Regenerative endodontic treatment performed with platelet-rich plasma presents better periapical healing than only induced blot clot: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.21219

Keywords:

regenerative endodontic treatment; Regenerative endodontics; Platelet-rich plasma; revascularization; revitalization; Regenerative medicine; Tooth apex.; platelet-rich plasma

Abstract

This study comprehensively reviewed two different treatments for regenerative endodontic: platelet-rich plasma and induced blot clot, in regarding to periapical healing.  Two investigators performed a systematic review. MEDLINE/PubMed, Cochrane Library and Scopus supplied relevant data from studies published until December 2020 to answer the PICO question. Primary outcome was periapical healing. Eight randomized clinical trials fulfilled eligibility criteria. Primary outcome indicated that platelet-rich plasma results in similar or better periapical healing compared to blot clot group. The reported failures were related to blot clot group due to incomplete radiographic parameters, pain and reinfection; however, few cases of unsuccess were reported to platelet-rich plasma group. Only two studies observed better results to blot clot group in relation to increase of radiographic area and partial pulp canal obliteration. This review showed that procedures using platelet-rich plasma were successful in treating permanent teeth with root development.

References

Leonardo MR. Endodontia. Tratamento de Canais Radiculares: Princípios Técnicos e Biológicos.; 2005.

Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative Endodontics: A Review of Current Status and a Call for Action. J Endod. 2007;33(4):377-390. doi:10.1016/j.joen.2006.09.013

Shah N, Logani A, Bhaskar U, Aggarwal V. Efficacy of Revascularization to Induce Apexification/Apexogensis in Infected, Nonvital, Immature Teeth: A Pilot Clinical Study. J Endod. 2008;34(8):919-925. doi:10.1016/j.joen.2008.05.001

Jadhav G, Shah N, Logani A. Revascularization with and without platelet-rich plasma in nonvital, immature, anterior teeth: A pilot clinical study. J Endod. 2012;38(12):1581-1587. doi:10.1016/j.joen.2012.09.010

Metlerska J, Fagogeni I, Nowicka A. Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies. J Endod. 2019;45(1):20-30.e1. doi:10.1016/j.joen.2018.09.003

Bezgin T, Yilmaz AD, Celik BN, Kolsuz ME, Sonmez H. Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. J Endod. 2015;41(1):36-44. doi:10.1016/j.joen.2014.10.004

Bezgin T, Yilmaz AD, Çelik BN, Sönmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J. 2014;47(1):41-49. doi:10.1111/iej.12144

ElSheshtawy AS, Nazzal H, El Shahawy OI, et al. The effect of platelet-rich plasma as a scaffold in regeneration/revitalization endodontics of immature permanent teeth assessed using 2-dimensional radiographs and cone beam computed tomography: a randomized controlled trial. Int Endod J. 2020;53(7):905-921. doi:10.1111/iej.13303

Rizk HM, AL-Deen MSS, Emam AA. Regenerative Endodontic Treatment of Bilateral Necrotic Immature Permanent Maxillary Central Incisors with Platelet-rich Plasma versus Blood Clot: A Split Mouth Double-blinded Randomized Controlled Trial. Int J Clin Pediatr Dent. 2019;12(4):332-339. doi:10.5005/jp-journals-10005-1656

Ulusoy AT, Turedi I, Cimen M, Cehreli ZC. Evaluation of Blood Clot, Platelet-rich Plasma, Platelet-rich Fibrin, and Platelet Pellet as Scaffolds in Regenerative Endodontic Treatment: A Prospective Randomized Trial. J Endod. 2019;45(5):560-566. doi:10.1016/j.joen.2019.02.002

Alagl A, Bedi S, Hassan K, AlHumaid J. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. J Int Med Res. 2017;45(2):583-593. doi:10.1177/0300060517692935

Narang I, Mittal N, Mishra N. A comparative evaluation of the blood clot, platelet-rich plasma, and platelet-rich fibrin in regeneration of necrotic immature permanent teeth: A clinical study. Contemp Clin Dent. 2015;6(1):63-68. doi:10.4103/0976-237X.149294

Shivashankar VY, Johns DA, Maroli RK, et al. Comparison of the effect of PRP, PRF and induced bleeding in the revascularization of teeth with necrotic pulp and open apex: A triple blind randomized clinical trial. J Clin Diagnostic Res. 2017;11(6):ZC34-ZC39. doi:10.7860/JCDR/2017/22352.10056

Sachdeva GS, Sachdeva LT, Goel M, Bala S. Regenerative endodontic treatment of an immature tooth with a necrotic pulp and apical periodontitis using platelet-rich plasma (PRP) and mineral trioxide aggregate (MTA): A case report. Int Endod J. 2015;48(9):902-910. doi:10.1111/iej.12407

Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2006;101(3). doi:10.1016/j.tripleo.2005.07.008

Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Cochrane Collab. 2011.

Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Br Med J. 2009;339:b2700. doi:10.1136/bmj.b2700

Kim JH, Kim Y, Shin SJ, Park JW, Jung IY. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: A case report. J Endod. 2010;36(6):1086-1091. doi:10.1016/j.joen.2010.03.031

B D, E A, DD V, J R, S S. Clinical complications in the revascularization of immature necrotic permanent teeth. Pediatr Dent. 2012;34(5):414-417. https://pubmed.ncbi.nlm.nih.gov/23211919/.

Adel Ragab R, El Lattif AEA, El Wahab El Dokky NA. Comparative study between revitalization of necrotic immature permanent anterior teeth with and without platelet rich fibrin: A randomized controlled trial. J Clin Pediatr Dent. 2019;43(2):78-85. doi:10.17796/1053-4625-43.2.2

Downloads

Published

13/10/2021

How to Cite

MARTINS, C. M.; KNECHT, M. F.; MORAES, L. dos S. de .; BATISTA, V. E. de S. . Regenerative endodontic treatment performed with platelet-rich plasma presents better periapical healing than only induced blot clot: a systematic review . Research, Society and Development, [S. l.], v. 10, n. 13, p. e147101321219, 2021. DOI: 10.33448/rsd-v10i13.21219. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21219. Acesso em: 16 apr. 2024.

Issue

Vol. 10 No. 13

Section

Health Sciences

License

Copyright (c) 2021 Christine Men Martins; Milena Filippini Knecht; Larissa dos Santos de Moraes; Victor Eduardo de Souza Batista

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.