Use of photobiomodulation in the treatment of acute tendon injury
DOI:
https://doi.org/10.33448/rsd-v9i10.8744Keywords:
Tendon injury; Photobiomodulation.Abstract
In the face of controversies about the treatment of tendon injuries, non-surgical treatment using photobiomodulation therapy has been shown to be effective in repair. Objective was to evaluate the effects of photobiomodulation therapy on the tendon repair process. 42 Rattus norvegicus belonging to the wistar lineage were used, which were randomly divided into 2 experimental groups: Control (CG); Photobiomodulation (PBM). The groups were subdivided into 3 experimental periods: 7, 14 and 21 days. PBM started 24 hours after injury induction and followed for 7, 14, 21 days. For FBM, the 660 nm, 40 mW, 0.23 J and 6 s laser was used. The volume of the edema was evaluated, immediately before the tendon transection; 24 hours later; on the day of euthanasia, following their respective experimental periods. Histopathological analysis of the region of the transect and the quantification of blood vessels were performed using HE. Edema results: 24 hours after injury induction, there was no statistical difference between the experimental groups. After the experimental periods, 7, 14 and 21 days, the PBM group was effective in reducing the edema compared to the control. Histological results revealed that the PBM group had a greater tendon injury compared to the control after 7 days. After 14 and 21 days, the PBM group showed a better repair process compared to the control group. Likewise, PBM showed a greater number of blood vessels when compared to the control, after all experimental periods. The PBM treatment was effective in reducing the volume of the edema, preventing degenerative morphological alterations of the tendon, after 21 days.
References
Aimbire, F., Albertine, R., De Magalhães, R. G., Lopes-Martins, R. A. B., Castro-Faria-Neto, H. C., Zângaro, R. A., Chavantes, M. C., & Pacheco, M. T. T. (2005). Effect of LLLT Ga-Al-As (685 nm) on LPS-induced inflammation of the airway and lung in the rat. Lasers in Medical Science, 20(1), 11–20. https://doi.org/10.1007/s10103-005-0339-9
Albertini, R., Aimbire, F. S. C., Correa, F. I., Ribeiro, W., Cogo, J. C., Antunes, E., Teixeira, S. A., De Nucci, G., Castro-Faria-Neto, H. C., Zângaro, R. A., & Lopes-Martins, R. A. B. (2004). Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema. Journal of Photochemistry and Photobiology B: Biology, 74(2–3), 101–107. https://doi.org/10.1016/j.jphotobiol.2004.03.002
Aller, M. A., Arias, J. L., Sánchez-Patán, F., & Arias, J. (2006). The inflammatory response: An efficient way of life. Medical Science Monitor, 12(10), 225–234.
Andarawis-Puri, N., Flatow, E. L., & Soslowsky, L. J. (2015). Tendon basic science: Development, repair, regeneration, and healing. Journal of Orthopaedic Research, 33(6), 780–784. https://doi.org/10.1002/jor.22869
Arias, J. I., Aller, M. A., & Arias, J. (2009). Surgical inflammation: A pathophysiological rainbow. Journal of Translational Medicine, 7, 1–15. https://doi.org/10.1186/1479-5876-7-19
Bogaerts, S., Desmet, H., Slagmolen, P., & Peers, K. (2016). Strain mapping in the Achilles tendon - A systematic review. Journal of Biomechanics, 49(9), 1411–1419. https://doi.org/10.1016/j.jbiomech.2016.02.057
Boschi, E. S., Leite, C. E., Saciura, V. C., Caberlon, E., Lunardelli, A., Bitencourt, S., Melo, D. A. S., & Oliveira, J. R. (2008). Anti-inflammatory effects of low-level laser therapy (660 nm) in the early phase in carrageenan-induced pleurisy in rat. Lasers in Surgery and Medicine, 40(7), 500–508. https://doi.org/10.1002/lsm.20658
De Freitas, L. F., & Hamblin, M. R. (2016). Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE Journal on Selected Topics in Quantum Electronics, 22(3). https://doi.org/10.1109/JSTQE.2016.2561201
de Mattos, L. H. L., Álvarez, L. E. C., Yamada, A. L. M., Hussni, C. A., Rodrigues, C. A., Watanabe, M. J., & Alves, A. L. G. (2014). Effect of phototherapy with light-emitting diodes (890 nm) on tendon repair: an experimental model in sheep. Lasers in Medical Science, 30(1), 193–201. https://doi.org/10.1007/s10103-014-1641-1
Deng, S., Sun, Z., Zhang, C., Chen, G., & Li, J. (2017). Surgical Treatment Versus Conservative Management for Acute Achilles Tendon Rupture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Foot and Ankle Surgery, 56(6), 1236–1243. https://doi.org/10.1053/j.jfas.2017.05.036
Dietrich, F. (2012). Comparação Do Efeito Do Plasma Rico Em Plaquetas E Fibrina Rica Em Plaquetas No Reparo Do Tendão De. 1–104.
Egger, A. C., & Berkowitz, M. J. (2017). Achilles tendon injuries. Current Reviews in Musculoskeletal Medicine, 10(1), 72–80. https://doi.org/10.1007/s12178-017-9386-7
Frauz, K., Teodoro, L., Carneiro, G., Cristina da Veiga, F., Lopes Ferrucci, D., Luis Bombeiro, A., Waleska Simões, P., Elvira Alvares, L., Leite R. de Oliveira, A., Pontes Vicente, C., Seabra Ferreira, R., Barraviera, B., do Amaral, M., Augusto M. Esquisatto, M., de Campos Vidal, B., Rosa Pimentel, E., & Aparecida de Aro, A. (2019). Transected Tendon Treated with a New Fibrin Sealant Alone or Associated with Adipose-Derived Stem Cells. Cells, 8(1), 56. https://doi.org/10.3390/cells8010056
Hamblin, M. R. (2018). Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation. Photochemistry and Photobiology, 94(2), 199–212. https://doi.org/10.1111/php.12864
Hamblin, M. R., Huang, Y. Y., Sharma, S. K., & Carroll, J. (2011). Biphasic dose response in low level light therapy - an update. Dose-Response, 9(4), 602–618. https://doi.org/10.2203/dose-response.11-009.Hamblin
James, R., Kesturu, G., Balian, G., & Chhabra, A. B. (2008). Tendon: Biology, Biomechanics, Repair, Growth Factors, and Evolving Treatment Options. Journal of Hand Surgery, 33(1), 102–112. https://doi.org/10.1016/j.jhsa.2007.09.007
Karaaslan, F., Mermerkaya, M. U., Çıraklı, A., Karaoğlu, S., & Duygulu, F. (2016). Surgical versus conservative treatment following acute rupture of the Achilles tendon: Is there a pedobarographic difference? Therapeutics and Clinical Risk Management, 12, 1311–1315. https://doi.org/10.2147/TCRM.S116385
Karvat, J., Antunes, J. S., Bernardino, G. R., Kakihata, C. M. M., & Bertolini, G. R. F. (2014). Effect of low-level LASER and neural mobilization on nociceptive threshold in experimental sciatica. Revista Dor, 15(3), 207–210. https://doi.org/10.5935/1806-0013.20140045
Khan, R. J., & Carey Smith, R. L. (2010). Surgical interventions for treating acute Achilles tendon ruptures. Cochrane Database of Systematic Reviews, 9. https://doi.org/10.1002/14651858.cd003674.pub4
Martignago, C. C. S., Tim, C. R., Assis, L., Andrade, A. L. M., Brassolati, P., Bossini, P. S., Leiebano, R. E., & Parizotto, N. A. (2019). Preemptive treatment with photobiomodulation therapy in skin flap viability. Journal of Photochemistry and Photobiology B: Biology, 201, 111634. https://doi.org/10.1016/j.jphotobiol.2019.111634
Meulenkamp, B., Stacey, D., Fergusson, D., Hutton, B., Mlis, R. S., & Graham, I. D. (2018). Protocol for treatment of Achilles tendon ruptures; A systematic review with network meta-analysis. Systematic Reviews, 7(1), 1–7. https://doi.org/10.1186/s13643-018-0912-5
Naterstad, I. F., Rossi, R. P., Marcos, R. L., Parizzoto, N. A., Frigo, L., Joensen, J., Lopes Martins, P. S. L., Bjordal, J. M., & Lopes-Martins, R. A. B. (2018). Comparison of Photobiomodulation and Anti-Inflammatory Drugs on Tissue Repair on Collagenase-Induced Achilles Tendon Inflammation in Rats. Photomedicine and Laser Surgery, 36(3), 137–145. https://doi.org/10.1089/pho.2017.4364
Ochen, Y., Beks, R. B., Van Heijl, M., Hietbrink, F., Leenen, L. P. H., Van Der Velde, D., Heng, M., Van Der Meijden, O., Groenwold, R. H. H., & Houwert, R. M. (2019). Operative treatment versus nonoperative treatment of Achilles tendon ruptures: Systematic review and meta-analysis. BMJ (Online), 364. https://doi.org/10.1136/bmj.k5120
Pereira, A. S., Shitsuka, Dorlivete Moreira Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica - Licenciatura em Computação. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.
Sommer, A. P., Pinheiro, A. L. B., Mester, A. R., Franke, R. P., & Whelan, H. T. (2001). Biostimulatory windows in low-intensity laser activation: Lasers, scanners, and NASA’s light-emitting diode array system. Journal of Clinical Laser Medicine and Surgery, 19(1), 29–33. https://doi.org/10.1089/104454701750066910
Stavenuiter, X. J. R., Lubberts, B., Prince, R. M., Johnson, A. H., DiGiovanni, C. W., & Guss, D. (2019). Postoperative Complications Following Repair of Acute Achilles Tendon Rupture. Foot and Ankle International, 40(6), 679–686. https://doi.org/10.1177/1071100719831371
Thorpe, C. T., Peffers, M. J., Simpson, D., Halliwell, E., Screen, H. R. C., & Clegg, P. D. (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Scientific Reports, 6(October 2015), 1–12. https://doi.org/10.1038/srep20455
Tim, C. R., Bossini, P. S., Kido, H. W., Malavazi, I., von Zeska Kress, M. R., Carazzolle, M. F., Rennó, A. C., & Parizotto, N. A. (2016). Low-level laser therapy induces an upregulation of collagen gene expression during the initial process of bone healing: a microarray analysis. Journal of Biomedical Optics, 21(8), 088001. https://doi.org/10.1117/1.jbo.21.8.088001
Vaghardoost, R., Momeni, M., Kazemikhoo, N., Mokmeli, S., Dahmardehei, M., Ansari, F., Nilforoushzadeh, M. A., Sabr joo, P., Mey Abadi, S., Naderi Gharagheshlagh, S., & Sassani, S. (2018). Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial). Lasers in Medical Science, 33(3), 603–607. https://doi.org/10.1007/s10103-017-2430-4
Volpi, P. (2016). Arthroscopy and sport injuries : applications in high-level athletes.
Wilkins, R., & Bisson, L. J. (2012). Operative versus nonoperative management of acute achilles tendon ruptures: A quantitative systematic review of randomized controlled trials. American Journal of Sports Medicine, 40(9), 2154–2160. https://doi.org/10.1177/0363546512453293
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Eneas de Freitas Dutra Jr; Silvia Maria Cardoso Magalhães Hidd; Marcello Magri Amaral; Antonio Luiz Martins Maia Filho; Lívia Assis; Cintia Cristina Santi Martignago; José Figueredo-Silva; Carla Roberta Tim
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.