Effects of the synthetic analog of feline pheromone on vital parameters, cortisol and glucose concentration of cats submitted to physical and ophthalmic examination





Cortisolemia; Feline behavior; Stress.


This study examines the effects of the synthetic analog of feline pheromone (FFPA) in cats submitted to physical and ophthalmologic examination. Plasma cortisol, plasma glucose, vital parameters and blood count were evaluated for this study. Therefore, 14 felines of both sexes and clinically healthy were selected and separated into two groups: non-exposed (7), and experimental group (7). The experimental group was exposed to FELIWAY CLASSIC® diffuser associated with FELIWAY CLASSIC® spray. The animals of the exposed group remained in contact with the pheromone before and during the veterinary evaluation, totaling 3 hours and 30 minutes. After the observation period, hemogram was performed in both groups and all results were within the reference values for the species. Plasma concentrations of cortisol in the non-FFPA group ranged from 0.5 to 1.99 μg / dL, with an average of 1.3 μg / dL and in the experimental group of 0.3 to 2.88 μg / dL, with an average of 1.51 μg / dL, presenting no significant variance between groups (p>0,05). In contrast, the animals exposed to synthetic FFPA had their plasma glucose concentration and the vital parameters decreased (83.0 mg / dL and FC = 182 bpm, RR = 44.0 mpm) when compared with the animals that were not exposed (FC = 192 bpm, FR = 54.2 mpm and 87.5 mg / dL). In addition, the animals exposed to FFPA were, according to their examiners, calmer and more receptive during the procedures performed in comparison to their habitual behavior. The results of this study suggest that the use of FFPA, even in short periods, can be beneficial to cats in stressful situations, such as outpatient visits.


Chan, D. L., Freeman, L. M., Rozanski, E. A., Rush, J. E. (2006). Alterations in carbohydrate metabolismin critically ill cats. Journal of Veterinary Emergency and Critical Care, 16, 7-13.

Conti L. M., Champion, T., Guberman, U. C., Mathias, C. H., Fernandes, S. L., Silva, E. G., Lázaro, M. A., Lopes, A. D., Fortunato, V. (2016). Evaluation of environment and a feline facil pheromone analogue on physiologic and behavioral measures in cats. Journal of Veterinary Internal Medicine, 19, 165-170.

Contreras E. T., Hodgkins, E., Tynes, V., Beck, A., Olea-Popelka, F., Lappin, M. R. (2017). Effect of a Pheromone on Stress-Associated Reactivation of Feline Herpesvírus- 1 in Experimentally Inoculated Kittens. Journal of Veterany Internal Medicine, 32(1), 406-417.

Förster, H. C. (2017). Interactions between psychosocial stress and the circadian endogenous clock. Psych Journal. 6, 277-289.

Kronen, P. W., Ludders, J. W., Erb, H. N., Moon, P. F., Gledd, R. D., Koski, S. (2006). A synthetic fraction of feline facial pheromones calms but does not reduce struggling in cats before venous catheterization. Veterinary Anaesthesia And Analgesia, 33, 258-265.

Nibblett, B. M., Ketzis, J. K., Grigg, E. K. (2015). Comparison of stress exhibited by cats examined in a clinicversus a home setting. International Society for Applied Ethology, 173, 68-75.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R.(2018). Metodologia da pesquisa científica. [e -book]. Santa Maria. Ed. UAB/NTE/UFSM. Recuperado dehttps://reposito rio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_MetodologiaPesquisa-Cientifica. pdf?sequence=1.

Selye H. (1950). The physiology and pathology of exposure to stress. Oxford, England: Acta.

Seyle H. (1956). The stress of life. New York: McGraw Hill.

Silva, B. P. L., Knackfuss, F. B., Labarthe, N., Mendes-de-Almeida, F. (2017). Effect of a synthetic analogue of the feline facial pheromone on salivary cortisol levels in the domestic cat. Pesquisa Veterinária Brasileira, 37(3), 287-290.

Van Haaften K. A., Forsythe, L. R. E., Stelow, E. A., Bain, M. J. (2017). Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination. Journal Of The American Veterinary Medical Association, 251(10), 1175-1181.



How to Cite

Viaes, E. dos S., Assis, M. F. de, Lopes, G. J., Merlini, N. B., & Marcusso, P. F. . (2020). Effects of the synthetic analog of feline pheromone on vital parameters, cortisol and glucose concentration of cats submitted to physical and ophthalmic examination. Research, Society and Development, 9(11), e1369119312. https://doi.org/10.33448/rsd-v9i11.9312



Agrarian and Biological Sciences