The efficacy of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review




Ulcerative colitis; Fecal microbiota transplantation; Patient; Intervention.


Ulcerative colitis (UC) is a chronic inflammatory bowel disease restricted to the mucosa, characterized by diarrhea and most often accompanied by major bleeding. The usual current treatment, demonstrating low efficacy, thus, the fecal microbiota transplant (FMT) was proposed as a therapy option. Given the above, the objective of this article is to evaluate the effectiveness of TMF for the treatment of active UC. The research was structured by the PICO methodology (Patient, Intervention, Comparison and Result), inclusion and exclusion criteria and assessment of reliability and quality by Jadad and Chochrane tool. The results were favorable regarding the use of FMT for the treatment of mild and moderately active UC, however, the route of administration, the time of treatment and the identification of the microbial profile necessary for the clinical remission of the disease were divergent in some studies. Through the analysis it was possible to conclude that the FMT has potential in order to provide benefits to patients with UC and more research in the area is necessary to define the best type of treatment for each patient.

Author Biographies

Marcela Jorge Bozza, União das Faculdades dos Grandes Lagos

Discente do curso de Medicina

União das Faculdades dos Grandes Lagos (UNILAGO)

Julia Maria Moreira Vilar, Universidade Brasil

Discente do curso de Medicina

Universidade Brasil (UB)


Adams, S. M., et al. (2013). Ulcerative colitis. American family physician, 87(10), 699–705. Recuperado de <>.

Benech, N., et al., (2019). Fecal Microbiota Transplantation for Ulcerative Colitis. JAMA, 321(22), 2240, Recuperado de <>.

Carvalho, A. P. V. C. (2013). Avaliação do risco de viés de ensaios clínicos randomizados pela ferramenta da colaboração Cochrane. Revista Diagnóstico & Tratamento. 18(1), 38-44. Recuperado de <>.

Chen, W. X., et al. (2014). Enteric microbiota leads to new therapeutic strategies for ulcerative colitis. World Journal of Gastroenterology, 20(42), 15657-15763. Recuperado de <>.

Costello, S. P., et al. (2019). Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial. JAMA. [S.l.], 321(2), 156-164, Recuperado de < ma/fullarticle/2720727>.

Fuentes, S., et al. (2017) Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation. ISME Journal, 11(8), 1877-89. Recuperado de <>.

Jadad, A. R., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clinical Trials. 17(1), 1-12.

Koche, J. C. (2011). Fundamentos de metodologia científica. Petrópolis: Vozes. 3%A9-Carlos0D0AFundamentos-de-metodologia-cient%C3%ADfica-_-teoria-da0D0 Aci%C3%AAncia-e-inicia%C3%A7%C3%A3o-%C3%A0-pesquisa.pdf.

Ludke, M., & Andre, M. E. D. A. (2013). Pesquisas em educação: uma abordagem qualitativa. São Paulo: E.P.U. Recuperado de 091392/mod_resource/content/1/Lud_And_cap3.pdf.

Moayyedi, P., et al. (2015). Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial. Gastroenterology. 49(1), 102-109. Recuperado de <>.

Neeraj, N., et al. (2017). Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. Inflammatory Bowel Diseases. 23(10), 1702-1709. Recuperado de < ticle/23/10/1702/4791645>.

Ordás, I., et al. (2012) Ulcerative colitis. The Lancet, [S.l.], 380(9853), 1606-1619. Recuperado de <>.

Paramsothy, S., et al. (2017) Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial. Lancet. [S.l.], 389(10075), 1218-1228. Recuperado de < cet/article/PIIS0140-6736(17)30182-4/fulltext>.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da Pesquisa Científica. [e-book]. Ed. UAB/NTE/UFSM. Santa Maria/RS. Recuperado de

Rossen, N. G., et al.(2015). Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis. Gastroenterology. [S.l.], 149(1) 110-118. Recuperado de <>.

Shi, Y., et al. (2016). Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis. PloS one. [S.l.], 11(6), 1-23. Recuperado de <>.

Tian, Y., et al. (2019). Fecal microbiota transplantation for ulcerative colitis: a prospective clinical study. BMC Gastroenteroogyl, 19(1169), 1-12. Recuperado de <>.

Vindigni, S. M. et al. (2017). Fecal Microbiota Transplantation. Gastroenterology clinics of North America, 46(1), 171–185. Recuperado de < 6/j.gtc.2016.09.012>.



How to Cite

Bozza, M. J. ., Vilar, J. M. M. ., & Kozusny-Andreani, D. I. (2020). The efficacy of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review. Research, Society and Development, 9(11), e1269119648.



Health Sciences