Estudio comparativo de la composición química, actividades larvicidas, antimicrobianas y citotóxicas de aceites volátiles de hojas de E. punicifolia de Minas Gerais y Goiás
DOI:
https://doi.org/10.33448/rsd-v10i11.19354Palabras clave:
Aceite essencial; Quimodiversidad; Planta medicinal; Actividades biológicas; Myrtaceae.Resumen
Eugenia punicifolia (Kunth) D.C., Myrtaceae, conocida como “pedra-ume-caá”, se usa popularmente en el tratamiento de inflamación, infecciones, fiebre, gripe, diabetes y diarrea. El objetivo de este trabajo fue realizar un estudio comparativo de la composición química del aceite volátil de hojas de E. punicifolia recolectadas en Goiás y Minas Gerais, así como evaluar la actividad larvicida frente a larvas de Aedes aegypti L3, la actividad antimicrobiana frente a bacterias, hongos patógenos y ambientales, y actividad citotóxica para las células Balb 3T3 (fibroblastos murinos). Los aceites volátiles se obtuvieron por hidrodestilación en un aparato Clevenger y se analizaron mediante cromatografía de gases acoplada a espectrometría de masas (CG MS). Se identificaron un total de 60 compuestos, siendo los principales componentes encontrados en las hojas de Goiás Germacrene D, biciclogermacreno y β-longipenene y en las hojas recolectadas en Minas Gerais fueron (Z) -cariofileno, γ-cadineno, spathulenol, óxido de cariofileno. y α-cadinol. El efecto larvicida fue moderado contra Ae. aegypti, con CL50 de 85,53 µg / mL para muestras de Goiás y CL50 de 91,52 µg/mL para muestras de Minas Gerais. Ambos aceites mostraron un potencial bactericida moderado contra K. rhiziphyla (ATCC 9341), M. luteus (ATCC 10240) y S. aureus (ATCC 29737). En cuanto a la citotoxicidad, los aceites de Goiás (IC50 706,7 µg / mL) y Minas Gerais (IC50 160,7 µg / mL) presentaron una concentración citotóxica menor que la acción tóxica para larvas y bacterias, evidenciando un perfil de seguridad y un interesante potencial terapéutico, principalmente con respecto al aceite volátil de Goiás. Por lo tanto, los aceites volátiles de las hojas de E. punicifolia recolectadas en Goiás y Minas Gerais presentaron un potencial larvicida moderado para Ae. aegypti, actividad bactericida y menor citotoxicidad frente a fibroblastos murinos. Este es el primer estudio de la actividad larvicida, antimicrobiana y citotóxica de los aceites volátiles de las hojas de E. punicifolia.
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Derechos de autor 2021 Liliane de Sousa Silva; Christiane França Martins; Fernando Yano Abrão; Camila Aline Romano; Soraia Ferreira Bezerra; Leonardo Luiz Borges; Adelair Helena dos Santos ; Luiz Carlos da Cunha; Jerônimo R. Oliveira Neto ; Tatiana de Sousa Fiuza ; José Realino de Paula
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Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
