Importance of antibiotics in the treatment of Covid-19
DOI:
https://doi.org/10.33448/rsd-v9i10.8481Keywords:
COVID-19; Antibiotics; Treatment.Abstract
Antibiotics are being used as an experimental treatment in patients infected with coronavirus, in some patients there was an improvement in signs and symptoms and a reduction in viral load. Based on these facts, studies are being conducted to prove the efficacy of antibiotics, especially macrolides, due to their ability to act at the site of infection, having immunomodulatory action, also having activity against intracellular pathogens. The aim of this study is to verify in the current literature the importance of antibiotics in the treatment of COVID-19 carriers. The methodology used was an integrative review study in lilacs and pubmed databases. The results showed that antibiotics, especially macrolides, showed positive results regarding the reduction of viral load and immunomodulatory function. However, the small number of studies conducted and few patients analyzed are reflections of a challenge to be faced, . In addition, there is a need to understand the mechanisms of action and drug interactions at the molecular level, and phylogenetic studies are also needed.
References
Andreani J., Bideau, M., Duflot, I., Jardot, P., Rolland, C., Boxberger, M., wiurtz, N., Rolain, J., Colson, P., Scola, B., & Raoult, D. (2020). In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microbial pathogenesi 2020: 104228. DOI: https://doi.org/10.1016/j.micpath.2020.104228
Brasil, Ministério da saúde (2020). Secretaria de Políticas de Saúde. Coronavírus, DF.
Comitê de Infecção e Sepse da AMIB (2020). Terapia antimicrobiana empírica na síndrome respiratória aguda grave. Recuperado de https://www.amib.org.br/fileadmin/user_upload/amib/2020/marco/26/19_Terapia_antimicrobiana_empirica_na_sindrome_respiratoria_aguda_grave_pelo_Comite_de_Infeccao_e_Sepse_da_AMIB.pdf
De Araújo Prudente, A. L., Neto, F. C. C. (2020). Protocolo de tratamento do novo coronavírus. Versão 2 (Casos suspeitos/confirmados).
Derendorf H. (2020). Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin. International Journal of Antimicrobial Agents 2020: 106007. DOI: https://doi.org/10.1016/j.ijantimicag.2020.106007
El Kik, C. Z. (2020). Combinação de medicamentos é a nova arma contra COVID-19. Boletim P&D. 6(3), 5-6.
Gautret P., et al. (2020). Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study. Travel medicine and infectious disease 2020: 101663. DOI: https://doi.org/10.1016/j.tmaid.2020.101663.
Gautret, P., et al. (2020). Hidroxicloroquina e azitromicina como tratamento de COVID19: resultados de um ensaio clínico não randomizado de rótulo aberto. Revista Internacional de Agentes Antimicrobianos 2020: 105949.
Hui, D. S., Lee, N., Chan, P. K., Beigel, J. H. (2018). The role of adjuvant immunomodulatory agents for treatment of severe influenza. Antiviral research, 2018, 150, 202-216. Doi: https://doi.org/10.1016/j.antiviral.2018.01.002.
Malavolta, M., Giacconi, R., Brunetti, D., Proviciali, M., & Maggi, F. (2020). Exploring the relevance of senotherapeutics for the current SARS-CoV-2 emergency and similar future global health threats. 4(9), 909. DOI: https://doi.org/10.3390/cells9040909
Millán-oñate, J., Millan, W., Mendoza, L. A., Sánchez, C. G., Fernandez Suarez, H., D. Bonilla Aldana, K., Rodríguez Morales, A. J. (2020). Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin. Annals of Clinical.
NIH. NTM-CBI. (2020). Pub Chem: Compound Sumary. Azytromicin. 2020a. Disponível em: https:// pubchem.ncbi.nlm.nih.gov/compound/447043.
Quintella, C. M., Silva, L. A. C., Quintella, H. M., Silva, G. H. R., Silva, S. C. R., Uchoa, S. B., Mata, P. M. A. L. T. (2020). Fármacos para COVID-19: muito além da cloroquina (testes clínicos para o coronavírus SARS-CoV-2). Cadernos de Prospecção 2020. 13(3), 599.
Ronco, C., Reis, T., Husain-Syed, F. (2020). Management of acute kidney injury in patients with COVID-19. The Lancet Respiratory Medicine, available online. DOI: https://doi.org/10.1016/S2213-2600(20)30229-0
Sargiacomo, C., Sotgia, F., Lisanti, Michael P. (2020). COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?. Aging (Albany NY). 12(8), 6511. DOI: 10.18632/aging.103001
Spezzani, V., Piunno, A., Iselin, H. (2020). Benign. COVID-19 in an immunocompromised cancer patient-the case of a married couple. Swiss Medical Weekly 2020: 150: 1516. DOI: https://doi.org/10.4414/smw.2020.20246
Ulrich, H., Pillat, Micheli M. (2020). CD147 as a target for COVID-19 treatment: suggested effects of azithromycin and stem cell engagement. Stem Cell Reviews and Reports 2020: 1-7. DOI: https://doi.org/10.1007/s12015-020-09976-7
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Copyright (c) 2020 Lucas de Moraes Andrade; José Leonardo Gomes Coelho; Natália dos Santos Almeida; Dayse Christina Rodrigues Pereira Luz; Emanuel Cardooso Monte; Aretha Feitosa de Araújo; Juliana Ribeiro Francelino Sampaio; José Rafael Eduardo Campos; Jessika Brenda Rafael campos; Maria Eduarda Correia dos Santos; Mikaelle Sales Esmeraldo; Willma José de Santana
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