Is obesity an independent risk factor for the progression of kidney disease?
DOI:
https://doi.org/10.33448/rsd-v13i9.45690Keywords:
Obesity; Nephrology; Kidney diseases.Abstract
Obesity is defined as excess adiposity, resulting from a prolonged state of positive energy balance capable of causing a state of chronic inflammation in individuals, with subsequent deposition of ectopic fat in the kidney, as well as the storage of lipids in the breast. kidney, causing renal lip toxicity. The main objective of the present study is to relate the presence of kidney damage with obesity, using microalbuminuria (MA) research, considered an early marker of glomerular damage. Methodology: This is a clinical, cross-sectional, prospective study, with 100 patients with a body mass index (BMI) ≥ 30 kg/m², who were being monitored for bariatric surgery. The urine strip test was used to quantify albumin in urine, with albuminuria defined as values greater than 30 mg of albumin per gram of creatinine. Furthermore, epidemiological data were collected with the aim of correlating them with albuminuria. Results: The statistical analysis carried out in this study was based on a variety of statistical methods, based on data from 100 patients participating in the research, where 22% of patients presented some degree of albuminuria, among them, around 63.6 % of them reported not having any type of previous comorbidity. Conclusion: The present study demonstrates a possible relationship between the presence of obesity and the progression of kidney damage, and it is important to highlight that more than half of the patients with changes in the albuminuria test reported the absence of previous pathologies.
References
Alagh, A.R., Shukla, S., Acharya, S., Vagha, S., & Dhingra, L. (2022). Avaliação da microalbuminúria em fenótipos de obesidade. Jornal de Medicina de Família e Comunidade , 29(2), 162.
Braga, D., Lemos, L. B., Silva, C. R., Andrade, C. E. B., Reis, J. T. R., Oliveira, L. L., & Moreira, R. O. (2019). Avaliação dos níveis de albuminúria em adultos obesos e sua associação com marcadores de risco cardiovascular. HU Revista, 44(2), 183–189. https://doi.org/10.34019/1982-8047.2018.v44.13965
Burgos, P. F. M., Costa, W., Bombig, M. T. N. & Bianco, H. T. (2014). A obesidade como fator de risco para a hipertensão. Revista Brasileira de Hipertensão, 21(2), 68-74.
Carvalho, A. A, Fonseca, P. C. A., Machado, S. P., Santos, S. P., Santos, A. M. & Silva, A. A. M. (2015). Associação entre fatores de risco cardiovascular e indicadores antropométricos de obesidade em universitários de São Luís, Maranhão, Brasil. Ciência & saúde coletiva, 20(2): 479-490.
GBD - The Global Burden of Disease e cols. (2017). Efeitos do sobrepeso e da obesidade na saúde em 195 países ao longo de 25 anos. Jornal de medicina da Nova Inglaterra, 377(1), 13-27.
Guimarães D. E. D., Sardinha F. L. C., Mizurini D. M., & Carmo M. G. T. (2007). Adipocitocinas: uma nova visão do tecido adiposo. Rev. Nutr. 20(5). https://doi.org/10.1590/S1415-52732007000500010
Hall, M. E., do Carmo, J. M., da Silva, A. A., Juncos, L. A., Wang, Z., & Hall, J. E. (2014). Obesity, hypertension, and chronic kidney disease. International journal of nephrology and renovascular disease, 7, 75–88. https://doi.org/10.2147/IJNRD.S39739
Izquierdo-Lahuerta, A., Martínez-García, C., & Medina-Gómez, G. (2016). Lipotoxicity As A Trigger Factor Of Renal Disease. Journal Of Nephrology, 29(5), 603–610.
Kovesdy C. P., Furth S. L., & Zocalli, C. (s.d.). Obesidade e doença renal: consequências ocultas da epidemia. J. Bras. Nefrol. 39(1), 1-10.
Lima-Costa M.F. & Sandhi M.B. (2003) Tipos de estudos epidemiológicos: conceitos básicos e aplicações na área do envelhecimento. Epidemiol. Serv. Saúde [Internet]. 12(4):189-201. http://dx.doi.org/10.5123/S1679-49742003000400003
Mann C.J. (2003). Observational research methods. Research design II: cohort, cross sectional, and case-control studies. Emerg Med J [Internet]. 20:54-60. https://doi.org/10.1136/emj.20.1.54
Medeiros, V. C., Albuquerque, C. M., Dias, C. D., Oliveira, A. C. & Santos, J. C. (2021). Albuminúria e fatores associados a doença renal crônica na obesidade. Research, Society and Development. 10(12), e316101220490-e316101220490. https://doi.org/10.33448/rsd-v10i12.20490
Naumnik, B., & Mysliwiec, M. (2010). Renal Consequences Of Obesity. Medical Science Monitor. 16(8), 163-170.
Organização Mundial da Saúde (OMS). (2020, 4 de março). A obesidade e suas raízes. https://www.who.int/news-room/events/detail/2020/03/04/default-calendar/world-obesity-day
Piccolli, A. P., Nascimento, M. M. , & Riella, M. C. (2017). Prevalência da doença renal crônica em uma população do Sul do Brasil (estudo Pro-Renal). Braz. J. Nephrol., 39(4), 384-390. https://doi.org/10.5935/0101-2800.20170070
Pinho, A. P., Pepato, M. T., Almeida, C. A. N. (2012). Síndrome metabólica em adolescentes do sexo feminino com sobrepeso e obesidade. Revista Paulista de Pediatria [online], 30(1), 51-56. https://doi.org/10.1590/S0103-05822012000100008
Salles, G. F., Cardoso, C. R., Fiszman, R., & Muxfeldt, E. S. (2011). Prognostic importance of baseline and serial changes in microalbuminuria in patients with resistant hypertension. Atherosclerosis, 216(1), 199-204. https://doi.org/10.1016/j.atherosclerosis.2011.01.026
Silva Junior, et al. (2017). Obesity And Kidney Disease. Jornal Brasileiro De Nefrologia. 39(1), 65-69.
Van der Heide, F. C. T., Eussen, S. J. P. M., Houben, A. J. H. M., Henry, R. M. A., Kroon, A. A., van der Kallen, C. J. H., Dagnelie, P. C., van Dongen, M. C. J. M., Berendschot, T. T. J. M., Schouten, J. S. A. G., Webers, C. A. B., Van Greevenbroek, M. M. J., Wesselius, A., Schalkwijk, C. G., Koster, A., Jansen, J. F. A., Backes, W. H., Beulens, J. W. J., & Stehouwer, C. D. A. (2023). Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study. Cardiovascular diabetology, 22(1), 67. https://doi.org/10.1186/s12933-023-01783-x
Zhu, Q., & Scherer, P. E. (2018). Immunologic And Endocrine Functions Of Adipose Tissue: Implications For Kidney Disease. Nature Reviews Nephrology, 14(2), 105–120.
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Copyright (c) 2024 Igor Henrique Cruz Souza Santos; Luana Teles de Resende; Silvia Alice Falcão dos Anjos; Jennifer Camila de Souza Fornari ; Susan Soares de Carvalho; Maria Fernanda Malaman
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