Avaliação da biocompatibilidade de cimentos reparadores biocerâmicos: Estudo in vivo em ratos wistar

Autores

DOI:

https://doi.org/10.33448/rsd-v10i7.14422

Palavras-chave:

Pulpotomia; Inflamação; Teste de materiais; Endodontia.

Resumo

O objetivo deste estudo foi avaliar a biocompatibilidade do cimento biocerâmico reparador Biodentine® quando comparado ao MTA Branco Angelus® e hidróxido de cálcio. Para isso foram utilizados vinte e quatro ratos Wistar (n=6 animais/grupo), divididos em quatro tempos experimentais de 7, 15, 30 e 60 dias. Os animais receberam implantes subcutâneos de tubos de polietileno contendo os 3 materiais e um tubo vazio utilizado como controle. Após os períodos experimentais os animais foram eutanasiados e os tubos, juntamente com o tecido circundante, foram removidos e processados histologicamente para avalição da biocompatibilidade. Infiltrado inflamatório e espessura de cápsula fibrosa foram analisados por coloração de HE através de escores de inflamação. Os dados foram submetidos ao teste de Kruskal Wallis e Dunn (p<0,05). O Biodentine® aos 15 dias gerou menor resposta inflamatória que o controle e o Ca(OH)2 (p<0,05). No grupo hidróxido de cálcio, apartir dos 15 dias em diante houve diminuição do infiltrado inflamatório, assim como diminuição da cápsula fibrosa. O MTA Branco Angelus® mostrou capsula fibrosa fina e baixa intensidade inflamatório em todos os períodos. Após os períodos experimentais, todos materiais apresentaram inflamação leve e capsula fibrosa fina. Conclui-se que o Biodentine® demonstrou biocompatibilidade tecidual pois induziu baixa inflamação, que reduziu ao longo do tempo, comparável ao MTA Angelus Branco® e hidróxido de cálcio.

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11/06/2021

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VALENTIM, D. .; BUENO, C. R. E. .; MARQUES, V. A. S. .; BENETTI, F.; VASQUES, A. M. V.; CURY, M. T. S. .; SILVA, A. C. R. da; JACINTO, R. C.; SIVIERI-ARAUJO, G. .; CINTRA, L. T. A.; DEZAN-JUNIOR, E. Avaliação da biocompatibilidade de cimentos reparadores biocerâmicos: Estudo in vivo em ratos wistar. Research, Society and Development, [S. l.], v. 10, n. 7, p. e1610714422, 2021. DOI: 10.33448/rsd-v10i7.14422. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14422. Acesso em: 17 jul. 2024.

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