Antiparasitary potential and cytotoxic effect of Spondias tuberosa Arruda (Anacardiaceae)
DOI:
https://doi.org/10.33448/rsd-v9i9.7967Keywords:
Umbu; Antiprotozoan; Cytotoxicity; Kinetoplastide.Abstract
The objective of this work was to evaluate the antiparasitic potential and cytotoxic effect of extracts by the leaves and roots of S. tuberosa. The results show that the extracts of S. tuberosa have low antipromastigote activity against strains of L. braziliensis, since there was no action at concentrations ≤ 500 µg/mL. While for L. infantum there was a significant action of the hydroalcoholic extract of the roots against promastigote forms, since there was 29.33 ± 1.94% of mortality for the treatment of 1000 µg/mL. The same extract showed antiepimastigote action against T. cruzi at a concentration ≥ 1000 µg/mL. Despite the low antiparasitic activities, it is possible to observe that the extracts of S. tuberosa have no cytotoxic action, except the hydroalcoholic extract of the roots. In this extract there was a total of 27.85 ± 2.41% of cytotoxicity against fibroblastic cells, in the highest concentration evaluated (1000 µg/mL).
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Copyright (c) 2020 Maria Celeste Vega Gomez ; Míriam Rolón; Cathia Coronel ; Antonia Thassya Lucas dos Santos ; José Weverton Almeida Bezerra; Joara Nályda Pereira Carneiro ; Maria Audilene de Freitas; Ana Cleide Alcântara Morais Mendonça; Saulo Almeida de Menezes; Benedito Yago Machado Portela; Henrique Douglas Melo Coutinho ; Maria Flaviana Bezerra Morais-Braga
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