Rheological properties of hyaluronic acid-based fillers for facial cosmetic aesthetics
DOI:
https://doi.org/10.33448/rsd-v12i1.39676Keywords:
Hyaluronic acid; Soft tissue fillers; Rheological properties; Viscoelastic properties.Abstract
Hyaluronic acid-based dermal fillers are the most used materials in cosmiatry, and their clinical implications are linked to their viscoelastic properties. This study aimed to determine the rheological behavior of HA products used in Brazil by changing specific physicochemical characteristics under different test frequencies. Laboratory analyses of 0.9 mL of samples were performed in a TA-Instruments AR-1500ex Rheometer at 25 °C, at oscillation frequencies of 100, 10, 1, and 0.1 radians/second, considering the measurements of G′, G′′, and Tan δ. The value of G' increased as the oscillation frequencies were increased. In parallel, the changes in G" were the ones that varied the most for frequencies 0.1 and 1 radian/second. The maximum G' was observed with Hialurox Ultra Lift® 26 mg/g (793.45; 554.06; 423.44 Pa, 100, 10 and 1 rad/s, respectively). While the lowest G' values were obtained with Rennova Ultra Deep® (43.01; 19.75; 10.75 and 10.42 Pa at 100, 10, 1, 0.1 rad/sec, respectively). The changes that occurred in the investigated properties indicated that hyaluronic acid-based fillers vary when subjected to different conditions of shear rate, which should be considered in their clinical indication for choosing the most appropriate material according to the region to be treated.
References
Borell, M., Leslie, D. B. & Tezel, A. (2011). Lift capabilities of hyaluronic acid fillers. Journal of Cometic and Laser Therapy. 13(1), 21-27.
Borzacchiello, A., Russo, L., Malle, B. M., Schwach-Abdellaoui, K., & Ambrosio, L. (2015). Hyaluronic acid-based hydrogels for regenerative medicine applications. Biomed Research International. 2015(1),871218.
Casabona, G., Frank, K., Koban, K. C., Freytag, D. L., Schenck, T. L., Lachman, N. & et al. (2019). Lifting vs volumizing: The difference in facial minimally invasive procedures when respecting the line of ligaments. Journal of Cosmetic Dermatology. 18(5), 1237-1243.
Choi, M. S. (2020). Basic rheology of dermal filler. Archives of Plastic Surgery. 47(4), 301-304.
Cotofana, S. & Lachman, N. (2019). Anatomy of the facial fat compartments and their relevance in aesthetic surgery. Journal der Deutschen Dermatolgischen Gesellschaft. 17(4), 399-413.
Cotofana, S., Hamade, H., Bertucci, V., Fagien, S., Green, J. B., Pavicic, T. & et al. (2021). Change in Rheologic Properties of Facial Soft-Tissue Fillers across the Physiologic Angular Frequency Spectrum. Plastic and Reconstructive Surgery. 142(2), 320-331.
Fagien, S., Bertucci, V., von Grote, E. & Mashburn, J.H. (2019). Rheologic and physicochemical properties used to differentiate injectable hyaluronic acid filler products. Plastic and Reconstructive Surgery. 143(4), 707-720.
Faivre, J., Gallet, M., Tremblais, E., Trévidic, P. & Bourdon, F. (2021). Advanced Concepts in Rheology for the Evaluation of Hyaluronic Acid–Based Soft Tissue Fillers. Dermatologic Surgery.47(5), e159-e167.
Fallacara, A., Manfredini, S., Durini, E. & Vertuani, S. (2017). Hyaluronic acid fillers in soft tissue regeneration. Facial Plastic Surgery. 33(1), 87-96.
Fundarò, S. P., Salti, G., Malgapo, D. M. H. & Innocenti, S. (2022). The Rheology and Physicochemical Characteristics of Hyaluronic Acid Fillers: Their Clinical Implications. International Journal of Molecular Sciences. 23(10518), 1-19.
Kablik, J., Monheit, G. D., Yu, L., Chang, G. & Gershkovich, J. (2009). Comparative physical properties of hyaluronic acid dermal fillers. Dermatologic Surgery. 35(1), 302-312.
Leonardi, G. R. & Mais Campos, P. M. B. G. (2001). Stability of cosmetic formulations. International Journal of Pharmaceutics Compounding. 3:154-156.
Lorenc, Z. P., Ohrlund, A. & Edsman, K. (2017). Factors affecting the rheological measurement of hyaluronic acid gel fillers. Journal of Drugs in Dermatology. 16(9), 876-882.
Michaud, T. (2018). Rheology of hyaluronic acid and dynamic facial rejuvenation: topographical specificities. Journal of Cosmetic Dermatology. 17(5), 736-743.
Micheels, P., Sarazin, D., Tran, C, & Salomon, D. (2016). Effect of different crosslinking technologies on hyaluronic acid behavior: A visual and microscopic study of seven hyaluronic acid gels. Journal of Drugs in Dermatology. 15(5), 600-606.
Micheels, P., Besse, S., Sarazin, D., Quinodoz, P., Elias, B., Safa, M. et al. (2017). Ultrasound and histologic examination after subcutaneous injection of two volumizing hyaluronic acid fillers: a preliminary study. Plastic Reconstructive Surgery Global Open. 5(2), e222.
Molliard, S. G., Albert, S. & Mondon, K. (2016). Key importance of compression properties in the biophysical characteristics of hyaluronic acid soft-tissue fillers. Journal of the Mechanical Behavior of Biomedical Materials. 61, 290-298.
Molliard, S. G., Bétemps, J. B., Hadjab, B., Topchian, D., Micheels, P., Salomon, D. et al. (2018). Key rheological properties of hyaluronic acid fillers: tissue integration and product degradation. Plastic and Reconstructive Research. 5(17), 2-8.
Pierre, S., Liew, S. & Berardin, A. (2015). Basics of dermal filler rheology. Dermatologic Surgery. 41(1), S120-S126.
Rayess, H. M., Svider, P. F., Hanba, C., Patel, V. S., DeJoseph, L. M., Carron, M. & et al. (2018). A cross-sectional analysis of adverse events and litigation for injectable fillers. JAMA Facial Plastic Surgery. 20(30), 207-214.
Rosamilia, G., Hamade, H., Freytag, D. L., Frank, K., Green, J. B., Devineni, A. & et al. (2020). Soft tissue distribution pattern of facial soft tissue fillers with different viscoelastic properties. Journal of Cosmetic Dermatology. 2020;19:312-320.
Silva, T. C. (2019). Synthesis and thermal evaluation of hyaluronic acid gels: use in facial fillers and viscosupplementation. Dissertation (Master’s) – São Paulo State University, 83 f.
Sundaram, H. & Cassuto, D. (2013). Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. Plastic and Reconstructive Surgery. 132(4), 5S-21S.
Swift, A. & Remington, K. (2011). BeautiPHIcation: A global approach to facial beauty. Clinics in Plastic Surgery. 38(3), 347-377.
Sykes, J. M., Cotofana, S., Trevidic, P., Solich, N., Carruthers, J., Carruthers, A. & et al. (2015). Upper face: Clinical anatomy and regional approaches with injectable fillers. Plastic and Reconstructive Surgery. 136(5), 204S–218S.
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Copyright (c) 2023 Gisele Rosada Dônola Furtado; Kledson Lopes Barbosa; Alessandra Cristina Dametto; Andréa Lisboa Sisnando; Luiz Carlos Foletto da Silva ; José Reinaldo Araújo Souza; Ricardo César Gobbi de Oliveira; José Ricardo de Albergaria-Barbosa; Célia Marisa Rizzatti-Barbosa
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