Concepts and applicability of photodynamic therapy in periodontics: literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v10i15.22931

Keywords:

Photodynamic Therapy; Photochemotherapy; Low intensity light therapy.

Abstract

Introduction: Photodynamic Therapy is an oxygen-dependent photochemical reaction initiated by a low-power laser with an appropriate wavelength. And it has been widely used in periodontics because it allows the reduction of periodontopathogens with no systemic side effects and minimal possibilities of bacterial resistance. Objective: To carry out a literature review on photodynamic therapy and its importance in the treatment of periodontal diseases. Methodology: A literature search was carried out in the Pubmed, Scielo and Lilacs databases, with the help of the following health descriptors: “Photodynamic Therapy” (Photodynamic Therapy); “Photochemotherapy” (Photochemotherapy); “Low Power Laser Therapy” between 1991 and 2021. Results: Looking at the facts, it was seen that choosing one of a photosensitizers and applying it with a correct and specific wavelength leads to the success of this therapy. Conclusion: It is necessary to carry out more studies aimed at its use in the treatment of periodontal diseases. Specific therapeutic protocols are defined that allow its execution based on science.

References

Al-Hamoudi N. (2017). Is antimicrobial photodynamic therapy an effective treatment for chronic periodontitis in diabetes mellitus and cigarette smokers: a systematic review and meta-analysis. Photodiagnosis and photodynamic therapy, 19, 375–382. https://doi.org/10.1016/j.pdpdt.2017.05.018.

Allison, R. R., Bagnato, V. S., Cuenca, R., Downie, G. H., & Sibata, C. H. (2006). The future of photodynamic therapy in oncology. Future oncology (London, England), 2(1), 53–71. https://doi.org/10.2217/14796694.2.1.53.

Cao, R., Li, Q., Wu, Q., Yao, M., Chen, Y., & Zhou, H. (2019). Efeito da terapia periodontal não cirúrgica no controle glicêmico do diabetes mellitus tipo 2: uma revisão sistemática e meta-análise da rede Bayesiana. BMC oral health, 19 (1), 176. https://doi.org/10.1186/s12903-019-0829-y.

Carrera, E. T., Dias, H. B., Corbi, S., Marcantonio, R., Bernardi, A., Bagnato, V. S., Hamblin, M. R., & Rastelli, A. (2016). The application of antimicrobial photodynamic therapy (aPDT) in dentistry: a critical review. Laser physics, 26(12), 123001. https://doi.org/10.1088/1054-660X/26/12/123001.

Castano, A. P., Demidova, T. N., & Hamblin, M. R. (2004). Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization. Photodiagnosis and photodynamic therapy, 1(4), 279–293. https://doi.org/10.1016/S1572-1000(05)00007-4.

Cobb, C. M. (2006). Lasers in periodontics: a review of the literature. Journal of periodontology, 77(4), 545-564.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Fernandes, L. A., de Almeida, J. M., Theodoro, L. H., Bosco, A. F., Nagata, M. J., Martins, T. M., Okamoto, T., & Garcia, V. G. (2009). Treatment of experimental periodontal disease by photodynamic therapy in immunosuppressed rats. Journal of clinical periodontology, 36(3), 219–228. https://doi.org/10.1111/j.1600-051X.2008.01355.x.

Garg AD, Maes H, Romano E, & Agostinis P. Autophagy a major adaptation pathway shaping cancer cell death and anti cancer immunity responses following photodynamic therapy. Photochem Photobiol Sci. 14:1410-1424. https://doi.org/10.1039/C4PP00466C.

Giannelli, M., Lasagni, M., & Bani, D. (2019). Terapia fotônica em doenças periodontais uma visão geral com avaliação da literatura e recomendações de tratamento fundamentadas. Jornal internacional de ciências moleculares, 20 (19), 4741. https://doi.org/10.3390/ijms20194741.

Gillies, M., Ranakusuma, A., Hoffmann, T., Thorning, S., McGuire, T., Glasziou, P., & Del Mar, C. (2015). Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 187(1), E21–E31. https://doi.org/10.1503/cmaj.140848.

Habashneh, RA, Mashal, MA, Khader, Y., & Qudah, R. (2019). Efeitos clínicos e biológicos da terapia fotodinâmica adjuvante na periodontite refratária. Journal of lasers in medical sciences, 10 (2), 139–145. https://doi.org/10.15171/jlms.2019.22.

Javali, M. A., AlQahtani, N. A., Ahmad, I., & Ahmad, I. (2019). Antimicrobial photodynamic therapy (light source; methylene blue; titanium dioxide): Bactericidal effects analysis on oral plaque bacteria: An in vitro study. Nigerian journal of clinical practice, 22(12), 1654–1661. https://doi.org/10.4103/njcp.njcp_189_19.

Jiang, C., Yang, W., Wang, C., Qin, W., Ming, J., Zhang, M., Qian, H., & Jiao, T. (2019). Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis. Oxidative medicine and cellular longevity, 2019, 1529520. https://doi.org/10.1155/2019/1529520.

Konopka, K., & Goslinski, T. (2007). Photodynamic therapy in dentistry. Journal of dental research, 86(8), 694–707. https://doi.org/10.1177/154405910708600803.

Kumar, V., Sinha, J., Verma, N., Nayan, K., Saimbi, C. S., & Tripathi, A. K. (2015). Scope of photodynamic therapy in periodontics. Indian journal of dental research : official publication of Indian Society for Dental Research, 26(4), 439–442. https://doi.org/10.4103/0970-9290.167636.

Macedo, G., Novaes, A. B., Jr, Souza, S. L., Taba, M., Jr, Palioto, D. B., & Grisi, M. F. (2014). Additional effects of aPDT on nonsurgical periodontal treatment with doxycycline in type II diabetes: a randomized, controlled clinical trial. Lasers in medical science, 29(3), 881–886. https://doi.org/10.1007/s10103-013-1285-6.

Mallineni, S., Nagarakanti, S., Gunupati, S., Bv, RR, Shaik, MV, & Chava, VK (2020). Efeitos clínicos e microbiológicos da terapia adjuvante com laser de diodo fotodinâmico no tratamento da periodontite crônica: um ensaio clínico randomizado. Journal of Dental Research, Dental Clinics, Dental Prossers , 14 (3), 191–197. https://doi.org/10.34172/joddd.2020.030

Meimandi, M., Talebi Ardakani, M. R., Esmaeil Nejad, A., Yousefnejad, P., Saebi, K., & Tayeed, M. H. (2017). The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature. Journal of lasers in medical sciences, 8(Suppl 1), S7–S11. https://doi.org/10.15171/jlms.2017.s2.

Meisel, P., & Kocher, T. (2005). Terapia fotodinâmica para doenças periodontais: estado da arte. Journal of photochemistry and photobiology B: Biology , 79 (2), 159-170.

Mielczarek-Badora, E., & Szulc, M. (2013). Photodynamic therapy and its role in periodontitis treatment. Postepy higieny i medycyny doswiadczalnej (Online), 67, 1058–1065. https://doi.org/10.5604/17322693.1075915.

Moan, J., & Berg, K. (1991). The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochemistry and photobiology, 53(4), 549–553. https://doi.org/10.1111/j.1751-1097.1991.tb03669.x.

Nagahara, A., Mitani, A., Fukuda, M., Yamamoto, H., Tahara, K., Morita, I., Ting, C. C., Watanabe, T., Fujimura, T., Osawa, K., Sato, S., Takahashi, S., Iwamura, Y., Kuroyanagi, T., Kawashima, Y., & Noguchi, T. (2013). Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis. Journal of periodontal research, 48(5), 591–599. https://doi.org/10.1111/jre.12042.

Oliveira, C. L. de, Santos, K. de S., Fernandes Neto, J. de A., Batista, A. L. A., Medeiros, C. L. S. G. de, & Catão, M. H. C. de V. (2017). A eficácia da terapia fotodinâmica no tratamento periodontal não cirúrgico. ARCHIVES OF HEALTH INVESTIGATION, 6(6). https://doi.org/10.21270/archi.v6i6.2072.

Park, D., Choi, E. J., Weon, K. Y., Lee, W., Lee, S. H., Choi, J. S., Park, G. H., Lee, B., Byun, M. R., Baek, K., & Choi, J. W. (2019). Non-Invasive Photodynamic Therapy against -Periodontitis-causing Bacteria. Scientific reports, 9(1), 8248. https://doi.org/10.1038/s41598-019-44498-4.

Petersilka, G. J., Tunkel, J., Barakos, K., Heinecke, A., Häberlein, I., & Flemmig, T. F. (2003). Subgingival plaque removal at interdental sites using a low-abrasive air polishing powder. Journal of periodontology, 74(3), 307–311. https://doi.org/10.1902/jop.2003.74.3.307.

Prażmo, E. J., Kwaśny, M., Łapiński, M., & Mielczarek, A. (2016). Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases. Advances in clinical and experimental medicine: official organ Wroclaw Medical University, 25(4), 799–807. https://doi.org/10.17219/acem/32488.

Qi, M., Chi, M., Sun, X., Xie, X., Weir, MD, Oates, TW, Zhou, Y., Wang, L., Bai, Y., & Xu, HH (2019). Novas terapias fotodinâmicas antibacterianas baseadas em nanomateriais para combater biofilmes bacterianos orais e doenças infecciosas. International journal of nanomedicine , 14 , 6937-6956. https://doi.org/10.2147/IJN.S212807.

Raghavendra, M., Koregol, A., & Bhola, S. (2009). Photodynamic therapy: a targeted therapy in periodontics. Australian dental journal, 54 Suppl 1, S102–S109. https://doi.org/10.1111/j.1834-7819.2009.01148.x.

Rajesh, S., Koshi, E., Philip, K., & Mohan, A. (2011). Antimicrobial photodynamic therapy: An overview. Journal of Indian Society of Periodontology, 15(4), 323–327. https://doi.org/10.4103/0972-124X.92563.

Ramanauskaite, E., Sakalauskaite, U. M., & Machiulskiene, V. (2020). The Efficacy of Adjunctive Aids in Periodontal Maintenance Therapy: A Systematic Literature Review and Meta-analysis. Oral health & preventive dentistry, 18(1), 889–910. https://doi.org/10.3290/j.ohpd.a45406.

Romeo, U., Nardi, G. M., Libotte, F., Sabatini, S., Palaia, G., & Grassi, F. R. (2016). The Antimicrobial Photodynamic Therapy in the Treatment of Peri-Implantitis. International journal of dentistry, 2016, 7692387. https://doi.org/10.1155/2016/7692387.

Sgolastra, F., Petrucci, A., Gatto, R., Marzo, G., & Monaco, A. (2013). Photodynamic therapy in the treatment of chronic periodontitis: a systematic review and meta-analysis. Lasers in medical science, 28(2), 669–682. https://doi.org/10.1007/s10103-011-1002-2.

Tanner AC. Anaerobic culture to detect periodontal and caries pathogens. J Oral Biosci. 2015;57(1):18-26. 10.1016/j.job.2014.08.001.

Tsai, C. Y., Tang, C. Y., Tan, T. S., Chen, K. H., Liao, K. H., & Liou, M. L. (2018). Subgingival microbiota in individuals with severe chronic periodontitis. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 51(2), 226–234. https://doi.org/10.1016/j.jmii.2016.04.007.

Wadhwa, A., Mallapragada, S., & Sharma, P. (2021). Novel indocyanine green mediated antimicrobial photodynamic therapy in the management of chronic periodontitis - A randomized controlled clinico-microbiological pilot study. Journal of oral biology and craniofacial research, 11(1), 57–62. https://doi.org/10.1016/j.jobcr.2020.11.005.

Wang, H., Li, W., Zhang, D., Li, W., & Wang, Z. (2019). Adjunctive photodynamic therapy improves the outcomes of peri-implantitis: a randomized controlled trial. Australian dental journal, 64(3), 256–262. https://doi.org/10.1111/adj.12705.

Zhao, Y., Pu, R., Qian, Y., Shi, J., & Si, M. (2021). Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: A systematic review and meta-analysis. Photodiagnosis and photodynamic therapy, 34, 102231. https://doi.org/10.1016/j.pdpdt.2021.102231.

Published

26/11/2021

How to Cite

PIMENTEL, J. K. P.; DIAS, K. S. P. A. . Concepts and applicability of photodynamic therapy in periodontics: literature review. Research, Society and Development, [S. l.], v. 10, n. 15, p. e277101522931, 2021. DOI: 10.33448/rsd-v10i15.22931. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22931. Acesso em: 29 nov. 2024.

Issue

Section

Health Sciences