Applicability of PRF- platelet-rich fibrin in Dentistry and it’s benefits
DOI:
https://doi.org/10.33448/rsd-v10i13.21570Keywords:
Platelet-rich fibrin; Platelet rich plasma; Growth factors.Abstract
Providing a quick healing of soft tissue and hard tissue became the greatest goal of surgeons in general, this search started the studies of autologous bioactive surgical additives such as: adhesive fibrin, platelet concentrate rich in plasma and fibrin. Platelet-rich fibrin-PRF was produced in France and is a second-generation platelet concentrate that, due to its properties, provided satisfactory results applied to dentistry, allowing for excellent healing and repair of surgical lesions, aiding in tissue regeneration. It is a 100% autologous safe biomaterial, quick to acquire, more economical, without contraindication, product of the centrifugation of the patient's natural venous blood. Today, much research has been done reporting the use of PRF as a clot and PRF membranes. It is generally applied in oral surgeries for bone augmentation, maxillary sinus elevation, in periodontics, acting in the correction of intraosseous defects and gingival recession, it can also be used for regeneration in open apex, regenerative pulpotomies and periapical surgeries. The present work is a qualitative literature review that aims to carry out a study planning to deepen the knowledge about the application of PRF-Fibrina Rica in platelets. The searches were carried out through selective research of articles, monographs and theses found in electronic databases such as: Pubmed, Scielo and Academic Google with the objective of describing the growth factors present in the PRF, detailing the applicability of the PRF in procedures dental clinics and report the benefits and advantages of PRF over PRP.
References
Agrawal, M., & Agrawal, V. (2014). Platelet rich fibrin and its applications in dentistry-A review article. National Journal of Medical and Dental Research, 2(3), 51.
Alves, R., & Granja, M. D. C. (2019). Fibrina rica em plaquetas (PRF)-Aplicações em Periodontologia e Implantologia. Revista OMD, 40, 27-35.
Anversa Pereira Borges, E. (2016). PRF: Aplicabilidade Clínica em Odontologia (Publication No. 53) [Master's thesis, Instituto Latino Americano de Pesquisa e Ensino Odontológico]. Trabalho de Conclusão de Curso (Pós-Graduação em Implantodontia)
Brandão, G. F. (2005). Estudo comparativo entre eficácia clínica de enxertos ósseos (autógenos, alógenos e aloplásticos) com e sem utilização de Pplasma Rrico em Pplaquetas. Odontologia.
Cardoso, M. L., & Lopes, S. M. (2015). Fibrina Rica Em Plaquetas E Leucócitos (L-Prf). Diminuindo A Morbidade Em Procedimentos De Reconstruções Teciduais Orais. Monografia. Universidade Federal Fluminense.
Chandradas, N. D., Ravindra, S., Rangaraju, V. M., Jain, S., & Dasappa, S. (2016). Efficacy of platelet rich fibrin in the treatment of human intrabony defects with or without bone graft: A randomized controlled trial. Journal of International Society of Preventive & Community Dentistry, 6(Suppl 2), S153.
Choukroun, J., Adda, F., Schoeffler, C., & Vervelle, A. P. R. F. (2001). Une opportunité en paro-implantologie: le PRF. Implantodontie, 42(55), e62.
Choukroun, J., & Ghanaati, S. (2018). Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European journal of trauma and emergency surgery, 44(1), 87-95.
Del Corso, M., Toffler, M., & Dohan Ehrenfest, D. M. (2010). Use of an autologous leukocyte and platelet-rich fibrin (L-PRF) membrane in post-avulsion sites: an overview of Choukroun’s PRF. J Implant Adv Clin Dent, 1(9), 27-35.
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Gogly, B. (2006a). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 101(3), e37–e44. https://doi.org/10.1016/j.tripleo.2005.07.008
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Gogly, B. (2006b). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 101(3), e45–e50. https://doi.org/10.1016/j.tripleo.2005.07.009
Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Gogly, B. (2006c). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 101(3), e51–e55. https://doi.org/10.1016/j.tripleo.2005.07.010
Ehrenfest, D. M. D., Rasmusson, L., & Albrektsson, T. (2009). Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF). Trends in biotechnology, 27(3), 158-167.
Ehrenfest, DD, Sammartino, G., Shibli, JA, Wang, HL, Zou, DR, & Bernard, JP (2013). Diretrizes para publicação de artigos relacionados a concentrados de plaquetas (Plasma Rico em Plaquetas-PRP ou Fibrina Rica em Plaquetas-PRF): a classificação internacional da POSEIDO. Poseido J, 1 , 17-28.
El Bagdadi, K., Kubesch, A., Yu, X., Al-Maawi, S., Orlowska, A., Dias, A., & Ghanaati, S. (2019). Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). European Journal of Trauma and Emergency Surgery, 45(3), 467-479.
Geeta, I. B., Galagali, G., Kulkarni, S., Suran, P., & Noushin, F. (2013). A natural meliorate: revolutionary tissue engineering in endodontics. Journal of clinical and diagnostic research: JCDR, 7(11), 2644.
Ghanaati, S., Booms, P., Orlowska, A., Kubesch, A., Lorenz, J., Rutkowski, J., & Choukroun, J. (2014). Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. Journal of Oral Implantology, 40(6), 679-689.
Gupta, V., Bains, V. K., Singh, G. P., Mathur, A., & Bains, R. (2011). Regenerative potential of platelet rich fibrin in dentistry: Literature review. Asian J Oral Health Allied Sci, 1, 23-8.
Hassan, H., Quinlan, D. J., & Ghanem, A. (2020). Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study. Journal of Cosmetic Dermatology, 19(12), 3213-3221.
Hartshorne, J., & Gluckman, H. (2016). A comprehensive clinical review of Platelet Rich Fibrin (PRF) and its role in promoting tissue healing and regeneration in dentistry. Int. Dentistry Afr. Ed, 6(5), 14-24.
Karimi, K. & Rockwell, H. (2019). Os benefícios da fibrina rica em plaquetas. Clínicas de Cirurgia Plástica Facial, 27 (3), 331-340.
LEMOS, J., ROSSI JUNIOR, R., & PÍSPICO, R. (2005). Utilização de plasma rico em plaquetas em enxertos ósseos–proposta de um protocolo de obtenção simplificado. 2002. Capturado em, 12.
Lins, V. F., Brandão, D. G., & Rocha, S. M. W. (2021). A utilização da fibrina rica em plaquetas em procedimentos estéticos orofaciais: uma revisão integrativa. Research, Society and Development, 10(3), e27910313477-e27910313477.
Martínez-González, J. M., Cano-Sánchez, J., Gonzalo-Lafuente, J. C., Campo-Trapero, J., Esparza-Gómez, G. C., & Seoane Lestón, J. M. (2002). ¿ Existen riesgos al utilizar los concentrados de plasma rico en plaquetas (PRP) de uso ambulatorio. Medicina Oral, 7(5), 375-90.
Marx, R. E. (2004). Platelet-rich plasma: evidence to support its use. Journal of oral and maxillofacial surgery, 62(4), 489-496.
Mourão, C. F. D. A. B., Valiense, H., Melo, E. R., Mourão, N. B. M. F., & Maia, M. D. C. (2015). Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft. Revista do Colégio Brasileiro de Cirurgiões, 42, 421-423.
Naik, B., Karunakar, P., Jayadev, M., & Marshal, V. R. (2013). Role of Platelet rich fibrin in wound healing: A critical review. Journal of conservative dentistry: JCD, 16(4), 284.
Preeja, C., & Arun, S. (2014). Platelet-rich fibrin: Its role in periodontal regeneration. The Saudi Journal for Dental Research, 5(2), 117-122.
Roveri, P. R. (2018). Obtenção de fibrina leocoplaquetaria na odontologia PRF e IPRF: revisão literária [Master's thesis, Faculdade Sete Lagoas]. Especialização em estetica orofacial. https://faculdadefacsete.edu.br/monografia/items/show/260.
Sánchez, A. R., Sheridan, P. J., & Kupp, L. I. (2003). Is platelet-rich plasma the perfect enhancement factor? A current review. International Journal of Oral & Maxillofacial Implants, 18(1).
Sclafani, A. P. (2010). Platelet‐rich fibrin matrix for improvement of deep nasolabial folds. Journal of cosmetic dermatology, 9(1), 66-71.
Shah, M., Deshpande, N., Bharwani, A., Nadig, P., Doshi, V., & Dave, D. (2014). Effectiveness of autologous platelet-rich fibrin in the treatment of intra-bony defects: A systematic review and meta-analysis. Journal of Indian Society of Periodontology, 18(6), 698.
Shah, R., Thomas, R., & Mehta, D. S. (2017). An Update on the Protocols and Biologic Actions of Platelet Rich Fibrin in Dentistry. The European journal of prosthodontics and restorative dentistry, 25(2), 64-72.
Sharma, A., & Pradeep, A. R. (2011). Autologous platelet‐rich fibrin in the treatment of mandibular degree II furcation defects: A randomized clinical trial. Journal of periodontology, 82(10), 1396-1403.
Shivashankar, V. Y., Johns, D. A., Vidyanath, S., & Kumar, M. R. (2012). Platelet rich fibrin in the revitalization of tooth with necrotic pulp and open apex. Journal of conservative dentistry: JCD, 15(4), 395.
Shivashankar, V. Y., Johns, D. A., Vidyanath, S., & Sam, G. (2013). Combination of platelet rich fibrin, hydroxyapatite and PRF membrane in the management of large inflammatory periapical lesion. Journal of conservative dentistry: JCD, 16(3), 261.
Takamori, E. R., Teixeira, M. V. T., Menezes, K., Carias, R. B. V., & Borojevic, R. (2018). Fibrina rica em plaquetas: preparo, definição da qualidade, uso clínico. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 6(1), 118-124.
Varela, H. A., Souza, J. C., Nascimento, R. M., Araújo, R. F., Vasconcelos, R. C., Cavalcante, R. S., & Araújo, A. A. (2019). Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clinical oral investigations, 23(3), 1309-1318.
Vendramin, F. S., Franco, D., Nogueira, C. M., Pereira, M. S., & Franco, T. R. (2006). Plasma rico em plaquetas e fatores de crescimento: técnica de preparo e utilização em cirurgia plástica. Revista do Colégio Brasileiro de Cirurgiões, 33, 24-28.
Wang, X., Yang, Y., Zhang, Y., & Miron, R. J (2019). A fibrina rica em plaquetas no fluido estimula uma maior migração, proliferação e síntese de colágeno de fibroblastos cutâneos dérmicos quando comparada ao plasma rico em plaquetas. Journal of cosmético dermatology, 18 (6), 2004-2010.
Winkler, R., Pasleau, F., Boussif, N., & Hodzic, D. (2000). Le système IGF: synthèse et données récentes [The IGF system: summary and recent data]. Revue medicale de Liege, 55(7), 725–739.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Nathane Araujo de Carvalho; Carlos Eduardo Côrtes Morais; Fernando Nascimento; Lia Dietrich; Marcelo Dias Moreira de Assis Costa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.