Drug interactions between patients with HIV/AIDS
DOI:
https://doi.org/10.33448/rsd-v10i15.22838Keywords:
Drug interactions; HIV Infections; Nursing.Abstract
Objective: To analyze through scientific evidence the occurrence of drug-drug interactions in patients diagnosed with HIV/AIDS. Methodology: This is an integrative review. Data collection took place through the Virtual Health Database held on November 22, 2020. Therefore, the Rayyan application was used to optimize the selection of articles and the synthesis matrix was the method for carrying out the data analysis. Results: It was possible to identify that few studies are carried out with the elderly population that has a diagnosis of HIV/AIDS. Furthermore, it was observed that the main drug interactions occur between antiretrovirals and proton pump inhibitor drugs. Conclusion: The occurrence of drug interactions is frequent in patients diagnosed with HIV/AIDS, especially in the elderly. Therefore, it is essential that further research be carried out on this topic, aiming to formulate strategies to minimize drug-drug interactions and their consequences for the patient.
References
Andrade, K. V. F., & Souza, A. M. (2018). Prevalência de interações medicamentosas potenciais em indivíduos hipertensos acompanhados na estratégia de saúde da família. Journal of Health & Biological Sciences, 6(4), 405-411.
Antunes, J. D. F. S., Okuno, M. F. P., Lopes, M. C. B. T., Campanharo, C. R. V., & Batista, R. E. A. (2015). Interação medicamentosa em idosos internados no serviço de emergência de um hospital universitário. Revista Mineira de Enfermagem, 19(4), 907-918.
Baecke, C., Gyssens, I. C., Decoutere, L., van der Hilst, J. C. H., & Messiaen, P. (2017). Prevalence of drug-drug interactions in the era of HIV integrase inhibitors: a retrospective clinical study. Neth J Med, 75(6), 235-240.
Bastida, C., Grau, A., Márquez, M., Tuset, M., De Lazzari, E., Martínez, E., & Gatell, J. M. (2017). Polypharmacy and potential drug-drug interactions in an HIV-infected elderly population. Farmacia Hospitalaria, 41(5), 618-624.
Bouzillé, G., Morival, C., Westerlynck, R., Lemordant, P., Chazard, E., Lecorre, P., ... & Cuggia, M. (2019, August). An Automated Detection System of Drug-Drug Interactions from Electronic Patient Records Using Big Data Analytics. In MedInfo (pp. 45-49).
Carvalho, B. M. D., Morandi, M. S., Parro, M. C., & Moreno, A. D. H. (2016). Avaliação de prescrições e análise da ocorrência de interações medicamentosas. CuidArte, Enferm, 123-130.
Costa, D. F., Gonçalves, A. S. R., dos Santos Vieira, J. R., & Guerreiro, J. F. (2018). Adesão à terapia antirretroviral de pacientes portadores de HIV/Aids com lipodistrofia. Revista Enfermagem UERJ, 26, 31156.
Cunha, P. L. P., Cunha, C. S., & Alves, P. F. (2014). Manual Revisão Sistemática Integrativa: a pesquisa baseada em evidências. Belo Horizonte, 63.
Etelvino, M. A. L., dos Santos, N. D., Aguiar, B. G. C., & de Assis, T. G. (2019). Segurança do paciente: uma análise do aprazamento de medicamentos. Enfermagem em Foco, 10(4).
Gervasoni, C., Formenti, T., & Cattaneo, D. (2019). Management of polypharmacy and drug-drug interactions in HIV patients: a 2-year experience of a multidisciplinary outpatient clinic. AIDS reviews, 21(1), 40-49.
Hasler, S., Senn, O., Rosemann, T., & Neuner-Jehle, S. (2015). Effect of a patient-centered drug review on polypharmacy in primary care patients: study protocol for a cluster-randomized controlled trial. Trials, 16(1), 1-7.
Iniesta‐Navalón, C., Franco‐Miguel, J. J., Gascón‐Cánovas, J. J., & Rentero‐Redondo, L. (2015). Identification of potential clinically significant drug interactions in HIV‐infected patients: a comprehensive therapeutic approach. HIV medicine, 16(5), 273-279.
Joaquim, F. L., Silva, R. M. C. R. A., Garcia-Caro, M. P., Cruz-Quintana, F., & Pereira, E. R. (2018). Impact of venous ulcers on patients' quality of life: an integrative review. Revista brasileira de enfermagem, 71, 2021-2029.
Kara, E., İnkaya, A. Ç., HAKLI, D. A., DEMIRKAN, S. K., & Ünal, S. (2019). Polypharmacy and drug-related problems among people living with HIV/AIDS: a single-center experience. Turkish journal of medical sciences, 49(1), 222-229.
Marzolini, C., Back, D., Weber, R., Furrer, H., Cavassini, M., Calmy, A., ... & Yerly, S. (2011). Ageing with HIV: medication use and risk for potential drug–drug interactions. Journal of antimicrobial chemotherapy, 66(9), 2107-2111.
Fernández Cañabate, S., & Ortega Valín, L. (2019). Polypharmacy among HIV infected people aged 50 years or older. Colombia Médica, 50(3), 142-152.
Medscape. Drug Interaction Checker. (2021) https://reference.medscape.com/drug-interactionchecker
Monteiro, C. R. D. A., Schoueri, J. H. M., Cardial, D. T., Linhares, L. D. C., Turke, K. C., Steuer, L. V., ... & Giglio, A. D. (2019). Evaluation of the systemic and therapeutic repercussions caused by drug interactions in oncology patients. Revista da Associação Médica Brasileira, 65, 611-617.
Monteiro, S. C. M., Belfort, I. K. P., Sousal, W. R., Barros, C. S., & Campos, K. V. S. (2015). Estudo de potenciais interações medicamentosas em pacientes hipertensos. Infarma Ciências Farmacêuticas, 27(2), 117-25.
Moreira, M. B., Mesquita, M. G. D. R., Stipp, M. A. C., & Paes, G. O. (2017). Potential intravenous drug interactions in intensive care. Revista da Escola de Enfermagem da USP, 51.
Nunes Júnior, S. S., & Ciosak, S. I. (2018). Terapia antirretroviral para HIV/AIDS: o estado da arte. Rev. enferm. UFPE on line, 1103-1111.
Osorio, L., Rivera, M., Pino-Marín, D. E., Giraldo, N. A., & Amariles, P. (2019). Relevancia clínica de las interacciones medicamentosas en pacientes infectados con el virus de la inmunodeficiencia humana: actualización 2015-2017. Revista chilena de infectología, 36(4), 475-489.
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan—a web and mobile app for systematic reviews. Systematic reviews, 5(1), 1-10.
Pontelo, B. M., Greco, D. B., Guimarães, N. S., Rotsen, N., Braga, V. A. R., Pimentel, P. H. N., ... & Tupinambás, U. (2020). Profile of drug-drug interactions and impact on the effectiveness of antiretroviral therapy among patients living with HIV followed at an Infectious Diseases Referral Center in Belo Horizonte, Brazil. Brazilian Journal of Infectious Diseases, 24, 104-109.
Popets, J. C., Andrade, G. B., Stroka, A., & Rostelato-Ferreira, S. (2015). Estudo das interações medicamentosas em prescrições de pacientes de uma Clínica-Escola de Fisioterapia. Infarma-Ciências Farmacêuticas, São Paulo, 28(1), 22-26.
Ranzani, A., Oreni, L., Agrò, M., van den Bogaart, L., Milazzo, L., Giacomelli, A., ... & Ridolfo, A. L. (2018). Burden of exposure to potential interactions between antiretroviral and non-antiretroviral medications in a population of HIV-positive patients aged 50 years or older. JAIDS Journal of Acquired Immune Deficiency Syndromes, 78(2), 193-201.
Rodrigues, S. B., Louro, D., Souza, E. M. O., & da Cunha, M. A. (2020). Estabelecimento da comunicação terapêutica entre enfermeiro e clientes frente a tentativas de autoextermínio: revisão integrativa da literatura. Brazilian Journal of Health Review, 3(3), 5943-5958.
Santos, W. M., Secoli, S. R., & de Mello Padoin, S. M. (2016). Potenciais interações de drogas em pacientes de terapia antirretroviral. Revista Latino-Americana de Enfermagem, 24, 1-9.
Siefried, K. J., Mao, L., Cysique, L. A., Rule, J., Giles, M. L., Smith, D. E., ... & PAART study investigators. (2018). Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on suppressive antiretroviral therapy. AIDS (London, England), 32(1), 35.
Silva, H. F. N., Dourado, C. S. D. M. E., Silva, H. G. N., & Silva, H. F. N. (2019). Avaliação do tratamento antirretroviral de pessoas convivendo com HIV/aids que participam de um grupo de adesão. Medicina (Ribeirao Preto), 52(3), 161-170.
Smit, M., Brinkman, K., Geerlings, S., Smit, C., Thyagarajan, K., van Sighem, A., ... & Hallett, T. B. (2015). Future challenges for clinical care of an ageing population infected with HIV: a modelling study. The Lancet Infectious Diseases, 15(7), 810-818.
Sousa, L. M. M., Marques-Vieira, C. M. A., Severino, S. S. P., & Antunes, A. V. (2017). A metodologia de revisão integrativa da literatura em enfermagem. Nº21 Série 2-Novembro 2017, 17.
Stader, F., Kinvig, H., Battegay, M., Khoo, S., Owen, A., Siccardi, M., & Marzolini, C. (2018). Analysis of clinical drug-drug interaction data to predict magnitudes of uncharacterized interactions between antiretroviral drugs and comedications. Antimicrobial agents and chemotherapy, 62(7), e00717-18.
Tavares, D. S., Gomes, N. C., Rodriguês, L. R., & Tavares, D. M. D. S. (2018). Perfil de idosos com síndrome metabólica e fatores associados às possíveis interações medicamentosas. Revista Brasileira de Geriatria e Gerontologia, 21, 164-175.
Turgeon, J., & Michaud, V. (2016). Clinical decision support systems: Great promises for better management of patients’ drug therapy. Expert opinion on drug metabolism & toxicology, 12(9), 993-995.
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Copyright (c) 2021 Isabelle Aparecida de Sousa Bernardes; Jhenifer Alves de Araújo; Eduardo Nogueira Cortez; Maíla Martins Oliveira; Marlene Alves Ferreira; Deborah Franscielle da Fonseca; Heuler Souza Andrade
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