Síntesis, aplicaciones y Relación Estructura-Actividad (REA) de los derivados del ácido cinámico: una revisión
DOI:
https://doi.org/10.33448/rsd-v10i1.11691Palabras clave:
Compuestos fitoquímicos; Farmacología; Química Farmacéutica; Técnicas de síntesis química; Biosíntesis.Resumen
El artículo tiene como objetivo analizar el avance de la evolución de los derivados del ácido cinámico a través de una revisión bibliográfica, describiendo las principales vías sintéticas en la obtención de esta clase, así como las aplicaciones biológicas destacables y la aplicación de la relación estructura-actividad (SAR) como estrategia para diseñar moléculas farmacológicamente activas. La metodología empleada consiste en la lectura y análisis de artículos, cuyo abordaje es descriptivo, recogiéndose datos sobre el potencial terapéutico de los derivados del ácido cinámico y su relación con el andamiaje estructural, así como los abordajes sintéticos más utilizados. Como resultado, se observó que el ácido cinámico y sus derivados de fuentes naturales pueden sintetizarse en cantidades apreciables con variadas rutas sintéticas, además de ser candidatos a agentes terapéuticos, ya que tienen varias aplicaciones terapéuticas contra la diabetes, enfermedades infecciosas y degenerativas, entre otros, además de presentar actividades como el control de plagas, que ha llamado la atención de investigadores académicos e industriales. Estos compuestos son muy versátiles ya que su actividad está intrínsecamente asociada con el modo de interacción entre la estructura y su objetivo molecular. Sin embargo, en la naturaleza se obtienen en pequeñas cantidades, por lo que el desarrollo de nuevos enfoques de metodologías sintéticas para obtener dichos compuestos en cantidades sustanciales y vinculados a la química médica puede contribuir al desarrollo de moléculas bioactivas muy efectivas en comparación con sus precursores.
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Derechos de autor 2021 Saraliny Bezerra França; Paulo Ricardo dos Santos Correia; Ilton Barros Daltro de Castro; Edeildo Ferreira da Silva Júnior; Maria Ester de Sá Barreto Barros; Dimas José da Paz Lima
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