Brain death in the adult patient: an integrative literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.38865

Keywords:

Brain death; Electroencephalogram; Diagnosis.

Abstract

Brain death can be defined as the irreversible state of brain functions, considering the cerebral hemispheres as well as the brainstem. Two tests are required that can confirm the absence or cessation of brain stem activities for diagnosis of ED in Brazil. The search was used through survey and critical analysis of the documents published through the search platforms PubMed, Scielo and Lilacs. The following descriptors were used: "Brain death", "diagnosis", "adult" and "electroencephalogram", "Brain death AND electroencephalogram", "Brain death AND Noise AND electroencephalogram", "electroencephalograms AND Brain death" and "Brain death AND electroencephalogram AND intensivecareunits". The opening of the ED protocol should encompass all patients who present themselves as non-perceive, in absence of supra-spinal reactivity and in persistent apnea of known cause, irreversible and capable of causing such end, following a protocol of observation in a hospital environment. To start the protocol opening, it is necessary that there is a brain injury of known cause, irreversible and capable of causing ED, and absence of treatable factors that may confuse the diagnosis, treatment and observation in a hospital environment for the minimum period described, body temperature greater than 35° C, arterial oxygen saturation above 94% and systolic blood pressure greater than or equal to 100 mmHg. Measures are used to assess the level of consciousness, such as the Glasgow scale, as well as tests for the assessment of brain stem activity and the apnea test, which is mandatory for such diagnosis. Among the graphic tests, the electroencephalogram (EEG), cerebral angiography, Doppler Fluxometria transcraniana of cerebral arteries and scintigraphy are extremely relevant, being the EEG considered a feasible method performed at the bedside, low cost and low risk to the patient when compared to scintigraphy and arteriography. For diagnostic purposes in the protocol, the trained physician, with experience, will be responsible for the final report.

References

American College Of Surgions Committee On Trauma (2018). Advanced Trauma Life Suport – ATLS. 10 ed.

André-Obadia, N. et al. (2014). Recommandations françaises sur l'électroencéphalogramme [French guidelines on electroencephalogram]. Neurophysiol Clin. 44(6) 515-612.

Arbune, A. A. et al. (2020). Ictal quantitative surface electromyography correlates with postictal EEG suppression. Neurology. 94(24) e2567-e2576.

Aredes, J. S.; Firmo, J. O. A.; Giacomin, K. C. (2018). A morte que salva vidas: complexidades do cuidado médico ao paciente com suspeita de morte encefálica. Cadernos de Saúde Pública [online]. 34(11) e00061718.

Carneiro, B. V. et al. (2019). Otimização de condições para teste de apneia em paciente hipoxêmico com morte encefálica. Revista Brasileira de Terapia Intensiva [online]. 31(1) 106-110.

Chehuen, J. A. et al. (2019). Atualização dos critérios diagnósticos de morte encefálica: aplicação e capacitação dos médicos. Revista Brasileira de Terapia Intensiva [online]. 31(3) 303-311.

Conselho Federal de Medicina. (2017). Resolução CFM no 2.173, de 23 de novembro de 2017. Define os critérios do diagnóstico de morte encefálica. Diário Oficial da União.

Ding, Z. Y. et al. (2015). A Comparison of Brain Death Criteria between China and the United States. Chin Med J (Engl). 128(21) 2896-2901.

Dreier, J. P. et al. (2018). Terminal spreading depolarization and electrical silence in death of human cerebral cortex. Ann Neurol. 83(2) 295-310.

Escudero, D. et al. (2015). Intensive care practices in brain death diagnosis and organ donation. Anaesthesia. 70(10) 1130-1139.

Fernández-Torres, J. L.; Hernández-Hernández, M. A.; Muñoz-Esteban, C. (2013). Non confirmatory electroencephalography in patients meeting clinical criteria for brain death: scenario and impact on organ donation. Clin Neurophysiol. 124(12) 2362-2367.

Fyntanidou, B. et al. (2012). Bispectral Index Scale variations in patients diagnosed with brain death. Transplant Proc. 44(9) 2702-2705.

Garrett, M. P. et al. (2017). Computed tomography angiography as a confirmatory test for the diagnosis of brain death. J Neurosurg. 128(2) 639-644.

Gobert, F. et al. (2018). Proving cortical death after vascular coma: Evoked potentials, EEG and neuroimaging. Clin Neurophysiol. 129(6) 1105-1116.

Hernández-Hernández, M. Á. Et al. (2019). The observation period after clinical brain death diagnosis according to ancillary tests: differences between supratentorial and infratentorial brain injury. J Neurol. 266(8) 1859-1868.

Ihara, S. et al. (2019). Amplitude-Integrated Electroencephalography and Brain Oxygenation for Postcardiac Arrest Patients with Targeted Temperature Management. Ther Hypothermia Temp Manag. 9(3) 209-215.

Jiang, M. et al. (2019). Predicting the non-survival outcome of large hemispheric infarction patients via quantitative electroencephalography: Superiority to visual electroencephalography and the Glasgow Coma Scale. Neurosci Lett. 706 88-92.

Koenig, M. A.; Kaplan, P. W. (2019). Brain death. Handb Clin Neurol. 161 89-102.

Migdady, I. et al. (2021). The use of apnea test and brain death determination in patients on extracorporeal membrane oxygenation: A systematic review. J Thorac Cardiovasc Surg. 162(3) 867-877.

Morato, E. G. (2009). Morte encefálica: conceitos essenciais, diagnóstico e atualização. Revista Médica de Minas Gerais, 19(3).

Moya Sánchez, J. et al. (2020). Portable gamma-camera for the diagnosis of brain death diagnosis. Med Intensiva (Engl Ed). 44(1) 1-8.

Paixão, J. T. C. et al. (2020). Analysis of brain death declaration process and its impact on organ donation in a reference trauma center. Einstein (São Paulo) [online]. 18 eAO5448.

Park, K. J.; Seyal, M. (2019). Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression. Epilepsia. 60(2) 268-274.

Perera, K. et al. (2022). EEG Patterns and Outcomes After Hypoxic Brain Injury: A Systematic Review and Meta-analysis. Neurocrit Care. 36(1) 292-301.

Rabinstein, A. A. (2018). Coma and Brain Death. Continuum (Minneap Minn). 24(6) 1708-1731.

Souza, D. R. S. et al. (2019). Morte Encefálica: Conhecimento e Opinião dos Médicos da Unidade de Terapia Intensiva. Revista Brasileira de Educação Médica [online]. 43(3) 115-122.

Tian, J. et al. (2021). The change index of quantitative electroencephalography for evaluating the prognosis of large hemispheric infarction. J Integr Neurosci. 20(2) 341-347.

Welschehold, S. et al. (2013). Computed tomographic angiography as a useful adjunct in the diagnosis of brain death. J Trauma Acute Care Surg. 74(5) 1279-1285.

Willems, L. M. (2021). EEG patterns and their correlations with short- and long-term mortality in patients with hypoxic encephalopathy. Clin Neurophysiol. 132(11) 2851-2860.

Yu Y. D. et al. (2016). Factors Delaying Organ Procurement After Declaration of Brain Death in Korea. Transplant Proc. 48(7) 2403-2406.

Zhu, L. et al. (2019). A Hybrid System for Distinguishing between Brain Death and Coma Using Diverse EEG Features. Sensors (Basel), 19(6).

Published

18/12/2022

How to Cite

PINHEIRO, F. E. da S.; SILVA, L.; DESTRO-FILHO, J.-B. Brain death in the adult patient: an integrative literature review. Research, Society and Development, [S. l.], v. 11, n. 16, p. e598111638865, 2022. DOI: 10.33448/rsd-v11i16.38865. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/38865. Acesso em: 22 dec. 2024.

Issue

Section

Health Sciences