Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo

Authors

DOI:

https://doi.org/10.33448/rsd-v9i9.7642

Keywords:

HIV; Death; Relative Risk; Cryptococcosis; Odds ratio.

Abstract

Infections caused by Cryptococus spp. are opportunistic, urban, and associated with immunosuppression. Mortality is estimated at 10% in developed countries and 43% in emerging countries. The objective was to evaluate the clinical-epidemiological aspects of cryptococcosis in the region of western São Paulo. This is a cross-sectional study, based on information from the medical records of patients in a hospital in the interior of São Paulo from 2006 to 2018. Descriptive analysis was applied through absolute (n) and relative (%) frequency; and statistics through the x2 and Fisher's Exact tests. Relative Risk (RR) and Odds Ratio (OD) for death were also calculated. Neurocriptococcosis was the primary clinical manifestation of 64.50%. The direct search for CSF was positive in 85.71% of the samples, the immunodiagnosis in 93.80% and the culture, gold standard for fungus, in 55.55% of the cases. The x2 test and Fisher's exact test showed no difference between sex, age group, clinical form of death. RR and OD were considered low. The association of the epidemiological aspects of cryptococcosis with its clinical signs allows the early diagnosis of the disease, reducing severe conditions. Besides, high-performance antiretroviral therapies have dramatically decreased the occurrence of deaths in patients with HIV.

Author Biography

Maikiane Aparecida Nascimento, Hospital Estadual de Doenças Tropicais Dr. Anuar Auad (HDT/GO) e Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros (LACEN/GO), Goiânia, Goiás, Brasil.

Atualmente, residente do Programa de Residência Multiprofissional da Secretaria do Estado de Goiás, alocado no Hospital de Doenças Tropicais Dr. Anuar Auad, com atuação na área de infectologia e no Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros (LACEN/GO). Possui graduação em Biomedicina (2018) pela universidade do Oeste Paulista (UNOESTE), anteriormente realizou graduação Sanduíche na Faculdade de Farmácia da Universidade do Porto - Portugal pelo programa Santander Universidades - Bolsas de mobilidade Ibero-Americanas. Linhas de pesquisa: Microbiologia, Micologia Clinica, doenças tropicais, infectologia.

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Published

30/08/2020

How to Cite

NASCIMENTO, M. A.; SANTOS, E. C. M. .; CARVALHO, V. M. de; BORGES, M. S. .; EDERLI, J. P. B. .; ALBUQUERQUE, C. A. N. de .; SILVA, S. F. S. .; EDERLI, R. B. .; SOTO, B. A. S. .; PORTELINHA FILHO, A. M. .; MORIS, D. V. . Profile of patients with cryptococcosis in a regional hospital in the interior of São Paulo. Research, Society and Development, [S. l.], v. 9, n. 9, p. e598997642, 2020. DOI: 10.33448/rsd-v9i9.7642. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/7642. Acesso em: 12 nov. 2024.

Issue

Vol. 9 No. 9

Section

Health Sciences

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Copyright (c) 2020 Maikiane Aparecida Nascimento; Elorraine Coutinho Mathias Santos; Valéria Moura de Carvalho; Marielly Sousa Borges; João Pedro Brambilla Ederli; Camila Aparecida Nunes de Albuquerque; Savyla Franciele Soares Silva; Rosana Brambilla Ederli; Bruno Alexandre Soto Soto; Alexandre Martins Portelinha Filho; Daniela Vanessa Moris

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