Drug treatments for acne vulgaris in adolescents and young adults
DOI:
https://doi.org/10.33448/rsd-v10i5.15094Keywords:
Acne vulgaris; Therapeutics; Adolescent.Abstract
Objective: To describe the drug treatments available for acne vulgaris in adolescents and young adults. Methodology: this is an integrative review, with searches in the databases: Medical Literature Analysis and Retrieval System (MEDLINE/PubMed), Scientific Electronic Library Online (SciELO) and Latin American and Caribbean Literature in Health Sciences (LILACS), using Health Sciences Descriptors (DECS): “acne vulgar”, “terapêutica”, “adolescentes” e “adulto jovem”, combined through Boolean operators, from 2015 to 2020. Results: Were selected 15 articles. Because it is a disease of multifactorial etiology, several therapies need to be adopted for effective treatment. The available treatments involve retinoids, antibiotics, corticosteroids, benzoyl peroxide, adapalene, oral contraceptives, formulations of natural extracts, strains of bacteria, nanoparticles, including topical and systemic treatments. Conclusion: the treatments for acne vulgaris are multiple and varied, and have been improved and even more diversified, however, the need for more scientific studies to develop effective treatments with fewer side effects is emphasized, contributing to accessibility and greater adherence affected.
References
Almeida-Junior, S., Cruz, R. C. R., Castellane, J. A. S., Marrafon, A. A., Gomes, S. F. A., Oliveira, K. R. P., & Furtado, R. A. (2020). Application of Melaleuca alternifolia essential oils associated with phototherapy in acneic inflammatory injury. Research, Society and Development, 9(11), e9889119856. https://doi.org/10.33448/rsd-v9i11.9856
Bagatin, E., Timpano, D. L., Guadanhim, L. R. S., Nogueira, V. M. A., Terzian, L. R., Steiner, D., & Florez, M. (2014). Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil. Anais Brasileiros de Dermatologia, 89(3), 428-435. https://doi.org/10.1590/abd1806-4841.20142100
Costa, F. V., Souza, L. S., Conradesque, P. R., Carniel, P., & Zago, A. (2020). Indução percutânea de colágeno como tratamento de cicatrizes da Acne vulgar: uma revisão integrativa. Research, Society and Development, 9(8), e252985706. https://doi.org/10.33448/rsd-v9i8.5706.
Costa, I. V., Velho, G. M. C. C. (2018). Acne Vulgar no Adulto. Revista Sociedade Portuguesa de Dermatologia e Venereologia, 76(3), 299-312. https://dx.doi.org/10.29021/spdv.76.3.953
Dikicier, B. S. (2019). Topical treatment of acne vulgaris: efficiency, side effects, and adherence rate. Journal of International Medical Research, 47(7), 2987-2992.
Eichenfield, L. F., Sugarman, J. L., Guenin, E., Harris, S., & Bhatt, V. (2019). Novel tretinoin 0.05% lotion for the once‐daily treatment of moderate‐to‐severe acne vulgaris in a preadolescent population. Pediatric Dermatology, 36,193–199.
Fuchs, A., Matonog, A., Sieradzka, P., Pilarska, J., Hauzer, A., Czech, I., & Drosdzol-Cop, A. (2019). Anti-androgenic therapy in Young patients and its impact on intensity of hirsutism, acne, menstrual pain intensity and sexuality — a preliminary study. Ginekologia Polska, 90(9), 520–526.
Garcia, A. K. A., Fonseca, L. F., Aroni, P., & Galvão, C. M. (2016). Estratégias para o alívio da sede: revisão integrativa da literatura. Revista Brasileira de Enfermagem, 69(6), 1148-55.
Gold, L. S., Weiss, J., Rueda, M. J., Liu, H., & Tanghetti, E. (2016). Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3 %/Benzoyl Peroxide 2.5 % Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study. Am J Clin Dermatol, 17, 293–303.
Gupta, P., Timothy S., Sopkovich, J., Massick, S., & Kaffenberger, B. H. (2017). Generic twice daily minocycline vs. branded extended-release minocycline for acne: a retrospective comparison of treatment escalation. J Am Acad Dermatol, 76(6), 1195–1197.
Karoglan, A., Paetzold, B., Lima, J. P., Brüggemann, H., Tüting, T., Schanze, D., Güell, M., & Gollnick, H. (2019). Safety and efficacy of topically applied selected cutibacterium Acnes strains over five weeks in patients with acne vulgaris: an Open-label, pilot study. Acta derm venereol, 99, 1243-1257.
Lima, M. F. S, Barros, V. J. S, & Lúcio, M. P., Neto. (2020). Analysis of oral isotretinoin consumption in the specialized component of pharmaceutical assistance in the state of Piauí. Research, Society and Development, 9(2), e170922235. https://doi.org/10.33448/rsd-v9i2.2235
Montagner, S., Costa, A. (2010). Guidelines in the treatment of acne. Surgical & Cosmetic Dermatology, 2(3), 205-213.
Monfrecola, G., Capasso, C., Russo, G., & Fabbrocini, G. (2018). UV-selective face cream (Acne RA-1,2) in acne patients: clinical study of its effects on epidermal barrier function, sebum production, tolerability and therapy adherence. Giornale Italiano di Dermatologia e Venereologia, 153(1), 26-32.
National Center for Biotechnology Information – NCBI (2009). Young adult. MeSH terms. Recuperado em 3 fevereiro, 2021, de https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300428.
Pan-In, P., Wongsomboon, A., Kokpol, C., Chaichanawongsaroj, N., & Wanichwecharungruang, S. (2015). Depositing a-mangostin nanoparticles to sebaceous gland área for acne treatment. Journal of Pharmacological Sciences, 129, 226-232.
Patwardhan, S. V., Richter, C. Vogt, A., Blume‑Peytavi, U., Canfield, D., & Kottner, J. (2017). Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study. Arch Dermatol Res, 309, 59–167.
Pavithra, G., Upadya, G. M., & Rukmini, M. S. (2019). A randomized controlled trial of topical benzoyl peroxide 2.5% gel with a low glycemic load diet versus topicalbenzoyl peroxide 2.5% gel with a normal diet in acne (grades 1-3). Indian Journal of Dermatology, Venereoly and Leprology, 85, 486-90.
Proença, N. G. (2017). Acne fulminans. Anais Brasileiros de Dermatologia, 92, 8-10.
Richter, C., Trojahn, C., Hillmann, K., Dobos, G., Stroux, A., Kottner, J., & Blume-Peytavi, U. (2016). Reduction of Inflammatory and Noninflammatory Lesions with Topical Tyrothricin 0.1% in the Treatment of Mild to Severe Acne Papulopustulosa: A Randomized Controlled Clinical Trial. Skin Pharmacol Physiol, 29, 1–8.
Rodrigues, F. M., Leite, R. S., Yoshida, E. H., Carneiro, F. P., & Santos, N. S. (2019). Tratamento dermatológico da acne vulgar. Revista Saúde em Foco, 11, 339-345.
Santos, L. S., Martins, P. C. M. L., Perez, F. S. B. Terapia de indução de colágeno no tratamento de cicatrizes de acne: revisão de literatura. Saúde & Ciência em Ação, 5(01), 98-110.
Saraiva, T. A., Souza, L. S., Costa, K. F., Leroy, P. L. A., Hermínio, M. R. S. (2020). A laserterapia no tratamento da acne vulgar. Revista Brasileira Militar de Ciências, 6(15), 59-66.
Saviuc, C., Ciubucã, B., Dincã, G., Bleotu, C., Drumea, V., Chifiriuc, M., Popa, M., Pircalabioru , G. G., Marutescu, L., & Lazãr, V. (2017). Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-
Derived Antimicrobial and Anti-Inflammatory Compounds. International Journal o f Molecular Sciences, 18, 175.
Shemer, A., Shiri, J., Mashiah, J., Farhi, R., & Gupta, A. K. (2016). Topical minocycline foam for moderate to severe acne vulgaris: Phase 2 randomized double-blind, vehicle-controlled study results. Journal of de American Academy of Dermatology, 74(6), 1251-2.
Silva, J. C., Pereira, P. C. (2018). Avaliação e tratamento estético da acne vulgar. Revista Científica Universitas, 5(1), 114-123.
Silva, M. C. J., Nascente, F. M., Souza, C. M. D., Cardoso, A. M., Ferreira, L. D. L. P., & Sobrinho, H. M. R. (2020). Os benefícios da limpeza de pele no tratamento coadjuvante da acne vulgar. Revista Brasileira Militar de Ciências, 6(16), 28-36.
Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102-106.
Soyuduru, G., Adişen, E. Ö., Özer, İ., & Aksakal, A. B. (2019). The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients. Turkish journal of medical sciences, 49(1), 238-244.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Giovanna Stefanne Lópes Barbosa; Camila Pereira Miranda Costa; Mariana Veras Rocha Borges; Marinice Saraiva Attem; Bianca Lopes Cacau; Maria Simone Lopes; Daniela Winckler Mass ; Breno Serafim Pereira; Mary Ângela de Oliveira Canuto Coutinho; Fernando Aguiar Luz; Karina Rodrigues dos Santos; Ludmilla Figueiredo Vale Fontenelle
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.