Ethnopharmacological Potential of Tithonia diversifolia (Hemsl) A. Gray
DOI:
https://doi.org/10.33448/rsd-v9i10.8370Keywords:
Asteraceae; Ethnopharmacology; Mexican Sunflower.Abstract
Tithonia diversifolia (Hemsl) A. Gray, commonly known as “Mexican Sunflower”, is a perennial herbaceous plant of the Asteraceae family, native to Mexico and Central America. At present, however, this species is widely found in many countries outside of these areas, including Brazil. It has been the subject of many scientific studies which by highlighting the chemical constitution of its main structures such as leaves, inflorescences, stalk and roots, consequently bring to light this species’ nutritional and therapeutic potential in current literature. The aim of this study is to produce a literature review on the ethnobotanical aspects and possible pharmacological applications of T. diversifolia, with emphasis on its chemical composition, morphological characteristics and pharmacotherapeutic applications. The present study is a bibliographical, exploratory and qualitative research, carried out due to the need to elucidate the proposed theme and fulfills the role of reviewing the specific bibliography on the addressed topic. Based on the produced bibliography, it is noticeable that Tithonia diversifolia (Hemsl) A. Gray is a plant of potential nutritional and pharmacological interest. In general, the studies reviewed here strengthen and highlight the evidence of the diverse applications of this species by traditional medicine, which, in turn, contribute to the development of studies that guarantee the identification of active constituents and their respective biotechnological applications.
References
Abe, A. E., Oliveira, C. E. d., Dalboni, T. M., Chagas-Paula, D. A., Rocha, B. A., Oliveira, R. B. d., . . . Campanelli, A. P. (2015). Anti-inflammatory sesquiterpene lactones from Tithonia diversifolia trigger different effects on human neutrophils. Revista Brasileira de Farmacognosia, 25, 111-116.
Ajao, A. A., & Moteetee, A. N. (2017). Tithonia diversifolia (Hemsl) A. Gray. (Asteraceae: Heliantheae), an invasive plant of significant ethnopharmacological importance: A review. South African Journal of Botany, 113, 396-403. doi:https://doi.org/10.1016/j.sajb.2017.09.017
Alen, Y., Melati, A., Sarina, G., & Djamaan, A. (2018). Isolation of Secondary Metabolite A. niger “In-Habiting” Queen M. gilvus Hagen.’s Nest. Indonesian Journal of Pharmaceutical Science and Technology, 5, 61. doi:10.24198/ijpst.v5i2.15364
Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E.-M., Linder, T., Wawrosch, C., Uhrin, P., . . . Stuppner, H. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 33(8), 1582-1614. doi:https://doi.org/10.1016/j.biotechadv.2015.08.001
Barboza, B., da Silva Barros, B., #225, rbara, Ramos, B., #225, . . . de Melo, C. (2018). Phytochemical bioprospecting, antioxidant, antimicrobial and cytotoxicity activities of saline extract from Tithonia diversifolia (Hemsl) A. Gray leaves. Asian Pacific Journal of Tropical Biomedicine, 8(5), 245-253. doi:10.4103/2221-1691.233005
Barreiro, E. J., & Bolzani, V. d. S. (2009). Biodiversidade: fonte potencial para a descoberta de fármacos. Química Nova, 32, 679-688.
BORCARD, G. G., CONDE, B. E., ALVES, M. J. M., CHEDIER, L. M., & PIMENTA, D. S. (2015). Estudo etnofarmacológico em entorno de floresta urbana como subsídio para a implantação da Fitoterapia no Sistema Único de Saúde. Revista Brasileira de Plantas Medicinais, 17, 928-936.
Castro, M., Barros, M., Rodrigues-Das-Dôres, R., & Stefani, R. (2011). ATIVIDADE ANTIFÚNGICA E TOXICIDADE DAS INFLORESCÊNCIAS DE FLOR-DO-AMAZONAS (TITHONIA DIVERSIFOLIA). 7. doi:10.5216/ref.v7i3.12898
Chagas-Paula, D. A., Oliveira, R. B., da Silva, V. C., Gobbo-Neto, L., Gasparoto, T. H., Campanelli, A. P., . . . Da Costa, F. B. (2011). Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones. J Ethnopharmacol, 136(2), 355-362. doi:10.1016/j.jep.2011.04.067
Chagas-Paula, D. A., Oliveira, R. B., Rocha, B. A., & Da Costa, F. B. (2012). Ethnobotany, chemistry, and biological activities of the genus Tithonia (Asteraceae). Chem Biodivers, 9(2), 210-235. doi:10.1002/cbdv.201100019
Chaudhury, A., Duvoor, C., Reddy Dendi, V. S., Kraleti, S., Chada, A., Ravilla, R., . . . Mirza, W. (2017). Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Front Endocrinol (Lausanne), 8, 6. doi:10.3389/fendo.2017.00006
Dávalos, J., Gutiérrez-Lomelí, M., Siller, F., Rodriguez-Sahagun, A., Del Rio, J. A., Guerrero, P., & Del Toro, L. (2013). SCREENING FITOQUÍMICO Y CAPACIDAD ANTIINFLAMATORIA DE HOJAS DE Tithonia tubaeformis. BIOtecnia, 15, 53. doi:10.18633/bt.v15i2.150
Debbarma, M., Pala, N. A., Kumar, M., & Bussmann, R. W. (2017). TRADITIONAL KNOWLEDGE OF MEDICINAL PLANTS IN TRIBES OF TRIPURA IN NORTHEAST, INDIA. Afr J Tradit Complement Altern Med, 14(4), 156-168. doi:10.21010/ajtcam.v14i4.19
Dias Rde, O., Machado Ldos, S., Migliolo, L., & Franco, O. L. (2015). Insights into animal and plant lectins with antimicrobial activities. Molecules, 20(1), 519-541. doi:10.3390/molecules20010519
Duarte, M. d. R., & Empinotti, C. B. (2012). Leaf and stem microscopic identification of Tithonia diversifolia (Hemsl.) A. Gray (Asteraceae). Brazilian Journal of Pharmaceutical Sciences, 48, 109-116.
Etejere, E. O., & Olayinka, B. U. (2014). Seed Production, Germination, Emergence and Growth of Tithonia diversifolia (HEMSL) A. Gray as Influenced by Different Sowing Depths and Soil Types.
Funari, C. S., Castro-Gamboa, I., Cavalheiro, A. J., & Bolzani, V. d. S. (2013). Metabolômica, uma abordagem otimizada para exploração da biodiversidade brasileira: estado da arte, perspectivas e desafios. Química Nova, 36, 1605-1609.
Gallego-Castro, L. A., Mahecha-Ledesma, L., & Angulo-Arizala, J. (2014). Potencial forrajero de Tithonia diversifolia Hemsl: A Gray en la producción de vacas lecheras. Agronomía Mesoamericana, 25, 393-403.
Garcia, I. (2017). Potencialidades de Tithonia diversifolia (Hemsl.) Gray en la alimentación animal. Livestock Research for Rural Development, 29.
González-Castillo, J. C., Hahn von-Hessberg, C. M., & Narváez-Solarte, W. (2014). CARACTERÍSTICAS BOTÁNICAS DE Tithonia diversifolia (ASTERALES: ASTEACEAE) Y SU USO EN LA ALIMENTACIÓN ANIMAL. Boletín Científico. Centro de Museos. Museo de Historia Natural, 18, 45-58.
Gualberto, R., Júnior, O., Costa, N., Braccialli, C., & Gaion, L. A. (2011). INFLUÊNCIA DO ESPAÇAMENTO E DO ESTÁDIO DE DESENVOLVIMENTO DA PLANTA NA PRODUÇÃO DE BIOMASSA E VALOR NUTRICIONAL DE Tithonia diversifolia (HEMSL.) Gray. Nucleus, 8, 241-255. doi:10.3738/1982.2278.362
Hamuel, J. D. (2012). Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents. In.
Hiransai, P., Tangpong, J., Kumbuar, C., Hoonheang, N., Rodpech, O., Sangsuk, P., . . . Inkaow, W. (2016). Anti-nitric oxide production, anti-proliferation and antioxidant effects of the aqueous extract from Tithonia diversifolia. Asian Pacific Journal of Tropical Biomedicine, 6(11), 950-956. doi:https://doi.org/10.1016/j.apjtb.2016.02.002
John-Dewole, J.-D. (2013). Phytochemical and Antimicrobial Studies of Extracts from the Leaves of Tithonia Diversifolia for Pharmaceutical Importance. IOSR Journal of Pharmacy and Biological Sciences, 6, 21-25. doi:10.9790/3008-0642125
Juiz, P. J. L., Alves, R. J. C., & Barros, T. F. (2010). Uso de produtos naturais como coadjuvante no tratamento da doença periodontal. Revista Brasileira de Farmacognosia, 20, 134-139.
Lee, M. Y., Liao, M. H., Tsai, Y. N., Chiu, K. H., & Wen, H. C. (2011). Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract. J Agric Food Chem, 59(6), 2347-2355. doi:10.1021/jf105003n
Lu, M. R., Huang, H. L., Chiou, W. F., & Huang, R. L. (2017). Induction of Apoptosis by Tithonia diversifolia in Human Hepatoma Cells. Pharmacogn Mag, 13(52), 702-706. doi:10.4103/0973-1296.218113
Mabou Tagne, A., Marino, F., & Cosentino, M. (2018). Tithonia diversifolia (Hemsl.) A. Gray as a medicinal plant: A comprehensive review of its ethnopharmacology, phytochemistry, pharmacotoxicology and clinical relevance. J Ethnopharmacol, 220, 94-116. doi:10.1016/j.jep.2018.03.025
Matheus Mendes, R., Leandro Roberto da, C., Gustavo Amaral, C., Rodrigo Eduardo, B., & Leonardo David Tuffi, S. (2015). Potencial forrageiro de Tithonia diversifolia na alimentação Animal. Caderno de Ciências Agrárias, 7(Suppl). doi:10.35699/2447-6218.2015.2832
Miranda, M. A., Varela, R. M., Torres, A., Molinillo, J. M., Gualtieri, S. C., & Macías, F. A. (2015). Phytotoxins from Tithonia diversifolia. J Nat Prod, 78(5), 1083-1092. doi:10.1021/acs.jnatprod.5b00040
Mota, J. C. d., Campos, M. R., Schramm, J. M. d. A., & Costa, M. d. F. d. S. (2014). Estimativa de taxa de mortalidade e taxa de incidência de sequelas cardíacas e digestivas por doença de Chagas no Brasil, 2008. Epidemiologia e Serviços de Saúde, 23, 711-720.
Ojo, O. A., Ojo, A. B., Ajiboye, B. O., Olaiya, O., Okesola, M. A., Boligon, A. A., . . . Kappo, A. P. (2018). HPLC-DAD fingerprinting analysis, antioxidant activities of Tithonia diversifolia (Hemsl.) A. Gray leaves and its inhibition of key enzymes linked to Alzheimer’s disease. Toxicology Reports, 5, 585-592. doi:https://doi.org/10.1016/j.toxrep.2018.05.003
Omokhua, A., Abdalla, M., van Staden, J., & McGaw, L. (2018). A comprehensive study of the potential phytomedicinal use and toxicity of invasive Tithonia species in South Africa. BMC Complementary and Alternative Medicine. doi:10.1186/s12906-018-2336-0
Orsomando, G., Agostinelli, S., Bramucci, M., Cappellacci, L., Damiano, S., Lupidi, G., . . . Petrelli, R. (2016). Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD). Industrial Crops and Products, 85, 181-189. doi:https://doi.org/10.1016/j.indcrop.2016.03.003
Owoyele, B., Wuraola, C., Ojuawo, A., & Olaleye, S. (2004). Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract. J Ethnopharmacol, 90, 317-321. doi:10.1016/j.jep.2003.10.010
Pan, S.-Y., Zhou, S., Gao, S.-H., Yu, Z.-L., Zhang, S.-F., Tang, M., . . . Ko, K.-M. (2013). New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics. Evidence-based complementary and alternative medicine : eCAM, 2013, 627375. doi:10.1155/2013/627375
Parr, C. S., Wilson, N., Leary, P., Schulz, K. S., Lans, K., Walley, L., . . . Corrigan, R. J., Jr. (2014). The Encyclopedia of Life v2: Providing Global Access to Knowledge About Life on Earth. Biodivers Data J(2), e1079. doi:10.3897/BDJ.2.e1079
Passoni, F. D., Oliveira, R. B., Chagas-Paula, D. A., Gobbo-Neto, L., & Da Costa, F. B. (2013). Repeated-dose toxicological studies of Tithonia diversifolia (Hemsl.) A. gray and identification of the toxic compounds. J Ethnopharmacol, 147(2), 389-394. doi:https://doi.org/10.1016/j.jep.2013.03.024
Pinto, A. C., Zucco, C., Galembeck, F., Andrade, J. B. d., & Vieira, P. C. (2012). Química sem fronteiras. Química Nova, 35, 2092-2097.
Pretty, J., & Bharucha, Z. P. (2014). Sustainable intensification in agricultural systems. Annals of Botany, 114(8), 1571-1596. doi:10.1093/aob/mcu205
Reis, M. M., Santos, L. D. T., Pegoraro, R. F., Colen, F., Rocha, L. M., & Ferreira, G. A. d. P. (2016). Nutrition of Tithonia diversifolia and attributes of the soil fertilized with biofertilizer in irrigated system. Revista Brasileira de Engenharia Agrícola e Ambiental, 20, 1008-1013.
Senarathne, S., Atapattu, A. A. A. J., Raveendra, T., Mensah, S., & Dassanayake, K. (2018). Biomass allocation and growth performance of Tithonia diversifolia (Hemsl.) A.Gray in coconut plantations in Sri Lanka. Agroforestry Systems. doi:10.1007/s10457-018-0290-y
Shi, Z., Chen, Y., Chen, Y., Yuou-ruen, L., Liu, S., Ge, X.-J., . . . Gottschlich, G. (2011). Asteraceae. Wu, Z. Y., Raven, P. H. & Hong, D. Y., eds., Flora of China Volume 20–21 (Asteraceae).
Silva, V. P., Almeida, F. Q. d., Morgado, E. d. S., França, A. B., Ventura, H. T., & Rodrigues, L. M. (2009). Digestibilidade dos nutrientes de alimentos volumosos determinada pela técnica dos sacos móveis em eqüinos. Revista Brasileira de Zootecnia, 38, 82-89.
Sut, S., Dall'Acqua, S., Baldan, V., Ngahang Kamte, S. L., Ranjbarian, F., Biapa Nya, P. C., . . . Petrelli, R. (2018). Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation. Fitoterapia, 124, 145-151. doi:10.1016/j.fitote.2017.11.002
Thang, T., Ogunmoye, A., Eresanya, O., Ogunwande, I., Dai, D., Dai, T., . . . Ogunwande, I. (2015). Chemical constituents of essential oils from the leaves of Tithonia diversifolia, Houttuynia cordata and Asarum glabrum grown in Vietnam. 17-21.
Toledo, J. S., Ambrósio, S. R., Borges, C. H., Manfrim, V., Cerri, D. G., Cruz, A. K., & Da Costa, F. B. (2014). In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes. Molecules, 19(5), 6070-6079. doi:10.3390/molecules19056070
Wanzala, W., Hassanali, A., Mukabana, W. R., & Takken, W. (2014). Repellent Activities of Essential Oils of Some Plants Used Traditionally to Control the Brown Ear Tick, Rhipicephalus appendiculatus. J Parasitol Res, 2014, 434506. doi:10.1155/2014/434506
Wu, Y., Wang, D., Gao, Y., Feng, J., & Zhang, X. (2016). New α-Methylene-γ-Butyrolactone Derivatives as Potential Fungicidal Agents: Design, Synthesis and Antifungal Activities. Molecules, 21(2), 130. doi:10.3390/molecules21020130
Yang, J., Tang, L., Weibang, S., & Yl, G. (2012). Genetic Diversity of an Alien Invasive Plant Mexican Sunflower (Tithonia diversifolia) in China. Weed Science, 60. doi:10.2307/23363042
Yuan, H., Ma, Q., Ye, L., & Piao, G. (2016). The Traditional Medicine and Modern Medicine from Natural Products. Molecules, 21(5). doi:10.3390/molecules21050559
Zhao, G., Li, X., Chen, W., Xi, Z., & Sun, L. (2012). Three new sesquiterpenes from Tithonia diversifolia and their anti-hyperglycemic activity. Fitoterapia, 83(8), 1590-1597. doi:https://doi.org/10.1016/j.fitote.2012.09.007
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