Revisión de las actividades terapéuticas del género Trichilia

Autores/as

DOI:

https://doi.org/10.33448/rsd-v10i5.14916

Palabras clave:

Género Trichilia; Familia Meliaceae; Tratamiento; Enfermedades; Plantas medicinales.

Resumen

El género Trichilia (familia Meliaceae) ha despertado interés en la Flora Brasileña, debido a las actividades biológicas de sus metabolitos secundarios. Este género tiene especies distribuidas por toda América tropical, reconocidas por su gran importancia económica y alto valor comercial. Su composición está formada principalmente por terpenoides (triterpenos, sesquiterpenos, limonoides y esteroides) y polifenoles (flavonoides y taninos). En la medicina popular, este género se utiliza en preparaciones como antimicrobianos, antimaláricos, antivirales y antioxidantes. Estudios realizados con varias especies del género Trichilia muestran que estas plantas tienen actividad antioxidante, anticolinesterasa, antimicrobiana frente a patógenos de gran importancia clínica, neuroprotectora, antiinflamatoria y antiinflamatoria. Además, las actividades analgésicas, antineoplásicas, hepatoprotectoras e inmunomoduladoras también se han investigado y probado en la literatura. Con base en el gran potencial biotecnológico del género Trichilia, a partir de los escasos estudios sobre sus aplicaciones en salud y en vista de la importancia de la búsqueda de sustancias naturales que tengan actividades terapéuticas efectivas, esta revisión destaca las principales aplicaciones terapéuticas de las especies de este género encontrado. en la literatura, y para estimular nuevos estudios sobre el uso de estas plantas en el tratamiento de varias enfermedades. Para ello, se realizó una encuesta sobre el tema en las principales fuentes de investigación científica en el período 2005 a 2020, llevándonos a concluir que este género puede ser un poderoso aliado en la búsqueda de nuevas medicinas a base de plantas.

Citas

Applequist, W. L., Brinckmann, J. A., Cunningham, A. B., Hart, R. E., Heinrich, M., Katerere, D. R., & Van Andel, T. (2020). Scientists warning on climate change and medicinal plants. Planta Medica, 86(1), 10-18. https://doi.org/10.1055/a-1041-3406.

Ben, I. O., Woode, E., Koffuor, G. A., & Asiamah, E. A. (2016). Anti-anaphylactic effects of Trichilia monadelpha (Thonn.) J. J. De Wilde extracts on rodent models of anaphylaxis. Research in pharmaceutical sciences, 11(5), 397–404. https://doi.org/10.4103/1735-5362.192491.

Bernardo, J., Ferreres, F., Gil-Izquierdo, Á., Videira, R. A., Valentão, P., Veiga, F., & Andrade, P. B. (2018). In vitro multimodal-effect of Trichilia catigua A. Juss. (Meliaceae) bark aqueous extract in CNS targets. Journal of ethnopharmacology, 211, 247–255. https://doi.org/10.1016/j.jep.2017.09.039.

Campos, M. M., Fernandes, E. S., Ferreira, J., Santos, A. R., & Calixto, J. B. (2005). Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms. Psychopharmacology, 182(1), 45–53. https://doi.org/10.1007/s00213-005-0052-1.

Da Silva, J. V., Dos Santos, R. C., Júnior, P., Pederiva, M., do Carmo Vieira, M., Kassuya, C., Cardoso, C., Pereira, Z. V., Ruiz, A., Foglio, M. A., De Carvalho, J. E., & Formagio, A. (2018). Anti-inflammatory, Antioxidant and Antiproliferative Activities from Trichilia silvatica (C.DC). Current pharmaceutical biotechnology, 19(12), 973–981. https://doi.org/10.2174/1389201020666181123121817.

Da Silva, M. F., Ottor, R. G., & David, D. (1984). Evolution of limonoids in Meliaceae. Biochemical Systematics and Ecology, 12(3), 299-310. https://doi.org/10.1016/0305-1978(84)90053-X.

David, B., Wolfender, J., & Dias, D. (2014). The pharmaceutical industry and natural products: historical status and new trends. Phytochemistry Reviews, 14, 299-315. https://doi.org/10.1007/s11101-014-9367-z.

do Nascimento Bonato Panizzon, C. P., de Miranda Neto, M. H., Ramalho, F. V., Longhini, R., de Mello, J., & Zanoni, J. N. (2019). Ethyl Acetate Fraction from Trichilia catigua Confers Partial Neuroprotection in Components of the Enteric Innervation of the Jejunum in Diabetic Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(1), 76–86. https://doi.org/10.33594/000000122.

do Nascimento Bonato Panizzon, C. P., de Miranda Neto, M. H., Ramalho, F. V., Longhini, R., de Mello, J., & Zanoni, J. N. (2019). Ethyl Acetate Fraction from Trichilia catigua Confers Partial Neuroprotection in Components of the Enteric Innervation of the Jejunum in Diabetic Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(1), 76–86. https://doi.org/10.33594/000000122.

Eldeen, I. M., Elgorashi, E. E., & van Staden, J. (2005). Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. Journal of ethnopharmacology, 102(3), 457–464. https://doi.org/10.1016/j.jep.2005.08.049.

Eldin, S., & Dunford, A. Phytotherapy in primary health care. (2011). São Paulo: Manole; P.163. https://doi.org/https://doi.org/10.1590/S0102-311X2007000600021.

Espada, S. F., Faccin-Galhardi, L. C., Rincao, V. P., Bernardi, A. L., Lopes, N., Longhini, R., de Mello, J. C., Linhares, R. E., & Nozawa, C. (2015). Antiviral Activity of Trichilia catigua Bark Extracts for Herpesvirus and Poliovirus. Current pharmaceutical biotechnology, 16(8), 724–732. https://doi.org/10.2174/1389201016666150505125235.

Estevão, L. R. M., Mendonça, F. S., Baratella-Evênci, L., Simões, R. S., Barros, M. E. G., Arantes, R. M. E., Rachid, M. A., & Evêncio-Neto, J. (2013). Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats. Acta Cirúrgica Brasileira, 28(3), 202-209. https://doi.org/10.1590/s0102-86502013000300008.

Geyid, A., Abebe, D., Debella, A., Makonnen, Z., Aberra, F., Teka, F., Kebede, T., Urga, K., Yersaw, K., Biza, T., Mariam, B. H., & Guta, M. (2005). Screening of some medicinal plants of Ethiopia for their anti-microbial properties and chemical profiles. Journal of ethnopharmacology, 97(3), 421–427. https://doi.org/10.1016/j.jep.2004.08.021.

Germanò, M. P., D'Angelo, V., Sanogo, R., Catania, S., Alma, R., De Pasquale, R., & Bisignano, G. (2005). Hepatoprotective and antibacterial effects of extracts from Trichilia emetica Vahl. (Meliaceae). Journal of ethnopharmacology, 96(1-2), 227–232. https://doi.org/10.1016/j.jep.2004.09.011.

Godinho, J., de Oliveira, R., de Sa-Nakanishi, A. B., Bacarin, C. C., Huzita, C. H., Longhini, R., Mello, J., Nakamura, C. V., Previdelli, I. S., Dal Molin Ribeiro, M. H., & Milani, H. (2018). Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats. Behavioural brain research, 337, 173–182. https://doi.org/10.1016/j.bbr.2017.08.050.

Godinho, J., de Sa-Nakanishi, A. B., Moreira, L. S., de Oliveira, R., Huzita, C. H., Mello, J., da Silva, A., Nakamura, C. V., Previdelli, I. S., Ribeiro, M., & Milani, H. (2018). Ethyl-acetate fraction of Trichilia catigua protects against oxidative stress and neuroinflammation after cerebral ischemia/reperfusion. Journal of ethnopharmacology, 221, 109–118. https://doi.org/10.1016/j.jep.2018.04.018.

Gomes, R. M., de Paulo, L. F., Bonato Panizzon, C., Neves, C. Q., Cordeiro, B. C., Zanoni, J. N., Francisco, F. A., Piovan, S., de Freitas Mathias, P. C., Longhini, R., de Mello, J., de Oliveira, J. C., Pedrino, G. R., da Silva Reis, A. A., Cecchini, A. L., & Marçal Natali, M. R. (2017). Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(3), 1087–1097. https://doi.org/10.1159/000478761.

Hayouni, E. A., Miled, K., Boubaker, S., Bellasfar, Z., Abedrabba, M., Iwaski, H., Oku, H., Matsui, T., Limam, F., & Hamdi, M. (2011). Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine: international journal of phytotherapy and phytopharmacology, 18(11), 976–984. https://doi.org/10.1016/j.phymed.2011.02.011.

Hernandez, E., González, B., Díaz, A., González, M., Morris, H. J., Delgado, L., & Martínez, C. E .M. (2013). Ethnopharmacological evaluation of Trichilia hirta L. as anticancer source in traditional medicine of Santiago de Cuba. Bol. latinoam. Caribe de plantas medicinales y aromáticas, 12, 176-185. https://corpus.co.id/en/lil-722790.

Kamdem, J. P., Stefanello, S. T., Boligon, A. A., Wagner, C., Kade, I. J., Pereira, R. P., Preste, A., Roos, D. H., Waczuk, E. P., Appel, A. S., Athayde, M. L., Souza, D. O., & Rocha, J. B. (2012). In vitro antioxidant activity of stem bark of Trichilia catigua Adr. Juss. Acta pharmaceutica (Zagreb, Croatia), 62(3), 371–382. https://doi.org/10.2478/v10007-012-0026-x.

Konaté, K., Yomalan, K., Sytar, O., Zerbo, P., Brestic, M., Patrick, V. D., Gagniuc, P., & Barro, N. (2014). Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves of Trichilia emetica and Opilia amentacea in an Animal Model of Type 2 Diabetes Mellitus. Evidence-based complementary and alternative medicine: eCAM, 2014, 867075. https://doi.org/10.1155/2014/867075.

Krief, S., Huffman, M. A., Sévenet, T., Hladik, C. M., Grellier, P., Loiseau, P. M., & Wrangham, R. W. (2006). Bioactive properties of plant species ingested by chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, Uganda. American journal of primatology, 68(1), 51–71. https://doi.org/10.1002/ajp.20206.

Kuglerova, M., Halamova, K., Kokoska, L., Van Damme, P., & Grade, J. (2007). Antimicrobial activity of Ugandan Medicinal Plants. Planta Medica, 73, 113. https://doi.org/10.1055/s-2007-986895.

Martins, N. O., de Brito, I. M., Araújo, S., Negri, G., Carlini, E. A., & Mendes, F. R. (2018). Antioxidant, anticholinesterase and antifatigue effects of Trichilia catigua (catuaba). BMC complementary and alternative medicine, 18(1), 172. https://doi.org/10.1186/s12906-018-2222-9.

Naidoo, D., van Vuuren, S. F., van Zyl, R. L., & de Wet, H. (2013). Plants traditionally used individually and in combination to treat sexually transmitted infections in northern Maputaland, South Africa: antimicrobial activity and cytotoxicity. Journal of ethnopharmacology, 149(3), 656–667. https://doi.org/10.1016/j.jep.2013.07.018.

Opawale, B., Oyetayo, A., & Agbaje, R. (2015). Phytochemical Screening, Antifungal and Cytotoxic Activities of Trichilia heudelotii Planc (Harm). International Journal of Sciences: Basic and Applied Research, 24(6), 267-276. https://corpus.co.id/en/56442254.

Pennington, T. D., Styles, B. S., & Taylor, D. A. H. (1981). Meliaceae. Flora Neotropica, 28, 1-470. https://doi.org/10.11646/phytotaxa.259.1.5.

Pennington, T. D., & Styles, B. S. (1975). A generic monograph of Meliaceae. Blumea, 22, 419-540. https://doi.org/10.2307/4110009

Pennington, T. D. (2016). Systematic treatment of American Trichilia (Meliaceae). Phytotaxa, 259. https://doi.org/10.11646/phytotaxa.259.1.5.

Ramírez, M. C., Toscano, R. A., Arnason, J., Omar, S., Cerda-Garcia-Rojas, C. M., & Mata R. (2000). Structure, conformation and absolute configuration of new antifeedant dolabellanes from Trichilia trifolia. Tetrahedron, 56(29), 5085-5091. https://doi.org/10.1016/S0040-4020(00)00423-3.

Ritter, M. R., Tempesta de, O. M., Makimori, R. Y., Sereia, A. L., Simionato, A. S., Chierrito, D., Galdino, A. F., Gonçalves de, O. A., Brentan da, S. D., Novello, C. R., Cristina de, M. D., Benedito Prado, D. F., & João Carlos Palazzo de, M. (2019). Dimeric glycosylated flavan-3-ol and antimicrobial in vitro evaluation of Trichilia catigua extracts. Natural product research, 1–8. Advance online publication. https://doi.org/10.1080/14786419.2019.1698569.

Silva, M.F., Gottlieb, O., & Dreyer, D.L. (1984). Evolution of limonoids in the Meliaceae. Biochemical Systematics and Ecology, 12, 299-310. https://doi.org/10.1016/0305-1978(84)90053-X.

Stefano, M. V., Calazans, L. S., & Sakuragui, C. M. (2014). Meliaceae In: List of Species of Flora of Brazil. Botanical Garden of Rio de Janeiro. http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB162.

Schenkel, E. P. (1995). Watch your medications. Medicinal plants, teas and herbal medicines. Saga, Deluzzata.

Sosa, E. H., Duharte, A. B., Portuondo, D., Tamayo, O. V., Mora, González, N., Morris Quevedo, H. J., & Manrique, C. E. (2010). Immunorestorative in immunosuppressed Balb/c mice and cytotoxic activity of water extract from Trichilia hirta root. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 9(6), 457-464. https://corpus.co.id/en/lil-644984.

Sosa, E. H., Castejón, Y. M., Duharte, A. B., Portuondo, D., Tamayo, V., Quevedo, H. J., & Manrique, C. E. (2011). Leukocyte-stimulating effect and phytochemical screening of Trichilia hirta extracts. Journal of medicinal food, 14(9), 1057–1059. https://doi.org/10.1089/jmf.2010.0166.

Sosa, E. H., Mora Gonzalez, N., Morris, Q., & Humberto, J. (2013). Actividad citotóxica de extractos acuosos de hojas de Trichilia hirta sobre células tumorales humanas. Cuban Journal of Biomedical Research, 32(1), 93-101. https://corpus.co.id/en/lil-673097.

Subbarao, P. G., & Ashok, P. (2011). Antihyperlipidemic effect of Trichilia connaroides in hypercholesterolemic rats and its possible mechanism. Journal of pharmacy & bioallied sciences, 3(2), 230–235. https://doi.org/10.4103/0975-7406.80777.

Taciany Bonassoli, V., Micheli Chassot, J., Longhini, R., Milani, H., Mello, J. C., & de Oliveira, R. M. (2012). Subchronic administration of Trichilia catigua ethyl-acetate fraction promotes antidepressant-like effects and increases hippocampal cell proliferation in mice. Journal of ethnopharmacology, 143(1), 179–184. https://doi.org/10.1016/j.jep.2012.06.021.

Terra, W., Vieira, I. J., Braz-Filho, R., Freitas, W. R., Kanashiro, M. M., & Torres, M. C. (2013). Lepidotrichilins A and B, new protolimonoids with cytotoxic activity from Trichilia lepidota (Meliaceae). Molecules (Basel, Switzerland), 18(10), 12180–12191. https://doi.org/10.3390/molecules181012180.

Truiti, M. T., Soares, L., Longhini, R., Milani, H., Nakamura, C. V., Mello, J. C., & de Oliveira, R. M. (2015). Trichilia catigua ethyl-acetate fraction protects against cognitive impairments and hippocampal cell death induced by bilateral common carotid occlusion in mice. Journal of ethnopharmacology, 172, 232–237. https://doi.org/10.1016/j.jep.2015.05.060.

Viana, A. F., Maciel, I. S., Motta, E. M., Leal, P. C., Pianowski, L., Campos, M. M., & Calixto, J. B. (2011). Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects. Evidence-based complementary and alternative medicine: eCAM, 2011, 120820. https://doi.org/10.1093/ecam/nep144.

Vicentini, F. A., Barbosa, M., Fortunato, M. C., Amado, C., Comar, J. F., Longhini, R., de Mello, J., & Natali, M. (2018). Treatment with Trichilia catigua ethyl-acetate fraction improves healing and reduces oxidative stress in TNBS-induced colitis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 194–202. https://doi.org/10.1016/j.biopha.2018.07.160.

Descargas

Publicado

27/04/2021

Cómo citar

SILVA, L. L. da .; ALMEIDA , R. de .; SILVA, F. T. e .; VERÍCIMO, M. A. . Revisión de las actividades terapéuticas del género Trichilia. Research, Society and Development, [S. l.], v. 10, n. 5, p. e29610514916, 2021. DOI: 10.33448/rsd-v10i5.14916. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14916. Acesso em: 26 nov. 2024.

Número

Sección

Revisiones