Quantitative evaluation of leukocyte and immunoglobulin production in women undergoing treatment for depression





Leukocytes; Antibody-producing cells; Depression; Mental health.


Objective: to verify possible changes in immune system cells (leukogram) and immunoglobulins in women with depression. Methodology: this is an observational, cross-sectional and analytical study conducted with 50 women (with depression n=25; no depression n=25) living in the Araguaia Valley region, Brazil. The women were investigated by collecting a peripheral blood sample, and the concentrations of leukocytes were determined by counting cells by flow cytometry and immunoglobulin concentrations by immunoturbidimetry. The data obtained were analyzed by the Kruskal-Wallis and DUNN tests. This study was approved by an Ethics and Research Committee (CAAE: 34568014.8.0000.5587). Results: the sample consisted of women with a mean age of 37±10,59 years, white/brown and single. Non-smoking women who did not have a habit of consuming alcoholic beverages prevailed. Depression was present among 50% of the sample. Regarding the evaluation of leukogram between the groups (with depression and without depression), a significant difference was observed in the serum value of basophils and the total concentrations of Immunoglobulins did not present significant differences between the groups. Conclusion: in this study, depression did not interfere in the concentration of leukocytic cells or in the production of immunoglobulins, and may be related to the long-term use of psychiatric drugs, because they have immunomodulatory properties, highlighting the importance of performing a treatment and follow-up for Depression.

Author Biographies

Alisséia Guimarães Lemes, Universidade Federal de Mato Grosso

Alisséia Guimarães Lemes

ORCID: https://orcid.org/0000-0001-6155-6473

Docente na Universidade Federal de Mato Grosso, Campus Universitário do Araguaia (UFMT/CUA). Barra do Garças-MT, Brasil.

E-mail: alisseia@hotmail.com

Rosa Jacinto Volpato, Universidade de São Paulo

Enfermeira. Doutoranda pelo Programa de Pós-Graduação em Enfermagem da Escola de Enfermagem da Universidade de São Paulo (EE/USP).

Adaene Alves Machado de Moura , Universidade de São Paulo

Enfermeira. Doutoranda em Enfermagem Psiquiátrica pela Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo (EERP-USP).

Tatiele Estefâni Schönholzer, Faculdades do Vale do Juruena

Enfermeira. Doutora em Ciências pela Universidade de São Paulo e Universidade autónoma de Madrid. Professora do departamento de enfermagem da Faculdade AJES. Juína- MT, Brasil.

Vagner Ferreira do Nascimento, Universidade Estadual de Mato Grosso

Enfermeiro. Doutor em Bioética pelo Centro Universitário São Camilo (CUSC). Docente no curso de Enfermagem da Universidade Estadual de Mato Grosso. Tangará da Serra, MT, Brasil. E-mail: vagnerschon@hotmail.com

Paula Cristina de Souza Souto, Universidade Federal de Mato Grosso

Doutora em Genética e Biologia Molecular. Profa. Associado II no Programa de Pós-graduação em Imunologia e Parasitologia Básica e Aplicadas do Instituto de Ciências Biológicas e da Saúde no Campus Universitário do Araguaia da Universidade Federal de Mato Grosso. Barra do Garças-MT, Brasil.


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How to Cite

Lemes, A. G., Volpato, R. J. ., Moura , A. A. M. de, Schönholzer, T. E., Nascimento, V. F. do ., & Souto, P. C. de S. . (2020). Quantitative evaluation of leukocyte and immunoglobulin production in women undergoing treatment for depression. Research, Society and Development, 9(9), e535997614. https://doi.org/10.33448/rsd-v9i9.7614



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