & Kim, E. et al. (2019). Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis. BMC Cancer, 19(1). https://doi.org/10.1186/s12885-019-6231-y

Leocádio, P., Antunes, M., Teixeira, L., Leonel, A., Alvarez-Leite, J., & Machado, D. et al. (2015). L-Arginine Pretreatment Reduces Intestinal Mucositis as Induced by 5-FU in Mice. Nutrition And Cancer, 67(3), 486-493. https://doi.org/10.1080/01635581.2015.1004730

Li, C., Ko, J., Ou, C., Lin, W., Yen, C., Hsu, C., & Hsiao, Y. (2019). The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis. Integrative Cancer Therapies, 18, 153473541983379. https://doi.org/10.1177/1534735419833795

Liu, Z., Xie, W., Li, M., Teng, N., Liang, X., & Zhang, Z. et al. (2017). Oral Administration of Polaprezinc Attenuates Fluorouracil-induced Intestinal Mucositis in a Mouse Model. Basic & Clinical Pharmacology & Toxicology, 121(6), 480-486. https://doi.org/10.1111/bcpt.12841

Levit, R., Savoy de Giori, G., de Moreno de LeBlanc, A., & LeBlanc, J. (2018). Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice. Nutrition, 54, 165-172. https://doi.org/10.1016/j.nut.2018.03.056

Macacare, O., Rocha, M., Cruz, E., Lima, L., Otomura, F., & Ekuni, R. (2018). Semana do Cérebro: divulgando a neurociência e integrando ensino, pesquisa e extensão. Expressa Extensão, 23(3), 52-65. https://doi.org/10.15210/ee.v23i3

Magalhães, T., Souza, M., Gomes, S., Mendes e Silva, R., Martins, F., Freitas, R., & Amaral, J. (2020). Açaí (Euterpe oleracea Martius) Promotes Jejunal Tissue Regeneration by Enhancing Antioxidant Response in 5-Fluorouracil-Induced Mucositis. Nutrition And Cancer, 1-11. https://doi.org/10.1080/01635581.2020.1759659

Mahmoud, M., Selim, M., Mohamed, S., Hassan, A., & Abdal-Aziz, S. (2019). Study of the chemical structure of exopolysaccharide produced from streptomycete and its effect as an attenuate for antineoplastic drug 5-fluorouracil that induced gastrointestinal toxicity in rats. Animal Biotechnology, 1-16. https://doi.org/10.1080/10495398.2019.1610416

Mashtoub, S., Feo, B., Whittaker, A., Lymn, K., Martinez-Puig, D., & Howarth, G. (2015). Oral Nucleotides Only Minimally Improve 5-Fluorouracil-Induced Mucositis in Rats. Nutrition And Cancer, 67(6), 994-1000. https://doi.org/10.1080/01635581.2015.1062118

Mashtoub, S., Lampton, L., Eden, G., Cheah, K., Lymn, K., Bajic, J., & Howarth, G. (2016). Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis. Nutrition And Cancer, 68(7), 1171-1180. https://doi.org/10.1080/01635581.2016.1208829

Medeiros, A., Azevedo, Í., Lima, M., Araújo Filho, I., & Moreira, M. (2018). Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos. Revista Do Colégio Brasileiro De Cirurgiões, 45(5). https://doi.org/10.1590/0100-6991e-20181968

Miranda, J., Barreto, J., Martins, D., de Souza Pimentel, P., da Silva Costa, D., & e Silva, R. et al. (2019). Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. Pharmaceuticals, 12(2), 51. https://doi.org/10.3390/ph12020051

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., & Petticrew, M. et al. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1). https://doi.org/10.1186/2046-4053-4-1

Murray, D., & Abell, T. (2018). Neural Control of the Gastrointestinal System. Neuromodulation, 1373-1378. https://doi.org/10.1016/b978-0-12-805353-9.00114-5

Oh, N., Lee, J., Lee, J., Lee, K., & Kim, Y. (2017). Mulberry leaf extract fermented withLactobacillus acidophilusA4 ameliorates 5-fluorouracil-induced intestinal mucositis in rats. Letters In Applied Microbiology, 64(6), 459-468. https://doi.org/10.1111/lam.12741

Paes, Â. (1998). Itens essenciais em bioestatística. Arquivos Brasileiros De Cardiologia, 71(4), 575-580. https://doi.org/10.1590/s0066-782x1998001000003

Porto, B., Monteiro, C., Souza, É., Leocádio, P., Alvarez-Leite, J., & Generoso, S. et al. (2019). Treatment with selenium-enriched Saccharomyces cerevisiae UFMG A-905 partially ameliorates mucositis induced by 5-fluorouracil in mice. Cancer Chemotherapy And Pharmacology, 84(1), 117-126. https://doi.org/10.1007/s00280-019-03865-8

Quaresma, M., Damasceno, S., Monteiro, C., Lima, F., Mendes, T., & Lima, M. et al. (2019). Probiotic mixture containing Lactobacillus spp. and Bifidobacterium spp. attenuates 5-fluorouracil-induced intestinal mucositis in mice. Nutrition And Cancer, 1-11. https://doi.org/10.1080/01635581.2019.1675719

Song, M., Baik, H., Hong, S., & Sung, M. (2016). Wheat bran arabinoxylan supplementation alleviates 5-fluorouracil induced mucositis and myelosuppression in BALB/c mice. Journal Of Functional Foods, 21, 312-320. https://doi.org/10.1016/j.jff.2015.12.001

Tang, Y., Wu, Y., Huang, Z., Dong, W., Deng, Y., & Wang, F. et al. (2017). Administration of probiotic mixture DM#1 ameliorated 5-fluorouracil–induced intestinal mucositis and dysbiosis in rats. Nutrition, 33, 96-104. https://doi.org/10.1016/j.nut.2016.05.003

Wang, H., Jatmiko, Y., Bastian, S., Mashtoub, S., & Howarth, G. (2017). Effects of Supernatants from Escherichia coli Nissle 1917 and Faecalibacterium prausnitzii on Intestinal Epithelial Cells and a Rat Model of 5-Fluorouracil-Induced Mucositis. Nutrition And Cancer, 69(2), 307-318. https://doi.org/10.1080/01635581.2017.1263747

Wei, L., Wang, J., Yan, L., Shui, S., Wang, L., & Zheng, W. et al. (2020). Sulforaphane attenuates 5-fluorouracil induced intestinal injury in mice. Journal Of Functional Foods, 69, 103965. https://doi.org/10.1016/j.jff.2020.103965

Wenqin, D., Yaodong, Z., Wanji, S., Fengli, Z., Li, S., & Haili, J. et al. (2019). Armillariella Oral Solution Ameliorates Small Intestinal Damage in a Mouse Model of Chemotherapy-Induced Mucositis. Nutrition And Cancer, 71(7), 1142-1152. https://doi.org/10.1080/01635581.2019.1599029

Whittaker, A., Zhu, Y., Howarth, G., Loung, C., Bastian, S., & Wirthensohn, M. (2017). Effects of commercially produced almond by-products on chemotherapy-induced mucositis in rats. World Journal Of Gastrointestinal Pathophysiology, 8(4), 176-187. https://doi.org/10.4291/wjgp.v8.i4.176

Xiang, D., Yang, J., Xu, Y., Zhang, S., Li, M., & Zhu, C. et al. (2020). Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway. Life Sciences, 252, 117612. https://doi.org/10.1016/j.lfs.2020.117612

Yan, X., Li, H., Zhang, Y., Wu, S., Lu, H., & Yu, X. et al. (2019). A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice. Acta Pharmacologica Sinica, 41(3), 348-357. https://doi.org/10.1038/s41401-019-0295-8

Yazbeck, R., Lindsay, R., Geier, M., Butler, R., & Howarth, G. (2019). Prebiotics Fructo-, Galacto-, and Mannan-Oligosaccharide Do Not Protect against 5-Fluorouracil–Induced Intestinal Mucositis in Rats. The Journal Of Nutrition, 149(12), 2164-2173. https://doi.org/10.1093/jn/nxz192

Yeung, C., Chan, W., Jiang, C., Cheng, M., Liu, C., & Chang, S. et al. (2015). Amelioration of Chemotherapy-Induced Intestinal Mucositis by Orally Administered Probiotics in a Mouse Model. PLOS ONE, 10(9), e0138746. https://doi.org/10.1371/journal.pone.0138746

Zhang, L., Jin, Y., Peng, J., Chen, W., Lisha, L., & Lin, J. (2019). Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage. Biomedicine & Pharmacotherapy, 118, 109223. https://doi.org/10.1016/j.biopha.2019.109223

Zheng, H., Gao, J., Man, S., Zhang, J., Jin, Z., & Gao, W. (2019). The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice. Phytomedicine, 54, 308-317. https://doi.org/10.1016/j.phymed.2018.07.006

Downloads

Published

17/08/2020

How to Cite

OLIVEIRA, J. K. S. de; PAIVA, D. F. F.; ARAÚJO, A. A. de; SILVA, G. G. da; OLIVEIRA, F. J. D. de; SILVA, L. A. M. da; SILVA, C. A.; XAVIER FILHO, L. G. Comparison between methods of treatment of intestinal mucositis in animal model – systematic literature review. Research, Society and Development, [S. l.], v. 9, n. 9, p. e273997221, 2020. DOI: 10.33448/rsd-v9i9.7221. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/7221. Acesso em: 12 nov. 2024.

Issue

Vol. 9 No. 9

Section

Health Sciences

License

Copyright (c) 2020 Jennifer Kelly Silva de Oliveira; Daniel Felipe Fernandes Paiva; Aurigena Antunes de Araújo; Gabriel Gomes da Silva; Francisca Jennifer Duarte de Oliveira; Luana Amorim Morais da Silva; Camila Alexandre Silva; Luiz Gustavo Xavier Filho

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.