Factors associated with the use of non-steroidal anti-inflammatory drugs in patients with dyspeptic symptoms
DOI:
https://doi.org/10.33448/rsd-v9i7.3961Keywords:
Anti-inflammatory drugs; Helicobacter pylori; InfectionAbstract
Objective: To identify socioeconomic factors and gastrointestinal disorders associated with the use of non-steroidal anti-inflammatory drugs in patients with dyspeptic symptoms. Method: Cross-sectional study, carried out with 751 patients seen at a public endoscopy service. The association between socioeconomic factors and gastrointestinal disorders with the use of non-steroidal anti-inflammatory drugs was verified using Pearson's correlation tests and measuring their effect using the odds ratio. The research was approved by the Ethics Committee on Research with Human Beings, according to opinion No. 1,304,308. Results: The prevalence of the use of non-steroidal anti-inflammatory drugs was 57.1%. There was an association between the use of non-steroidal anti-inflammatory drugs and smoking (RC: 1.85; p = 0.002), alcoholism (RC: 1.46; p = 0.01), H.pylori infection (RC = 0 , 75; p = 0.036) and with peptic ulcer disease (RC: 2.29; p = 0.005). Conclusions: The study showed that the use of non-steroidal anti-inflammatory drugs is frequent in patients who seek the endoscopy service. Smoking and alcoholic patients were more likely to use these drugs and their use increase the chances of developing peptic ulcers.
References
Bhala, N., Emberson, J., Merhi, A., Abramson, S., Arber, N., Baron, J. A., ... & Goss, P. (2013). Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet, 382(9894), 769-779.
Carli, D. M. D., Pires, R. C., Rohde, S. L., Kavalco, C. M., & Fagundes, R. B. (2015). Peptic ulcer frequency differences related to h. Pylori or aines. Arquivos de gastroenterologia, 52(1), 46-49.
Kanbayashi, Y., & Konishi, H. (2015). Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?. Hepato-gastroenterology, 62(140), 787-789.
Kono, Y., Okada, H., Takenaka, R., Miura, K., Kanzaki, H., Hori, K., ... & Yamamoto, K. (2016). Does Helicobacter pylori exacerbate gastric mucosal Injury in users of nonsteroidal anti-inflammatory drugs? A multicenter, retrospective, case-control study. Gut and liver, 10(1), 69-75.
Kuna, L., Jakab, J., Smolic, R., Raguz-Lucic, N., Vcev, A., & Smolic, M. (2019). Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. Journal of clinical medicine, 8(2), 179.
Lanas, Á., Carrera-Lasfuentes, P., Arguedas, Y., García, S., Bujanda, L., Calvet, X., ... & Sostres, C. (2015). Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants. Clinical Gastroenterology and Hepatology, 13(5), 906-912.
Liang, C. M., Yang, S. C., Wu, C. K., Li, Y. C., Yeh, W. S., Tai, W. C., ... & Chuah, S. K. (2019). Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs. Journal of clinical medicine, 8(10), 1722.
Masclee, G. M., Valkhoff, V. E., Coloma, P. M., de Ridder, M., Romio, S., Schuemie, M. J., ... & Scotti, L. (2014). Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology, 147(4), 784-792.
McCain, R. S., McManus, D. T., McQuaid, S., James, J. A., Salto-Tellez, M., Reid, N. B., ... & Parkes, E. (2020). Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study. Cancer Causes & Control, 31(1), 1-11.
Nagasue, T., Nakamura, S., Kochi, S., Kurahara, K., Yaita, H., Kawasaki, K., & Fuchigami, T. (2015). Time trends of the impact of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs on peptic ulcer bleeding in Japanese patients. Digestion, 91(1), 37-41.
Narayanan, M., Reddy, K. M., & Marsicano, E. (2018). Peptic ulcer disease and Helicobacter pylori infection. Missouri medicine, 115(3), 219-224.
Park, S. C., Chun, H. J., Kang, C. D., & Sul, D. (2011). Prevention and management of non-steroidal anti-inflammatory drugs-induced small intestinal injury. World journal of gastroenterology: WJG, 17(42), 4647-4653.
Reding, K.W., Caim, K.C., Jarrett, M.E., Eugenio, M.D., & Heitkemper, M.M. (2013). Relação entre padrões de consumo de álcool e sintomas gastrointestinais em pacientes com síndrome do intestino irritável. O jornal americano de gastroenterologia , 108 (2), 270.
Silver, K., Littlejohn, A., Thomas, L., Bawa, B., & Lillich, J. D. (2017). Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum. Toxicology, 383, 1-12.
Silver, K., Littlejohn, A., Thomas, L., Marsh, E., & Lillich, J. D. (2015). Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration by disrupting calpain signaling. Biochemical pharmacology, 98(4), 614-628.
Sonnenberg, A. (2013). historic changes of Helicobacter pylori‐associated diseases. Alimentary pharmacology & therapeutics, 38(4), 329-342.
Søreide, K., Thorsen, K., Harrison, E. M., Bingener, J., Møller, M. H., Ohene-Yeboah, M., & Søreide, J. A. (2015). Perforated peptic ulcer. The Lancet, 386(10000), 1288-1298.
Sostres, C., Carrera-Lasfuentes, P., Benito, R., Roncales, P., Arruebo, M., Arroyo, M. T., ... & Lanas, A. (2015). Peptic ulcer bleeding risk. The role of Helicobacter pylori infection in NSAID/low-dose aspirin users. American Journal of Gastroenterology, 110(5), 684-689.
Uotani, T., & Graham, D. Y. (2015). Diagnosis of Helicobacter pylori using the rapid urease test. Annals of translational medicine, 3(1), 9.
Walker, M. M., Potter, M. D., & Talley, N. J. (2019). Tangible Pathologies in Functional Dyspepsia. Best Practice & Research Clinical Gastroenterology, 40-41:101650.
Wongrakpanich, S., Wongrakpanich, A., Melhado, K., & Rangaswami, J. (2018). A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging and disease, 9(1), 143-150.
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