Analysis of dispensation of opioids in Brazil: 2014-2018
DOI:
https://doi.org/10.33448/rsd-v11i3.26240Keywords:
Psychotropic drugs; Analgesics, opioid; Drug prescriptions; Pain; Narcotics.Abstract
The aim of this study was to describe the opioid dispensing profile in Brazil between 2014 and 2018. Data were collected on the number and type of opioid dispensed after professional prescription, between January 2014 and December 2018, from the National Controlled Products Management System (SNGPC), managed by the National Health Surveillance Agency (ANVISA), having as object of study the analysis of the variables: (1) Active Principle; (2) Quantity dispensed by state and (3) Origin of Professional Registration. A total of 60.675.488 drugs were marketed, with codeine phosphate being the most widely dispensed active ingredient, followed by tramadol hydrochloride, which together accounted for 95.9% (2014), 96.6% (2015), 96.2% (2016), 95.4% (2017) and 95.7% (2018). In practically every year, the average of medicines sold remained above 5,000 units per 100,000 inhabitants. São Paulo was the state that most commercialized opioids, and regarding the origin of the prescriber's professional record, doctors accounted for 93.2% of the medication dispensed. It was concluded that codeine phosphate was the most prescribed among the opioids dispensed. There was no trend towards an increase in dispensing in the period evaluated.
References
Brasil. (2012). Uso racional de medicamentos: temas selecionados. Série A. Normas e Manuais Técnicos.
Brasil (2006). Assistência farmacêutica na atenção básica: instruções técnicas para sua organização. Série A. Normas e Manuais Técnicos, 2 Ed.
Calônego, M. A. M. (2020) Dificuldades sociais, legais e burocráticas para prescrição de opioides [tese]. Botucatu (SP): Universidade Estadual Paulista "Júlio de Mesquita Filho.
Coluzzi, F., Taylor, R., Jr, Pergolizzi, J. V., Jr, Mattia, C., & Raffa, R. B. (2016). Good clinical practice guide for opioids in pain management: the three Ts - titration (trial), tweaking (tailoring), transition (tapering). Brazilian journal of anesthesiology (Elsevier), 66(3), 310–317. https://doi.org/10.1016/j.bjane.2014.09.005
Duminelli, M. V., Redivo, T. S., & Yamaguchi. C. K. (2016). Perspectiva da crise econômica e política no Brasil: reflexos para o desenvolvimento da economia com foco no setor do comércio. Revista Contribuciones a las Ciencias Sociales. 1(12): 01-04.
Evangelista, M. C., Silva, R. A., Cardozo, L. B., Kahvegian, M. A., Rossetto, T. C., Matera, J. M., & Fantoni, D. T. (2014). Comparison of preoperative tramadol and pethidine on postoperative pain in cats undergoing ovariohysterectomy. BMC veterinary research, 10, 252. https://doi.org/10.1186/s12917-014-0252-1
Gomes, T., Tadrous, M., Mamdani, M. M., Paterson, J. M., & Juurlink, D. N. (2018). The Burden of Opioid-Related Mortality in the United States. JAMA network open, 1(2), e180217. https://doi.org/10.1001/jamanetworkopen.2018.0217
Gomes, V. P., Silva, M. T., & Galvão, T. F. (2017). Prevalence of medicine use among Brazilian adults: a systematic review. Prevalência do consumo de medicamentos em adultos brasileiros: uma revisão sistemática. Ciencia & saude coletiva, 22(8), 2615–2626. https://doi.org/10.1590/1413-81232017228.29412016
Kahan, M., Mailis-Gagnon, A., & Tunks, E. (2011). Canadian guideline for safe and effective use of opioids for chronic non-cancer pain: implications for pain physicians. Pain research & management, 16(3), 157–158. https://doi.org/10.1155/2011/434298
Krawczyk, N., Greene, M. C., Zorzanelli, R., & Bastos, F. I. (2018). Rising Trends of Prescription Opioid Sales in Contemporary Brazil, 2009-2015. American journal of public health, 108(5), 666–668. https://doi.org/10.2105/AJPH.2018.304341
Marangoni. J.M., Franca, L.G., & Palazzo, E.L. (2014). Uso do Tramadol em Cães e Gatos – Revisão. Nucleus. 11(2): 1.
Meyboom, R. H., Lindquist, M., & Egberts, A. C. (2000). An ABC of drug-related problems. Drug safety, 22(6), 415–423. https://doi.org/10.2165/00002018-200022060-00001
Meyer, A., LeClair, C., & McDonald, J. V. (2020). Prescription Opioid Prescribing in Western Europe and the United States. Rhode Island medical journal (2013), 103(2), 45–48.
Nascimento, D. C. H., & Sakata, R. K. (2011). Dependência de opioide em pacientes com dor crônica. Revista dor, 12, 160-165.
Ngoundo-Mbongue, T. B., Niezborala, M., Sulem, P., Briant-Vincens, D., Bancarel, Y., Jansou, P., Chastan, E., Montastruc, J. L., & Lapeyre-Mestre, M. (2005). Psychoactive drug consumption: performance-enhancing behaviour and pharmacodependence in workers. Pharmacoepidemiology and drug safety, 14(2), 81–89. https://doi.org/10.1002/pds.1006
Paula, L.F., & Pires, M. (2017). Crise e perspectivas para a economia brasileira. Estudos avançados. 31 (89): 125-144.
Pereira, M. de M., Andrade, L. de P., & Takitane, J. (2017). Evolução do uso abusivo de derivados de ópio. Saúde Ética & Justiça , 21(1), 12-17. https://doi.org/10.11606/issn.2317-2770.v21i1p12-17
Priest, C. R., Kenney, B. C., Brummett, C. M., Waljee, J. F., Englesbe, M. J., & Nalliah, R. P. (2020). Increased opioid prescription fills after dental procedures performed before weekends and holidays. Journal of the American Dental Association (1939), 151(6), 388–398.e1. https://doi.org/10.1016/j.adaj.2020.03.014
Rudd, R. A., Seth, P., David, F., & Scholl, L. (2016). Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. MMWR. Morbidity and mortality weekly report, 65(50-51), 1445–1452. https://doi.org/10.15585/mmwr.mm655051e1
Salamonde, G. L., Verçosa, N., Barrucand, L., & Costa, A. F. (2006). Análise clínica e terapêutica dos pacientes oncológicos atendidos no programa de dor e cuidados paliativos do Hospital Universitário Clementino Fraga Filho no ano de 2003 [Clinical and therapeutic analysis of oncology patients treated at the pain and palliative care program of the Hospital Universitário Clementino Fraga Filho in 2003.]. Revista brasileira de anestesiologia, 56(6), 602–618. https://doi.org/10.1590/s0034-70942006000600005
Sudheer, P. S., Logan, S. W., Terblanche, C., Ateleanu, B., & Hall, J. E. (2007). Comparison of the analgesic efficacy and respiratory effects of morphine, tramadol and codeine after craniotomy. Anaesthesia, 62(6), 555–560. https://doi.org/10.1111/j.1365-2044.2007.05038.x
Volkow, N. D., McLellan, T. A., Cotto, J. H., Karithanom, M., & Weiss, S. R. (2011). Characteristics of opioid prescriptions in 2009. JAMA, 305(13), 1299–1301. https://doi.org/10.1001/jama.2011.401
Wilken, I. S., & de Abreu, M. H. N. G. (2017). Utilização de analgésicos opioides após exodontia de terceiros molares: uma revisão da literatura científica. Arquivos Em Odontologia, 53. https://periodicos.ufmg.br/index.php/arquivosemodontologia/article/view/3728
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Rosiane Lima de Castro; Luciane Zanin; Leopoldo Augusto Moraes; Juliana Cama Ramacciato; Cristiane de Cássia Bergamaschi; Flávia Martão Flório
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.