Efecto del extracto de tribulus terrestris sobre la histomorfología cardíaca y la fisiología testicular de ratas
DOI:
https://doi.org/10.33448/rsd-v10i10.18634Palabras clave:
Testosterona; Corazón; Aumento de peso; Testículos.Resumen
Tribulus terrestris (TT) es una planta originaria de la India, conocida como Abrolo o “Puncture Vine”. Existen muchas incertidumbres relacionadas con los efectos del TT en la potencia física del atleta, los niveles de testosterona y como afrodisíaco. Hay pocos informes sobre el efecto de la TT en el sistema cardiovascular; sin embargo, mencionan que puede haber una correlación negativa entre la TT y la actividad de la enzima convertidora de angiotensina. En este estudio evaluamos el efecto de TT sin aumento de peso sobre la concentración sérica de testosterona y la morfometría cardíaca en ratas. Tres ratas se dividieron aleatoriamente en 2 grupos experimentales (n = 15): Grupo CT, tratado con solución salina al 0,9%; Grupo TT, tratado con extracto de Tribulus terrestris. Después de 60 días de tratamiento, los animales que recibieron TT ganaron menos peso corporal y no disiparon los niveles séricos de testosterona ni la morfometría cardíaca en comparación con las ratas del grupo CT. Nuestros resultados obtuvieron que el TT evitó el aumento de peso sin alterar el balance energético de la dieta, sin alterar la secreción de testosterona y sin alterar la morfometría cardíaca. Por lo tanto, el TT puede tener un futuro prometedor en la preservación del peso corporal, lo que hace que sea más fácil prevenir el aumento de peso que perder y mantener esa pérdida.
Citas
Antonio, J., Uelmen, J., Rodriguez, R., & Earnest, C. (2000). The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. International journal of sport nutrition and exercise metabolism, 10(2), 208–215. https://doi.org/10.1123/ijsnem.10.2.208.
Arcasoy, H. B., Erenmemisoglu, A., Tekol, Y., Kurucu, S., & Kartal, M. (1998). Effect of Tribulus terrestris L. saponin mixture on some smooth muscle preparations: a preliminary study. Bollettino chimico farmaceutico, 137(11), 473–475.
Armstrong, L. E., Soto, J. A., Hacker, F. T., Jr, Casa, D. J., Kavouras, S. A., & Maresh, C. M. (1998). Urinary indices during dehydration, exercise, and rehydration. International journal of sport nutrition, 8(4), 345–355. https://doi.org/10.1123/ijsn.8.4.345.
Asadmobini, A., Bakhtiari, M., Khaleghi, S., Esmaeili, F., & Mostafaei, A. (2017). The effect of Tribulus terrestris extract on motility and viability of human sperms after cryopreservation. Cryobiology, 75, 154–159. https://doi.org/10.1016/j.cryobiol.2017.02.005.
Brown, G. A., Vukovich, M. D., Reifenrath, T. A., Uhl, N. L., Parsons, K. A., Sharp, R. L., & King, D. S. (2000). Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. International journal of sport nutrition and exercise metabolism, 10(3), 340–359. https://doi.org/10.1123/ijsnem.10.3.340.
Chhatre, S., Nesari, T., Somani, G., Kanchan, D., & Sathaye, S. (2014). Phytopharmacological overview of Tribulus terrestris. Pharmacognosy reviews, 8(15), 45–51. https://doi.org/10.4103/0973-7847.125530.
Do, J., Choi, S., Choi, J., & Hyun, J. S. (2013). Effects and Mechanism of Action of a Tribulus terrestris Extract on Penile Erection. Korean journal of urology, 54(3), 183–188. https://doi.org/10.4111/kju.2013.54.3.183.
GamalEl Din, S. F., Abdel Salam, M. A., Mohamed, M. S., Ahmed, A. R., Motawaa, A. T., Saadeldin, O. A., & Elnabarway, R. R. (2019). Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study. Urologia, 86(2), 74–78. https://doi.org/10.1177/0391560318802160.
Gauthaman, K., & Ganesan, A. P. (2008). The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine: international journal of phytotherapy and phytopharmacology, 15(1-2), 44–54. https://doi.org/10.1016/j.phymed.2007.11.011.
Gauthaman, K., Adaikan, P. G., & Prasad, R. N. (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life sciences, 71(12), 1385–1396. https://doi.org/10.1016/s0024-3205(02)01858-1.
Guo, Y., Shi, D. Z., Yin, H. J., & Chen, K. J. (2007). Effects of Tribuli saponins on ventricular remodeling after myocardial infarction in hyperlipidemic rats. The American journal of Chinese medicine, 35(2), 309–316. https://doi.org/10.1142/S0192415X07004837.
Hussain A., Abbas A. Mohammed, Heba. H. Ibrahim, & Amir H. Abbas. (2009). Study the Biological Activities of Tribulus Terrestris Extracts. 3:9-24. http://doi.org/10.5281/zenodo.1085151.
Junqueira, L. C., Bignolas, G., & Brentani, R. R. (1979). Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. The Histochemical journal, 11(4), 447–455. https://doi.org/10.1007/BF01002772.
Khaleghi, S., Bakhtiari, M., Asadmobini, A., & Esmaeili, F. (2017). Tribulus terrestris Extract Improves Human Sperm Parameters In Vitro. Journal of evidence-based complementary & alternative medicine, 22(3), 407–412. https://doi.org/10.1177/2156587216668110.
Kohut, M. L., Thompson J. R., Campbell J., Brown G. A., Vukovich M. D., Jackson D. A., & King D. S. (2003). Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. Journal of the American College of Nutrition. 22:363–371. https://doi.org/10.1080/07315724.2003.10719319.
Lemos Júnior L. P. H., Lemos A. L. A., Lemos L. M. D. (2011). Tribulus terrestris. Diagn Tratamento. 16:170-173.
Ma, Y., Guo, Z., & Wang, X. (2017). Tribulus terrestris extracts alleviate muscle damage and promote anaerobic performance of trained male boxers and its mechanisms: Roles of androgen, IGF-1, and IGF binding protein-3. Journal of sport and health science, 6(4), 474–481. https://doi.org/10.1016/j.jshs.2015.12.003.
Malviya, N., Jain, S., Gupta, V. B., & Vyas, S. (2011). Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Acta poloniae pharmaceutica, 68(1), 3–8.
Malviya, N., Malviya, S., Jain, S., & Vyas, S. (2016). A review of the potential of medicinal plants in the management and treatment of male sexual dysfunction. Andrologia, 48(8), 880–893. https://doi.org/10.1111/and.12677.
Neychev, V., & Mitev, V. (2016). Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction. Journal of ethnopharmacology, 179, 345–355. https://doi.org/10.1016/j.jep.2015.12.055.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.br/bitstream/ handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.
Pokrywka, A., Obmiński, Z., Malczewska-Lenczowska, J., Fijałek, Z., Turek-Lepa, E., & Grucza, R. (2014). Insights into Supplements with Tribulus Terrestris used by Athletes. Journal of human kinetics, 41, 99–105. https://doi.org/10.2478/hukin-2014-0037.
Prathapan, A., Vineetha, V. P., & Raghu, K. G. (2014). Protective effect of Boerhaavia diffusa L. against mitochondrial dysfunction in angiotensin II induced hypertrophy in H9c2 cardiomyoblast cells. PloS one, 9(4), e96220. https://doi.org/10.1371/journal.pone.0096220.
Prescott, H., & Khan, I. (2020). Medicinal plants/herbal supplements as female aphrodisiacs: Does any evidence exist to support their inclusion or potential in the treatment of FSD? Journal of ethnopharmacology, 251, 112464. https://doi.org/10.1016/j.jep.2019.112464.
Qureshi, A., Naughton, D. P., & Petroczi, A. (2014). A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. Journal of dietary supplements, 11(1), 64–79. https://doi.org/10.3109/19390211.2014.887602.
Reshma, P. L., Binu, P., Anupama, N., Vineetha, R. C., Abhilash, S., Nair, R. H., & Raghu, K. G. (2019). Pretreatment of Tribulus terrestris L. causes anti-ischemic cardioprotection through MAPK mediated anti-apoptotic pathway in rat. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 111, 1342-1352. https://doi.org/10.1016/j.biopha.2019.01.033.
Reshma, P. L., Lekshmi, V. S., Sankar, V., & Raghu, K. G. (2015). Tribulus terrestris (Linn.) Attenuates Cellular Alterations Induced by Ischemia in H9c2 Cells Via Antioxidant Potential. Phytotherapy research: PTR, 29(6), 933–943. https://doi.org/10.1002/ptr.5336.
Reshma, P. L., Sainu, N. S., Mathew, A. K., & Raghu, K. G. (2016). Mitochondrial dysfunction in H9c2 cells during ischemia and amelioration with Tribulus terrestris L. Life sciences, 152, 220–230. https://doi.org/10.1016/j.lfs.2016.03.055.
Roaiah, M. F., Elkhayat, Y. I., Abd El Salam, M. A., & Din, S. (2017). Prospective Analysis on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Semen Parameters in Males with Unexplained Infertility. Journal of dietary supplements, 14(1), 25–31. https://doi.org/10.1080/19390211.2016.1188193.
Rogerson, S., Riches, C. J., Jennings, C., Weatherby, R. P., Meir, R. A., & Marshall-Gradisnik, S. M. (2007). The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. Journal of strength and conditioning research, 21(2), 348–353. https://doi.org/10.1519/R-18395.1.
Salgado, R. M., Marques-Silva, M. H., Gonçalves, E., Mathias, A. C., Aguiar, J. G., & Wolff, P. (2017). Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men. Andrologia, 49(5), 10.1111/and.12655. https://doi.org/10.1111/and.12655.
Samaha, A. A., Nasser-Eddine, W., Shatila, E., Haddad, J. J., Wazne, J., & Eid, A. H. (2008). Multi-organ damage induced by anabolic steroid supplements: a case report and literature review. Journal of medical case reports, 2, 340. https://doi.org/10.1186/1752-1947-2-340.
Samani, N. B., Jokar, A., Soveid, M., Heydari, M., & Mosavat, S. H. (2016). Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Journal of evidence-based complementary & alternative medicine, 21(4), NP91–NP97. https://doi.org/10.1177/2156587216650775.
Sanagoo, S., Sadeghzadeh Oskouei, B., Gassab Abdollahi, N., Salehi-Pourmehr, H., Hazhir, N., & Farshbaf-Khalili, A. (2019). Effect of Tribulus terrestris L. on sperm parameters in men with idiopathic infertility: A systematic review. Complementary therapies in medicine, 42, 95–103. https://doi.org/10.1016/j.ctim.2018.09.015.
Sankar, V., Pangayarselvi, B., Prathapan, A., & Raghu, K. G. (2013). Desmodium gangeticum (Linn.) DC. exhibits antihypertrophic effect in isoproterenol-induced cardiomyoblasts via amelioration of oxidative stress and mitochondrial alterations. Journal of cardiovascular pharmacology, 61(1), 23–34. https://doi.org/10.1097/FJC.0b013e3182756ad3.
Santos, H. O., Howell, S., & Teixeira, F. J. (2019). Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters. Journal of Ethnopharmacology, 235, 392-405. https://doi.org/10.1016/j.jep.2019.02.033.
Shahid, M., Riaz, M., Talpur, M. M., & Pirzada, T. (2016). Phytopharmacology of Tribulus terrestris. Journal of biological regulators and homeostatic agents, 30(3), 785–788.
Shirani, J., Pick, R., Roberts, W. C., & Maron, B. J. (2000). Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death. Journal of the American College of Cardiology, 35(1), 36–44. https://doi.org/10.1016/s0735-1097(99)00492-1.
Souza, A. da S., Ribeiro Junior, O. C., Ribeiro, J. S. S., Mendonça, L. B., Melo, J. M. R. de, & Araújo, T. S. de. (2020). The use of phytotherapy in the management of women in climacteric/menopause. Research, Society and Development, 9(9), e415997416. https://doi.org/10.33448/rsd-v9i9.7416.
Ștefănescu, R., Tero-Vescan, A., Negroiu, A., Aurică, E., & Vari, C. E. (2020). A Comprehensive Review of the Phytochemical, Pharmacological, and Toxicological Properties of Tribulus terrestris L. Biomolecules, 10(5), 752. https://doi.org/10.3390/biom10050752.
Wang, B., Ma, L., & Liu, T. (1990). Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 10(2), 85–68.
Wu, Y., Yang, H., & Wang, X. (2017). The function of androgen/androgen receptor and insulin growth factor 1/insulin growth factor 1 receptor on the effects of Tribulus terrestris extracts in rats undergoing high intensity exercise. Molecular medicine reports, 16(3), 2931–2938. https://doi.org/10.3892/mmr.2017.6891.
Yin, L., Wang, Q., Wang, X., & Song, L. N. (2016). Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms. Canadian journal of physiology and pharmacology, 94(11), 1193–1201. https://doi.org/10.1139/cjpp-2016-0086.
Yuan, Z., Du, W., He, X., Zhang, D., & He, W. (2020). Tribulus terrestris Ameliorates Oxidative Stress-Induced ARPE-19 Cell Injury through the PI3K/Akt-Nrf2 Signaling Pathway. Oxidative medicine and cellular longevity, 2020, 7962393. https://doi.org/10.1155/2020/7962393.
Zhang, H., Tong, W. T., Zhang, C. R., Li, J. L., Meng, H., Yang, H. G., & Chen, M. (2019). Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum. Diabetes, metabolic syndrome and obesity: targets and therapy, 12, 1705–1716. https://doi.org/10.2147/DMSO.S205722.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2021 Leonardo Luca Luciano; Evelise Aline Soares; Samuel José Fernandes de Lima; Rayzza Tomaz Griebeler ; Raissa Forgerini ; Michelli Pereira ; Ester Caixeta; Vitória Lima Boaventura; Diego Furtado da Cunha; Gérsika Bitencourt Santos Barros; José Antonio Dias Garcia
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
