Post-infectious bronchiolitis obliterans in children: A highlight on adenovirus infection

Authors

DOI:

https://doi.org/10.33448/rsd-v13i7.46430

Keywords:

Bronchiolitis obliterans; Adenovirus; Child.

Abstract

Introduction: Post-infectious Bronchiolitis Obliterans (BOPI) is a chronic and irreversible pulmonary disorder that affects the lower airways. It represents a rare condition that is more common in children following a severe episode of viral infection, particularly by Adenovirus. Objective: To gather the main updates on BOPI in its various aspects, especially resulting from AV infection. Materials and Methods: This is an integrative literature review on the general clinical characteristics of esophageal varices. The PICO strategy was used to formulate the guiding question. Additionally, the descriptors "Bronchiolitis Obliterans," "Adenovirus," "Pediatrics," and "Child" were cross-referenced in the National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO), Ebscohost, Google Scholar, and Virtual Health Library (VHL) databases. Results and Discussion: It is essential to pay attention to risk factors and the patient profile, which is generally a boy under one year of age. Hypoxemia and the need for mechanical ventilation are important risk factors. Symptoms suggestive of BOPI include tachypnea, cough, wheezing, exercise intolerance, and persistent hypoxemia for at least 6 weeks after a severe bronchiolitis episode or pneumonia with respiratory failure. The assessment of diagnostic criteria is an important tool to aid in case elucidation. Conclusion: There is still a lack of specific knowledge to facilitate early recognition, prevention, and treatment of the disease, especially after adenovirus infections.

Author Biographies

Bárbara Salvador Carvalhais, Centro Universitário da Fundação Assis Gurgacz

Médica, formada pelo Centro Universitário da Fundação Assis Gurgacz (FAG).

Ana Laura Costa Ferreira, Universidade Professor Edson Antônio Velano

Acadêmica de Medicina.

Jordana Fernandes Almeida, Universidade Professor Edson Antônio Velano

Acadêmica de Medicina.

Gabriel Starling Costa, Faculdade Ciências Médicas de Minas Gerais

Acadêmico de Medicina.

References

Castro-Rodriguez, J. A., Giubergia, V., Fischer, G. B., Castaños, C., Sarria, E. E., Gonzalez, R., Mattiello, R., Vega-Briceño, L. E., & Murtagh, P. (2014). Postinfectious bronchiolitis obliterans in children: the South American contribution. Acta Paediatrica (Oslo, Norway: 1992), 103(9), 913–921. https://doi.org/10.1111/apa.12689

Chen, I-Chen., Hsu, J.-S., Chen, Y.-W., Liu, Y.-C., Wu, Y.-H., Hsu, J.-H., Cheng, Y.-F., & Dai, Z.-K. (2020). Post-infectious Bronchiolitis Obliterans: HRCT, DECT, Pulmonary Scintigraphy Images, and Clinical Follow-up in Eight Children. Frontiers in Pediatrics, 8. https://doi.org/10.3389/fped.2020.622065

Colom, A. J., & Teper, A. M. (2018). Post‐infectious bronchiolitis obliterans. Pediatric Pulmonology. https://doi.org/10.1002/ppul.24221

Colom, A. J., Maffey, A., Garcia Bournissen, F., & Teper, A. (2015). Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up. Thorax, 70(2), 169–174. https://doi.org/10.1136/thoraxjnl-2014-205328

Flanagan, F., Casey, A., Reyes- Múgica, M., & Kurland, G. (2022). Post-infectious bronchiolitis obliterans in children. Paediatric Respiratory Reviews. https://doi.org/10.1016/j.prrv.2022.01.007

Huang, F., Ma, Y.-C., Li, Y.-N., & Wang, F. (2021). Clinical analysis of adenovirus postinfectious bronchiolitis obliterans and nonadenovirus postinfectious bronchiolitis obliterans in children. Lung India, 38(2), 117. https://doi.org/10.4103/lungindia.lungindia_374_20

Jerkic, S.-P., Brinkmann, F., Calder, A., Casey, A., Dishop, M., Griese, M., Kurland, G., Niemitz, M., Nyilas, S., Schramm, D., Schubert, R., Tamm, M., Zielen, S., & Rosewich, M. (2020). Postinfectious Bronchiolitis Obliterans in Children: Diagnostic Workup and Therapeutic Options: A Workshop Report. Canadian Respiratory Journal, 2020, 1–16. https://doi.org/10.1155/2020/5852827

Kavaliunaite, E., & Aurora, P. (2019). Diagnosing and managing bronchiolitis obliterans in children. Expert Review of Respiratory Medicine, 13(5), 481–488. https://doi.org/10.1080/17476348.2019.1586537

Lee, E., & Young Lee, Y. (2020). Risk factors for the development of post-infectious bronchiolitis obliterans after Mycoplasma pneumoniae pneumonia in the era of increasing macrolide resistance. Respiratory Medicine, 175, 106209. https://doi.org/10.1016/j.rmed.2020.106209

Lee, E., Park, S., & Yang, H.-J. (2022). Pulmonary Function in Post-Infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis. Pathogens, 11(12), 1538. https://doi.org/10.3390/pathogens11121538

Li, Y.-N., Liu, L., Qiao, H.-M., Cheng, H., & Cheng, H.-J. (2014). Post-infectious bronchiolitis obliterans in children: a review of 42 cases. BMC Pediatrics, 14(1). https://doi.org/10.1186/1471-2431-14-238

Liu, D., Liu, J., Zhang, L., Chen, Y., & Zhang, Q. (2022). Risk Factors for Post-infectious Bronchiolitis Obliterans in Children: A Systematic Review and Meta-Analysis. Frontiers in Pediatrics, 10, 881908. https://doi.org/10.3389/fped.2022.881908

Onay, Z. R., Ramasli Gursoy, T., Aslan, A. T., Sismanlar Eyuboglu, T., Kibar, B. S., Pekcan, S., Hangul, M., Kose, M., Budakoglu, I. I., & Gokturk, B. (2020). Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma. Pediatric Pulmonology, 55(4), 1007–1011. https://doi.org/10.1002/ppul.24690

Sarria, E. E., Mundstock, E., Denise Cantarelli Machado, Helena Teresinha Mocelin, Gilberto Bueno Fischer, Furlan, S. P., Carlos, I., Stein, R., & Mattiello, R. (2017). Health-related quality of life in patients with bronchiolitis obliterans. 94(4), 374–379. https://doi.org/10.1016/j.jped.2017.07.021

Souza, M. T. de, Silva, M. D. da, & Carvalho, R. de. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8(1), 102–106. https://doi.org/10.1590/s1679-45082010rw1134.

Wang, Z., Liu, C., Wang, M., Zhang, Y., Li, H., & Liu, G. (2015). Clinical features of post-infectious bronchiolitis obliterans in children undergoing long-term azithromycin treatment. Experimental and Therapeutic Medicine, 9(6), 2379–2383. https://doi.org/10.3892/etm.2015.2418

Yazan, H., Khalif, F., Shadfaan, L. A., Bilgin, S., Nursoy, M., Cakir, F. B., Cakin, Z. E., Uzuner, S., & Cakir, E. (2021). Post-infectious bronchiolitis obliterans in children: Clinical and radiological evaluation and long-term results. Heart & Lung, 50(5), 660–666. https://doi.org/10.1016/j.hrtlng.2021.05.001

Yoon Young Jang, Hye Jin Park, & Hai Lee Chung. (2017). Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. European Journal of Pediatrics, 176(7), 971–978. https://doi.org/10.1007/s00431-017-2940-x

Yuan, J., Wei, M., Chen, M., Wang, R., Diao, J., Tian, M., Zhao, D., & Chen, M. (2023). Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia. Frontiers in Pediatrics, 11, 1335543. https://doi.org/10.3389/fped.2023.1335543

Zheng, H.-Q., Ma, Y.-C., Chen, Y.-Q., Xu, Y.-Y., Pang, Y.-L., & Liu, L. (2022). Clinical Analysis and Risk Factors of Bronchiolitis Obliterans After Mycoplasma Pneumoniae Pneumonia. Infection and Drug Resistance, Volume 15, 4101–4108. https://doi.org/10.2147/idr.s372940

Zhong, L., Lin, J., & Dai, J. (2020). Risk factors for the development of bronchiolitis obliterans in children with severe adenovirus pneumonia: A retrospective study with dose‐response analysis. Journal of Medical Virology, 92(12), 3093–3099. https://doi.org/10.1002/jmv.25703

Published

22/07/2024

How to Cite

CARVALHAIS, B. S.; FERNANDES, M. G. M. .; FERREIRA, A. L. C.; ALMEIDA, J. F.; COSTA, G. S. Post-infectious bronchiolitis obliterans in children: A highlight on adenovirus infection. Research, Society and Development, [S. l.], v. 13, n. 7, p. e11113746430, 2024. DOI: 10.33448/rsd-v13i7.46430. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/46430. Acesso em: 22 nov. 2024.

Issue

Section

Health Sciences