Potential drug interactions between RENISUS medicinal plants and HIV antiretroviral therapy drugs
DOI:
https://doi.org/10.33448/rsd-v12i7.42636Keywords:
Plants; Drug interactions; HIV.Abstract
The use of medicinal plants as an alternative or complementary treatment is very common in society, including among people living with HIV. There are studies that address clinically significant drug interactions with antiretroviral drugs, increasing the risk of negative outcomes such as toxicity or loss of virological control. So, we aim to carry out a survey on RENISUS plants that can interact with antiretrovirals used to treat HIV infection and cause harmful effects. Eighteen plant species with the potential for drug interactions with antiretroviral drugs for HIV were found. This study provides scientific evidence on possible interactions between anti-HIV drugs and medicinal plants, contributing to the expansion of collective and individual care for people with chronic diseases, such as people living with HIV/AIDS on antiretroviral therapy.
References
Ashafa A. T. O., Sunmonu T. O., Abass A. A., & Ogbe A. A. (2011). Laxative potential of the ethanolic leaf extract of Aloe vera (L.) Burm. f. in Wistar rats with loperamide-induced constipation. Journal of Natural Pharmaceuticals; 2(3), 158-162. 10.4103/2229-5119.86268
Block, K. I., & Mead, M. N. (2003). Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review. Integrative Cancer Therapies, 2(3), 247–267. https://doi.org/10.1177/1534735403256419
Castro, M. R., & Figueiredo, F. F. (2019). Saberes tradicionais, biodiversidade, práticas integrativas e complementares: o uso de plantas medicinais no SUS. Hygeia - Revista Brasileira de Geografia Médica e da Saúde, 15(31), 56–70. https://doi.org/10.14393/hygeia153146605
Chang, B. L., van Servellen, G., & Lombardi, E. (2003). Factors Associated with Complementary Therapy Use in People Living with HIV/AIDS Receiving Antiretroviral Therapy. The Journal of Alternative and Complementary Medicine, 9(5), 695–710. https://doi.org/10.1089/107555303322524544
Chaves R. C., & Lima R. A. (2020). Um Estudo Bibliográfico Sobre Plantas Medicinais Utilizadas No Tratamento Hiv/Aids. Educamazônia-Educação, Sociedade e Meio Ambiente.; 20(1),91-112. Disponível em: https://periodicos.ufam.edu.br/index.php/educamazonia/article/view/7668
Cordeiro, C. H. G., Chung, M. C., & Sacramento, L. V. S. do. (2005). Interações medicamentosas de fitoterápicos e fármacos: Hypericum perforatum e Piper methysticum. Revista Brasileira de Farmacognosia, 15(3), 272–278. https://doi.org/10.1590/s0102-695x2005000300019
de Maat, M. M. R., Hoetelmans, R. M. W., Mathôt, R. A. A., van Gorp, E. C. M., Meenhorst, P. L., Mulder, J. W., & Beijnen, J. H. (2001). Drug interaction between St John’s wort and nevirapine. AIDS, 15(3), 420–421. https://doi.org/10.1097/00002030-200102160-00019
DiCenzo, R., Shelton, M., Jordan, K., Koval, C., Forrest, A., Reichman, R., & Morse, G. (2003). Coadministration of Milk Thistle and Indinavir in Healthy Subjects. Pharmacotherapy, 23(7), 866–870. https://doi.org/10.1592/phco.23.7.866.32723
Gurley, B. J., Barone, G. W., Williams, D. K., Carrier, J., Breen, P., Yates, C. R., Song, P., Hubbard, M. A., Tong, Y., & Cheboyina, S. (2005). Effect of Milk Thistle (Silybum Marianum) and Black Cohosh (Cimicifuga Racemosa) Supplementation on Digoxin Pharmacokinetics in Humans. Drug Metabolism and Disposition, 34(1), 69–74. https://doi.org/10.1124/dmd.105.006312
Hakkola J., Hukkanen J., Turpeinen M., & Pelkonen O. (2020) Inhibition and induction of CYP enzymes in humans: An update. Archives of Toxicology; 94(11), 3671-3722. https://doi.org/10.1007/s00204-020-02936-7
Haron, M. H., Avula, B., Gurley, B. J., Chittiboyina, A. G., Khan, I. A., & Khan, S. I. (2020). Possible Herb-Drug Interaction Risk of Some Nutritional and Beauty Supplements on Antiretroviral Therapy in HIV Patients. Journal of Dietary Supplements, 1–16. https://doi.org/10.1080/19390211.2020.1846658
Hu, Z., Yang, X., Ho, P. C. L., Chan, S. Y., Heng, P. W. S., Chan, E., Duan, W., Koh, H. L., & Zhou, S. (2005). Herb-Drug Interactions. Drugs, 65(9), 1239–1282. https://doi.org/10.2165/00003495-200565090-00005
Kehinde I., Khan R., Nlooto M., Gordon M. (2021). Modulatory influences of antiviral bioactive compounds on cell viability, mRNA and protein expression of cytochrome P450 3A4 and P-glycoprotein in HepG2 and HEK293. Cells. Bioorganic Chemistry; 107. https://doi.org/10.1016/j.bioorg.2020.104573
Kent, U. M., Aviram, M., Rosenblat, M., & Hollenberg, P. F. (2002). The Licorice Root Derived Isoflavan Glabridin Inhibits the Activities of Human Cytochrome P450S 3A4, 2B6, and 2C9. Drug Metabolism and Disposition, 30(6), 709–715. https://doi.org/10.1124/dmd.30.6.709
Ladenheim, D., Horn, O., Werneke, U., Phillpot, M., Murungi, A., Theobald, N., & Orkin, C. (2008). Potential health risks of complementary alternative medicines in HIV patients. HIV Medicine, 9(8), 653–659. https://doi.org/10.1111/j.1468-1293.2008.00610.x
Li Y., Meng Q., Yang M., Liu D., Hou X., Tang, L., & Bi H (2019). Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B.; 9(6), 1113-1144. https://doi.org/10.1016/j.apsb.2019.10.001
López Galera, R. M., Ribera Pascuet, E., Esteban Mur, J. I., Montoro Ronsano, J. B., & Juárez Giménez, J. C. (2008). Interaction between cat’s claw and protease inhibitors atazanavir, ritonavir and saquinavir. European Journal of Clinical Pharmacology, 64(12), 1235–1236. https://doi.org/10.1007/s00228-008-0551-1
Madabushi, R., Frank, B., Drewelow, B., Derendorf, H., & Butterweck, V. (2006). Hyperforin in St. John’s wort drug interactions. European journal of clinical pharmacology; 62(3), 225-233. https://doi.org/10.1007/s00228-006-0096-0
Mazzari, A. L. D. A., & Prieto, J. M. (2014). Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions. Frontiers in Pharmacology, 5. https://doi.org/10.3389/fphar.2014.00162
Mncwangi, N., Chen, W., Vermaak, I., Viljoen, A. M., & Gericke, N. (2012). Devil’s Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. Journal of Ethnopharmacology, 143(3), 755–771. https://doi.org/10.1016/j.jep.2012.08.013
Monera, T. G., Wolfe, A. R., Maponga, C. C., Benet, L. Z., & Guglielmo, J. (2008). Moringa oleifera leaf extracts inhibit 6β-hydroxylation of testosterone by CYP3A4. The Journal of Infection in Developing Countries, 2(05). https://doi.org/10.3855/jidc.201
Oga, E. F., Sekine, S., Shitara, Y., & Horie, T. (2015). Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences. European Journal of Drug Metabolism and Pharmacokinetics, 41(2), 93–108. https://doi.org/10.1007/s13318-015-0296-z
Piscitelli, S. C., Burstein, A. H., Welden, N., Gallicano, K. D., & Falloon, J. (2002). The effect of garlic supplements on the pharmacokinetics of saquinavir. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 34(2), 234–238. https://doi.org/10.1086/324351
Stolbach, A., Paziana, K., Heverling, H., & Pham, P. (2015). A Review of the Toxicity of HIV Medications II: Interactions with Drugs and Complementary and Alternative Medicine Products. Journal of Medical Toxicology, 11(3), 326–341. https://doi.org/10.1007/s13181-015-0465-0
Tanigawara, Y. (2000). Role of P-Glycoprotein in Drug Disposition. Therapeutic Drug Monitoring, 22(1), 137–140. https://doi.org/10.1097/00007691-200002000-00029
Tassotti Gelatti, G., De Oliveira, K. R., & Colet, C. de F. (2016). Potential drug interactions in relation with the use, medicine plants and herbal in premenopausal women period. Revista de Pesquisa Cuidado é Fundamental Online, 8(2), 4328–4346. https://doi.org/10.9789/2175-5361.2016.v8i2.4328-4346
Whittemorer, R., & Knaflk, K. (2005). The integrative review: updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x.
Yan den Bout-van den Beukel, C. J. P., Koopmans, P. P., van der Ven, A. J. A. M., De Smet, P. A. G. M., & Burger, D. M. (2006). Possible Drug–Metabolism Interactions of Medicinal Herbs with Antiretroviral Agents. Drug Metabolism Reviews, 38(3), 477–514. https://doi.org/10.1080/03602530600754065
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Copyright (c) 2023 Jhone Robson da Silva Costa; Adenilson Pereira Galvão Filho; Yuri Sandro Lima de Azevedo; Keyliane Santos Lima; Silvia Cristina Viana Silva Lima
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