The journal Research, Society and Development (abbreviated as Res. Soc. Dev.) is a multidisciplinary scientific publication focused on promoting the dissemination of knowledge, using scientific methodologies for social, scientific and technological development through the publication of manuscripts, results and conclusions of research, in the various areas of knowledge. It is a monthly online journal. Submissions are evaluated by peers (Double Blind Review) with experience in the area of ​​the manuscript. Ad hoc revisors 2024 We thank all of the more than 340 “ad hoc” reviewers who contributed to this Journal in their evaluations (double-blind peer review). Reviewers 2024
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Heat generation mechanisms in batteries of electric and hybrid vehicles: Effects on performance and thermal management solutions
This study investigates the heat-generation mechanisms in lithium-ion batteries used in electric and hybrid vehicles, analyzing their impact on performance and the solutions adopted to control temperature. Based on a literature review, the main thermal management strategies currently applied were examined, including air cooling, liquid cooling, phase-change materials, and heat pipes. The literature indicates that the optimal thermal operating range lies between 25 °C and 40 °C; temperatures above this threshold compromise cell integrity, accelerate aging processes, and significantly increase the risk of thermal runaway, considered the primary safety challenge. The reviewed studies demonstrate that geometric optimizations, material adjustments, and improvements in thermal-management system arrangements contribute to greater temperature uniformity, enhanced heat dissipation, and mitigation of thermal failures. Improving cooling systems is essential and integrating them with intelligent technologies represents a promising solution for the future of electric vehicles.
Copyright (c) 2025 José Moraes Guedes da Silva Neto, Rogério Soares da Silva, Denis Keuton Alves, Sérgio Vladimir Barreiro DeGiorgi https://creativecommons.org/licenses/by/4.0
Proliferation, migration, and osteogenic differentiation of mesenchymal stem cells exposed to a nanocomposite of hydroxyapatite and doped gelan gum
Early tissue loss requires research aimed at developing innovative approaches for treatment and accelerating the regenerative process. Bone tissue injuries cause significant social and economic impacts and are the focus of studies seeking to improve regeneration. Bone marrow-derived mesenchymal stem cells (BMSCs) are promising candidates for this type of application. In this study, a novel biomaterial composed of hydroxyapatite and gellan gum doped with cerium ions was used. This composite exhibits structural similarities to gum arabic, previously employed in other studies, and provides relevant and significant advantages for application in osteogenesis. The aim of this work was to evaluate the cytotoxicity of the biomaterial and its effects on the proliferation, adhesion, migration, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Complete bone regeneration depends on the presence of osteoinductive agents such as cells or biomolecules. Several biomaterials have been developed and applied in animal models to accelerate this process, including calcium phosphate cements and biopolymers. One of the major advances in this field is the use of biomaterials as scaffolds for cell integration, maintenance, and differentiation. The cells that constitute tissues and organs are embedded in a complex molecular network known as the extracellular matrix (ECM), whose molecules promote signaling pathways that direct cell growth and differentiation.
Copyright (c) 2025 Joselma Aparecida de Oliveira; Melissa Camassola https://creativecommons.org/licenses/by/4.0
The contribution of nursing to the management of gestational diabetes: Health education and self-care – An integrative review
Gestational diabetes is characterized by hyperglycemia, resulting in glucose accumulation in the pregnant woman's blood. This condition occurs due to a deficiency in the secretion or action of insulin, a hormone produced by beta cells in the pancreas. It is a serious condition that can have consequences for both the baby and the mother. Prenatal nursing care is an important strategy for controlling and monitoring risks. Therefore, the objective of this study is to analyze the contribution of nursing to the control of gestational diabetes, considering the importance of health education and self-care. To achieve this objective, an integrative review was conducted using a descriptive approach. Data collected from online journals and articles were selected from 2008 to 2025. Studies have shown that gestational diabetes is a common condition during pregnancy, due to several factors, including poor diet and a sedentary lifestyle. It is important to emphasize that this condition is responsible for complications for the mother, such as premature birth, excess amniotic fluid, and postpartum hemorrhage. For the baby, the consequences include overweight birth (macrosomia), hypoglycemia (low blood sugar), and jaundice. Health education has been shown to significantly reduce gestational diabetes mellitus and promote women's health.
Copyright (c) 2025 Esther Maria de Souza Coutinho, Marcos Vinicius Ferreira dos Santos, Sandy Thallya Vidal Madureira Machado, Thaynara Nogueira de Oliveira https://creativecommons.org/licenses/by/4.0
Public Health and Biological Risks: An integrative review on infectious diseases in meat processing industry workers
Occupational infectious diseases are a growing challenge for public health, especially among workers in the meatpacking industry, who are continuously exposed to biological agents of epidemiological relevance. Recent evidence shows a high prevalence of zoonoses such as leptospirosis, bovine tuberculosis and brucellosis, directly associated with the structural, sanitary and operational conditions of these environments. In view of this scenario, the objective of this study was to carry out an integrative review on biological risks and the occurrence of infectious diseases among workers in the meatpacking industry, identifying patterns of vulnerability, transmission mechanisms and structural gaps that explain the persistence of these diseases in the sector. An integrative literature review was carried out, with searches in the PubMed, Scopus, ScienceDirect, Web of Science, EMBASE, Google Scholar, EBSCO Medline, and VHL databases, including studies published between 2019 and 2024. The results showed that the seroprevalence of leptospirosis ranged from 16% to 28% in workers and slaughtered animals, while bovine tuberculosis reached up to 18.4% of the records analyzed. Hygiene failures, poor adherence to the use of PPE, and inadequate infrastructure were identified as critical factors that amplify biological risk. It is concluded that integrated interventions, improvements in biosafety, professional training and continuous epidemiological surveillance are essential, recommending new longitudinal and comparative studies to strengthen preventive strategies in the sector.
Copyright (c) 2025 André Vinicius da Silva Macedo, Nathalia Azulay Caliri de Andrade, Joaquim Albuquerque Viana https://creativecommons.org/licenses/by/4.0
Profile of hospitalizations for schizophrenia, schizotypal and delusional disorders in the municipality of Belém, state of Pará, from 2020 to 2024
Hospitalizations for schizophrenia and schizotypal and delusional disorders showed a continuous increase in the municipality of Belém (PA) between the years 2020 and 2024, reflecting the impact of these severe mental disorders on quality of life. A higher occurrence was observed among young adults, especially in the age groups of 20–29 and 30–39 years, which together accounted for more than half of all hospitalizations during the analyzed period. The study aimed to analyze the annual evolution of these hospitalizations and their characteristics according to sex, race/skin color, and age group. For this purpose, a cross-sectional quantitative epidemiological study was conducted using data extracted from TABNET/DATASUS for the municipality of Belém. Descriptive analyses, comparative graphs, and nonparametric tests (Kruskal–Wallis and Dunn post-hoc) were performed. The results showed a significant increase in hospitalizations, with emphasis on males, who presented a marked discrepancy in 2024, with 1,294 hospitalizations. Additionally, a predominance of individuals self-identified as brown (pardo) was observed across all analyses, confirming the greater representation of this group in the epidemiological profile of hospitalizations. It is concluded that hospitalizations due to psychotic disorders show an upward trend and are mainly concentrated among young adults, reinforcing the need for prevention strategies, early care, and psychosocial rehabilitation, as well as strengthening public mental health policies.
Copyright (c) 2025 Aline Juliane Souza Santos, Diana Nunes Queiroz, Lucas Felipe Santos Fernandes, Karina Faine Freitas Takeda https://creativecommons.org/licenses/by/4.0
Development of plant-based cookies free of allergenic ingredients with rice flour and beetroot
The objective was to evaluate the effect of partially replacing rice flour (RF) with beet flour (BF) on the technological characteristics of gluten-, milk-, and egg-free cookies. Five formulations with different proportions of RF and BF were developed: F1 (100:0), F2 (98.5:1.5), F3 (97:3.0), F4 (95.5:4.5), and F5 (94:6.0). Moisture, water activity (WA), and color of the flours and corn starch (CS) were evaluated, as well as moisture, WA, specific volume (SV), texture, and color of the cookies. The flours and CS had moisture content between 6.13% and 12.90%, within standards, and WA below 0.63, which prevents microbial growth. BF had a dark red hue, while RF and CS tended to be white. The increasing addition of BF did not show linear behavior in relation to moisture values (12.68–17.24%) and WA values (0.72–0.84). However, it increased SV (from 1.32 to 1.57 cm³·g⁻¹), reduced the expansion factor (from 2.83 to 2.17) and hardness (from 12.55 N to 7.59 N), making the cookies less crunchy. The incorporation of BF intensified the red color of the cookies, proportional to the level of substitution. The formulation with 3% BF (F3) presented acceptable technological characteristics, not influencing SV, and hardness, in addition to giving an attractive color due to betalains, natural pigments present in beetroot. Thus, the partial replacement of RF with BF proves to be a viable alternative to produce gluten-, milk-, and egg-free cookies with potentially better nutritional value.
Copyright (c) 2025 Luiz Henrique Garcia Pires, João Matheus Soares Falcão, Leomar Hackbart da Silva, Paula Fernanda Pinto da Costa https://creativecommons.org/licenses/by/4.0
Prevalence and sociodemographic-epidemiological profile of metabolic syndrome in rural communities exposed to pesticides in the Amazon: a cross-sectional study in Belterra, Pará
This study addresses metabolic syndrome in rural communities environmentally exposed to pesticides in the Amazon, with an emphasis on sociodemographic and epidemiological profiles in the municipality of Belterra, in the state of Pará. The research is justified by the concern about cardiometabolic impacts on vulnerable populations dependent on natural resources, where the intensive use of herbicides exacerbates health risks. The general objective of this study is to evaluate the prevalence of metabolic syndrome in the population of the municipality of Belterra. The specific objectives include understanding the sociodemographic profile of the sample, developing the epidemiological profile, and identifying metabolic syndrome using established criteria. The methodology adopts a cross-sectional design with primary data from n = 284 adults residing near agricultural crops, incorporating descriptive analyses of anthropometric, biochemical, and sociodemographic variables. The results indicate a prevalence of 46.1% for metabolic syndrome, higher than urban estimates, with a female predominance of 63.7%, a mean age of 51.31 years, overweight in 41.2% and obesity in 27.5%, in addition to biochemical alterations such as average triglycerides of 170.12 mg/dL. The conclusions highlight the demographic multifactoriality of the condition, proposing interventions such as adapted environmental surveillance to mitigate rural vulnerabilities in the Amazon.
Copyright (c) 2025 Mateus Augusto do Amaral Castro, Antônio Marcos Mota Miranda, Cássia Christina Silva Rocha, Kleber Raimundo Freitas Faial, Rosivaldo de Alcântara Mendes https://creativecommons.org/licenses/by/4.0
Liquorology: A tool in the diagnosis of multiple sclerosis and other neurodegenerative and demyelinating diseases
Neurodegenerative diseases are characterized by their insidious onset and the severe complications they cause during their course, resulting in many disabilities and even death. This study aimed to evaluate the application of cerebrospinal fluid (CSF) laboratory analyses in the diagnosis and prognosis of multiple sclerosis and other demyelinating diseases. This research is a narrative literature review, which searched databases such as SciELO (Scientific Electronic Library Online), BVS (Virtual Health Library), Google Scholar, and PubMed for current academic articles that supported this study. The studies unanimously demonstrated the importance of CSF analysis in the diagnosis of neurodegenerative diseases such as multiple sclerosis, particularly in the assessment of intrathecal albumin synthesis and the application of the Reiber diagram to distinguish whether the elevation of immunoglobulins is due to passive diffusion due to blood-brain barrier damage or to intrathecal synthesis, as is characteristic of multiple sclerosis. Technological and scientific advances in CSF analysis make it a central tool in the diagnosis and prognosis of neurodegenerative diseases such as multiple sclerosis.
Copyright (c) 2025 Laura Maria de Araújo Pereira, Talyta Valeria Siqueira do Monte Guedes, Rafaell Batista Pereira, Davi Abrantes Lucena Messias, Marfran José Cunha Urtiga, Davi Rodrigues Vieira, Samuel da Costa Chaves Trindade Martins, José Guedes da Silva Júnior https://creativecommons.org/licenses/by/4.0
Care strategies offered to families of children with Autism Spectrum Disorder in health services in Brazil: A scoping review
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood and is characterized by deficits in communication and social interaction, as well as by restricted and repetitive patterns of behavior, interests, or activities. The challenges in managing the symptoms and the scarcity of services for this population necessitate greater dedication to the care of the child, leading to emotional and physical strain on other family members. Shared care, information exchange, and strengthening the social and support network for the family can mitigate the impacts of ASD. Objective: This study aimed to map the care strategies provided to families of children with ASD in healthcare services in Brazil. Method: This is a scope review based on the Joanna Briggs Institute, conducted using the Virtual Health Library and Scielo databases, including scientific articles in Portuguese published in national journals over the last ten years. Results: It was identified that the strategies implemented with the families of children with ASD mostly occurred in the Child and Adolescent Psychosocial Care Centers. The most common strategies were therapeutic groups, support, individual care, and family guidance, developed in a multiprofessional manner. These actions facilitated the development of a social network among family members, the formation and strengthening of bonds between them and the team, coordination with the health network, family empowerment, and family participation as an agent in the child's treatment. The mother was the primary caregiver and the central point of contact with the team.Conclusion: The study revealed that the strategies led to the development and strengthening of bonds between participants and the health team, family empowerment, coordination between the network and service professionals, and access to rights for families and children with ASD. The need to consider gender perspective in implementing care strategies for families of children with ASD is highlighted.
Copyright (c) 2025 Maria Yasmin Nunes Ramos, Daniela Tavares Gontijo, Ivonete Silva Carneiro Monteiro, Sayonara Queiroz Coelho, Isabelle Cruz do Nascimento, Sidiane Barros da Silva, Vera Lúcia Dutra Facundes https://creativecommons.org/licenses/by/4.0
Between autonomy and collective memory: Freedom as the foundational axis of personality rights in Brazilian constitutional law
The article aims to analyze freedom as a personality right through a theoretical, bibliographic, deductive, and hermeneutic-critical approach. Based on classical and modern philosophical foundations, the study demonstrates how freedom evolves from an ethical-political ideal to a structuring legal value within contemporary constitutionalism. Through a comparative perspective, it analyzes the development of Western constitutional traditions and the mechanisms by which freedom becomes a fundamental right, highlighting the insufficiency of its merely negative conception and the need for material guarantees to ensure its concrete realization. In the Brazilian context, the 1988 Constitution inaugurates a personalist shift by establishing human dignity as a foundational principle, thereby radiating freedom throughout the entire legal system, including private relations. The civil-constitutional analysis reveals that protecting freedom requires both preventive and reparatory measures, as well as an interpretive framework committed to overcoming historical forms of suppression. The study further demonstrates that cases such as Gomes Lund and Herzog, decided by the Inter-American Court of Human Rights, reinforce the duty of memory and underscore the centrality of freedom within transitional justice, a necessary condition for strengthening the Democratic Rule of Law. It concludes that freedom, as a personality right, constitutes a legal power of subjective self-constitution expressed in existential autonomy, psychic inviolability, and personal development. Its effectiveness depends on institutional practices, public policies, and constitutional interpretation guided by human dignity.
Cleide Aparecida Gomes Rodrigues Fermentão
Copyright (c) 2025 Laila Caroline Franklin Vivian, Cleide Aparecida Gomes Rodrigues Fermentão https://creativecommons.org/licenses/by/4.0
Epidemiological profile of patients hospitalized for thyrotoxicosis between 2013 and 2023 in a Southern Brazil state (Paraná)
This study aims to present an analysis of the epidemiological profile of hospitalizations (sex and age group) of patients admitted for thyrotoxicosis in the state of Paraná between 2013 and 2023, with comparisons made to data from the Southern region and from Brazil as a whole over the same period. The data presented are available from the DataSUS online platform of the Brazilian Ministry of Health. In this context, in Paraná, a predominance of hospitalizations among women was observed, with the highest incidence between 30 and 39 years of age, the same age group represented in part of the deaths. In the Southern region, the pattern of hospitalizations was also predominantly female, with emphasis on the same age group; however, deaths were concentrated among women aged 70 to 79 years. At the national level, both hospitalizations and deaths showed a predominance of females, with higher frequency in the 40–49-year age group. The data reveal consistency in the sex profile but regional variations in the most affected age groups. Therefore, further studies are suggested to determine whether these trends will persist over time and to achieve a better understanding of the epidemiology of this endocrinological disorder.
Copyright (c) 2025 Heloísa Gemelli Tansini da Silva, Clarissa Vasconcelos de Oliveira, Alessandro Tansini da Silva, Dylson Junyor Neckel Linden, Nicoli Liber Baratieri, Carolina Magnani Fernandes Richard, Kelly Ribeiro Antunes https://creativecommons.org/licenses/by/4.0
Trends and factors associated with advanced maternal age in Brazil
Considering the social, economic, and public health relevance of advanced maternal age (AMA), this study aimed to examine temporal and regional patterns and the impact of socioeconomic factors (education, marital status, income, and health service access) on birth rates in Brazil. A cross-sectional observational analytical approach was used with data from DATASUS and IBGE (2000–2019). Descriptive and statistical analyses of demographic and socioeconomic variables were performed. The results show a rising trend of AMA in Brazil, with maternal education level and marital status significantly associated with this increase. Most women received excellent prenatal care, although little information is available to assess the quality of this care in most cases. Annual GDP per capita was highly correlated with childbirth to women with AMA. Finally, the number of deaths of women with late pregnancies varied greatly between Brazilian regions, being highest in the Southeast and Northeast. These findings emphasize the need for health policies targeting women of late reproductive age, ensuring access to quality care. Understanding the dynamics of late motherhood is vital for shaping effective reproductive health and family planning strategies that address regional and socioeconomic disparities.
Copyright (c) 2025 Vinicius Guerra, Layla Pires, Kamila Duarte, Maria Eduarda Oliveira, Larissa Schiavo, Vitória Cristhyne, Isadora Ribeiro, Débora Vieira https://creativecommons.org/licenses/by/4.0
Iron deficiency anemia: Pathophysiology and Hemogram Parameters in a Narrative Literature Review
Iron deficiency anemia is the most prevalent nutritional disorder worldwide and results from insufficient iron availability, an essential mineral for erythropoiesis and hemoglobin synthesis. It is classified as a microcytic and hypochromic anemia, presenting clinically with fatigue, pallor, and reduced functional capacity. This study aimed to synthesize recent evidence on the pathophysiology of iron deficiency anemia, the main hematological parameters involved in its diagnosis, and general preventive considerations. A narrative literature review was conducted in PubMed/MEDLINE, SciELO, LILACS, and Google Scholar databases, using Portuguese and English descriptors related to iron deficiency anemia and hematological alterations. Articles published in the last five years addressing physiopathological mechanisms, laboratory indicators, and general aspects of prevention were included. The reviewed literature indicates that iron deficiency progresses gradually, beginning with decreased ferritin levels, followed by reduced serum iron, microcytosis, hypochromia, and decreased hemoglobin. The complete blood count remains fundamental, with MCV, MCH, MCHC, and RDW highlighted as key markers for the identification of erythrocyte alterations. It is concluded that integrating hematological parameters with an understanding of the underlying physiology is essential for the proper identification of iron deficiency anemia and the implementation of preventive strategies.
Copyright (c) 2025 Osvaldo Júnior Morais Moreira, Maria da Paixão Morais Moreira, Jaine Ferreira Boaes, Thalia Costa Liam, Manuely Pereira Costa, Adrielle Costa Duarte, Pablo de Matos Monteiro https://creativecommons.org/licenses/by/4.0
Assistive Artificial Intelligence as a Cognitive Right: A proposal for neurodivergent equity in the 21st century
This article proposes the recognition of Assistive Artificial Intelligence (AAI) as a fundamental cognitive right for neurodivergent people. We argue that responsive AI systems operate as Cognitive Navigation Interfaces, reducing executive overload, filtering informational noise, increasing environmental predictability, and making institutional complexity more accessible. We introduce the concept of the Assistive Cognitive Ecosystem (ACE), a configuration in which one or multiple AI systems operate in parallel to support internal organization, emotional regulation, institutional communication, and decision-making. We also propose the creation of the Assistive Digital Architecture (ADA), a national protocol for the certification, ethical standardization, and integration of AAI into Brazil’s Digital SUS. AAI is presented as an emerging pillar of cognitive democracy capable of reducing structural inequality and expanding the autonomy of neurodivergent populations.
Copyright (c) 2025 Marco Antonio Martins Caldeira https://creativecommons.org/licenses/by/4.0
The use of creatine as a neuroprotective agent in Alzheimer’s disease
Alzheimer’s disease is a progressive neurodegenerative condition marked by cognitive decline, synaptic loss, and biochemical disturbances associated with beta-amyloid deposition, tau aggregation, and mitochondrial dysfunction. This study aimed to examine, through a narrative literature review, the biochemical mechanisms underlying the use of creatine as an adjunct intervention in the management of Alzheimer’s disease, as well as to evaluate the existing clinical evidence, its methodological limitations, and future research directions. The methodology involved a structured search in the PubMed, SciELO, and ScienceDirect databases for articles published between 2008 and 2025, focusing on experimental studies in animal models and human clinical trials assessing the effects of creatine supplementation in Alzheimer’s disease or related at-risk conditions, such as mild cognitive impairment. The findings indicate that preclinical research reports improvements in mitochondrial function, increased cellular energy stores, reduced excitotoxicity, and modulation of neurotrophic factors following supplementation. Pilot clinical studies suggest feasibility, safety, and potential cognitive benefits in early disease stages, although limitations persist regarding dose standardization, intervention duration, and sample size. Overall, creatine appears to be a promising nutritional intervention with potential to enhance cerebral bioenergetics; however, available evidence remains inconclusive, and rigorous, long-term randomized trials are required to confirm its therapeutic effectiveness.
Copyright (c) 2025 Elisa Di-Tano Moraes Oliveira, Maria Claudia da Silva https://creativecommons.org/licenses/by/4.0
Subcutaneous ureteral diversion and urethral stenting in the treatment of malignant urinary obstructions in cats: An integrative review of retrospective studies
Ureteral obstruction secondary to malignant disease in cats represents a significant clinical challenge due to the rapid progression of renal dysfunction and the aggressive local behavior of urogenital neoplasms. This study aimed to analyze, through an integrative review composed exclusively of retrospective investigations, the clinical outcomes associated with subcutaneous ureteral bypass (SUB) devices and ureteral stents in the management of malignant ureteral obstructions in felines. Methodological procedures included comprehensive extraction of data from seven retrospective studies, focusing on population characteristics, interventions, device patency, complication profiles and renal function outcomes. Findings demonstrated that SUB devices achieved superior long-term patency and functional stability compared to ureteral stents, particularly in cases involving infiltrative transitional cell carcinoma, although late complications such as recurrent urinary infection, partial obstruction and transmural gastrointestinal migration were identified. Ureteral stents, while effective for immediate decompression, exhibited higher rates of tumor-related reobstruction and lower tolerability in the lower urinary tract. Results emphasize that maintenance of device patency and infection control are critical determinants of survival and renal preservation. It is concluded that SUB devices offer superior long-term performance, though clinical decision-making should integrate individual tumor behavior and systemic condition. Future investigations should explore novel biomaterials, imaging-guided monitoring strategies and early predictors of device failure.
Copyright (c) 2025 Hithelly Silva de Araújo, Joaquim Albuquerque Viana https://creativecommons.org/licenses/by/4.0
Pre- and postoperative rehabilitation protocols in coronary artery bypass graft surgery: Literature review
Objective: To synthesize scientific evidence on the effectiveness of physiotherapy protocols applied before and after coronary artery bypass grafting (CABG) surgery. Methodology: Narrative review of the literature conducted in the PubMed, PEDro, SciELO, Lilacs, and Cochrane databases between 2010 and 2025, in English and Portuguese. Randomized clinical trials, systematic reviews, and meta-analyses that evaluated physiotherapy rehabilitation protocols in the pre- and/or postoperative period of CABG were included. After screening and evaluation, 11 studies remained (eight RCTs and three reviews/meta-analyses). Results: Physiotherapy protocols applied at different stages of cardiac rehabilitation after coronary artery bypass grafting (CABG) vary significantly in approach, intensity, and duration. Pre-rehabilitation with aerobic and respiratory exercise protocols promoted significant gains in functional and cardiorespiratory capacity and reduced hospital stay. In phase I (intra-hospital), protocols combined with aerobic exercise, early mobilization, and respiratory training improved functional capacity and pulmonary function and reduced hospital stay. In phase II (outpatient), the combination of aerobic and resistance exercise associated with inspiratory muscle training brought improvements in functional and cardiorespiratory capacity with the potential for sustained gains. Conclusion: Physical therapy is essential and safe in post-myocardial revascularization rehabilitation, with robust evidence in phase I (in-hospital) and promising evidence in pre-rehabilitation. In phase II (outpatient), there is a lack of robust evidence, compromising the continuity of benefits and the evaluation of long-term outcomes.
Copyright (c) 2025 Fernanda da Silva Boni, Gabriela Lopes do Nascimento, Gabriela Victória Vanzo Ferreira, Jéssica Macedo da Silva, Ana Caroline Silva de Freitas https://creativecommons.org/licenses/by/4.0
Nutritional status of indigenous children in the health regions of the state of Pará in 2024
The assessment of children's nutritional status constitutes an essential indicator of public health, especially among indigenous populations, who historically face situations of social, economic and health vulnerability. The objective of this study is to analyze the nutritional status of indigenous children in the three health regions of the State of Pará in the year 2024, based on two data from the Food and Nutrition Surveillance System (SISVAN). The research, from a quantitative approach, used secondary information made available by the Ministry of Health, allowing the identification of the rates of malnutrition, eutrophy and excess weight among the indigenous infant populations. The results show a scenario marked by a double burden of more nutrition, with the coexistence of cases of malnutrition in more vulnerable regions, such as Tapajós and Lago de Tucuruí, and the increase in overweight in other localities, reflecting the nutritional transition and the insertion of industrialized foods in the villages. These data reveal social and territorial inequalities that compromise the full development of children and evidence the need for intersectoral, culturally sensitive and participatory public policies. It is concluded that the strengthening of SISVAN and the valorization of traditional food knowledge are fundamental for the promotion of food security, equity in health and sovereignty of indigenous peoples of Pará.
Copyright (c) 2025 Renato dos Santos Anicá, Luísa Margareth Carneiro da Silva https://creativecommons.org/licenses/by/4.0
Development of bakery products from the mesocarp of the baru (Dipteryx alata Vogel)
This study aimed to develop and evaluate bakery products enriched with flour obtained from the mesocarp of baru (Dipteryx alata Vog.), a native fruit of the Brazilian Cerrado. Cake and bread were formulated with the addition of this flour, and their proximate composition, texture, and sensory acceptance were analyzed. The enriched cake showed a significant increase in protein (10.37 g/100 g) and fiber (4.20 g / 100 g) content, along with lower hardness and chewiness, improving the texture. Sensory evaluations indicated that it was well accepted by the panelists. The bread formulation also showed increased protein (18.38 g / 100 g) and fiber (1.03 g / 100 g) levels; however, it exhibited greater hardness and reduced elasticity, cohesiveness, and resilience, compromising its structure and sensory acceptance. The results suggest that baru mesocarp flour has high potential as a functional ingredient, particularly in cakes, by enhancing nutritional value.
Copyright (c) 2025 Adriana Régia Marques de Souza, Miriam Fontes Araujo Silveira, Maria Assima Bittar Gonçalves, Fabrícia Arantes de Medeiros, Gabrielly Paula de Carvalho https://creativecommons.org/licenses/by/4.0
Case report: Mixed infection by Ancylostoma spp. and Toxocara canis in a dog – Clinical and Public Health implications
The objective of the present study is to present a mixed infection by Ancylostoma spp. and Toxocara canis in a puppy, describing the clinical signs, diagnosis, and treatment provided, as well as discussing the possible public health implications, reinforcing the importance of preventing these zoonoses within the context of veterinary and collective medicine. This case report describes a mixed infection by Ancylostoma spp. and Toxocara canis in a seven-month-old mixed-breed female dog, presented during a routine check-up with complaints of pasty stools. Based on anamnesis, physical examination, complete blood count, and fecal parasitological analysis, the presence of both parasites was confirmed. Treatment involved antiparasitic administration and environmental control measures. The discussion highlights the importance of early diagnosis and proper treatment, especially considering the zoonotic potential of these parasites, which pose a significant public health risk. The report reinforces the need for integrated surveillance and health education strategies, aligned with the One Health approach, to effectively control helminth infections in companion animals and prevent human transmission.
Copyright (c) 2025 Sofia Eduarda Santos Bueno, Genaldo Martins de Almeida https://creativecommons.org/licenses/by/4.0
Artificial intelligence in blood transfusion management: Global reduction of blood component waste and the emergence of predictive models that save millions of lives
Blood transfusion management faces persistent challenges related to demand variability, the risk of shortages, and high levels of blood component waste, especially platelets. Artificial intelligence models have been highlighted for predicting transfusion patterns and optimizing stocks, offering more precise responses to healthcare systems. This study aims to investigate how artificial intelligence is being applied to blood component management, with an emphasis on two main axes: (1) the overall reduction of blood component waste and (2) the emergence of predictive models that effectively save lives by optimizing the availability, logistics, and use of these products. More specifically, it intends to review the literature from 2021 to 2025, identify practices, technologies, results, and gaps, and provide recommendations for the efficient and ethical adoption of these solutions in the transfusion healthcare sector. This is a hybrid systematic review, conducted according to PRISMA 2020, which analyzed 12 international studies applying AI, machine learning, deep learning, or optimization models to blood transfusion management. The results show that such models exhibit high accuracy in demand forecasting and contribute to more efficient inventory adjustments, loss reduction, and logistical streamlining. Multicenter evidence also points to increased availability of blood components and reduced operational costs. It is concluded that AI constitutes a strategic tool for improving transfusion efficiency and safety, although challenges such as interoperability, data governance, and large-scale validations still need to be overcome.
Copyright (c) 2025 Weber de Santana Teles, Max Cruz da Silva, Douglas Abilio, Ana Paula Barreto Prata Silva, Mariamália Newton Andrade, Orleane Souza Rezende, Ádamo Newton Marinho Andrade, Raphael Davisson Lopes Santos, Lorena Eugênia Rosa Coelho, Rute dos Santos Souza https://creativecommons.org/licenses/by/4.0
Nursing care for children diagnosed with Autism Spectrum Disorder (ASD)
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that affects communication, social interaction, and behavior, with manifestations generally identified in early childhood. The complexity of the condition requires a multidisciplinary approach, where nursing care stands out as fundamental to promoting child development, well-being, and autonomy, respecting their individual characteristics. Objective: To analyze the healthcare demands of children diagnosed with Autism Spectrum Disorder (ASD), identifying the main challenges faced by healthcare professionals in caring for this population, the barriers to accessing specialized services, and the strategies used to improve the quality of care. Methodology: This is an integrative literature review. The search was conducted in the LILACS, SciELO, and BDENF databases, using the combination of the descriptors "Autism Spectrum Disorder" and "Healthcare". The search period encompassed publications between 2019 and 2025. Results: The results allowed for the systematization of information on the most critical aspects of healthcare, such as: the need for interdisciplinary approaches, gaps in professional training, communication difficulties, and the management of health conditions associated with ASD. These findings provide support for the implementation of evidence-based practices. Conclusion: The research contributed to the improvement of care practices, benefiting not only children with ASD, but also their families, who play an essential role in the continuity of interventions.
Copyright (c) 2025 Karita Geovana Alves da Fonseca, Isadora Rezende Lacerda Farias, Osmar Nascimento Silva https://creativecommons.org/licenses/by/4.0
Clinical and psychiatric profile of burn victims from suicide attempts: An integrative literature review
Self-inflicted burns resulting from suicide attempts represent a severe public health concern, often linked to intense psychological distress, impulsivity, and barriers to specialized mental health care. This study aimed to identify the clinical and psychiatric profile of burn victims who attempted suicide. An integrative review was conducted using the Virtual Health Library (VHL), with the descriptors “burns” AND “suicide.” The initial search yielded 68 articles; after applying inclusion criteria (full text, quantitative studies), 15 articles were reviewed in full. Results indicated a predominance of female victims (77.8%), especially among individuals aged 15–24 years (36.8%). Alcohol was the primary etiological agent (85.2%), functioning both as a combustible substance and as a facilitator of disinhibition and suicidal impulsivity. Psychiatric diagnoses were present in 95% of cases, most notably major depressive disorder (69%) and anxiety disorders. Additionally, 23% of victims had alcohol use disorder and 21.4% reported previous suicide attempts, reflecting a high risk of recurrence. Contemporary literature suggests that such behaviors cluster in populations marked by emotional vulnerability, limited social support, and high exposure to interpersonal violence. Findings highlight that self-inflicted burn injuries constitute a complex and multifactorial phenomenon requiring integrated interventions, including psychiatric treatment, pain management, psychosocial support, and strengthened protection networks. Future studies should explore cultural factors and gender dynamics that influence the choice of burns as a suicidal method.
Copyright (c) 2025 Luma Teles de Resende, Ana Laura Mendes Abud, Ana Maria Sousa Santos, Clarisse Andrielly da Silva Gorgonho, Nicole Andrade da Cunha, Thiago Vaz de Andrade, Luana Teles de Resende https://creativecommons.org/licenses/by/4.0
Preparation of pan bread enriched with quinoa flour
This study aimed to evaluate the effect of partially replacing wheat flour (WF) with quinoa flour (QF) on the physicochemical characteristics of loaves of bread. Six formulations were prepared with partial replacement of WF by QF in the following proportions: F1 (100:0), F2 (95:5), F3 (90:10), F4 (85:15), F5 (80:20), and F6 (70:30), respectively. The moisture content, water activity (Wa), and instrumental color of the flours were analyzed, as well as the weight loss after baking (WLAB), moisture, Wa, specific volume (SV), texture, and color of the crust and crumb of the bread. The results indicated that the flours had moisture content between 12.0 and 13.0%, within legal limits, and Wa varied between 0.53 and 0.64, considered low, which hinders microbial growth. QF had a hue angle of 92.09, tending towards light yellow, while WF had 90.29, tending towards white. The preparation of bread with increasing amounts of QF did not significantly alter the SV (3.44 to 4.16 cm³/g), but reduced the Wa (from 0.94 to 0.93) and increased the moisture (from 37.47% to 40.88%), WLAB (from 7.69% to 8.51%), and hardness (from 300 gf to 700 gf). In addition, it intensified the brown color of the crust and light-yellow color of the bread crumb. The replacement of up to 20% of WF with QF (F5) did not influence SV, hardness, and crumb color, making it a viable alternative for the production of bread with higher nutritional value potential.
Copyright (c) 2025 João Matheus Soares Falcão, Luiz Henrique Garcia Pires, Leomar Hackbart da Silva, Paula Fernanda Pinto da Costa https://creativecommons.org/licenses/by/4.0
Knowledge of digital information and communication technologies (ICTs) in education: A curricular approach
The article discusses the use of Digital Information and Communication Technologies (DICTs) in the Brazilian educational system, especially regarding the teaching-learning process, aiming to integrate content, skills, and curricular abilities in which the teacher's role is to incorporate technologies, adapting them to teaching practice with the goal of developing innovative methods. Objective: to address the importance of using DICTs with applicability to curriculum content for the development of teaching and learning. Methodology: The study uses the descriptive method, followed by documentary research of indirect sources in scientific articles in a quantitative study regarding the number of 21 (twenty-one) articles selected to compose the research 'corpus' and a qualitative nature in the analysis and discussion of the selected articles. Results: 21 publications analyzed in the databases were selected. Final considerations: It is necessary to expand the use of ICTs, increasing interactions between teachers and students through didactic-pedagogical innovations and transformative curricular practices.
Copyright (c) 2025 Candida Celia Cesar Teles, Fabiola Chaves de Oliveira, Michelly da Silva Sousa, Raimunda da Silva Santos Dias, Fabio Coelho Pinto https://creativecommons.org/licenses/by/4.0
Virtual Literary Communities: Fostering the reading of English language books by Brazilian readers
This article analyzes how digital literary communities Booktwitter (X), Bookgram (Instagram) and Skoob contribute to the dissemination of English-language books among Brazilian readers on social networks. Based on a qualitative and bibliographic approach using public posts as illustrations of online trends, it was observed that these platforms are environments that illustrate participatory culture and collective intelligence (Jenkins, 2015), the social concept of literature (Candido, 2006; Botelho & Hoelz, 2016) and the dynamism of the reading activity (Pinto, 2015). The results indicate that while Booktwitter promotes textual debates and collective curatorship through real-time interactions, Bookgram emphasizes visual aesthetics, transforming books into objects of desire and identity performance, and Skoob combines both communities into quantitative data. It was concluded that the sharing of English-language books varies depending on the platform used and the member's reasons for that also diverge. Regardless of that, these communities offer a space that fosters inclusive and diverse literary debates, contributing to the ongoing evolution of literature.
Copyright (c) 2025 Maria Clara Luiza Silva Batista, Rosamaria Reo Pereira, Rosana Assef Faciola https://creativecommons.org/licenses/by/4.0
Potential of Trichoderma asperellum against root-rot caused by Fusarium equiseti in tomato plants
The aim of this study was to evaluate the effects of Trichoderma asperellum, Rhizolex-T (a chemical fungicide), and their combinations with Fusarium equiseti on fruit yield and disease inhibition in plants. Trichoderma asperellum and Fusarium equiseti were isolated from the soil surrounding robust tomato roots in various parts of Brazil, and molecularly identified by 5.8S-ITS region sequencing. The biocontrol agent T. asperellum exhibited strong antagonistic activity, surpassing the efficacy of the chemical fungicide Rhizolex-T. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis confirmed that most T. asperellum exhibited potent antagonistic activity in terms of mechanistic insights. Fresh fruit weight increased by 14.70%, dry fruit weight increased by 14.81%, fruit size increased by 3.75%, and the number of fruits per plant increased by 12.50% as a consequence of the application of T. asperellum (T). Additionally, antioxidant activity and total phenol contents increased in response to T. asperellum treatment. These results highlight the potential of T. asperellum as a sustainable, eco-friendly alternative to chemical fungicides for managing Fusarium wilt in tomatoes. The study advocates for the integration of biocontrol agents into disease management strategies to reduce chemical inputs and promote sustainable agriculture.
Copyright (c) 2025 Louis Antoniel Joseph, Manoucheca Jean, Frantzdy Luc, Kerley-Vivaldi Jean, Bento Gil Uane, Marisa Aida Diogo Matsinhe, Meque Samuel Tivane, Inocêncio Oliveira Mulaveia https://creativecommons.org/licenses/by/4.0
Mancozeb inclusion complex with (2-hydroxypropyl)-β-cyclodextrin: A search of articles and patents
Mancozeb is a broad-spectrum fungicide widely used in agriculture; however, its poor water solubility limits its operational efficiency and increases environmental impact. Cyclodextrins, particularly 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), have emerged as promising carriers capable of enhancing the solubility, stability, and agronomic performance of poorly soluble active ingredients. This article presents a technological prospecting study covering scientific publications and patents, focusing on inclusion complex formation, analytical evidence of molecular interactions, and potential applications in agrochemical formulations. The findings reveal a significant gap in the literature regarding the mancozeb/HP-β-CD inclusion complex, highlighting the innovative potential of this strategy for developing more efficient and environmentally friendly formulations.
Copyright (c) 2025 Gilberto Tomaz Filho, George Laylson da Silva Oliveira https://creativecommons.org/licenses/by/4.0
Biodegradability of materials reinforced with banana fiber (Musa sp.) in a polymeric matrix
The objective of this study is to evaluate the biodegradability of PLA biocomposites reinforced with banana fibers under different conditions, aiming to encourage the reduction of synthetic raw materials through the valorization of agro-industrial waste. One of the main environmental impacts of large-scale industrial production is the generation of synthetic waste that is difficult to degrade. In this context, the development of new materials obtained from natural raw materials has gained prominence in recent decades, seeking to reduce the negative effects associated with conventional production processes and promote more sustainable practices in the industry. In order to present a sustainable and biodegradable material, this study developed a polymeric composite reinforced with banana fiber, an agro-industrial residue. Banana fibers, both treated and untreated (in natura), were incorporated into a PLA polymeric matrix at 5% and 10% compositions via the extrusion process to obtain the biocomposites. The biodegradability test was performed following ASTM 71 D6003 and ASTM G160 standards in prepared organic soil, where the biocomposites were buried for 30, 60, and 90 days. Degradation analysis was performed by macroscopic evaluation, and mass loss by weighing. The composite that presented the highest degradation rate was the one reinforced with 10% fiber treated for 1.5 h. The results demonstrate that the incorporation of banana fibers increases mass loss in the composite, indicating an influence on accelerating the degradation of the composite in controlled soil.
Copyright (c) 2025 Eduarda Bertoletti Duarte, Felipe Nakamura Bassani, Leonardo Miguel Guzzoni, Dênis Martins de Oliveira, Flávia Aparecida Reitz Cardoso, Luciana Cristina Soto Herek https://creativecommons.org/licenses/by/4.0
Physiotherapy with manual lymphatic drainage in post-mastectomy lymphedema
Upper-limb lymphedema is one of the most prevalent complications after mastectomy and is directly associated with axillary lymph node removal and radiotherapy, resulting in interstitial protein accumulation, pain, functional limitation, and impaired quality of life. Manual lymphatic drainage (MLD) is one of the main physiotherapeutic resources used to reduce edema, stimulate lymphatic return, and improve functionality. Objective: To discuss the role of physiotherapy using manual lymphatic drainage in the treatment of post-mastectomy lymphedema, highlighting the benefits and effectiveness of this technique. Methods: This is an integrative literature review. Searches were performed in Google Scholar, PubMed, and SciELO using descriptors related to manual lymphatic drainage and post-mastectomy lymphedema. Articles published in the last five years were included, screened by title and abstract, selecting only studies in which MLD was the main intervention. After applying inclusion and exclusion criteria, seven articles comprised the final sample. Results: A total of 124 studies were initially identified across the platforms, which were reduced after applying time and relevance criteria. The analysis of titles, abstracts, and full texts resulted in a final sample of seven studies. Conclusion: Manual lymphatic drainage is an effective and safe resource for the treatment of post-mastectomy lymphedema, especially when integrated into comprehensive physiotherapy programs. Despite favorable results, standardized clinical trials are needed regarding the technique, frequency, and intensity of interventions.
Copyright (c) 2025 Kairone da Silva Roldão, Richely Nogueira da Silva, Manoel Dias de Oliveira Neto https://creativecommons.org/licenses/by/4.0