Update on schistosomiasis mansoni in Brazil: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i5.41626

Keywords:

Helminthis; Helminthiasis; Public Health; Schistosomiasis.

Abstract

The present work performs an integrative review of the literature on schistosomiasis in Brazil, a parasitic and waterborne disease caused by flatworms of the genus Schistosoma (S. mansoni; S. japonicum; S. haematobium), and which still manifests itself as a problem significant public health problem in this country. It aims to highlight clinical data, as well as epidemiological data, presenting the most affected regions, individuals most vulnerable to infection and factors associated with its occurrence. In addition, it aims to update the current scenario with regard to the development of a vaccine against the parasites that cause schistosomiasis. The study carried out analyzes in the PubMed and Latin American and Caribbean Literature in Health Sciences (LILACS), ScienceDirect databases, as well as using data from the World Health Organization (WHO), the Centers For Disease Control and Prevention (CDC) and the Ministry of Health of Brazil (MS). It is concluded that schistosomiasis remains a disease of high national relevance, since it still manifests itself as a public health problem, responsible for intensifying situations of social inequality and having a direct connection with poverty, as a cause, but also as a consequence of same. Currently, several vaccines are in the clinical trial phase, but none is commercially available, and investment in research is of great importance.

References

Molehin, A. J. (2020). Schistosomiasis vaccine development: update on human clinical trials. Journal of biomedical science, 27(1), 28.

Molehin, A. J. (2020). Current understanding of immunity against schistosomiasis: impact on vaccine and drug development. Research and reports in tropical medicine, 119-128.

Levecke, B., Vlaminck, J., Andriamaro, L., Ame, S., Belizario, V., Degarege, A., & Vercruysse, J. (2020). Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs. International Journal for Parasitology: Drugs and Drug Resistance, 14, 183-187.

Crisostomo, B. L., de Lima, M. M., & Crisostomo, L. M. L. (2019). Prevalência e caracterização de enteroparasitos em análises de fezes em um distrito da Bahia, Brasil. Revista Baiana de Saúde Pública, 43(4), 44-56.

de Araújo Soares, D., de Azevedo Souza, S., da Silva, D. J., Silva, A. B., Cavalcante, U. M. B., & Lima, C. M. B. L. (2019). Avaliação epidemiológica da esquistossomose no estado de Pernambuco através de um modelo de regressão beta. Archives of Health Sciences, 26(2), 116-120.

McManus, D. P., Bergquist, R., Cai, P., Ranasinghe, S., Tebeje, B. M., & You, H. (2020, June). Schistosomiasis—from immunopathology to vaccines. In Seminars in immunopathology (Vol. 42, pp. 355-371). Springer Berlin Heidelberg.

McManus, D. P. (2021). The search for a schistosomiasis vaccine: Australia’s contribution. Vaccines, 9(8), 872.

De Oliveira, E. C. A., Da Silva, I. E. P., Ferreira, R. J., de Paula Souza, R. J., de Souza Gomes, E. C., & Barbosa, C. S. (2020). Mapping the risk for transmission of urban schistosomiasis in the Brazilian Northeast. Geospatial Health, 15(2).

Driciru, E., Koopman, J. P. R., Cose, S., Siddiqui, A. A., Yazdanbakhsh, M., Elliott, A. M., & Roestenberg, M. (2021). Immunological considerations for Schistosoma vaccine development: transitioning to endemic settings. Frontiers in immunology, 12, 635985.

Luna, E. J. D. A., & Campos, S. R. D. S. L. D. C. (2020). O desenvolvimento de vacinas contra as doenças tropicais negligenciadas. Cadernos de saúde pública, 36, e00215720.

de França, F. S. (2020). Esquistossomose: uma endemia de importância no Brasil. RBAC, 52(3), 224-7.

Oti, S. O., van de Vijver, S. J., Agyemang, C., & Kyobutungi, C. (2013). The magnitude of diabetes and its association with obesity in the slums of N airobi, K enya: results from a cross‐sectional survey. Tropical Medicine & International Health, 18(12), 1520-1530.

Gomes de Amorim Santos, I., Santos Ramos, R. E., Soares Gomes, D., Pereira Bezerra, L., Oliveira Silva, L., Martins Cirilo, T., Carlos Alves, L., & André Brayner, F. (2020). Analysis and spatial distribution of schistosomiasis mansoni in a historically endemic area of northeastern Brazil. Tropical medicine & international health : TM & IH, 25(9), 1085–1092. https://doi.org/10.1111/tmi.13458

de Amorim Santos, I. G., Bezerra, L. P., Cirilo, T. M., Silva, L. O., Machado, J. P. V., Lima, P. D., ... & Brayner, F. A. (2020). New epidemiological profile of schistosomiasis from an area of low prevalence in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 53.

Santos, I. G. D. A., Bezerra, L. P., Cirilo, T. M., Silva, L. O., Machado, J. P. V., Lima, P. D., ... & Brayner, F. A. (2021). Aspects related to positivity for schistosomiasis: a cross-sectional study in a low prevalence area in Alagoas, Brazil, 2020. Epidemiologia e Serviços de Saúde, 30.

Silva, J. D. D., Pinheiro, M. C. C., Sousa, M. S., Gomes, V. D. S., Castro, I. M. N. D., Ramos, A. N., & Bezerra, F. S. D. M. (2017). Detection of schistosomiasis in an area directly affected by the Sao Francisco River large-scale water transposition project in the Northeast of Brazil. Revista da Sociedade Brasileira de Medicina Tropical, 50, 658-665.

Silva-Moraes, V., Shollenberger, L. M., Siqueira, L. M. V., Castro-Borges, W., Harn, D. A., Grenfell, R. F. Q., ... & Coelho, P. M. Z. (2019). Diagnosis of Schistosoma mansoni infections: what are the choices in Brazilian low-endemic areas?. Memórias do Instituto Oswaldo Cruz, 114.

Ebisawa, I. (1998). Epidemiology and eradication of Schistosomiasis japonica in Japan. Journal of travel medicine, 5(1), 33-35.

Sousa, M. S., Pinheiro, M. C. C., Ramos Júnior, A. N., Silva Filho, J. D. D., & Bezerra, F. S. M. (2020). Epidemiology and predictors of occurrence of SCHISTOSOMA MANSONI infection in a low-endemicity area in northeast Brazil. Rev. patol. trop, 177-190.

Nacife, M. B. P., Leite, S., Siqueira, L. M. V., Martins, R., Vianna, V. N., Barbosa, K. F., ... & Machado-Coelho, G. L. L. (2018). Prevalence of schistosomiasis mansoni in indigenous Maxakali villages, Minas Gerais, Brazil. Revista do Instituto de Medicina Tropical de São Paulo, 60.

Ramírez, A. D. P., Favero, V., Lindholz, C. G., Veríssimo, C. D. M., Pascoal, V. F., Candido, R. R. F., ... & Graeff-Teixeira, C. (2020). Schistosomiasis: an epidemiological update on Brazil's southernmost low endemic area in Esteio. Revista da Sociedade Brasileira de Medicina Tropical, 53.

Calasans, T. A. S., Souza, G. T. R., Melo, C. M., Madi, R. R., & Jeraldo, V. D. L. S. (2018). Socioenvironmental factors associated with Schistosoma mansoni infection and intermediate hosts in an urban area of northeastern Brazil. Plos one, 13(5), e0195519.

Nascimento, G. L., Pegado, H. M., Domingues, A. L. C., Ximenes, R. A. D. A., Itria, A., Cruz, L. N., & Oliveira, M. R. F. D. (2019). The cost of a disease targeted for elimination in Brazil: the case of schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, 114.

Cruz, J. I. N., de Oliveira Salazar, G., & La Corte, R. (2020). Retrocesso do Programa de Controle da Esquistossomose no estado de maior prevalência da doença no Brasil. Revista Pan-Amazônica de Saúde, 11, 9-9.

BRASIL. Ministério da Saúde. Doenças Tropicais Negligenciadas. ISSN 9352-7864. Boletim Epidemiológico, Brasília, Mar. 2021.

Published

10/05/2023

How to Cite

SOUZA, I. S. M. de .; PEREIRA, L. M. de A. .; NEVES, S. M. das .; FARIAS, D. de S. .; INOCÊNCIO, J. S. .; LUCENA NETO, L. M. de .; DIAS, J. A. B.; VITAL JÚNIOR, A. C.; GONÇALVES , D. J. .; PEREIRA, H. N. .; SILVA JÚNIOR, J. G. da . Update on schistosomiasis mansoni in Brazil: an integrative review. Research, Society and Development, [S. l.], v. 12, n. 5, p. e11612541626, 2023. DOI: 10.33448/rsd-v12i5.41626. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41626. Acesso em: 21 nov. 2024.

Issue

Section

Health Sciences