Periodic deworming programme in Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.10722

Keywords:

Parasitic diseases; Therapeutics; Epidemiology; Public health; Cost-benefit analysis.

Abstract

To evaluate the periodic deworming programme (PDP) against soil-transmitted helminth infection and estimate the cost-benefit of this action in a Northeastern Brazilian State. An observational descriptive study was peformed by two branches: an epidemiological analysis of parasitological stool tests positivity in the 7 health micro-regions of Sergipe State, from January to June 2019, and a cost-benefitial analysis through comparison between estimated costs of PDP and conventional diagnose and treatment method from 2014 to 2018. From the 1110 parasitological stool tests evaluated, 317 were positive: 20 (1.8 %) for helminths and 307 (26.7%) for protozoan parasites. Among positive tests, 61 (19.2%) were in PDP age target group (5-14 years). An annual average of 255,283 Albendazole tablets (400mg, single dose) were distributed with an annual average coverage rate of 84.2%. To support the programme, approximately R$ 281,859.25 (US$ 89,775.67) were transferred per year to the state of Sergipe. PDP estimated cost-effectiveness was R$ 1.10 (US$ 0.34) per event prevented and generated a cost-minimization of approximately R$ 335.617,60 (US$124,568.00) when compared to the conventional diagnose and treat method. The positive rates of soil-transmitted helminth infection in parasitological tests in Sergipe were low and the recommendation for PDP seems to be currently inadequate. Most positive tests were for commensal protozoa species. PDP estimated cost is lower than conventional diagnose and treatment method. Protozoa infections prevention policies should be evaluated as they are the major parasitic infection in our community after PDP.

References

Bowman, D. D .G. (2009). Parasitolgy for Veterinarians. St. Louis, Missouri: Saunders Elsevier. 9 Ed.

Brazil. (1988). Constituição (1988). Constitution of the federative republico of Brazil. Brasília, DF: Federal senate articles, 194-200. Retrieved from: https://www2.senado.leg.br/bdsf/item/id/243334 .

Brazil. (1990) A. Law nº 8.142, de 28 de dezembro de 1990. Provides for community participation in the management of the Unified Health System (SUS) and for intergovernamental transfers of financial resources in the health área and provides other measures. Civil House. Retrieved from: http://www.planalto.gov.br/ccivil_03/leis/L8142.htm.

Brazil. (1990) B. Law nº 8.8080, de 19 de setembro de 1990. Provides for thje condition fot the promotion, protection and recovery of health, the organization and functioning of the corresponding services and provides other measures. Civil House. Retrieved from: http://www.planalto.gov.br/ccivil_03/leis/l8080.htm.

Brazil. (2014) A. Ordinance No. 1.253, of June 6,2014. Authorizes the transfer of the amounts of federal resources, related to the Nacional Campaing for Leprosy, verminoses and trachoma, for the year 2014. Ministry of Health. Retrieved from: http://bvsms.saude.gov.br/bvs/saudelegis/gm/2014/prt1253_06_06_2014.html.

Brazil. (2014) B. 2nd Economic Evaluation Guideline. Ministry of Health, Secretariat of Science, Technology and Strategic Inputs. Department of Science and Technology. Ministry of Health. Pages 24 and 25. Retrieved from: http://bvsms.saude.gov.br/bvs/publicacoes/diretrizes_metodologicas_diretriz_avaliacao_economica.pdf.

Brazil. (2015). Ordinance No.1.021, of july 21, 2015. Authorizes the transfer to Municipalities of the amounts of federal resources, related to the Nacional Campaing for Leprosy, verminoses and trachoma, for the year 2015. Ministry of Health. Retrieved from: http://bvsms.saude.gov.br/bvs/saudelegis/gm/2015/prt1021_21_07_2015.html.

Brazil. (2016) A. Government of Sergipe. State Health Plan 2016-2019. Secretariat Government of Sergipe. Aracaju. Pág. 15-18. Retrieved from: https://www.conass.org.br/pdf/planos-estaduais-de-saude/SE_Plano%20Estadual%20de%20Saude%202016%20-%202019%20SERGIPE.pdf.

Brazil. (2016) B. Secretariat of health surveillance. Practical guide for operationalizing the National Campaign for Leprosy, Verminosis, Trachoma and shistosomiasis, 2016, Ministry of Health. Department of surveillance of communicable disease general coordination of leprosy and diseases in elimination. Ministry of Health. Secretariat of health surveillance, Brasília. Ministry of health. Retrieved from: http://www.saude.gov.br/images/pdf/2017/fevereiro/11/Guia-Operacional-Campanha-2016-final.pdf.

Brazil. (2016) C. Ordinance No.1.231, of june 30, 2016. Authorizes the transfer to Municipalities, related to the Nacional Campaing for Leprosy, verminoses and trachoma, for the year 2016. Ministry of Health. Retrieved from: http://bvsms.saude.gov.br/bvs/saudelegis/gm/2016/prt1231_30_06_2016.html.

Brazil. (2016) D. Constitucional ammendment noº 95, of december 15, 2016. Amends the transitional constitutional provisions act, to institute the new tax regime, and takes other measures. Civil House. Retrieved from: http://www.planalto.gov.br/ccivil_03/constituicao/emendas/emc/emc95.htm.

Brazil. (2017). Basic Sanitation Panel. Brazil and Sergipe. Year 2017. Available for access: Retrieved from: https://www.painelsaneamento.org.br/explore/ano?SE%5Ba%5D=2017&SE%5Bo%5D=a.

Brazil. (2018). Ordinance No. 240, de 1º de fevereiro de 2018. Authorizes the transfer to resources from the National Health Fund to Municipal Health Funds, in the public health action and services costing block to be allocated in the health surveillance group for the implementation of the V National campaign for leprosy, verminoses, trachoma and schistosomiasis for the year 2018. Ministry of Health. Retrieved from: http://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0240_05_02_2018.html.

Brazil. Ministry of Health. National Health Surveillance Agency (ANVISA). (2013). Technical Note No. 215/213. Brasilia, May 2013. Retrieved from: http://www.saude.gov.br/images/pdf/2014/julho/31/Albendazol.pdf.

Brazilian Institute of Geograph and Statistics (IBGE) (2010). Census 2010. Retrieved from: <https://cidades.ibge.gov.br/brasil/se/panorama>.

Brazilian Institute of Geograph and Statistics (IBGE) (2018). Census 2018. Retrieved from: <https://cidades.ibge.gov.br/brasil/se/panorama>.

Brito, G.E.G., Mendes, A.C.G. & Neto, P.M.S. (2018). Purpose of work in the Family Health Strategy. Interface (Botucatu). V.22 (64):P. 77-86.

Brito, L.L., Barreto, M.L., Silva, R. de C., Assis, A.M. & Reis, M.G. (2006). Moderate- and Low-Intensity Co-Infections by Intestinal Helminths and Schistosoma Mansoni, Dietary Iron Intake, and Anemia in Brazilian Children. American Journal of Tropical Medicine & Hygiene. 75(5), pp. 939–944.

Curval, G.L., França, A.O., Fernandes, H.J., Mendes, R.P., Carvalho, L.R., Higa, G.M., Ferreira, E.C. & Dorvall, M.E.C. (2017). Prevalence of intestinal parasites among inmates in Midwest Brazil. Plos One. Setember. Retrieved from: https://repositorio.unesp.br/bitstream/handle/11449/163303/WOS000411339900003.pdf?sequence=1&isAllowed=y.

Diawara, A., Drake, L.J., Suswillo, R.R., Kihara, J., Bundy, D.A., Scott, M.E., Halpenny, C., Stothard, J.R. & Prichard, R.K.(2009). Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides. PLoS Negl. Trop. Dis. V.3 (3):e397.

Diawara, A., Halpenny, C.M., Churcher, T.S., Mwandawiro, C., Kihara, J., Kaplan R.M., Streit, T. G., Idaghdour. Y., Scott, M.E. & Basanez, M.G. (2013). Association between response to albendazole treatment and beta-tubulin genotype frequencies in soil-transmitted helminthes. Plos. Negl. Trop. Dis. May 30; V.7 (5):e2247.

Filho, A.A.O., Abrantes, H.F.L., Fernandes, H.M.B., Viana, P.W., Pinto, M.S.A., Cavalcanti, A.L. & Freitas, F.I.S. (2012). Enteroparasitological profile of the inhabitants of a city in northeastern Brazil. Brazilian Journal of Clinical Medicine. São Paulo. 10(3) maio-jun.

Furtado, L.F.V., DE Aguiar, P.H.N., Zuccherato, L.W., Teixeira, T.T.G., Alves, W.P., Silva, V.J., Gasser, R.B. & Rabelo, E.M.L. (2019). Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism. Parasitol. Res.118:837–849.

Hasen, T.V., Nejsum, P., Olsen, A. & Thamsborg, S.M. (2013). Genetic variation in codons 167, 198 and 200 of the beta-tubulin gene in whipworms (Trichuris spp.) from a range of domestic animals and wildlife. Vet, Parasitol. 193. 141–149.

Katz N. (2018). National Serbey on Prevalence of Schistosomiasis Mansoni and Geo-helminths. Belo Horizonte, Fio Cruz. Arca. 2018. Retrieved from: https://www.arca.fiocruz.br/handle/icict/25662.

Leone, G.S.G. (1981).Costs: Planning, implementation and control. 2.ed. São Paulo: Atlas.

Malta, D.C., Santos, M.A.S., Stopa, S.R., Vieira, J.E.B., Melo, E.A. & Reis, A.A.C. (2016). Coverage of the Family Health Strategy (FHS) in Brazil, according to the National Health Survey, 2013. Ciênc. Saúde Colet. 21 (2).P. 327-338.

Martins, E. (1996). Cost accounting. 5.ed. São paulo: Atlas.

Matamoros, G., Rueda, M.M., Rodriguez, C., Gabrie, J.A., Fontecha, G. & Sanchez, A. (2019). High Endemicity of Soil-Transmitted Helminths in a Population Frequently Exposed to Albendazole but No Evidence of Antiparasitic Resistance.Trop Med Infect Dis. Jun. 4(2): 73.

Nath, T.C., Padmawati, R.S. & Murhandarwati, E.H. (2019). Barries and gaps in utilization and coverage of mass drug administration program against soil transmitted helminth infection in Bangladesh: An implementation research. J. Infect. Public Health. Mar-Apr; 12(2):205-212.

National List of Essential Medicines (RENAME). (2013). Ministry of Health, Brasília -DF. Technical Note No. 215/213. Ministry of Health. Brasília –DF. Retrieved from: http://www.saude.gov.br/images/pdf/2014/julho/31/Albendazol.pdf.

National List of Essential Medicines (RENAME). (2014). Ministry of Health, Brasília-DF. Pgs. 19, 33, 131, 145. Retrieved from: http://bvsms.saude.gov.br/bvs/publicacoes/relacao_nacional_medicamentos_essenciais_rename_2014.pdf.

National List of Essential Medicines (RENAME). (2018). Ministry of Health, Brasília-DF 2018. Págs. 17, 33, 103, 119, 2018. Retrieved from: http://bvsms.saude.gov.br/bvs/publicacoes/medicamentos_rename.pdf.

National sanctuary surveillance agency (ANVISA). (2000). Medicinal Therapeutic Class' P01B0 - anthelmintics except schistosomicides (P1C). SUS price list. Retrieved from: http://portal.anvisa.gov.br/pesquisa-de-precos.

Neves, D.P., Linardi, P.M. & Vitor, R.W.A. (2013). Human parasitology. 11ª ed. São Paulo: Atheneu.

Oishi, C.Y., Klisiowicz, D.R., Seguí, R., Koster, P.C., Carmena, D., Toledo, R., Esteban, J.G. & Antoli, C.M. (2019). Reduced prevalence of soil-transmitted helminths and high frequency of protozoan infections in the surrounding urban area of Curitiba, Paraná, Brazil. Parasite Epidemiol Control. Nov. 7: e00115.

Oliveira, Y.L.D.C., Oliveira, L.M., Oliveira, Y.L.M., Nascimento, A.M.D., La Corte, R., Geraldi, R.M., Barbosa, L., Gazzinelli-guimarães, P.H., Fujuwara, R.T., Bueno, L.L. & Dolabella, S.S. (2020). Changes in the epidemiological profile of intestinal parasites after large-scale treatment at school for helminths transmitted by soil in a community in northeastern Brazil: Epidemiological profile after large scale treatment at school for STH. ACTA TROPICA. Vol. 202. Retrieved from: https://www.sciencedirect.com/science/article/abs/pii/S0001706X19309908?via%3Dihub.

Panilla, A.E., Myriam, M.C. & Viasus, D.F. (2008). History of Entamoeba histolytica. Revista médica de chile. V. 136. P.118-124.

Pullan, R.L., Bethony, J.M., Geiger, S.M., Cundill, B., Correa-oliveira, R., Quinnell, R. J. & Brokker S. (2008). Human helminth co-infection: Analysis of spatial patterns and risk factors in a Brazilian community. Plos Negl. Trop. Dis. Dec. V.2 (12): e352.

Santos, A. & Ribeiro, S.L.S. (2014).Monetary Correction: for a periodization of the Use of the Tool, from 1944 to 1995. Revista Cont. Finance. – USP, São Paulo, V. 25.

Silva, M.T., Silva, E.M. & Pereira, M.G. (2016). Outcomes in health economics evaluation studies. Epidemiol.Ser. Saúde. Brasília.Jul-Set. Vol.25 (3):P.663-666.

System of Management of the Table of Procedures, medicines and opm of sus. (SIGTAP- DATASUS). (2011). Ordinance 287 of 06/17/2011. Ministry of Health, Brasília-DF. 2011.

Retrieved from: http://bvsms.saude.gov.br/bvs/saudelegis/sas/2011/prt0287_17_06_2011.html.

System of Management of the Table of Procedures, medicines and opm of sus. (SIGTAP- DATASUS). (2013). Ordinance CGSI No. 12/2013 of 11/29/2013 CGSI. Ministry of Health, Brasília-DF 2013.

System of Management of the Table of Procedures, medicines and opm of sus. (SIGTAP- DATASUS). (2014). Ordinance CGSI No 02/2014, of 23/01/2014. Ministry of Health, Brasília-DF 2014.

System of Management of the Table of Procedures, medicines and opm of sus. (SIGTAP- DATASUS). (2017). Technical note no. 07/2017 de 25/06/17

CGSI. Ministry of Health, Brasília-DF.

Takamatsu, R. & Lamounier, W.M.A. (2006). Importance of monetary update of values for the analysis of financial statements. Revs. Accounting Vista E Rer. April/June. Vol. 17. N. 2. P. 67-87.

Tefera, E., Belay, T., Mekonnen, S.K., Zeynudin, A. & Belachew, T. (2015). Therapeutic efficacy of different brands of albendazole against helminths transmitted by soil among students at Mendera Elementary School, Jimma, southwestern Ethiopia. The Pan. African Medical Journal..22: 252.

Vanni, T., Luz, P.M., Ribeiro, R.A., Novaes, H.M.D. & Polanczyk, C.A. (2009). Economic evaluation in health: applications in infectious diseases. Cad. Public Health. Rio de Janeiro. vol.25 no.12. P. 2543-2552.

Vasconcelos, C.S., Almeida, M.B., Brito, R.G., Guimarães, A.O., Boaventura, R.F. & Brito, A.M.G. (2016). Human enteroparasitosis in Aracaju, SE. Brazilian Society of Clinical Analyzes, 48(4):356-62.

Weyne, G.R.S. (2004). Determination of the sample size in surveys. Arq. Med. ABC. Jul/Dec; Vol. 29. Nº 2.

World Health Organization. (2006). Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Retrieved from: https://www.who.int/intestinalworms/more/en/.

World Health Organization. (2016). Preventive chemotherapy for helminth diseases: Progress report, 2014. Wkly. Epidemiol. Rec. No. 8, 2016, 91, 89–104.

World Health Organization. (2017). Guideline: Preventive Chemotherapy to Control Soil-Transmitted Helminth Infections in At-Risk Population Groups. World Health Organization: Geneva. Switzerland. 2017. Retrieved from: https://www.who.int/nutrition/publications/guidelines/deworming/en/.

Zuccherato, L.W.; Furtado, L.F.; Medeiros, C.D.S.; Pinheiro, C.D.S. & Rabelo, E.M. (2018). PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil. PLoS Neg. Trop. Dis. Sep 17;12(9): e0006766.

Downloads

Published

10/12/2020

How to Cite

CELESTINO, A. O. .; LIMA, P. A. S. .; RODRIGUES, L. M. C. L. .; FRANÇA, C. M. .; LOPES, I. R. S. .; VIEIRA, S. C. F. .; BARRETO, I. D. de C. .; ESPERIDIÃO, F. .; GURGEL, R. Q. . Periodic deworming programme in Brazil. Research, Society and Development, [S. l.], v. 9, n. 11, p. e100091110722, 2020. DOI: 10.33448/rsd-v9i11.10722. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/10722. Acesso em: 26 nov. 2024.

Issue

Vol. 9 No. 11

Section

Health Sciences

License

Copyright (c) 2020 Ariel Oliveira Celestino; Pablo Amercio Silva Lima; Larissa Maria Cardoso Lima Rodrigues; Camila Mendonça França; Isabel Ribeiro Santana Lopes; Sarah Cristina Fontes Vieira; Ikaro Daniel de Carvalho Barreto; Fernanda Esperidião; Ricardo Queiroz Gurgel

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.