The development of Charcot arthropathy in patients with diabetic neuropathy

Authors

DOI:

https://doi.org/10.33448/rsd-v13i7.46172

Keywords:

Diabetes; Neurogenic arthropathy; Pathophysiology.

Abstract

Introduction: Charcot arthropathy is a degenerative and progressive disease that originates as a complication of peripheral neuropathy due to diabetes mellitus, causing joint deformities and serious consequences for diabetic patients. Objective: The aim of this study was to evaluate the clinical, epidemiological and pathophysiological aspects of the development of Charcot arthropathy in patients with diabetic neuropathy, building knowledge on the basis of case reports and knowledge based on the literature. Materials and Methods: This is an integrative literature review on the general clinical characteristics of the correlation between Charcot arthropathy and diabetic neuropathy. The PICO strategy was used to develop the guiding question. In addition, the descriptors “Charcot Arthropathy”; “Diabetic Neuropathy”; “Interrelation” was cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar and Virtual Health Library (VHL) databases. Results and Discussion: Most of the studies showed that Charcot arthropathy is a clinical condition that arises from the chronic evolution of diabetes mellitus, presenting a well-defined spectrum of clinical manifestations and requiring early intervention to avoid worsening the patient's condition. Conclusion: Patients diagnosed with Charcot arthropathy should be managed as soon as possible to minimize the serious complications that accompany it, such as limb amputation. In addition, understanding that prevention, combined with patient education, is essential if the number of cases is to be reduced.

References

Alexandru-Madalin, B. U. S. E., Mihai, D. A., Leonard, L. U. P. U., Salmen, T., Stegaru, D., & Radulian, G. (2020). The charcot neuroarthropathy as onset of type 2 diabetes–a diagnostic challenge. Maedica, 15(1), 122.

Bansod, H., Wanjari, A., & Dumbhare, O. (2023). A Review on Relationship Between Charcot Neuroarthropathy and Diabetic Patients. Cureus, 15(12): e50988. 10.7759/cureus.50988.

Calle, J. F., & Viadé-Julià, J. (2020). Artropatía de Charcot en el paciente diabético. Revisión de Conceptos Actuales. Revista Colombiana de Ortopedia y Traumatología, 34(1), 5-15.

Fernandes, M. P., Costa, M. T., & Ferreira, R. C. (2018). Systematic treatment of charcot arthropathy of the midfoot. Scientific Journal of the Foot & Ankle, 12(4), 324–31. https://doi.org/10.30795/scijfootankle.2018.v12.857

Johnson-Lynn, S. E., McCaskie, A. W., Coll, A. P., & Robinson, A. H. N. (2018). Neuroarthropathy in diabetes: pathogenesis of Charcot arthropathy. Bone & Joint Research, 7(5), 373-378.

La Fontaine, J., Lavery, L., & Jude, E. (2016). Current concepts of Charcot foot in diabetic patients. The Foot, 26, 7-14.

López-Gavito, E., Parra-Téllez, P., & Vázquez-Escamilla, J. (2016). La neuroartropatía de Charcot en el pie diabético. Acta ortopédica mexicana, 30(1), 33-45.

Marques, A. R., & Brito, I. (2016). Espectro clínico das manifestações musculoesqueléticas da diabetes mellitus. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, 11(2), 307-313.

Nóbrega, M. B. D. M., Aras, R., Netto, E. M., Couto, R. D., Marinho, A. M. D. N., Silva, J. L. D., & Nunes, M. A. L. (2015). Risk factors for Charcot foot. Archives of endocrinology and metabolism, 59, 226-230.

O’Loughlin, A., Kellegher, E., McCusker, C., & Canavan, R. (2017). Diabetic charcot neuroarthropathy: prevalence, demographics and outcome in a regional referral centre. Irish Journal of Medical Science (1971-), 186, 151-156.

Pitocco, D., Scavone, G., Di Leo, M., Vitiello, R., Rizzi, A., Tartaglione, L., & Pontecorvi, A. (2020). Charcot neuroarthropathy: from the laboratory to the bedside. Current Diabetes Reviews, 16(1), 62-72.

Rastogi, A., Prakash, M., & Bhansali, A. (2019). Varied presentations and outcomes of Charcot neuroarthropathy in patients with diabetes mellitus. International Journal of Diabetes in Developing Countries, 39, 513-522.

Rodríguez, J. H., González, A. I. C., & Calero, T. G. (2024). Elementos básicos para el diagnóstico de la Neuroartropatía de Charcot en personas con Diabetes mellitus. Revista Habanera de Ciencias Médicas, 22(5), 5083.

Salini, D., Harish, K., Minnie, P., Sundaram, K. R., Arun, B., Sandya, C. J., & Praveen, V. P. (2018). Prevalence of Charcot arthropathy in Type 2 diabetes patients aged over 50 years with severe peripheral neuropathy: A retrospective study in a Tertiary Care South Indian Hospital. Indian Journal of Endocrinology and Metabolism, 22(1), 107-111.

Schmidt, B. M., & Holmes, C. M. (2018). Updates on diabetic foot and charcot osteopathic arthropathy. Current diabetes reports, 18, 1-11.

Schneekloth, B. J., Lowery, N. J., & Wukich, D. K. (2016). Charcot neuroarthropathy in patients with diabetes: an updated systematic review of surgical management. The Journal of Foot and Ankle Surgery, 55(3), 586-590.

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134

Trieb, K. (2016). The Charcot foot: pathophysiology, diagnosis and classification. The bone & joint journal, 98(9), 1155-1159.

Vopat, M. L., Nentwig, M. J., Chong, A. C., Agan, J. L., Shields, N. N., & Yang, S. Y. (2018). Initial diagnosis and management for acute Charcot neuroarthropathy. Kansas Journal of Medicine, 11(4), 114.

Wukich, D. K., Frykberg, R. G., & Kavarthapu, V. (2024). Charcot neuroarthropathy in persons with diabetes: It's time for a paradigm shift in our thinking. Diabetes/Metabolism Research and Reviews, 40(3), e3754.

Zakin, E., Abrams, R. & Simpson, D. M. (2019). Diabetic neuropathy. Seminars in neurology. 39(5), 560-569.

Published

30/06/2024

How to Cite

MELO, M. J. C. de .; CAMPOS, E. R. .; PALLEY, N. G. T. .; SILVA , L. F. C. .; VALLE, H. N. da C. .; OLIVEIRA, C. A. L. de .; MATTOS, E. P. C. .; PAIVA, L. M. P. e .; ANACLETO, A. A. S. .; ALVES, A. B. A. . The development of Charcot arthropathy in patients with diabetic neuropathy. Research, Society and Development, [S. l.], v. 13, n. 7, p. e2713746172, 2024. DOI: 10.33448/rsd-v13i7.46172. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46172. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences