Effect of the gel based on Moringa oleifera lam. as a phytotherapy in wound healing

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.9957

Keywords:

Rats, Wistar; Wound Healing; Surgical Wound; Moringa oleífera.

Abstract

Objective: To evaluate the healing effects of Moringa oleifera in rats (Rattus norvegicus). Methodology: Moringa leaves were collected, dried, crushed, mixed with hexane solvent and filtered. After removing the solvent and moisture, he combined the resulting concentrate with the natrosol gel, reaching concentrations of 5% and 10%. 60 male rats were divided into 4 groups: negative control (without treatment), positive control (treated with AGE), Moringa 5% (treated with Moringa gel at 5%) and Moringa 10% (treated with Moringa gel at 10 %). It was subdivided into three groups of 5 animals according to the evaluation period (7, 14 and 21 days). A longitudinal incision (3.0 cm) was made in the cervical region; in the dorsal region an area of ​​2 cm² was demarcated and resected with a punch. Result: In the analysis of healing resistance, after 7 days, the 5% and 10% moringa groups showed a significant regression; after 14 and 21 days, the Moringa 10% group showed statistical significance when compared to the other groups. In the microscopic analysis, after 7 days, collagen fibers more evident in the Moringa groups 5% and 10%; after 14 and 21 days, few blood vessels, low intensity inflammatory reaction and more organized and intense collagen deposition in the Moringa 10% group. Conclusion: Moringa, especially at a concentration of 10%, proved to be beneficial in the repair process of surgically induced skin wounds in rats.

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Published

19/11/2020

How to Cite

Moura, W. P. F. ., Assunção, A. F. C. ., Silva, K. dos S. ., Silva, L. R. da ., Morais, A. A. C. de ., Ferreira, D. C. L. ., Figueredo-Silva, J., Marques, R. B. ., & Maia Filho, A. L. M. . (2020). Effect of the gel based on Moringa oleifera lam. as a phytotherapy in wound healing. Research, Society and Development, 9(11), e4109119957. https://doi.org/10.33448/rsd-v9i11.9957

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Section

Health Sciences