Obesity as a coefficient in the aggravation of patients affected by COVID-19

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7304

Keywords:

Coronavirus Infections; Obesity; Comorbidity.

Abstract

Objective: To demonstrate through systematic review the relationship between obesity and the new coronavirus, as well as to produce theoretical considerations on this subject. Methods: Systematic review research using search indexes in the electronic databases and portals PubMed and Virtual Health Library (BVS). The data were analyzed using tables and discussed according to the current and relevant literature. Results: Ten articles that met the defined criteria were selected. It was observed that obesity is related to other prevalent comorbidities in patients with COVID-19, such as systemic arterial hypertension and diabetes mellitus, as well as being associated with higher rates of hospitalizations in intensive care units and the use of invasive mechanical ventilation. It is believed that complications arising from obesity in patients with COVID-19 may be related to the cytokines present in the chronic inflammation state characteristic of obese patients. Conclusion: Obesity is related to worse outcomes in patients hospitalized with COVID-19. However, further primary studies are needed to elucidate the degree of influence of obesity in the context of patients with COVID-19.

References

Abbas, A. M., Fathy, S. K., Fawzy, A. T., Salem, A. S., & Shawky, M. S. (2020). The mutual effects of COVID-19 and obesity. Obesity Medicine.

Almerie, M. Q., & Kerrigan, D. D. (2020). The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast. Medical Hypotheses, 109883.

Barrasa, H., Rello, J., Tejada, S., Martín, A., Balziskueta, G., Vinuesa, C., ... & Cabañes, S. (2020). SARS-CoV-2 in Spanish intensive care: early experience with 15-day survival in Vitoria. Anaesthesia Critical Care & Pain Medicine.

Bourgeois, C., Gorwood, J., Barrail-Tran, A., Lagathu, C., Capeau, J., Desjardins, D., ... & Lambotte, O. (2019). Specific biological features of adipose tissue, and their impact on HIV persistence. Frontiers in microbiology, 10.

Busetto, L., Bettini, S., Fabris, R., Serra, R., Dal Pra’, C., Maffei, P., ... & Vettor, R. (2020). Obesity and COVID‐19: an Italian snapshot. Obesity.

Cai, Q., Chen, F., Wang, T., Luo, F., Liu, X., Wu, Q., ... & Chen, J. (2020). Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care.

CDC. 2020. 2019 Novel Coronavirus (2019-nCoV), Wuhan, China. Disponível em: HTTPS://WWW.CDC.GOV/CORONAVIRUS/NOVEL-CORONAVIRUS-2019. Acesso em: 20 ABR. 2020.

Chen, Q., Zheng, Z., Zhang, C., Zhang, X., Wu, H., Wang, J., ... & Zheng, C. (2020). Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection, 1-9.

Dias, P. C., Henriques, P., Anjos, L. A. D., & Burlandy, L. (2017). Obesidade e políticas públicas: concepções e estratégias adotadas pelo governo brasileiro. Cadernos de Saúde Pública, 33, e00006016.

Dietz, W. & Santos-Burgoa, C. (2020). Obesidade e suas implicações na mortalidade por COVID-19. Obesidade, 28 (6), 1005-1005.

Finer, N., Garnett, SP e Bruun, JM (2020). COVID ‐ 19 e obesidade. Obesidade Clínica, 10 (3).

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., ... & Cheng, Z. (2020). Características clínicas de pacientes infectados com o novo coronavírus de 2019 em Wuhan, China. The lancet, 395 (10223), 497-506.

Huttunen, R., & Syrjänen, J. (2013). Obesity and the risk and outcome of infection. International journal of obesity, 37(3), 333-340.

Kalligeros, M., Shehadeh, F., Mylona, E. K., Benitez, G., Beckwith, C. G., Chan, P. A., & Mylonakis, E. (2020). Association of Obesity with Disease Severity among Patients with COVID‐19. Obesity (Silver Spring, Md.).

Van Kerkhove, M. D., Vandemaele, K. A., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., ... & Vachon, J. (2011). Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med, 8(7), e1001053.

Michalakis, K., & Ilias, I. (2020). SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes & Metabolic Syndrome: Clinical Research & Reviews.

Moock, M., Mataloun, S. E., Pandolfi, M., Coelho, J., Novo, N., & Compri, P. C. (2010). O impacto da obesidade no tratamento intensivo de adultos. Revista Brasileira de Terapia Intensiva, 22(2), 133-137.

Movahed, M. R., Khoubyari, R., Hashemzadeh, M., & Hashemzadeh, M. (2019). Obesity is strongly and independently associated with a higher prevalence of pulmonary embolism. Respiratory investigation, 57(4), 376-379.

OECD. (2019). The Heavy Burden of Obesity: The Economics of Prevention. OECD.

OMS. 2020. In: Clinical management of service acute respiratory infection when Novel coronavirus (nCoV) infection is suspect: interim guidance. Disponível em: HTTPS://WWW.WHO.INT/INTERNAL-PUBLICATIONS-DETAIL/CLINICAL-MANAGEMENT-OF-SEVERE-ACUTE-RESPIRATORY-INFECTION-WHEN-NOVEL-CORONAVIRUS-(NCOV)-INFECTION-IS-SUSPECTED. Acesso em: 20 ABR. 2020.

OMS. 2020. Coronavirus disease 2019 (COVID-19) Situation Report – 87. Disponível em:

HTTPS://WWW.WHO.INT/DOCS/DEFAULTSOURCE/CORONAVIRUSE/SITUATION-REPORTS/20200416-SITREP-87-COVID-19.PDF?SFVRSN=9523115A_2. Acesso em: 20 ABR. 2020.

Peng, Y. D., Meng, K., Guan, H. Q., Leng, L., Zhu, R. R., Wang, B. Y., ... & Zeng, Q. T. (2020). Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV. Zhonghua xin xue guan bing za zhi, 48, E004-E004.

Petrakis, D., Margină, D., Tsarouhas, K., Tekos, F., Stan, M., Nikitovic, D., ... & Tsatsakis, A. (2020). Obesity a risk factor for increased COVID 19 prevalence, severity and lethality. Molecular Medicine Reports, 22(1), 9-19.

Piva, S., Filippini, M., Turla, F., Catteneo, S., Margola, A., De Fulviis, S., ... & Erbici, G. (2020). Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy. Journal of Critical Care.

Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020). Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive care medicine, 46(5), 846-848.

Ryan, D. H., Ravussin, E., & Heymsfield, S. (2020). COVID 19 and the patient with obesity–the editors speak out. Obesity (Silver Spring, Md.).

Ryan, P. M., & Caplice, N. M. (2020). Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?. Obesity.

Santana, B. S. B., Pires, C. M. L., & Schuengue, C. M. D. O. L. (2019). A OBESIDADE COMO UM FATOR DE IMPACTO E PROBLEMA NA SAÚDE PÚBLICA, E SEUS FATORES DE INFLUÊNCIA. Anais do Seminário Científico do UNIFACIG, (4).

Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., ... & LICORN and the Lille COVID‐19 and Obesity study group. (2020). High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation. Obesity.

Scheen, A. J. (2020). Obesity and risk of severe COVID-19. Revue Medicale Suisse, 16(695), 1115-1119.

OMS. Obesidade e excesso de peso: World Health Organization, 2020. Disponível em: < http://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight> Acesso em: 12 mar. 2020.

Yang, X., Yu, Y., Xu, J., Shu, H., Liu, H., Wu, Y., ... & Wang, Y. (2020). Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine.

Zabetakis, I., Lordan, R., Norton, C., & Tsoupras, A. (2020). COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation. Nutrients, 12(5), 1466.

Zheng, Y. Y., Ma, Y. T., Zhang, J. Y., & Xie, X. (2020). COVID-19 and the cardiovascular system. Nature Reviews Cardiology, 17(5), 259-260.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., ... & Guan, L. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The lancet.

Wu, Z., & McGoogan, J. M. (2020). Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. Jama, 323(13), 1239-1242.

Published

22/08/2020

How to Cite

COSTA, T. R. M. .; CORREIA, R. S. .; SILVA, P. H. dos S. .; LÓPES BARBOSA, G. S. .; OLIVEIRA, L. M. de .; CRUZ, V. T. da .; SOUZA, J. L. de .; ARAÚJO, . A. C. G. .; LIMA, . J. C. F. .; PEREIRA, S. A. .; SILVA JÚNIOR, A. P. da . Obesity as a coefficient in the aggravation of patients affected by COVID-19. Research, Society and Development, [S. l.], v. 9, n. 9, p. e395997304, 2020. DOI: 10.33448/rsd-v9i9.7304. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/7304. Acesso em: 22 nov. 2024.

Issue

Section

Review Article